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Translational Photoacoustic Imaging for Disease Diagnosis, Monitoring, and Surgical Guidance: introduction to the feature issue

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BIOMEDICAL OPTICS EXPRESS 2021年第7期12卷 4115-4118页

作者： Xia, Jun Bell, Muyinatu A. Lediju Laufer, Jan Yao, Junjie SUNY Buffalo Dept Biomed Engn Buffalo NY 14260 USA Johns Hopkins Univ Dept Elect & Comp Engn 3400 N Charles St Baltimore MD 21218 USA Martin Luther Univ Halle Wittenberg Inst Phys von Danckelmann Pl 3 D-06120 Halle Saale Germany Duke Univ Dept Biomed Engn Durham NC 27708 USA

This feature issue of Biomedical Optics Express covered all aspects of translational photoacoustic research. Application areas include screening and diagnosis of diseases, imaging of disease progression and therapeutic response, and image-guided treatment, such as surgery, drug delivery, and photothermal/photodynamic therapy. The feature issue also covers relevant developments in photoacoustic instrumentation, contrast agents, image processing and reconstruction algorithms. (C) 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

关键词： image processing algorithms image reconstruction Imaging systems Optical computed tomography Photoacoustic imaging Photodynamic therapy

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Depth imaging denoising of photon-counting lidar

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APPLIED OPTICS 2019年第16期58卷 4390-4394页

作者： Huang, Pengwei He, Weiji Gu, Guohua Chen, Qian Nanjing Univ Sci & Technol Nanjing 210094 Jiangsu Peoples R China

Photon-counting lidar systems have difficulty reconstructing target depth images due to ambient noise. In this paper, we propose a novel way of using correlative photons and spatial correlations to reduce the false alarm probability. Experimental results show that the root mean square error of the depth image reconstructed by the proposed algorithm can be 1.68 times and 1.11 times better than that of the fast depth imaging denoising algorithm and log-matched filter estimation. The experimental results show that the proposed algorithm can effectively improve the reconstructed image of photon-counting lidar. (c) 2019 Optical Society of America

关键词： Avalanche photodiodes Geiger modes image processing algorithms image reconstruction Photon correlations Photon counting

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Combined multiphoton fluorescence microscopy and photoacoustic imaging for stratigraphic analysis of paintings

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OPTICS LETTERS 2019年第5期44卷 1154-1157页

作者： Tserevelakis, George J. Tsafas, Vassilis Melessanaki, Kristalia Zacharakis, Giannis Filippidis, George Fdn Res & Technol Hellas Inst Elect Struct & Laser N Plastira 100 Iraklion Crete Greece Univ Crete Dept Phys Iraklion Crete Greece

We demonstrate the effective combination of multiphoton and photoacoustic (PA) imaging for the high-resolution stratigraphic analysis of multilayered art objects with emphasis on paintings. A novel convolution-based algorithm is additionally applied for the precise discrimination of nonlinear signals, providing valuable information in regard to the thickness and composition of successive varnish and paint layers in the mock-up samples. On the other hand, PA contrast complements the extracted data by revealing well-hidden graphite underdrawings below the paint at high sensitivity levels. The final composite images are directly compared with cross-sectional brightfield observations, validating the capabilities of the bimodal diagnosis in terms of measurement accuracy and contrast specificity. The presented hybrid diagnostic approach has the potential to optimize delicate interventions in works of art such as the selective removal of aged materials, thus promoting a significantly improved restoration outcome. (c) 2019 Optical Society of America

关键词： Absorption coefficient Attenuation coefficient image processing algorithms Imaging techniques Medical imaging Optical coherence tomography

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OPTICAL LOGARITHMIC TRANSFORMATION OF SPECKLE imageS WITH BACTERIORHODOPSIN FILMS

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OPTICS LETTERS 1995年第2期20卷 201-203页

作者： DOWNIE, JD []NASA Ames Research Center M/S 269-3 Moffett Field California 94035

The application of logarithmic transformations to speckle images is sometimes desirable in converting the speckle noise distribution into an additive, constant-variance noise distribution. The optical transmission properties of some bacteriorhodopsin films are well suited to implement such a transformation optically in a parallel fashion. I present experimental results of the optical conversion of a speckle image into a transformed image with signal-independent noise statistics, using the real-time photochromic properties of bacteriorhodopsin. The original and transformed noise statistics are confirmed by histogram analysis.

关键词： Digital image processing image metrics image processing image processing algorithms Optically addressed spatial light modulators Speckle noise

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Smart CMOS mid-infrared sensor array

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OPTICS LETTERS 2019年第17期44卷 4111-4114页

作者： Popa, Daniel Ali, Sped Zeeshan Hoppe, Richard Dai, Ying Udrea, Florin Univ Cambridge Dept Engn Cambridge CB30FA England Ams Sensors UK Ltd Cambridge CB4 0DL England

We present a novel single-chip thermopile sensor array for mid-infrared room temperature imaging. The array is fabricated on a single complementary metal-oxide-semiconductor (CMOS) dielectric membrane, composed of single-crystal silicon (Si) p(+) and n(+) elements, and standard CMOS tungsten metal layers for thermopile cold junction heatsinking, significantly reducing the chip size and simplifying its processing. We demonstrate a 16 x 16 pixel device with 34 V/W responsivity and enhanced optical absorption in the 8-14 mu m waveband, with a suitable performance for gesture recognition and people-counting applications. Our simple, low-cost sensor is an attractive on-chip array for a variety of applications in the mid-infrared spectral region. (C) 2019 Optical Society of America

