Discrete models for protein structure prediction embed the protein amino acid sequence into a discrete spatial structure, usually a lattice, where an optimal tertiary structure is predicted on the basis of simple assu...
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Discrete models for protein structure prediction embed the protein amino acid sequence into a discrete spatial structure, usually a lattice, where an optimal tertiary structure is predicted on the basis of simple assumptions relating to the hydrophobic-hydrophilic character of amino acids in the sequence and to relevant interactions for free energy minimization. While the prediction problem is known to be NP complete even in the simple setting of Dill's model with a 2D-lattice, a variety of bio-inspired algorithms for this problem have been proposed in the literature. immunological algorithms are inspired by the kind of optimization that immune systems perform when identifying and promoting the replication of the most effective antibodies against given antigens. A quick, state-of-the-art survey of discrete models and immunological algorithms for protein structure prediction is presented in this paper, and the main design and performance features of an immunological algorithm for this problem are illustrated in a tutorial fashion.
This work presents an analysis of the static Aging operator for different evolutionary algorithms: two immunological algorithms (OptIA and Clonalg), a standard genetic algorithm SGA, and Differential Evolution (DE) al...
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ISBN:
(纸本)9783540748281
This work presents an analysis of the static Aging operator for different evolutionary algorithms: two immunological algorithms (OptIA and Clonalg), a standard genetic algorithm SGA, and Differential Evolution (DE) algorithm. The algorithms were tested against standard benchmarks in both unconstrained and dynamic optimisation problems. This work analyses whether the aging operator improves the results when applied to evolutionary algorithms. With the exception of DE, the results report that every algorithm shows an improvement in performance when used in combination with Aging.
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