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Factors influencing resuscitation outcomes in obese out-of-hospital cardiac arrest patients: A LASSO logistic regression analysis in Wuhan, China

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NOTFALL & RETTUNGSMEDIZIN 2025年 1-7页

作者： Yu, Di-Hua Wang, Wei-Qing Wang, Ying-Lin Yu, Di-Hua Zhu, Zheng Zeng, Xiao-Xia Li, Gang Hubei Prov Hosp TCM Emergency Dept Wuhan 430074 Peoples R China Emergency Med Ctr Wuhan Wuhan Peoples R China

ObjectiveGiven limited prehospital emergency human resources, emergency transfer of obese out-of-hospital cardiac arrest (OHCA) patients is often associated with great difficulties. This study aims to identify and weigh factors influencing outcomes of emergency transfer in obese OHCA patients. MethodsWe conducted a retrospective analysis of 172 OHCA patients treated by emergency medical services (EMS). Spearman correlation analysis was used to examine the correlation between factors. Least absolute shrinkage and selection operator (LASSO) regression was employed to screen for significant factors. A multifactorial logistic risk regression model was then established. The influencing factors were evaluated using an odds ratio (OR) forest plot, and the predictive efficacy of the model was assessed using a working curve. ResultsAfter conducting Spearman correlation analysis and LASSO regression screening, body mass index (BMI), age, cardiopulmonary resuscitation (CPR) grade, timely detection and defibrillation, and bystander CPR duration were found to be correlated with return of spontaneous circulation (ROSC). logistic regression analysis indicated that obese OHCA patients with a BMI above 22.5 have a 9.25 times higher risk (95% confidence interval [CI] 1.23-82.13, p = 0.009) than those without obesity. Similarly, individuals above the age of 35 faced a 7.67 times higher risk (95%CI 1.07-98.4, p = 0.043) compared to those aged 35 or below. Additionally, the risk of low-quality CPR was 16.45 times higher (95%CI 2.45-207.39, p = 0.009) than high-quality CPR. Failing to defibrillate in a timely manner resulted in 8.15 times higher risk (95%CI 1.24-76.23, p = 0.036) compared to timely detection and defibrillation. Moreover, having a bystander CPR time exceeding 10 min carried a 2.36 times higher risk (95%CI 0.20-28.67, p = 0.047) compared to a bystander CPR time of 10 min or less. The logistic regression indicated a high predictive efficacy of the model. ConclusionThe ROSC

关键词： Wuhan, China Obesity logistic regression analysis Cardiopulmonary resuscitation Return of spontaneous circulation

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logistic regression analysis for glaucoma diagnosis using stratus optical coherence tomography

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OPTOMETRY AND VISION SCIENCE 2006年第7期83卷 527-534页

作者： Chen, Hsin-Yi Huang, Mei-Ling Hung, Por-Tying China Med Univ Hosp Dept Ophthalmol Glaucoma Serv Taichung 404 Taiwan Natl Chin Yi Inst Technol Dept Ind Engn & Management Taichung Taiwan

Purposes. The purposes of this study are to investigate the diagnostic performance of logistic regression analysis (LRA) applied to multidimensional information on glaucoma disease and to determine the area under receiver operator characteristic curves (AROCs) for differentiating between normal and glaucomatous eyes in the Taiwan Chinese population based on the summary data from the Stratus Optical Coherence Tomography (OCT). Methods. One randomly selected eye from each of the 89 patients with glaucoma and from each of the 88 age- and gender-matched normal individuals were included in the study. Nine glaucomatous eyes and eight normal eyes were excluded as a result of poor OCT scans. Finally, 80 normal eyes and 80 glaucomatous eyes (mean deviation, -4.5 +/- 4.12 dB) were analyzed. The whole dataset was split into four equal sets. Each set combines 20 patients with glaucoma and 20 normal individuals. Fourfold crossvalidation was conducted. Retinal nerve fiber layer thickness and optic nerve head were measured by Stratus OCT in each patient. Twenty-five OCT parameters were included in a LRA method to determine the best combination of parameters for discriminating between glaucomatous and healthy eyes based on AROCs. Results. With the LRA method, the AROC for glaucoma detection was 0.911 with sensitivity at 80% and 90% specificity were 83.7% and 80.0%, respectively. Conclusions. Compared with the OCT-provided parameters, the LRA method improved the ability to differentiate between normal and glaucomatous eyes in the Taiwan Chinese population.