关键词： Fourier transform infrared spectroscopy image processing image processing algorithms image sensors Infrared sensors Optical systems

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Video-rate lensless endoscope with self-calibration using wavefront shaping

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OPTICS LETTERS 2020年第13期45卷 3629-3632页

作者： Scharf, Elias Dremel, Jakob Kuschmierz, Robert Czarske, Juergen Tech Univ Dresden Lab Measurement & Sensor Syst Tech Dresden Germany

Lensless fiber endoscopes are of great importance for keyhole imaging. Coherent fiber bundles (CFB) can be used in endoscopes as remote phased arrays to capture images. One challenge is to image at high speed while correcting aberrations induced by the CFB. We propose the combination of digital optical phase conjugation, using a spatial light modulator, with fast scanning, for which a 2D galvo scanner and an adaptive lens are employed. We achieve the transmission of laser and image scanning through the CFB. Video-rate imaging at 20 Hz in 2D with subcellular resolution is demonstrated in 3D with 1 Hz. The sub-millimeter-diameter scanning endoscope has a great potential in biomedicine, for manipulation, e.g., in optogenetics, as well as in imaging. (C) 2020 Optical Society of America

关键词： Fiber bundles image processing algorithms Laser scanning Phase conjugation Phased arrays Scanners

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Computational nanosensing from defocus in single particle interferometric reflectance microscopy

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OPTICS LETTERS 2020年第23期45卷 6546-6549页

作者： Yurdakul, Celalettin Unlu, M. Selim Boston Univ Dept Elect & Comp Engn Boston MA 02215 USA Boston Univ Dept Biomed Engn Boston MA 02215 USA

Single particle interferometric reflectance (SPIR) microscopy has been studied as a powerful imaging platform for label-free and highly sensitive biological nanoparticle detection and characterization. SPIR's interferometric nature yields a unique 3D defocus intensity profile of the nanoparticles over a large field of view. Here, we utilize this defocus information to recover high signal-to-noise ratio nanoparticle images with a computationally and memory efficient reconstruction framework. Our direct inversion approach recovers this image from a 3D defocus intensity stack using the vectorial-optics-based forward model developed for sub-diffraction-limited dielectric nanoparticles captured on a layered substrate. We demonstrate proof-of-concept experiments on silica beads with a 50 nm nominal diameter. (C) 2020 Optical Society of America

关键词： High numerical aperture optics image processing algorithms image quality Imaging techniques Optical imaging Three dimensional imaging

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Estimating the parallax of the image of the meniscus of a growing crystal

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JOURNAL OF OPTICAL TECHNOLOGY 2008年第1期75卷 52-56页

作者： Mikhlyaev, S. V. Russian Acad Sci Inst Automat & Electrometry Siberian Sect Novosibirsk 630090 Russia

This paper proposes an approach that makes it possible to investigate the parallax of the image of the meniscus of a crystal being grown from the melt by pulling and to estimate how it affects the metrological charact... 详细信息

关键词： Digital image processing Digital imaging Gravity image processing algorithms Optical systems Silicon

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image ALGEBRA REPRESENTATION OF PARALLEL OPTICAL BINARY ARITHMETIC

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APPLIED OPTICS 1989年第6期28卷 1263-1278页

作者： HUANG, KS JENKINS, BK SAWCHUK, AA UNIV SO CALIF INST SIGNAL & IMAGE PROCDEPT ELECT ENGNLOS ANGELESCA 90089

A binary image algebra (BIA) that gives a mathematical description of parallel processing operations is described. Rigorous and concise BIA representations of parallel arithmetic and symbolic substitution operations are given. A sequence of programming steps for implementation of these operations on a parallel architecture is specified by the BIA representation. Examples of arithmetic operations implemented on a digital optical cellular image processor architecture are given.

关键词： Digital optical computing image processing image processing algorithms Optical computers Optical computing Parallel processing

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Improved texture reproduction assessment of camera-phone-based medical devices with a dead leaves target

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OSA CONTINUUM 2019年第6期2卷 1863-1879页

作者： Suresh, Nitin Pfefer, T. Joshua Su, Jiahao Chen, Yu Wang, Quanzeng US FDA Ctr Devices & Radiol Hlth 10903 New Hampshire Ave Silver Spring MD 20993 USA Univ Maryland Dept Elect & Comp Engn 2410 AV Williams Bldg College Pk MD 20742 USA Univ Maryland Fischell Dept Bioengn 4108 Clark Hall College Pk MD 20742 USA

Camera-phone-based medical devices (CPMDs) represent a major emerging platform for point-of-care diagnostic imaging of biological tissue. In order to evaluate degradation in texture reproduction due to visible light image processing performed by CPMDs, a method (MTFDL) involving the generation of a modulation transfer function (MTF) based on measurements of a 'dead leaves (DL)' target has been proposed. In this study, we have identified discrepancies in the quantification of noise based on gray patches of the DL target as compared to the textual region. To address this issue, we have proposed an approach (MTFDL-den) for accurate MTFDL calculation through the use of effectively denoised DL images. Furthermore, we demonstrate that our MTFDL-den approach provides superior robustness to simulated noise. These findings will help establish effective standardized test methods for realistic benchtop assessment of CPMD image quality. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

关键词： Digital image processing image processing image processing algorithms image quality Medical image processing Visible light

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