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The effects of process parameters on the mechanical properties and degradation behavior of Fe/ha biodegradable materials

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JOURNAL OF BIOMATERIALS APPLICATIONS 2025年第8期39卷 866-879页

作者： Feng, Yuzhen Huang, Nan Guo, Jing Chen, Shuwen Teng, Yingxue Chen, Shanshan Univ Sci & Technol Liaoning Sch Mat & Met 185 Qianshan Middle RdHigh tech Zone Anshan 114051 Liaoning Peoples R China Chinese Acad Sci Inst Met Res Shi Changxu Innovat Ctr Adv Mat Shenyang 110016 Peoples R China

ha/Fe composites were prepared by powder metallurgy. The effects of ball milling time, pressing pressure, and sintering temperature on the porosity and hardness of the composites were investigated, and their mechanical properties and biocompatibility were evaluated. The results show that as the ball milling time increases (30 similar to 60min), the average particle size initially decreases and then increases (82.91 similar to 53.49 similar to 77.98 mu m). Additionally, an appropriate increase in pressing pressure and sintering temperature can decrease the composite's porosity and increase its hardness. When the pressing pressure is 27 KN and the sintering temperature is 1000 degrees C, the composite material has excellent mechanical properties (hardness 268.5 Hv, compressive strength 106.736 MPa) and good in vitro biocompatibility. The hemolysis rate of the sample was 1.719518 %. When the concentration of the extract was 50 %, the cell proliferation rate could reach 136.26 %. Furthermore, the degradation properties of the composites were studied. At 12 months the corrosion rate of ha/Fe composites reached 0.3173 mm/a. It was also observed varying degradation mechanisms was different in different soaking cycles, and the dominant degradation mechanism was gradually changed from ha in the early stage to Fe in the later stage, which played a positive guiding role in the development of iron matrix composites with different degradation rates.

关键词： Bio-composite ha fe degradation biocompatibility

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The role of BSA protein on the skin regeneration ability of electrospun PCL/ha scaffolds, kinetics of release and essential in vitro tests

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JOURNAL OF THE TEXTILE INSTITUTE 2025年第2期116卷 263-275页

作者： Afza, Saba Esfahani, hamid Chinijani, Turan hassanzadeh Sharifi, Esmaeel Bu Ali Sina Univ Dept Mat Engn Hamadan Iran Hamadan Univ Med Sci Dept Tissue Engn & Biomat Hamadan Iran

This study focused on the skin regeneration ability of hybrid polycaprolactone (PCL) scaffolds incorporated by hydroxyapatite (ha) nanoparticles (NPs) and bovine serum albumin (BSA). The scaffolds were synthesized by the electrospinning method, and their microstructure, molecular groups, wettability, swelling, porosity, and mechanical properties were characterized. The results showed that the ha NPs and BSA protein could be incorporated within the PCL fibers without a significant effect on the main molecular groups of the PCL structure. Incorporation of both the ha NPs and BSA protein could reduce the superhydrophobicity of the PCL scaffold to the required amount for skin regeneration. It was also found that the incorporation of mentioned elements increased the water uptake by PCL fibrous scaffolds, and decreased the mechanical properties. The kinetics of BSA release from the hybrid scaffolds was also investigated. The Higuchi model was the best-fitting model to explain the protein release from the electrospun products. The cytocompatibility of scaffolds was evaluated by the human umbilical vein endothelial cells (HUVEC), and the higher ability of the PCL/BSA scaffold for skin regeneration was confirmed.

关键词： Electrospinning ha HUVEC tensile strength kinetics PCL protein

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Bovine serum albumin (BSA)-Loaded polyvinyl alcohol (PVA) / chitosan (CH) / hydroxyapatite (ha) electrospun nanofibers for bone tissue regeneration

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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 2025年 106卷

作者： Bozdag, Mehmet Urek, Ferhat Cesur, Sumeyye Sahin, Ali Gunduz, Oguzhan Marmara Univ Ctr Nanotechnol & Biomat Applicat & Res NBUAM Istanbul Turkiye Marmara Univ Fac Technol Dept Met & Mat Engn Istanbul Turkiye Abdullah Gul Univ Fac Life & Nat Sci Dept Bioengn Kayseri Turkiye Marmara Univ Sch Med Dept Biochem Genet & Metab Dis Res & Invest Ctr Istanbul Turkiye

