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non-coding rna and immune-checkpoint inhibitors: friends or foes?

IMMUNOTHERAPY 2020年第7期12卷 513-530页

作者： Shek, Dmitrii Read, Scott A. Akhuba, Liia Qiao, Liang Gao, Bo Nagrial, Adnan Carlino, Matteo S. Ahlenstiel, Golo Western Sydney Univ Blacktown Clin Sch & Res Ctr Sydney NSW Australia RUDN Univ Accreditat Ctr Moscow Russia Univ Sydney Storr Liver Ctr Westmead Inst Med Res Sydney NSW Australia Univ Sydney Westmead Hosp Sydney NSW Australia Univ Sydney Westmead Clin Sch Sydney NSW Australia Melanoma Inst Australia Sydney NSW Australia Blacktown Hosp Sydney NSW Australia

non-coding rnas (ncrnas) are an abundant component of the human transcriptome. Their biological role, however, remains incompletely understood. Nevertheless, ncrnas are highly associated with cancer development and progression due to their ability to modulate gene expression, protein translation and growth pathways. Immune-checkpoint inhibitors (ICIs) are considered one of the most promising and highly effective therapeutic approaches for cancer treatment. ICIs are monoclonal antibodies targeting immune checkpoints such as CTLA-4, PD-1 and PD-L1 signalling pathways that stimulate T cell cytotoxicity and can result in tumor growth suppression. This Review will summarize existing knowledge regarding ncrnas and their role in cancer and ICI therapy. In addition, we will discuss potential mechanisms by which ncrnas may influence ICI treatment outcomes.

关键词： anticancer monoclonal antibodies cancer immunotherapy CTLA-4 immune-checkpoint inhibitors immune checkpoints long non-coding rna microrna non-coding rna PD-1 PD-L1

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non-coding rna repertoires in malignant pleural mesothelioma

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LUNG CANCER 2015年第3期90卷 417-426页

作者： Quinn, Leah Finn, Stephen P. Cuffe, Sinead Gray, Steven G. Univ Dublin Trinity Coll Dept Clin Med Dublin 2 Ireland Univ Dublin Trinity Coll Dept Surg Dublin 2 Ireland Univ Dublin Trinity Coll MSc Translat Oncol Program Dublin 2 Ireland Univ Dublin Trinity Coll Dept Histopathol & Morbid Anat Dublin 2 Ireland St James Hosp HOPE Directorate Dublin 8 Ireland St James Hosp Inst Mol Med Thorac Oncol Res Grp Dublin 8 Ireland

Malignant pleural mesothelioma (MPM) is a rare malignancy, with extremely poor survival rates. There are limited treatment options, with no second line standard of care for those who fail first line chemotherapy. Recent advances have been made to characterise the underlying molecular mechanisms of mesothelioma, in the hope of providing new targets for therapy. With the discovery that non-coding regions of our DNA are more than mere junk, the field of research into non-coding rnas (ncrnas) has exploded in recent years. non-coding rnas have diverse and important roles in a variety of cellular processes, but are also implicated in malignancy. In the following review, we discuss two types of non-coding rnas, long non-coding rnas and micrornas, in terms of their role in the pathogenesis of MPM and their potential as both biomarkers and as therapeutic targets in this disease. (c) 2015 Elsevier Ireland Ltd. All rights reserved.

