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Up the Garden Path: A Chemical Trail through the Cambridge University Botanic Garden

JOURNAL OF CHEMICAL EDUCATION 2012年第11期89卷 1390-1394页

作者： Battle, Gary M. Kyd, Gwenda O. Groom, Colin R. Allen, Frank H. Day, Juliet Upson, Timothy CCDC Cambridge CB2 1EZ England Cambridge Univ Bot Garden Cambridge CB2 1JE England

The living world is a rich source of chemicals with many medicines, dyes, flavorings, and foodstuffs having their origins in compounds produced by plants. We describe a chemical trail through the plant holdings of the Cambridge University Botanic Gardens. Visitors to the gardens are provided with a laminated trail guide with 22 stopping points marked on a map. For each of the 22 familiar plants, the principal chemical component(s) and their applications are identified. The virtual trail on the gardens web site provides additional chemical information including links to the experimentally determined three-dimensional structures of the molecules from the Cambridge Structural Database. Visitors to the gardens with quick response (QR) code readers on their mobile phones will also be able to access this enhanced chemical information digitally. Our hope is that the trails (actual and virtual) will take advantage of students inherent interest in the chemistry of the natural world and encourage them to learn more about the myriad of vital chemicals that are available in the plant kingdom.

关键词： General Public High School/Introductory Chemistry First-Year Undergraduate/General Interdisciplinary/Multidisciplinary Public Understanding/Outreach internet/web-based learning Plant Chemistry X-ray Crystallography

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Students Using a Novel web-based Laboratory Class Support System: A Case Study in Food Chemistry Education

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JOURNAL OF CHEMICAL EDUCATION 2012年第1期89卷 103-108页

作者： van der Kolk, Koos Beldman, Gerrit Hartog, Rob Gruppen, Harry Wageningen Univ Food Chem Lab NL-6700 EV Wageningen Netherlands Wageningen Univ Wageningen MultiMedia Res Ctr NL-6706 KN Wageningen Netherlands

The design, usage, and evaluation of a web-based laboratory manual (webLM) are described. The main aim of the webLM is to support students while Working in the laboratory by providing them with just-in-time information. Design guidelines for this electronic manual were derived from literature on cognitive load and user interface design. The webLM was introduced in a Food, Chemistry course at the Wageningen University. The evaluation showed a positive attitude towards the webLM both by students (n = 79) and supervisors (n = 6). Furthermore, the webLM proved to be a flexible platform, easy to maintain by teachers, easy to extend for future projects, and a promising research tool for monitoring student behavior in the laboratory classes.

关键词： General Public Laboratory Instruction internet/web-based learning Multimedia-based learning

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Integrated Teaching of Structure-based Drug Design and Biopharmaceutics: A Computer-based Approach

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JOURNAL OF CHEMICAL EDUCATION 2012年第1期89卷 45-51页

作者： Sutch, Brian T. Romero, Rebecca M. Neamati, Nouri Haworth, Ian S. Univ So Calif Dept Pharmacol & Pharmaceut Sci Los Angeles CA 90089 USA Ligand Insight LLC Pasadena CA 91117 USA

Rational drug design requires expertise in, structural biology, medicinal chemistry, "physiology, and related fields. In teaching structure-based drug deign, it is important to develop an understanding of the need for early recognition of molecules with "drug-like" properties as a key component. That is, it is not merely sufficient to teach students how to design an effective inhibitor for a particular protein;instead, it is important to convey the need for simultaneous consideration of biopharmaceutical properties that will optimize the chances of the inhibitor becoming a drug. These are advanced concepts, but they can be addressed through computer-based methods. Here, an educational approach using a case study is described in which students "design" a potential drug through use of software, most of which is web-based and freely available.

