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Evaluation of castor pistillate lines and analysis of mode of inheritance for resistance to Fusarium wilt disease in castor (Ricinus communis L.)

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CURRENT PLANT BIOLOGY 2024年 37卷

作者： Deepika, C. Venkatachalam, S. R. Yuvaraja, A. Arutchenthil, P. Indra, N. Ravichandran, V. Veeramani, P. Kathirvelan, P. Tamil Nadu Agr Univ Tapioca & Castor Res Stn Salem 636119 Tamil Nadu India Natl Pulses Res Ctr Dept Genet & Plant Breeding Vamban 622303 Tamil Nadu India Tamil Nadu Agr Univ Forest Coll & Res Inst Dept Plant Pathol Mettupalayam 641301 Tamil Nadu India Tamil Nadu Agr Univ Agr Coll & Res Inst Dept Agron Coimbatore 641003 Tamil Nadu India Sethu Bhaskara Agr Coll & Res Fdn Karaikkudi 630306 Tamil Nadu India

Castor is an industrially economic and valuable oilseed crop cultivated worldwide. There is a constant upsurge in demand for its oil. But wilt caused by Fusarium spp. is a devastating disease that severely affects the productivity depending upon the crop stage. Stable high yielding pistillate lines serve as donors in heterosis breeding programme and for further biotechnological advancements. Genetic characterization of wilt resistance indicated the role of duplicate dominant epistasis in YTP 1 x TMV 5, complementary epistasis in DPC 9 x JP 65 and JP 65 x SKI 215, duplicate recessive epistasis in YRCP 1 x DPC 9. Monogenic recessive nature of wilt resistance was reported in other four cross combinations viz., YRCP 2 x JP 65, SKP 84 x JP 65, YRCP 2 x DPC 9 and YRCP 2 x SKP 84. Magnified images taken using LED phase contrast microscope portrayed the presence of microconidia and macroconidia and Scanning Electron Microscope (SEM) image analysis showed the presence of intact internal cell structures in resistant check (48-1) while the cell structures were disturbed with mycelial growth in the susceptible check (JI 35). Among 21 pistillate lines screened, seven viz., DPC 9, DPC 16, SKP 84, JP 96, GEETA, M 574 and M 619-1 were resistant. By screening P1, P2, F1, F2, BC1F1 (P1) and BC1F1 (P2) generations of eight crosses under field and pot test method, the stable pistillate line DPC 9 was found to be wilt resistant. F1 generation plants expressed 100% susceptibility indicating the recessive nature of wilt resistance. JP 65 x SKI 215 and YRCP 1 x DPC 9 showed the minimum incidence comparing other F2 populations. The backcross (YRCP 1 x DPC 9) x DPC 9 was found to possess the lowest wilt incidence compared to other populations under field and green house condition. Hence the identified lines could be better used to develop wilt resistant high yielding hybrid and for further identifying and introgressing genomic regions conferring wilt resistance to high yielding popular varie

关键词： Castor Fusarium wilt mode of inheritance Pistillate Resistance Sick pot test

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mode of inheritance for pesticide resistance, importance and prevalence: A review

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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 2024年 202卷 105964页

作者： Lu, Xue-Ping Xu, Li Wang, Jin-Jun Southwest Univ Coll Plant Protect Key Lab Entomol & Pest Control Engn Chongqing 400715 Peoples R China Southwest Univ Acad Agr Sci Minist Educ Key Lab Agr Biosafety & Green Prod Upper Yangtze R Chongqing 400715 Peoples R China