关键词： non-coding rna Microrna Long non-coding rna Mesothelioma TargomiR

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non-coding rna as future target for diagnose and treatment of perineural invasion in cancers

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BIOCELL 2024年第6期48卷 923-934页

作者： BINGJIE LI WENBO CAO JINJING XIAO YIXIAO CHEN QIYING WEI MINGJIN YUE SAIJUN MO Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhouChina Collaborative Innovation Center of Henan Province for Cancer Chemoprevention ZhengzhouChina State Key Laboratory of Esophageal Cancer Prevention and Treatment ZhengzhouChina Department of Research and Development Henan Tianxing Education and Media Company LimitedZhengzhouChina

Perineural invasion(PNI),a particularly insidious form of tumor metastasis distinct from hematogenous or lymphatic spread,has the capacity to extend well beyond the primary tumor site,inﬁltrating distant regions devoid of lymphatic or vascular *** often heralds a decrease in patient survival rates and is recognized as an indicator of an unfavorable prognosis across a variety of *** its clinical signiﬁcance,the underlying molecular mechanisms of PNI remain elusive,complicating the development of speciﬁc and efﬁcacious diagnostic and therapeutic *** the realm of cancer research,non-coding rnas(ncrnas)have attracted considerable attention due to their multifaceted roles and cancer-speciﬁc expression proﬁles,positioning them as promising candidates for applications in cancer diagnostics,prognostics,and *** the various types of ncrnas,micrornas(mirnas),long non-coding rnas(lncrnas),and circular rnas(circrnas)have emerged as inﬂuential players in *** involvement is increasingly recognized as a contributing factor to tumor progression and therapeutic *** study synthesizes and explores the diverse functions and mechanisms of ncrnas in relation to PNI in *** comprehensive review aims to shed light on cutting-edge perspectives that could pave the way for innovative diagnostic and therapeutic approaches to address the challenges posed by PNI in oncology.

关键词： Perineural invasion non-coding rna Diagnose and treatment Cancer Biomarker

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non-coding rna Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice

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NEUROSCIENCE RESEARCH 2019年第0期147卷 58-63页

作者： Park, Hongsun Miyazaki, Haruko Yamanaka, Tomoyuki Nukina, Nobuyuki Doshisha Univ Lab Struct Neuropathol Grad Sch Brain Sci 1-3 Miyakodanitatara Kyotanabe Kyoto 6100394 Japan

Huntington Disease (HD) is a neurodegenerative disorder caused by expanded CAG repeats in the exon1 of huntingtin gene (HTT). The mutant HTT affects the transcriptional profile of neurons by disrupting the activities of transcriptional machinery and alters expression of many genes. In this study, we identified dysregulated non-coding rnas (ncrnas) in medium spiny neurons of 4-week-old HD model mouse. Also, we observed the intracellular localizations of Abhd11os and Neat1 ncrnas by Viewrna in situ hybridization, which could provide more precise detection, suggesting that it is a useful method to investigate the expression changes of genes with low expression levels. (C) 2018 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.

关键词： Gene expression non-coding rna Huntington disease Abhd11os Neat1 Viewrna in situ hybridization Microarray

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non-coding rna and antisense rna. Nature's trash or treasure?

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BIOCHIMIE 2011年第11期93卷 1922-1927页

作者： Knowling, Stuart Morris, Kevin V. Scripps Res Inst Dept Mol & Expt Med La Jolla CA 92037 USA

Although control of cellular function has classically been considered the responsibility of proteins, research over the last decade has elucidated many roles for rna in regulation of not only the proteins that control cellular functions but also for the cellular functions themselves. In parallel to this advancement in knowledge about the regulatory roles of rna there has been an explosion of knowledge about the role that epigenetics plays in controlling not only long-term cellular fate but also the short-term regulatory control of genes. Of particular interest is the crossover between these two worlds, a world where rna can act out its part and subsequently elicit chromatin modifications that alter cellular function. Two main categories of rna are examined here, non-coding rna and antisense rna both of which perform vital functions in controlling numerous genes, proteins and rna itself. As the activities of non-coding and antisense rna in both normal and aberrant cellular function are elucidated, so does the number of possible targets for pharmacopeic intervention. (C) 2011 Elsevier Masson SAS. All rights reserved.

