Eukaryotic transcriptome analyses have revealed the presence of a huge number of mrna-type non-codingrnas (ncrnas). Expression of them is often developmentally regulated, but little is known about their function. We ...
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Eukaryotic transcriptome analyses have revealed the presence of a huge number of mrna-type non-codingrnas (ncrnas). Expression of them is often developmentally regulated, but little is known about their function. We have recently demonstrated that cascade of rna polymerase II (rnaPII)-mediated transcription initiation of such mrna-type long ncrnas (mlonrna) results in stepwise disruption of local chromatin structure at the fission yeast Schizosaccharomyces pombe fbp1(+) locus during transcriptional activation upon glucose derepression. Similar transition of rna transcripts coupled with local chromatin alteration is observed meiotically in the fission yeast recombination hotspot ade6-M26. Here, we hypothesize that rnaPII transcription of mlonrnas disrupts chromatin array. This idea may provide a new clue to understand why so many species of ncrnas are expressed in eukaryotic cells.
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