关键词： logistic regression analysis glaucoma diagnosis Stratus OCT

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logistic regression analysis for factors influencing cost performance of design-bid-build and design-build projects

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ENGINEERING CONSTRUCTION AND ARCHITECTURAL MANAGEMENT 2017年第1期24卷 118-132页

作者： Lu, Wenxue Hua, YuanYuan Zhang, SuJuan Tianjin Univ Sch Management Tianjin Peoples R China Univ Hong Kong Dept Real Estate & Construct Hong Kong Hong Kong Peoples R China Tianjin Univ Dept Construct Management Tianjin Peoples R China

Purpose - The purpose of this paper is to explore the influencing factors of cost performance of design-bid-build (DBB) and design-build (DB) projects and comparing the differences of influencing factors between these two delivery methods. Design/methodology/approach - This research identified and refined 14 influencing factors through literature review and academic expert discussions. Questionnaire survey was conducted to collect data about the influencing factors and project cost performance. Then those factors were reduced to four components by factor analysis. logistic regression analysis is used to investigate the relationship between four principal components and project cost performance. Findings - The results indicate that the significant influencing factors of project cost performance of DBB projects and DB projects are different. For DBB projects, owner abilities, such as owner team ability, owner experience, and owner finance, are important influencing factors causing cost overruns, while for DB projects cost performance is more sensitive to the contractor abilities, namely, contractor team ability, contractor finance, contractor experience, etc. Research limitations/implications - The results of the paper are mainly derived by quantitative research method based on the survey of 144 samples, so the results may need validation by qualitative studies. Further research could apply case study or interview to validate the findings in this research. In addition, project type and location are not considered as control variables due to the limited number of samples, future research could be conducted to investigate their relationship with project performance. Practical implications - The findings of this research not only help practitioners have a better understanding of the factors influencing project cost performance, but also provide some guidelines for practitioners to pay attention to different factors to better control the cost performance within different

关键词： Cost overrun Design-build Cost management Design-bid-build logistic regression analysis Procurement system

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logistic regression analysis for LncRNA-Disease Association Prediction Based on Random Forest and Clinical Stage Data

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IEEE ACCESS 2020年 8卷 35004-35017页

作者： Wang, Bo Zhang, Jing Harbin Engn Univ Coll Comp Sci & Technol Harbin 150001 Peoples R China Univ Jinan Sch Informat Sci & Engn Jinan 250022 Peoples R China Qiqihar Univ Coll Comp & Control Qiqihar 161006 Peoples R China

An increasing amount of studies have found that LncRNA plays an important role in various life processes of the body. In current prediction research on lncRNA-disease associations, correlation analysis of disease prognosis is overlooked. In this study, a logistic regression prediction model based on tumor clinical stage data and the expression quantity of lncRNA transcript is constructed. The proposed model is based on unknown human lncRNA-disease associations combining with the clinical stage data. Firstly, the importance of the characteristic variable is calculated by the proposed CVSgC-RF algorithm. Secondly, 95 lncRNAs, which are most closely related to prostate cancer, are calculated from 480 alternative lncRNAs by CASO and CVSe-CS-CF. On the basis of the above 95 lncRNAs, the CSPA-PL algorithm is used to select a further 22 lncRNAs that are most closely related to the tumor clinical stage for prostate cancer. Finally, 22 lncRNAs are used to construct a logistic regression prediction model. Additionally, this method is applied to lung cancer data;16 lncRNAs are selected to construct a logistic regression prediction model for lung cancer. Experimental results show that the best results for ROC Area, the accuracy and recall rate of the prediction model are achieved by the proposed method for prostate cancer and lung cancer, which provides a promising basis for subsequent prediction studies of lncRNA-disease associations.