关键词： Antisense rna non-coding rna Epigenetic Transcription Gene silencing

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non-coding rna identification based on topology secondary structure and reading frame in organelle genome level

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GENOMICS 2016年第1期107卷 9-15页

作者： Wu, Cheng-Yan Li, Qian-Zhong Feng, Zhen-Xing Inner Mongolia Univ Lab Theoret Biophys Sch Phys Sci & Technol Hohhot 010021 Peoples R China

non-coding rna (ncrna) genes make transcripts as same as the encoding genes, and ncrnas directly function as rnas rather than serve as blueprints for proteins. As the function of ncrna is closely related to organelle genomes, it is desirable to explore ncrna function by confirming its provenance. In this paper, the topology secondary structure, motif and the triplets under three reading frames are considered as parameters of ncrnas. A method of SVM combining the increment of diversity (ID) algorithm is applied to construct the classifier. When the method is applied to the ncrna dataset less than 80% sequence identity, the overall accuracies reach 95.57%, 96.40% in the five-fold cross-validation and the jackknife test, respectively. Further, for the independent testing dataset, the average prediction success rate of our method achieved 93.24%. The higher predictive success rates indicate that our method is very helpful for distinguishing ncrnas from various organelle genomes. (C) 2015 Elsevier Inc. All rights reserved.

关键词： non-coding rna Spatial structure rna motif Reading frame Increment of diversity

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non-coding rna basis of muscle atrophy

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MOLECULAR THERAPY-NUCLEIC ACIDS 2021年 26卷 1066-1078页

作者： Liu, Qi Deng, Jiali Qiu, Yan Gao, Juan Li, Jin Guan, Longfei Lee, Hangil Zhou, Qiulian Xiao, Junjie Shanghai Univ Sch Med Peoples Hosp Nantong 6 Affiliated Nantong HospInst Geriatr Nantong 226011 Peoples R China Shanghai Univ Shanghai Engn Res Ctr Organ Repair Sch Life Sci Inst Cardiovasc SciCardiac Regenerat & Ageing La Shanghai 200444 Peoples R China Capital Med Univ Beijing Luhe Hosp China Amer Inst Neurosci Beijing 101149 Peoples R China Wayne State Univ Dept Neurosurg Sch Med Detroit MI 48201 USA

Muscle atrophy is a common complication of many chronic healthy habits and usage of hormones such as dexamethasone can also lead to muscle atrophy. However, the underlying mechanisms of muscle atrophy are not completely understood. non-coding rnas (ncrnas), such as micrornas (mirnas), long ncrnas (lncrnas), and circular rnas (circrnas), play vital roles in muscle atrophy. This review mainly discusses the regulation of ncrnas in muscle atrophy induced by various factors such as heart failure, cancer cachexia, aging, chronic obstructive pulmonary disease (COPD), peripheral nerve and usage of hormones;highlights the findings of ncrnas as common regulators in multiple types of muscle atrophy;and summarizes current therapies and underlying mechanisms for muscle atrophy. This review will deepen the understanding of skeletal muscle biology and provide new strategies and insights into gene therapy for muscle atrophy.

关键词： muscle atrophy heart failure aging non-coding rna microrna lncrna

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non-coding rna therapeutics in the treatment of heart failure

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EUROPEAN HEART JOUrnaL-CARDIOVASCULAR PHARMACOTHERAPY 2024年第4期10卷 353-360页

作者： Paterek, Aleksandra Zaleska-Kociecka, Marta Surzykiewicz, Mateusz Wojdynska, Zuzanna Leszek, Przemyslaw Maczewski, Michal Ctr Postgrad Med Educ Dept Clin Physiol Marymoncka 99-103 PL-01813 Warsaw Poland Natl Inst Cardiol Heart Failure & Transplantol Dept Mech Circulatory Support & Transplant Dept Alpejska 42 PL-04628 Warsaw Poland

non-coding rna (ncrna) therapeutics can target either ncrnas or conventional messenger rna, offering both superior pharmacokinetics and selectivity to conventional therapies and addressing new, previously unexplored pathways. Although no ncrna has yet been approved for the treatment of heart failure, in this review we present five most promising pathways and agents that either are in human clinical trials or offer great promise in the near future.