Pesticides remain a cornerstone in pest control, yet their extensive and irrational use also fuel the evolution of resistance. This review analyzes globally published experimental data spanning from the 1970s to 2023 to focus on how phenotypic and underlying genotypic variations are shaped during the selective response. The discussion commences with an examination of sex-linked/maternal resistance. Observations related to maternal inheritance have enriched our understanding of pesticide mode of action, notably exemplified by bifenazate. However, the predominant control of the resistant phenotype is attributed to autosomal traits, with a high prevalence of dominance and monogenic inheritance observed, also evident in field strains. This observation raises concerns regarding resistance management strategies due to their potential to accelerate the spread of resistance. The interplay between dominance levels and monogenic inheritance is further explored, with dominant traits being significantly more prevalent in polygenic inheritance. This observation may be attributed to the accumulation of enhanced metabolism. Notably, further analysis indicated that field strains exhibit a higher incidence of monogenic inheritance compared to other selected strains, aligning with established theoretical frameworks. In conclusion, the genetic architecture of resistance warrants increased research focus for its pivotal role in guiding resistance management strategies and advancing fundamental research.

关键词： mode of inheritance Sex-linked Dominance Monogenic Resistance management strategies

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The role of fatal family history and mode of inheritance in prostate cancer for long-term outcomes following radical prostatectomy

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WORLD JOURNAL OF UROLOGY 2020年第12期38卷 3091-3099页

作者： Meissner, Valentin H. Strueh, Jamila G. H. Kron, Martina Liesenfeld, Lea A. Kranz, Stephanie Gschwend, Jurgen E. Herkommer, Kathleen Tech Univ Munich Sch Med Dept Urol Klinikum Rechts Isar Munich Germany Univ Ulm Inst Epidemiol & Med Biometr Ulm Germany

Purpose To determine whether fatal family history (FFH) or mode of inheritance in prostate cancer (PCa) has an impact on long-term outcomes following radical prostatectomy (RP). Methods 1076 PCa patients after RP with at least one deceased first-degree relative with PCa were included and stratified by FFH (four subgroups: fraternal, paternal, multiple, and none) and by mode of inheritance (two subgroups: male to male, non-male to male). We compared clinicopathological characteristics between subgroups with Fisher's exact or Chi-square tests. Biochemical recurrence-free survival (BRFS) and cancer-specific survival (CSS) were analyzed using the method of Kaplan and Meier. Simple and multiple Cox regression with backward elimination were performed to select prognostic factors for BRFS and CSS. Results Median age at surgery was 63.3 (range 35.9-79.4) years. The overall Kaplan-Meier estimated BRFS rate at 10 and 15 years was 65.6% and 57.0%, respectively. The overall Kaplan-Meier estimated CSS rate at 10 and 15 years was 98.1% and 95.7%, respectively. Neither FFH nor mode of inheritance were factors associated with worse BRFS. However, in multiple Cox regression, paternal FFH was an important prognostic factor for a better CSS (HR 0.19, CI 0.05-0.71,p = 0.014) compared to non-FFH. Conclusion FFH and mode of inheritance do not seem to be prognostic factors of worse long-term outcomes following RP. Rather, a paternal FFH was associated with a better CSS;however, the reasons remain unclear. Nevertheless, patients after RP and FFH could be reassured that their own PCa diagnosis is not associated with a worse long-term outcome.

关键词： Biochemical recurrence-free survival Cancer-specific survival Fatal family history mode of inheritance Prostatic neoplasms Radical prostatectomy

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ATG16L1 and IL23R Variants and Genetic Susceptibility to Crohn's Disease: mode of inheritance Based on Meta-analysis of Genetic Association Studies

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INFLAMMATORY BOWEL DISEASES 2015年第4期21卷 768-776页

作者： Grigoras, Christos A. Ziakas, Panayiotis D. Jayamani, Elamparithi Mylonakis, Eleftherios Warren Alpert Med Sch Brown Univ Div Infect Dis Providence RI USA Brown Univ Warren Alpert Med Sch Div Infect Dis Providence RI 02903 USA