The natural bone structure consists of three different nanocomposite layers;a porous polymer ceramic part, a lamellar, and a fiber-matrix composition gives the bone its unique physical and biological properties. During bone tissue regeneration bioactivity, and osteoinductivity are especially important with other parameters such as porosity, degradation rate, and cell adhesion. In this study, hydroxyapatite (ha) and bovine serum albumin (BSA) protein-loaded, polyvinyl alcohol (PVA) and chitosan (CH) nanofibers were fabricated via the electrospinning method. The mean diameters of PVA/CH/ha/BSA-5, PVA/CH/ha/BSA-10, and PVA/CH/ha/BSA-15 nanofibers were measured as 325.39 +/- 77.512 nm, 332.45 +/- 82.251 nm, 447.03 +/- 101.382 nm respectively, required porosity and properties for bone tissue engineering were considered achieved. BSA release profiles of BSA-5, BSA-10, and BSA-15 nanofibers were similar in terms of burst release which continued until the 12th hour, 58 %, 78 %, and 73 % of the BSA were released, respectively. After 72 h 100 % of BSA were released from all nanofibers. Cell viability tests showed that PVA/CH/ha/BSA nanofibers exceeded the control group in terms of cell viability by 119.9 %. In future bone injury treatment, PVA/CH/ha/BSA nanofibers can assist the healing process of cracks and fractures, and decrease the recovery time of bone as an alternative bone healing nanofiber.

关键词： Nanofibers BSA ha Osteoblast regeneration Bone tissue regeneration

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Facile synthesis of conductive PVA/ha/PEDOT composite hydrogel for human motion monitoring

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MATERIALS TODAY COMMUNICATIONS 2025年 43卷

作者： Ding, Xinbo Xu, Lisheng Wang, Yanmin Liu, Tao Yang, Lei Gao, Fulei Hu, Die Zhejiang Sci Tech Univ Coll Text Sci & Engn Hangzhou 310018 Peoples R China

Conductive hydrogel has attracted interests in developing flexible and wearable sensors due to the high electrical conductivity and exceptional mechanical property. Classic conductive polymers such as poly(3,4ethylenedioxythiophene) (PEDOT) are considered as one of the most promising conductive polymers with excellent chemical stability and easy processability. However, realizing excellent mechanical stability and electrical conductivity of processing sensors is still challenging. In this study, a facile and one-step strategy for synthesizing conductive PEDOT-based composite hydrogel was developed by in situ polymerization combining with freeze-thaw cycles, using EDOT as monomer and ammonium persulfate (APS) as initiator. Following this, a porous PVA/ha/PEDOT (PHP) composite hydrogel was firstly prepared by incorporating conductive hyaluronic acid (ha) and polyvinyl alcohol (PVA) into PEDOT polymerization process. The incorporation of ha contributed to the improvement of the mechanical performance and electrical conductivity of PHP hydrogels. The PHP1 hydrogel with 1 wt% EDOT content possessed the good electrical conductivity of about 1.97 S/m. This study introduced an innovative method for creating such PEDOT-based strain sensors, broadening potential application in wearable and flexible sensors.

关键词： Conductive hydrogel PEDOT ha Electrical conductivity Flexible strain sensors

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诱导型表达H5N1亚型禽流感病毒ha蛋白的乳酸乳球菌的构建及其对鸭的免疫原性分析

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畜牧兽医学报 2025年第2期56卷 774-787页

作者：吴佳辉沈世彦邓锦波吴海阳任芷欣吴杨博黄娟黄浩滨潘伟雄赵锃珏何容肖孙崇军张玲华华南农业大学生命科学学院广东省农业生物发育与环境适应重点实验室广州510642

禽流感是由禽流感病毒引起的高度传染性疾病,受到感染的雏禽死亡率高,给家禽健康和经济带来严重影响。尽管传统疫苗可以有效预防禽流感,但由于鸭类养殖方式多为散户散养,环境多变,在接种传统疫苗时存在操作繁琐和免疫应激强等问题。为... 详细信息

