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检索条件"主题词=Non-coding RNA"
2883 条 记 录,以下是1881-1890 订阅
排序:
MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patients
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BRITISH JOUrnaL OF CANCER 2014年 第6期110卷 1614-1621页
作者: Pichler, M. Ress, A. L. Winter, E. Stiegelbauer, V. Karbiener, M. Schwarzenbacher, D. Scheideler, M. Ivan, C. Jahn, S. W. Kiesslich, T. Gerger, A. Bauernhofer, T. Calin, G. A. Hoefler, G. Med Univ Graz MUG Dept Internal Med Div Oncol Graz Austria Univ Texas MD Anderson Canc Ctr Dept Expt Therapeut Houston TX 77030 USA Med Univ Graz MUG Inst Pathol Graz Austria Graz Univ Technol Inst Genom & Bioinformat RNA Biol Grp A-8010 Graz Austria Paracelsus Med Univ Salzburger Landeskliniken SALK Dept Internal Med 1 Salzburg Austria Paracelsus Med Univ Inst Physiol & Pathophysiol Salzburg Austria
Background: Micrornas (mirnas) regulate the biological properties of colorectal cancer (CRC) cells and might serve as potential prognostic factors and therapeutic targets. In this study, we therefore globally profiled... 详细信息
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Characterisation of novel micrornas in the Black flying fox (Pteropus alecto) by deep sequencing
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BMC GENOMICS 2014年 第1期15卷 1-13页
作者: Cowled, Christopher Stewart, Cameron R. Likic, Vladimir A. Friedlaender, Marc R. Tachedjian, Mary Jenkins, Kristie A. Tizard, Mark L. Cottee, Pauline Marsh, Glenn A. Zhou, Peng Baker, Michelle L. Bean, Andrew G. Wang, Lin-fa CSIRO Australian Anim Hlth Lab Geelong Vic 3220 Australia Bio21 Mol Sci & Biotechnol Inst Melbourne Australia Ctr Genom Regulat CRG Barcelona Spain Univ Pompeu Fabra UPF Barcelona Spain Duke NUS Grad Med Sch Program Emerging Infect Dis Singapore 169857 Singapore
Background: Bats are a major source of new and emerging viral diseases. Despite the fact that bats carry and shed highly pathogenic viruses including Ebola, Nipah and SARS, they rarely display clinical symptoms of inf... 详细信息
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Oligonucleotide Analogues as Modulators of the Expression and Function of noncoding rnas (ncrnas): Emerging Therapeutics Applications
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JOUrnaL OF MEDICINAL CHEMISTRY 2014年 第24期57卷 10220-10240页
作者: Avitabile, Concetta Cimmino, Amelia Romanelli, Alessandra Univ Naples Federico II Dipartimento Farm I-80134 Naples Italy CNR Ist Genet & Biofis Adriano Buzzati Traverso I-80131 Naples Italy Ist Ricovero & Cura Carattere Sci SDN IRCC I-80142 Naples Italy
ncrnas are emerging as key regulators of physiological and pathological processes and therefore have been identified as pharmacological targets and as markers for some diseases. Oligonucleotide analogues represent so ... 详细信息
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The Long noncoding rnas NEAT1 and MALAT1 Bind Active Chromatin Sites
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MOLECULAR CELL 2014年 第5期55卷 791-802页
作者: West, Jason A. Davis, Christopher P. Sunwoo, Hongjae Simon, Matthew D. Sadreyev, Ruslan I. Wang, Peggy I. Tolstorukov, Michael Y. Kingston, Robert E. Massachusetts Gen Hosp Dept Mol Biol Boston MA 02114 USA Harvard Univ Sch Med Dept Genet Boston MA 02115 USA Massachusetts Gen Hosp Dept Pathol Boston MA 02114 USA Harvard Univ Sch Med Boston MA 02114 USA
Mechanistic roles for many lncrnas are poorly understood, in part because their direct interactions with genomic loci and proteins are difficult to assess. Using a method to purify endogenous rnas and their associated... 详细信息
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Restitution of gene expression and histone acetylation signatures altered by hepatitis B virus through antiviral microrna-like molecules in nontransformed murine hepatocytes
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CLINICAL EPIGENETICS 2014年 第1期6卷 1-15页