Background:Autophagy and regulation of IL-23 signaling pathways have been implicated in the pathogenesis of Crohn's disease (CD). We studied the mode of inheritance and reviewed the association of 2 polymorphic variants of ATG16L1 and IL23R with ***:We searched the PubMed and ISI Web of Science databases (up to May 2014) for pertinent articles. We included all studies that had a case-control design, with cases having CD and controls being healthy and reported full genotype frequencies for the ATG16L1 and/or IL23R variant of interest. We quantified the relative genetic risk using the model-free approach of the generalized odds ratio metric (ORG) and reported 95% precision estimates. Also, we explored the mode of inheritance using the degree of dominance ***:Fifty-one studies fulfilled these requirements and were included in the analysis. These studies involved 12,762 patients and 16,735 controls evaluating the association of ATG16L1 (rs2241880 ***300Ala) and 8110 patients and 11,900 controls evaluating the association of IL23R (rs11209026 ***381Gln) with CD. The ATG16L1 variant rs2241880 was associated with increased susceptibility to CD (combined ORG = 1.38;95% confidence interval, 1.29-1.48) and a nondominant mode of inheritance (suggesting that the effect of heterozygosity lies exactly in the middle of extreme homozygotes, h = 0). The IL23R variant rs11209026 was associated with significant protection (ORG = 0.46;95% confidence interval, 0.41-0.53) and a recessive mode of inheritance, indicating that the effect of a heterozygous genotype would lie close to the wild-type homozygous genotype. In subgroup analysis, the significant effects persisted across Caucasian ancestry studies and pediatric populations but were lacking across studies in Asian ***:The ATG16L1 variant rs2241880 was associated with 38% increase in the risk for CD for higher mutational load, whereas IL23R variant rs11209026 decreased the risk by 54% for hig

关键词： autophagy interleukin Crohn's disease mode of inheritance

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Cross-resistance and genetics of field-evolved resistance to chlorfenapyr in Plutella xylostella

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Insect Science 2024年第2期31卷 533-541页

作者： Cheng Qian Jialin Li Shuwen Wu Yihua Yang Yidong Wu Xingliang Wang Sanya Institute of Nanjing Agricultural Universty SanyaHainanChinaand College of Plant Protection Nanjing Agricultural UniversNanjingChina

Chlorfenapyr is a broad-spectrum halogenated pyrrole insecticide with a unique mode of *** to the misuse and overuse of this chemical,resistance has been reported in several arthropods,including Plutella xylostella,which is one of the most destructive insect pests afflicting crucifers worldwide.A better understanding of the cross-resistance and genetics of field-evolved chlorfenapyr resistance could effectively guide resistance management ***,the chlorfenapyr resistance of a fieldderived population of P xylostella was introgressed into the susceptible IPP-S strain using a selection-assisted multigenerational backcrossing *** constructed nearisogenic strain,TH-BCsF2,shared 98.4%genetic background with the recurrent parent IPP-S *** TH-BCsF2 strain showed 275-fold resistance to chlorfenapyr,but no significant cross-resistance to spinosad,abamectin,chlorpyrifos,β-cypermethrin,indoxacarb,chlorantraniliprole,or broflanilide(no more than 4.2-fold).Genetic analysis revealed that resistance was autosomal,incompletely dominant,and conferred by 1 major gene or a few tightly linked *** synergism of metabolic inhibitors(PBO,DEM,and DEF)to chlorfenapyr was very weak(<1.7-fold),and the metabolic enzyme activities in the TH-BCsF2 strain were not significantly elevated compared with the IPP-S *** results enhances our understanding of the genetic traits of chlorfenapyr resistance,and provides essential information for improving resistance management strategies.