关键词： non-coding rna Heart failure Therapy Heart failure with reduced ejection fraction Microrna

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non-coding rna-Mediated Gene Regulation in Cardiovascular Disorders: Current Insights and Future Directions

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JOUrnaL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH 2024年第4期17卷 739-767页

作者： Abubakar, Muhammad Hajjaj, Mohsin Naqvi, Zil e Zehra Shanawaz, Hameed Naeem, Ammara Padakanti, Suraj Sai Nikhil Bellitieri, Christopher Ramar, Rajasekar Gandhi, Fenil Saleem, Ayesha Abdul Khader, Abul Hasan Shadali Faraz, Muhammad Ahmad Lahore Gen Hosp Ameer Ud Din Med Coll Dept Internal Med Lahore Punjab Pakistan Jinnah Hosp Dept Internal Med Lahore Punjab Pakistan Windsor Univ Sch Med Dept Internal Med Cayon St Kitts & Nevi Heart & Vasc Inst Dept Cardiol Dearborn MI USA MS Ramaiah Med Coll & Hosp Dept Internal Med Bengaluru Karnataka India Lower Bucks Hosp Dept Family Med Bristol PA USA Rajah Muthiah Med Coll Dept Internal Med Chidambaram Tamil Nadu India Govt Kilpauk Med Coll & Hosp Dept Internal Med Chennai Tamil Nadu India Postgrad Med Inst Dept Forens Med Lahore Punjab Pakistan

Cardiovascular diseases (CVDs) pose a significant burden on global health. Developing effective diagnostic, therapeutic, and prognostic indicators for CVDs is critical. This narrative review explores the role of select non-coding rnas (ncrnas) and provides an in-depth exploration of the roles of mirnas, lncrnas, and circrnas in different aspects of CVDs, offering insights into their mechanisms and potential clinical implications. The review also sheds light on the diverse functions of ncrnas, including their modulation of gene expression, epigenetic modifications, and signaling pathways. It comprehensively analyzes the interplay between ncrnas and cardiovascular health, paving the way for potential novel interventions. Finally, the review provides insights into the methodologies used to investigate ncrna-mediated gene regulation in CVDs, as well as the implications and challenges associated with translating ncrna research into clinical applications. Considering the broader implications, this research opens avenues for interdisciplinary collaborations, enhancing our understanding of CVDs across scientific disciplines.

关键词： non-coding rna mirna lncrna circrnas Cardiac hypertrophy Cardiac fibrosis Atherosclerosis Diagnostic indicator Prognostic indicator Targeted molecular therapy

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non-coding rna Molecules Connect Calorie Restriction and Lifespan

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JOUrnaL OF MOLECULAR BIOLOGY 2017年第21期429卷 3196-3214页

作者： Abraham, Karan J. Ostrowski, Lauren A. Mekhail, Karim Univ Toronto Fac Med Dept Lab Med & Pathobiol 1 Kings Coll Circle Toronto ON M5S 1A8 Canada Univ Toronto Fac Med Canada Res Chairs Program 1 Kings Coll Circle Toronto ON M5S 1A8 Canada

Calorie restriction (CR) is a broadly effective environmental intervention that extends life by operating through numerous biological processes. Here, we discuss how non-coding rna (ncrna) molecules act as mediators and targets of lifespan-extending CR. We also highlight how these rna molecules connect CR to its effects on genome stability, cell metabolism, programmed cell death, senescence, cancer, and neurodegeneration. We anticipate that an advanced understanding of the connections between CR and non-coding rna will provide unique insights into aging mechanisms while pointing to novel approaches aimed at modulating aging and age-related diseases. (C) 2016 Elsevier Ltd. All rights reserved.

关键词： aging calorie restriction non-coding rna human disease

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