禽流感是由禽流感病毒引起的高度传染性疾病,受到感染的雏禽死亡率高,给家禽健康和经济带来严重影响。尽管传统疫苗可以有效预防禽流感,但由于鸭类养殖方式多为散户散养,环境多变,在接种传统疫苗时存在操作繁琐和免疫应激强等问题。为了解决此难题,本研究旨在开发一种便捷且安全的雏鸭血凝素(hemagglutinin,ha)口服生物制剂。我们通过构建系列锚定序列(pgsA、BmpA、cA和M6)-GFP报告表达系统,可视化地评估了不同类型锚定序列对乳酸菌乳球表面展示系统的效果,成功筛选出BmpA和cA作为乳酸菌乳球中的高效锚定序列。比较优化密码子前后的ha在乳酸乳球菌的表达效果后,选取优化密码子的ha基因序列与BmpA、cA连接,构建乳酸菌表达质粒。然后把构建好的表达质粒转入基因组整合ha 1基因的乳酸乳球菌中,从而得到诱导型分泌联合表面展示ha蛋白的重组乳酸乳球菌(NZB-ha1-pNZ8148-BmpA-ha1和NZB-ha1-pNZ8148-ha1-cA)。ELISA检测结果表明,与口服单一表达型的重组乳酸乳球菌相比,口服诱导型分泌-表面展示乳酸乳球菌能诱生雏鸭血清中更佳的ha特异性IgG水平。本研究成功构建了锚定序列-GFP乳酸菌筛选系统,利用其筛选出了适合乳酸乳球菌的高效锚定序列。并将ha蛋白通过分泌联合表面展示的方式在乳酸乳球菌进行复合表达,成功获得了对雏鸭具有良好ha免疫原性的口服生物制剂,为后续开发操作简便、安全的鸭禽流感口服疫苗提供可行的实践路径。

关键词：锚定序列乳酸乳球菌禽流感雏鸭 ha

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Bone-like apatite formation on ha/316L stainless steel composite surface in simulated body fluid

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中国有色金属学会会刊：英文版 2009年第2期19卷 347-352页

作者：樊新陈剑邹俭鹏万千周忠诚阮建明 State Key Laboratory of Powder Metallurgy Central South University

ha/316L stainless steel(316L SS) biocomposites were prepared by hot-pressing technique. The formation of bone-like apatite on the biocomposite surfaces in simulated body fluid(SBF) was analyzed by digital pH meter,plasma emission spectrometer,scanning electron microscope(SEM) and energy dispersive X-ray energy spectrometer(EDX). The results indicate that the pH value in SBF varies slightly during the immersion. It is a dynamic process of dissolution-precipitation for the formation of apatite on the surface. With prolonging immersion time,Ca and P ion concentrations increase gradually,and then approach equilibrium. The bone-like apatite layer forms on the composites surface,which possesses benign bioactivity and favorable biocompatibility and achieves osseointegration,and can provide firm fixation between ha60/316L SS composite implants and human body bone.

关键词： 316L不锈钢类骨磷灰石模拟体液复合材料表面 ha 等离子发射光谱仪扫描电子显微镜

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Construction of bio-functional Mg/ha composite layered coating for orthopedic application

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Science China(Technological Sciences) 2021年第11期64卷 2541-2550页

作者： WAN Peng YAN XuDong LI Mei ZhaO MingChun ZhaNG Yu YANG Ke School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering Central South UniversityChangsha 410083China Research Center of Medical Sciences Guangdong Provincial People s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China

Magnesium was considered as a revolutionary biodegradable implant material for orthopedic application. Concerning the weakness of intrinsic strength and corrosion behavior, a novel strategy of Mg/metal hybrid system was proposed for extension of orthopedic application, especially at load-bearing site. In this work, an Mg and ha composite layered coating was constructed on titanium by means of chemical conversion and vapor deposition. The ha transition interlayer was introduced to enhance the bonding between Mg film and Ti substrate. Compared with the bare Mg coating, the Mg/ha coating presented good interface bonding, which avoided the occurrence of Mg film peeling off from the substrate. The Mg/ha coating showed a uniform degradation and kept integrity after immersion of 14 d. The Mg ions release by degradation played a crucial role in osteopromotion and antibacterial effect. Incubation of MC3T3-E1 osteoblasts with the Mg/ha coating showed significant promotion on osteogenic differentiation according to ALP activity and Alizarin Red staining assays. Meanwhile the degradation of Mg exhibited strong suppression of bacteria proliferation. It was believed that this novel Mg/ha composite layered coating could be potentially applied in further development of bio-functional hybrid orthopedic implants.