关键词： Tumors Predictive models Prognostics and health management Prostate cancer logistics LncRNA-disease association random forest logistic regression analysis clinical stage data

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logistic regression analysis of Conventional Ultrasound, and Contrast-Enhanced Ultrasound Characteristics Is It Helpful in Differentiating Benign and Malignant Superficial Lymph Nodes?

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JOURNAL OF ULTRASOUND IN MEDICINE 2022年第2期41卷 343-353页

作者： Wang, Bo Zhang, Meng Ke Zhou, Mao Ping Liu, Yuan Li, Nan Liu, Gang Wang, Zhi Li Chinese Peoples Liberat Army Gen Hosp Med Ctr 1 Dept Ultrasound Beijing Peoples R China Qingdao Univ Affiliated Hosp Dept Ultrasound Qingdao Peoples R China Chinese Peoples Liberat Army Gen Hosp Med Ctr 5 Dept Ultrasound Beijing Peoples R China Chinese Peoples Liberat Army Gen Hosp Med Ctr 1 Dept Radiol Beijing Peoples R China

Objectives This study aimed to screen the significant sonographic features for differentiation of benign and malignant superficial lymph nodes (LNs) by logistic regression analysis and fit a model to diagnose LNs. Methods A total of 204 pathological LNs were analyzed retrospectively. All the LNs underwent conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) examinations. A total of 16 suspicious sonographic features were used to assess LNs. All variables that were statistically related to the diagnosis of LNs were included in the logistic regression analysis in order to ascertain the significant features of diagnosing LNs, and to establish a logistic regression analysis model. Results The significant features in the logistic regression analysis model of diagnosing malignant LNs were absence of echogenic hilus, age, and absence of hilum after enhancement. According to the results of logistic regression analysis, the formula to predict whether LNs were malignant was established. The area under the receiver operating curve (ROC) was 0.908 and the accuracy, sensitivity, and specificity were 85.0%, 92.9%, and 85.3%, respectively. Conclusion The logistic regression model for the significant sonographic features of conventional US and CEUS is an effective and accurate diagnostic tool for differentiating malignant and benign LNs.

关键词： lymph nodes logistic regression analysis ultrasound features

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logistic regression analysis of small round cell neoplasms: A cytologic study

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DIAGNOSTIC CYTOPATHOLOGY 1999年第5期20卷 271-277页

作者： Layfield, LJ Liu, K Dodge, RK Univ Utah Hlth Sci Ctr Dept Pathol Salt Lake City UT 84132 USA

The diagnosis of small round cell neoplasms (SRCN) in children is difficult by both histologic and cytologic methods. These neoplasms are unified morphologically by the scanty cytoplasm surrounding relatively round nuclei containing a primitive chromatin pattern. Further categorization is achieved histologically by the recognition of architectural differentiation and cytoplasmic features. Numerous series and case reports documenting the cytologic features of SRCN have been published in the English-language literature, bur relatively few studies have statistically analyzed the diagnostic utility of these features. Our logistic regression analysis of 59 cases of SRCN indicates that the presence of an extremely scanty cytoplasm Savors the diagnosis of Ewing's sarcoma (P = 0.004), as does the positive expression of cytoplasmic vacuoles (P = 0.02). Strap or tadpole cells closely correlate with the diagnosis of rhabdomyosarcoma (P < 0.001). The positive expression of rosettes strongly supports the presence of a neuroblastoma (P < 0.001). The diagnosis of Wilms' tumor is confirmed by the expression of tubules (P < 0.001). The presence of lymphoglandular bodies strongly favors the diagnosis of lymphoma (P < 0.001). While some cytologic features ave highly correlated with specific SRCN, these features are not invariably present, and definitive diagnosis may require immunohistochemical or ultrastructural analysis performed on cell block material. Diagn. Cytopathol. 1999;20:271-277. (C) 1999 Wiley-Liss, Inc.