关键词： Graduate Education/Research Upper-Division Undergraduate Chemoinformatics Interdisciplinary/Multidisciplinary Computer-based learning internet/web-based learning Computational Chemistry Drugs/Pharmaceuticals

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web-based Applet Is a learning Tool that Simulates Ion-Exchange Chromatography Purification of Overexpressed Proteins from Escherichia coli Cell Lysate

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JOURNAL OF CHEMICAL EDUCATION 2012年第4期89卷 555-556页

作者： Usher, Ken C. Barrette-Ng, Isabelle H. Oregon Inst Technol Dept Nat Sci Klamath Falls OR 97601 USA Univ Calgary Dept Biol Sci Calgary AB T2N 1N4 Canada

A Java web applet is described that helps biochemistry students learn how varying ionic strength and pH can affect separation of proteins in an ion-exchange chromatography experiment. The applet simulates a common scenario: a foreign protein is overexpressed in bacteria and needs to be isolated from the other water-soluble proteins of the cell lysate. It allows visualization of proteins on the column, a protein output graph (absorbance at 280 nm), and polyacrylamide gel electrophoresis analysis of selected output fractions.

关键词： Upper-Division Undergraduate Biochemistry internet/web-based learning Chromatography Electrophoresis Ion Exchange Proteins/Peptides

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Prediction of log P: ALOGPS Application in Medicinal Chemistry Education

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JOURNAL OF CHEMICAL EDUCATION 2012年第1期89卷 64-67页

作者： Kujawski, Jacek Bernard, Marek K. Janusz, Anna Kuzma, Weronika Poznan Univ Med Sci Fac Pharm Dept Organ Chem PL-60780 Poznan Poland

Molecular hydrophobicity (lipophilicity), usually quantified as log P where P is the partition coefficient, is an important molecular characteristic in medicinal chemistry and drug design. The log P coefficient is one of the principal parameters for the estimation of lipophilicity of chemical compounds and pharmacokinetic properties. The understanding of log P parameter in the undergraduate medicinal chemistry course seems to be a pitfall for students. This parameter has typically been measured using experimental methods, but recently, log P has been determined using computational methods. The number of publications about lipophilicity predictions has gradually increased over the last 10 years, but the number of programs available for an online prediction of this important parameter remains limited. An interesting tool for calculation of log P coefficients is presented: the Virtual Computational Chemistry Laboratory (VCCLAB) package. The package includes the ALOGPS 2.1 program suitable for log P calculations. This software is accessible online and may be easily mastered by the undergraduate medicinal chemistry student.

关键词： Second-Year Undergraduate Chemoinformatics Organic Chemistry internet/web-based learning Bioanalytical Chemistry Drugs/Pharmaceuticals Laboratory Computing/Interfacing

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Integration of Information Literacy Components into a Large First-Year Lecture-based Chemistry Course

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JOURNAL OF CHEMICAL EDUCATION 2012年第4期89卷 487-491页

作者： Locknar, Angela Mitchell, Rudolph Rankin, Janet Sadoway, Donald R. MIT MIT Lib Cambridge MA 02139 USA MIT Teaching & Learning Lab Cambridge MA 02139 USA MIT Dept Mat Sci & Engn Cambridge MA 02139 USA

A first-year chemistry course is ideal for introducing students to finding and using scholarly information early in their academic careers. A four-pronged approach (lectures, homework problems, videos, and model solutions) was used to incorporate library research skills into a large lecture-based course. Pre- and post-course surveying demonstrated this to be effective and scalable way to teach these life-long skills, requiring minimal additional effort and time on the part of the lecturer.