关键词： chlorfenapyr cross-resistance mode of inheritance near-isogenic line Plutellaxylostella

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Blood DNA methylation provides an accurate biomarker of KMT2B-related dystonia and predicts onset

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BRAIN 2022年第2期145卷 644-654页

作者： Mirza-Schreiber, Nazanin Zech, Michael Wilson, Rory Brunet, Theresa Wagner, Matias Jech, Robert Boesch, Sylvia Skorvanek, Matej Necpal, Jan Weise, David Weber, Sandrina Mollenhauer, Brit Trenkwalder, Claudia Maier, Esther M. Borggraefe, Ingo Vill, Katharina Hackenberg, Annette Pilshofer, Veronika Kotzaeridou, Urania Schwaibold, Eva Maria Christina Hoefele, Julia Waldenberger, Melanie Gieger, Christian Peters, Annette Meitinger, Thomas Schormair, Barbara Winkelmann, Juliane Oexle, Konrad German Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Neurogen ING D-85764 Neuherberg Germany German Res Ctr Environm Hlth Inst Neurogen ING Helmholtz Zentrum Munchen Neurogenet Syst Anal Grp D-85764 Neuherberg Germany Tech Univ Munich Sch Med Inst Human Genet D-81675 Munich Germany German Res Ctr Environm Hlth Helmholtz Zentrum Munchen Res Unit Mol Epidemiol D-85764 Neuherberg Germany Charles Univ Prague Dept Neurol Fac Med 1 Prague 12108 Czech Republic Gen Univ Hosp Prague Prague 12108 Czech Republic Med Univ Dept Neurol A-6020 Innsbruck Austria Safarik Univ Dept Neurol Kosice 04011 Slovakia Univ Hosp L Pasteur Dept Neurol Kosice 04011 Slovakia Zvolen Hosp Dept Neurol Zvolen 96001 Slovakia Asklepios Fachklinikum Stadtroda Dept Neurol D-07646 Stadtroda Germany Univ Leipzig Dept Neurol D-04103 Leipzig Germany Univ Med Ctr Goettingen Dept Neurol Paracelsus Elena Klin D-34128 Kassel Germany Ludwig Maximilians Univ Munchen Dr von Hauner Childrens Hosp D-80337 Munich Germany Univ Childrens Hosp Dept Pediat Neurol CH-8032 Zurich Switzerland Ordensklinikum Linz Barmherzige Schwestern A-4010 Linz Austria Univ Hosp Heidelberg Ctr Pediat & Adolescent Med Dept Child Neurol & Metab Med D-69120 Heidelberg Germany Heidelberg Univ Inst Human Genet D-69120 Heidelberg Germany German Ctr Diabet Res DZD D-85764 Neuherberg Germany German Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Epidemiol D-85764 Neuherberg Germany Ludwig Maximilians Univ Munchen Med Fac Inst Med Informat Proc Biometry & Epidemiol Chair Epidemiol D-81377 Munich Germany Tech Univ Munich Sch Med Chair Neurogenet D-81675 Munich Germany Munich Cluster Syst Neurol SyNergy D-81377 Munich Germany

Dystonia is a prevalent, heterogeneous movement disorder characterized by involuntarily abnormal postures. Biomarkers of dystonia are notoriously lacking. Here, a biomarker is reported for histone lysine methyltransferase (KMT2B)-deficient dystonia, a leading subtype among the individually rare monogenic dystonias. It was derived by applying a support vector machine to an episignature of 113 DNA CpG sites, which, in blood cells, showed significant epigenome-wide association with KMT2B deficiency and at least 1x log-fold change of methylation. This classifier was accurate both when tested on the general population and on samples with various other deficiencies of the epigenetic machinery, thus allowing for definitive evaluation of variants of uncertain significance and identifying patients who may profit from deep brain stimulation, a highly successful treatment in KMT2B-deficient dystonia. Methylation was increased in KMT2B deficiency at all 113 CpG sites. The coefficients of variation of the normalized methylation levels at these sites also perfectly classified the samples with KMT2B-deficient dystonia. Moreover, the mean of the normalized methylation levels correlated well with the age at onset of dystonia (P = 0.003)-being lower in samples with late or incomplete penetrance-thus serving as a predictor of disease onset and severity. Similarly, it may also function in monitoring the recently envisioned treatment of KMT2B deficiency by inhibition of DNA methylation.

