Microarray is a potential tool to explore information inside *** simultaneously monitoring the expression levels of thousands of genes under specified experimental conditions and using clustering and statistical signa...
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ISBN:
(纸本)9781612848334
Microarray is a potential tool to explore information inside *** simultaneously monitoring the expression levels of thousands of genes under specified experimental conditions and using clustering and statistical signal processing techniques on these expression levels it is possible to classify biological specimens(***).However,a prime limitation of microarray data used for analytics and extrapolation is the presence of *** present a novel method utilizing the 2d music Algorithm for denoising,representation andclassification of microarray *** 2d music algorithm is a frequency estimation technique that separates the high dimensional microarray data into a signal and a noise subspace. It is therefore possible to extract the complex frequency components of a signal in presence of *** algorithm was implemented on a publicly available microarray dataset of lung epithelial cells of smokers with and without cancer. Further,a difference frequency estimator function was used to train an eigenvector basedclassification tool to distinguish between the microarray data from smokers with and without *** application of this 2d music Algorithm to the input dataset containing variegateddistribution of normal anddiseased samples,it was possible to distinguish discernibly between cancerous and non-cancerous samples with good *** technique has potential applications for prognosis and treatment of cancer.
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