关键词： First-Year Undergraduate/General Curriculum Interdisciplinary/Multidisciplinary Physical Chemistry Communication/Writing internet/web-based learning Student-Centered learning

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IM-Chem: The Use of Instant Messaging To Improve Student Performance and Personalize Large Lecture General Chemistry Courses

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JOURNAL OF CHEMICAL EDUCATION 2012年第4期89卷 474-476页

作者： Behmke, Derek A. Atwood, Charles H. Bradley Univ Mund Lagowski Dept Chem & Biochem Peoria IL 61625 USA Univ Utah Dept Chem Salt Lake City UT 84112 USA

Previous research has linked poor student performance with the depersonalized feeling of large lecture courses. Various forms of enhanced communication have been tried that appear to enhance personalization in large courses. For general chemistry classes taught in a 365-seat lecture hall at the University of Georgia, we have attempted to enhance communication by using 26 instant messaging (IM) devices. Implementation of this project, called IM-Chem, in large lecture general chemistry courses has had a positive impact on student performance. IM-Chem participants had a mean course grade that was 0.14 grade point average units higher than nonparticipants. Gains in student performance are attributed to the active learning environment that IM-Chem participants experienced. Additionally, an overwhelming majority of participants stated that IM-Chem personalized the large lecture setting by providing them with an unintimidating way to ask questions and individualized answers to those questions.

关键词： First-Year Undergraduate/General Chemical Education Research Communication/Writing Computer-based learning internet/web-based learning

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Online Gaming for Understanding Folding, Interactions, and Structure

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JOURNAL OF CHEMICAL EDUCATION 2012年第12期89卷 1543-1546页

作者： Franco, Jimmy Merrimack Coll Dept Chem N Andover MA 01843 USA

Foldit is a multiplayer online game that utilizes fundamental bonding concepts instead of computing power to resolve protein structures that have eluded researchers. Reported herein is the use of Foldit as a problem-based learning assignment for the understanding of protein folding, interactions, and structure. The program offers tutorial puzzles to introduce the student to both biochemistry and gaming concepts followed by scientific puzzles that allow the students to contribute to significant research. This assignment is ideal for biochemistry as well as general, organic, and biochemistry (GOB) courses.

关键词： Second-Year Undergraduate Biochemistry Computer-based learning Humor/Puzzles/Games internet/web-based learning Problem Solving/Decision Making Molecular Modeling Molecular Properties/Structure Noncovalent interactions Proteins/Peptides

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LIPID MAPS-Nature Lipidomics Gateway: An Online Resource for Students and Educators Interested in Lipids

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JOURNAL OF CHEMICAL EDUCATION 2012年第2期89卷 291-292页

作者： Sud, Manish Fahy, Eoin Cotter, Dawn Dennis, Edward A. Subramaniam, Shankar Univ Calif San Diego San Diego Supercomp Ctr La Jolla CA 92093 USA Univ Calif San Diego Dept Chem & Biochem La Jolla CA 92093 USA Univ Calif San Diego Dept Pharmacol La Jolla CA 92093 USA Univ Calif San Diego Dept Bioengn La Jolla CA 92093 USA

The LIPID MAPS-Nature Lipidomics Gateway is a free, comprehensive online resource providing tutorials and instructional material, experimental data for lipids and genes along with protocols and standards, databases of... 详细信息

关键词： Graduate Education/Research Upper-Division Undergraduate Biochemistry Interdisciplinary/Multidisciplinary Computer-based learning internet/web-based learning Lipids Mass Spectrometry

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Zotero: A Reference Manager for Everyone

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JOURNAL OF CHEMICAL EDUCATION 2012年第1期89卷 173-174页

作者： Murimboh, John D. Hollingdale, Christie R. Acadia Univ Dept Chem Wolfville NS B4P 2R6 Canada

A review of Zotero 3.0b2, an open-source, cross-platform, all-in-one reference manager, document archiver, citation manager, and collaboration tool is presented. This report will discuss features such as collecting references, annotating references, integration with Microsoft Word and Open Office, backing up and synchronizing references, and sharing references with students and collaborators. Some useful but less commonly known tips and tricks are also described.

关键词： Continuing Education First-Year Undergraduate/General Graduate Education/Research High School/Introductory Chemistry Second-Year Undergraduate Upper-Division Undergraduate Interdisciplinary/Multidisciplinary internet/web-based learning Textbooks/Reference Books

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