关键词： magnesium ha composite layered coating titanium orthopedic bio-function

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Synergistic improvement of ha and LaB 6 on the bio-tribological properties of Ti6Al4V alloy fabricated by laser direct energy deposition

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Ceramics International 2025年

作者： Xiang Dingding Yan Liang Leng Xiaoxin Wang Di Wang Yutang Wang Shu Yuquan Xu Zhou Xiaoshu School of Mechanical Engineering and Automation Northeastern University Shenyang 110819 China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Science Lanzhou 730000 China Foshan Graduate School of Innovation Northeastern University Foshan 528311 China State Key Laboratory of Tribology in Advanced Equipment Tsinghua University Beijing 100084 China Department of Orthopedics First Hospital of China Medical University Shenyang 110002 China

This study introduced rare earth boride (LaB 6 ) and bioactive ceramic (ha) to enhance the bio-tribological properties of Ti6Al4V alloy fabricated by laser direct energy deposition (LDED). The methods and instruments such as optical microscope (OM), scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive spectrometry (EDS), Vickers hardness tester, and UMT-3 tribometer were employed to examine the microstructure, phase composition, microhardness, and bio-tribological properties. The results showed that the La 2 O 3 and network-like TiBw formed through in-situ reactions, and the distribution of La 2 O 3 at the grain boundaries facilitated grain refinement through Zener pinning; Yet, the addition of ha weakened the effect of grain refinement. Besides, the microhardness was not significantly changed due to the promoting effect of P element on the formation of β-Ti and large grains. Furthermore, under the phosphate buffered saline (PBS) environment, a tribofilm containing phosphate on the worn surface formed, leading to a remarkable improvement in the bio-tribological properties. This study provides valuable insights for the further application of Ti6Al4V in orthopedic implants.

关键词： Bio-tribology Ti6Al4V ha LaB 6 Tribofilm

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Fabrication and Characterization of Nanopillar-Like ha Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali–Acid-Heat and Hydrothermal Treatments

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Acta Metallurgica Sinica(English Letters) 2019年第9期32卷 1075-1088页

作者： Jun-Lei Li Shuai Wang Fang Cao Xiao Lin Xiao-Wei Wei Zhen-Hua Zhao Xiao-Jie Dou Wei-Ting Yu Ke Yang De-Wei Zhao Department of Orthopaedics Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001China Orthopaedic Institute Medical CollegeSoochow UniversitySuzhou 215006China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

Porous titanium scaffold with suitable porous architecture exhibits enormous potentials for bone defect ***,insufficient osteointegration and osteoinduction still remain to open as one of the major problems to achieve satisfactory therapeutic *** solve this problem,many studies have been carried out to improve the bioactivity of porous titanium scaff old by surface *** this study,porous Ti6Al4V scaff olds were fabricated using additive manufacturing *** architectures were built up based on a diamond pore structure ***–acid-heat(AH)treatment was applied to create a TiO2 layer on the porous Ti6Al4V scaff old(AH-porous Ti6Al4V).Subsequently,a hydrothermal treatment was employed to enable the formation of ha coating with nanopillar-like morphology on the alkali–acid-heat-treated surface(HT/AH-porous Ti6Al4V).The effects of surface modifications on apatite-forming ability,protein adsorption,cell attachment,cell proliferation and osteogenic gene expression were studied using apatite-forming ability test,protein adsorption assay and in vitro cell culture *** was found that the HT/AH-porous Ti6Al4V exhibited the highest apatite formation ability and best affinity to fibronectin and *** vitro studies indicated that the mesenchymal stem cells(MSCs)cultured on the HT/AH-porous Ti6Al4V presented improved adhesion and differentiation compared with the porous Ti6Al4V and AH-porous Ti6Al4V.

关键词： Additive manufacturing Biomaterials Porous titanium scaffold ha coating

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PLASMA SPRAYED Ti AND ha COATINGS: A COMPARATIVE STUDY BETWEEN APS AND VPS

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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 339-344页

作者： X.B.Zheng H.Ji J.Q.Huang C.X.Ding ShanghaiInstituteofCeramics TheChineseAcademyofSciencesShanghai200050China

Titanium (Ti) and hydroxyapatite (ha) coatings have been prepared via air (APS) and vacuum plasma spraying (VPS), and then their composition, structure, bonding strength and bioactivity were examined. The results obtained reveal that in APS process many of Ti were oxidized, but in VPS the oxidization was avoided. VPS T i coating possesses better bonding condition than APS Ti coating. As for ha coat ing, higher crystallinity has been obtained while the coating was deposited by V PS as compared with APS. The simulated body fluid (SBF) tests show that both of APS and VPS ha coatings possess good bioactivity. As compared with APS, VPS is r ecommended as a better method to deposit Ti and ha coatings that can be applied as hard tissue replacement implants.

关键词： vacuum plasma spray Ti ha biocoating

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