关键词： small round cell neoplasms FNA logistic regression analysis

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logistic regression analysis of risk factors for prolonged pulmonary recovery in children from aspirated foreign body

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INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY 2013年第10期77卷 1677-1682页

作者： Hidaka, Hiroshi Obara, Taku Kuriyama, Shinichi Kurosawa, Shin Katori, Yukio Kobayashi, Toshimitsu Tohoku Univ Grad Sch Med Dept Otolaryngol Head & Neck Surg Sendai Miyagi 9808575 Japan Tohoku Univ Grad Sch Med Div Mol Epidemiol Environm & Genome Res Ctr Sendai Miyagi 9808575 Japan Tohoku Univ Grad Sch Med Dept Anesthesiol & Intens Care Med Sendai Miyagi 9808575 Japan

Objective: Foreign body aspiration is a life-threatening emergency for children. Fried chicken is available all over the world, but no cases have previously been reported addressing this food as a tracheobronchial foreign body. We report an extremely rare case of tracheobronchial aspiration of fried chicken complicated by severe bronchitis and postoperative atelectasis. To clarify predisposing factors related to bronchopulmonary complications, we also reviewed paediatric cases of tracheobronchial foreign bodies treated in our department over the past 14 years. Methods: We retrospectively reviewed a total of 77 cases of tracheobronchial foreign bodies from 1988 to 2011. The main outcome measure was duration of hospitalisation, reflecting postoperative therapy. logistic regression analyses were conducted to determine risk factors for longer hospitalisation. Results: Age, sex, and interval between the aspiration episode and bronchoscopy were not significantly associated with longer hospitalisation. Regarding kinds of foreign bodies, higher rates of longer hospitalisation were noted for patients who had aspirated peanut or animal material, as compared to patients who had aspirated non-organic material (odds ratio, 5.80;95% confidence interval, 1.12-30.43). Conclusions: In terms of predicting the risk of pulmonary complications, the type of foreign body aspirated offers a more meaningful factor than the interval between aspiration and operation. Specifically, peanuts or animal material containing oils appear to be associated with a more prolonged pulmonary recovery even after retrieval of the foreign body. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

关键词： Fried chicken Foreign body aspiration Bronchoscopy Lung recovery logistic regression analysis Odds ratio

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logistic regression analysis for febrile neutropenia (FN) induced by docetaxel in Japanese cancer patients

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CANCER CHEMOTHERAPY AND PHARMACOLOGY 2008年第3期62卷 551-557页

作者： Ozawa, Kazuhiro Minami, Hironobu Sato, Hitoshi Showa Univ Sch Pharmaceut Sci Dept Clin & Mol Pharmacokinet Pharmacodynam Shinagawa Ku Tokyo 1428555 Japan Natl Canc Ctr Hosp E Div Hematol Oncol Chiba Japan Kobe Univ Hosp Dept Med Hyogo Japan Grad Sch Med Hyogo Japan

Purpose Fever occurring in a neutropenic patient remains a common life-threatening complication of cancer chemotherapy, and febrile neutropenia (FN) is recognized as a dose-limiting factor (DLF) in cancer chemotherapy. The aim of this study is to evaluate the significant covariate associated with the risk of FN occurrence in Japanese patients. Methods A stepwise logistic regression was conducted using data from Japanese cancer patients treated with docetaxel. Based on those results, an equation was established which predicts the probability of FN occurrence. Results From the result of a stepwise multivariate logistic regression analysis, performance status factor (PS*), which is set to 1 if performance status factor is 2 or 3, and to 0 otherwise and area under the plasma concentration versus time curve (AUC) were selected as covariates significantly associated (p < 0.05) with FN occurrence. The obtained equation to predict the probability (P) of docetaxel-induced FN occurrence is P = 1/[1 + exp{-(1.29 x AUC + 1.41 x PS* -3.52)}]. A receiver operating characteristic (ROC) curve analysis revealed that the best cut-off value of FN probability to differentiate between the presence and absence of FN was 0.61. Conclusions An equation was developed to predict the probability of FN occurrence for Japanese patients treated with docetaxel. It was found that FN may not occur when the probability of FN occurrence calculated by the predictive equation is less than 0.61. Therefore, the predictive equation for FN occurrence may be used for selecting the appropriate dose to avoid the occurrence of FN.