关键词： dystonia KMT2B episignature age at onset mode of inheritance

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Overcoming constraints on the detection of recessive selection in human genes from population frequency data

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AMERICAN JOURNAL OF HUMAN GENETICS 2022年第1期109卷 33-49页

作者： Balick, Daniel J. Jordan, Daniel M. Sunyaev, Shamil Do, Ron Harvard Med Sch Brigham & Womens Hosp Div Genet Boston MA 02115 USA Harvard Med Sch Dept Biomed Informat Boston MA 02115 USA Icahn Sch Med Mt Sinai Charles Bronfman Inst Personalized Med New York NY 10029 USA Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA

The identification of genes that evolve under recessive natural selection is a long-standing goal of population genetics research that has important applications to the discovery of genes associated with disease. We found that commonly used methods to evaluate selective constraint at the gene level are highly sensitive to genes under heterozygous selection but ubiquitously fail to detect recessively evolving genes. Additionally, more sophisticated likelihood-based methods designed to detect recessivity similarly lack power for a human gene of realistic length from current population sample sizes. However, extensive simulations suggested that recessive genes may be detectable in aggregate. Here, we offer a method informed by population genetics simulations designed to detect recessive purifying selection in gene sets. Applying this to empirical gene sets produced significant enrichments for strong recessive selection in genes previously inferred to be under recessive selection in a consanguineous cohort and in genes involved in autosomal recessive monogenic disorders.

关键词： recessive selection genetic dominance recessive human genes mode of inheritance constraint scores inference of selection site frequency spectrum population genetics

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Tetraniliprole risk assessment: Unveiling a hidden threat for managing a generalist herbivore

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ENVIRONMENTAL RESEARCH 2024年 256卷 119273页

作者： Qu, Cheng Li, Yunyi Zhan, Qianyuan Wang, Jinda Luo, Chen Guedes, Raul Narciso C. Wang, Ran Beijing Acad Agr & Forestry Sci Inst Plant Protect Beijing 100097 Peoples R China Beijing Key Lab Environm Friendly Management Fruit Beijing 100097 Peoples R China Fujian Agr & Forestry Univ Natl Engn Res Ctr Sugarcane Fuzhou 350002 Peoples R China Univ Fed Vicosa Dept Entomol BR-36570900 Vicosa MG Brazil

Insecticide resistance poses a significant challenge in managing generalist herbivores such as the tobacco cutworm (TCW), Spodoptera litura. This study investigates the potential risks associated with using the novel diamide insecticide tetraniliprole to control TCW. A tetraniliprole-resistant strain was developed through twelve generations of laboratory selection, indicating an intermediate risk of resistance development. Field monitoring in China revealed a significant incidence of resistance, particularly in the Nanchang (NC) population (>100fold). Tetraniliprole showed moderate to high cross-resistance to multiple insecticides and was autosomally inherited with incomplete dominance, controlled by multiple genes, some of which belong to the cytochrome P450 family associated with enhanced detoxification. Life table studies indicated transgenerational hormesis, stimulating TCW female fecundity and increasing population net reproduction rates (R-0). These findings suggest a potential for pest resurgence under tetraniliprole use. The integrated risk assessment provides a basis for the sustainable management of TCW using tetraniliprole.

关键词： Tobacco cutworm Realized heritability Baseline of susceptibility mode of inheritance Biochemical mechanism Transgenerational hormesis

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Tetraniliprole resistance in field-collected populations of Tuta absoluta (Lepidoptera: Gelechiidae) from China: Baseline susceptibility, cross-resistance, inheritance, and biochemical mechanism

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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 2024年 203卷 106019页

作者： Qu, Cheng Yao, Jiaqi Huang, Jianlei Che, Wunan Fang, Yong Luo, Chen Wang, Ran Beijing Acad Agr & Forestry Sci Inst Plant Protect Beijing 100097 Peoples R China Heilongjiang Univ Dept Plant Protect Harbin 150080 Peoples R China Hebei North Univ Coll Agr & Forestry Technol Zhangjiakou 075000 Peoples R China Shenyang Agr Univ Dept Pesticide Sci Shenyang 110866 Peoples R China Yuelushan Lab Changsha 410128 Peoples R China Hunan Acad Agr Sci Agr Biotechnol Inst Changsha 410125 Peoples R China