作者: Jenke, Andreas C. W. Hensel, Kai O. Klein, Andreas Willuhn, Lisa Prax, Susanna Weil, Patrick P. Winkler, Theodor Deba, Timo Orth, Valerie Baiker, Armin Wirth, Stefan Postberg, Jan Univ Witten Herdecke Ctr Biomed Educ & Res ZBAF Fac HlthDept Paediat Ctr Clin & Translat Res CCTRHELIOS Med Ctr Wuppe D-42283 Wuppertal Germany Bavarian Hlth & Food Safety Author D-85764 Oberschleissheim Germany
Background: Virus-host interactions result in altered gene expression profiles in host cell nuclei and enable virus particle production, thus obligatorily involving changes in their epigenomes. Neither such epigenome ... 详细信息
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Mammary-Specific Gene Activation Is Defined by Progressive Recruitment of STAT5 during Pregnancy and the Establishment of H3K4me3 Marks
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MOLECULAR AND CELLULAR BIOLOGY 2014年 第3期34卷 464-473页
作者: Kang, Keunsoo Yamaji, Daisuke Yoo, Kyung Hyun Robinson, Gertraud W. Hennighausen, Lothar NIDDK Lab Genet & Physiol NIH Bethesda MD 20892 USA
Differentiation of mammary secretory epithelium during pregnancy is characterized by sequential activation of genes over several orders of magnitude. Although the transcription factor STAT5 is key to alveolar developm... 详细信息
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Global signatures of protein binding on structured rnas in Saccharomyces cerevisiae
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Science China(Life Sciences) 2014年 第1期57卷 22-35页
作者: YANG YuCheng UMETSU Jumpei LU Zhi John MOE Key Lab of Bioinformatics School of Life Sciences Tsinghua University Department of Biological Information Tokyo Institute of TechnologyTokyo 152-8850 Japan
Protein binding is essential to the transport,decay and regulation of almost all rna ***,the structural preference of protein binding on rnas and their cellular functions and dynamics upon changing environmental condi... 详细信息
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PREPARING THE NEXT GENERATION OF ACADEMIC CHIEF NURSE ADMINISTRATORS
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JOUrnaL OF PROFESSIONAL NURSING 2014年 第4期30卷 279-280页
作者: Morton, Patricia Gonce Univ Utah Salt Lake City UT 84112 USA
The non-coding rna (ncrna) elements in the 3′ Untranslated Regions (3′-UTRs) are known to participate in the genes' post-transcriptional regulations. Inferring co-expression patterns of the genes through cluster... 详细信息
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Mammalian Epigenetic Mechanisms
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IUBMB LIFE 2014年 第4期66卷 240-256页
作者: Zhang, Guoqiang Pradhan, Sriharsa New England Biolabs Inc Ipswich MA USA
The mammalian genome is packaged into chromatin that is further compacted into three-dimensional structures consisting of distinct functional domains. The higher order structure of chromatin is in part dictated by enz... 详细信息
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miR-888 is an expressed prostatic secretions-derived microrna that promotes prostate cell growth and migration
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CELL CYCLE 2014年 第2期13卷 227-239页
作者: Lewis, Holly Lance, Raymond Troyer, Dean Beydoun, Hind Hadley, Melissa Orians, Joseph Benzine, Tiffany Madric, Kenya Semmes, O. John Drake, Richard Esquela-Kerscher, Aurora Eastern Virginia Med Sch Dept Microbiol & Mol Cell Biol Leroy T Canoles Jr Canc Res Ctr Norfolk VA 23501 USA Eastern Virginia Med Sch Dept Urol Norfolk VA 23501 USA Urol Virginia Norfolk VA USA Eastern Virginia Med Sch Grad Program Publ Hlth Norfolk VA 23501 USA
micrornas (mirnas) are a growing class of small non-coding rnas that exhibit widespread dysregulation in prostate cancer. We profiled mirna expression in syngeneic human prostate cancer cell lines that differed in the... 详细信息
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