关键词： docetaxel febrile neutropenia logistic regression analysis neutrophils Japanese cancer patients

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logistic regression analysis of the risk factors of anastomotic fistula after radical resection of esophageal-cardiac cancer

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THORACIC CANCER 2017年第6期8卷 666-671页

作者： Huang, Jinxi Zhou, Yi Wang, Chenghu Yuan, Weiwei Zhang, Zhandong Chen, Beibei Zhang, Xiefu Zhengzhou Univ Dept Gen Surg Affiliated Canc Hosp Zhengzhou Henan Peoples R China Zhengzhou Univ Dept Anesthesiol Affiliated Canc Hosp Dongming Rd Zhengzhou 450003 Henan Peoples R China Zhengzhou Univ Affiliated Canc Hosp Dept Oncol Zhengzhou Henan Peoples R China Zhengzhou Univ Dept Gen Surg Affiliated Hosp 1 Zhengzhou Henan Peoples R China

BackgroundThis study was conducted to investigate the risk factors of anastomotic fistula after the radical resection of esophageal-cardiac cancer. MethodsFive hundred and forty-four esophageal-cardiac cancer patients who underwent surgery and had complete clinical data were included in the study. Fifty patients diagnosed with postoperative anastomotic fistula were considered the case group and the remaining 494 subjects who did not develop postoperative anastomotic fistula were considered the control. The potential risk factors for anastomotic fistula, such as age, gender, diabetes history, smoking history, were collected and compared between the groups. Statistically significant variables were substituted into logistic regression to further evaluate the independent risk factors for postoperative anastomotic fistulas in esophageal-cardiac cancer. ResultsThe incidence of anastomotic fistulas was 9.2% (50/544). logistic regression analysis revealed that female gender (P<0.05), laparoscopic surgery (P<0.05), decreased postoperative albumin (P<0.05), and postoperative renal dysfunction (P<0.05) were independent risk factors for anastomotic fistulas in patients who received surgery for esophageal-cardiac cancer. Of the 50 anastomotic fistulas, 16 cases were small fistulas, which were only discovered by conventional imaging examination and not presenting clinical symptoms. All of the anastomotic fistulas occurred within sevendays after surgery. Five of the patients with anastomotic fistulas underwent a second surgery and three died. ConclusionFemale patients with esophageal-cardiac cancer treated with endoscopic surgery and suffering from postoperative hypoproteinemia and renal dysfunction were susceptible to postoperative anastomotic fistula.

关键词： Anastomotic fistula esophageal-cardiac cancer logistic regression analysis risk factors surgical treatment

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logistic regression analysis of multiple interosseous hand-muscle activities using surface electromyography during finger-oriented tasks

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JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY 2019年 44卷 117-123页

作者： Yokoyama, Masayuki Yanagisawa, Masao Waseda Univ Dept Comp Sci & Commun Engn Shinjuku Ku 3-4-1 Okubo Tokyo 1698555 Japan

Intrinsic hand muscles are densely located in the hand, and the myoelectric observation from the surface is sometimes unreliable because of some outside influences that may interfere with the signals. In the present study, we evaluated the activities of multiple interosseous hand-muscles which densely located in the hand, through analyzing the surface electromyographic signals during finger-oriented tasks using univariate and multivariate logistic regression models. Ten healthy subjects participated in our experiment, and isometrically exercised each finger one by one in flexed form. The result of a univariate analysis with the power and amplitude domain predictor variables of the surface electromyographic signals showed significant consistency between the activated finger and the inserted finger of the dorsal interosseous muscles to the proximal phalanx (P < 0.001). Meanwhile, the results of a multivariate analysis showed a higher correlation of the regression model of the fourth dorsal interosseous muscle during the action of the ring finger using frequency-domain variables (the Nagelkerke R-2 = 0.716 when the median frequency was used), compared to the model without the frequency-domain variables (the Nagelkerke R-2 = 0.583). Our result showed that the logistic regression models have a particular possibility for the analysis of the surface electromyographic signals of densely located hand-muscle activities related to the finger-oriented tasks.

关键词： Muscle analysis Surface electromyography logistic regression analysis Interosseous hand muscle

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