Tuta absoluta is one of the most destructive and invasive insect pests throughout the world. It feeds on numerous solanaceous plant species and has developed resistance to most types of popular insecticides. Tetraniliprole is a novel diamide chemical agent that acts as a modulator of the ryanodine receptor. To establish T. absoluta susceptibility to tetraniliprole and to understand potential mechanisms of resistance, we monitored 18 field populations of T. absoluta collected from northern China. One field-evolved resistant population, Huailai (HL), showed moderate resistance to tetraniliprole (36.2-fold) in comparison with susceptible strain YN-S. Assays of cross-resistance, synergism, metabolic enzyme activity, and inheritance of resistance were performed with YN-S strain and HL population. The latter displayed 12.2- and 6.7-fold cross-resistance to chlorantraniliprole and flubendiamide, respectively, but little cross-resistance to broflanilide (1.6-fold), spinosad (2.1-fold), metaflumizone (1.5-fold), or indoxacarb (2.8-fold). Genetic analyses revealed that tetraniliprole resistance in HL population was autosomal, incompletely dominant, and polygenic. Piperonyl butoxide was found to significantly increase tetraniliprole toxicity, and enzymatic activities of P450 monooxygenase and glutathione S-transferase were significantly higher in HL than YN-S population. These results enhance our knowledge of the inheritance and mechanism of tetraniliprole resistance, enabling future optimization of resistance management strategies.

关键词： Tuta absoluta Tetraniliprole Cross -resistance Synergism Metabolic enzyme mode of inheritance

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Morphological variation of tail bone among two chicken breeds and their F1 progeny

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JOURNAL OF MORPHOLOGY 2024年第5期285卷

作者： Nyirimana, Prudence Kondoh, Daisuke Tomiyasu, Jumpei Watanabe, Momoka Okada, Yume Nishida, Yuma Goto, Tatsuhiko Obihiro Univ Agr & Vet Med Dept Life & Food Sci Obihiro Japan Obihiro Univ Agr & Vet Med Dept Vet Med Obihiro Japan Obihiro Univ Agr & Vet Med Res Ctr Global Agromed Obihiro Hokkaido 0808555 Japan

Fancy breeds of Japanese indigenous chicken display extensive morphological diversity, particularly in tail feathers. Although marked differences in tail and bone traits have been reported between Tosa-jidori (wild type) and Minohikichabo (rich type) breeds, little is known about the pattern of genetic inheritance in cross experiments. Therefore, this study aimed to investigate the strain and sex effects, and inheritance patterns, in the morphometric variation of pygostyle bones among Tosa-jidori, Minohikichabo, and their F-1 hybrids. Five morphological traits, angle of the apex of the pygostyle, pygostyle length, margo cranialis length, tail feather number, and body weight, were evaluated at the adult stage. A significant strain difference was detected in all traits, whereas significant sex differences were observed in only three traits, but not in the angle of the apex of the pygostyle and tail feather number. In F-1 hybrids, the angle of the apex of the pygostyle was significantly different to that of Tosa-jidori but not that of Minohikichabo, whereas the pygostyle length and tail number of F-1 hybrids were significantly different from those of Minohikichabo but not those of Tosa-jidori. A significant heterosis effect was found in the margo cranialis length and body weight. All five traits showed nonadditive inheritance patterns but varied in each trait between partial dominance (angle of the apex of pygostyle), full dominance (pygostyle length and tail feather number), and over-dominance (margo cranialis length and body weight). Interestingly, different patterns of genetic inheritance in the F-1 hybrid were observed at different locations, even within the same pygostyle bone. Using the Japanese indigenous chicken model, these results provide a substantial step toward understanding the genetic architecture of morphology in chickens.

关键词： cross experiment fowl mode of inheritance pygostyle tail morphology

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