检索结果-内蒙古大学图书馆

non-coding rna profiling of the developing murine lens

EXPERIMENTAL EYE RESEARCH 2016年 145卷 347-351页

作者： Khan, Shahid Y. Hackett, Sean F. Riazuddin, S. Amer Johns Hopkins Univ Sch Med Wilmer Eye Inst 600 N Wolfe StMaumenee 840 Baltimore MD 21287 USA

non-coding rnas (ncrnas) are emerging as an important player in the regulation of genome integrity and gene expression, and they have been implicated in the pathogenesis of many diseases. The aim of the present study is to identify the repertoire of ncrnas expressed in the developing mouse lens. We previously reported the mouse lens transcriptome, including mrna and microrna (mirna) profiling at two embryonic (E15 and E18) and four postnatal (P0, P3, P6, and P9) time points. We analyzed the data from small rna-Seq and mrna-Seq libraries to investigate the ncrna profile. Our analysis revealed expression of 12 different classes of ncrna in the murine lens at six developmental time points. Annotation of small rna data showed expression of 1,756 antisense ncrna (asncrna) in the mouse lens transcriptome. Likewise, we identified 82 P-element-induced wimpy testis (PIWI)-interacting rna (pirna), 345 transfer rna (trna), 12 small nuclear rna (snrna), 167 small nucleolar rna (snorna), 19 small Cajal body specific rna (scarna), six ribosomal rna (rrna), 18 trna-like structures, one MALAT1-associated small cytoplasmic rna (mascrna), one Vault rna (vtrna), and one Y rna expressed in the developing mouse lens. In parallel, bioinformatic investigation of mrna-Seq data identified expression of 1,952 long intergenic ncrna (lincrna) in the developing mouse lens. In conclusion, we report a comprehensive ncrna profile in the murine lens at six developmental time points. To the best of our knowledge, this is first report investigating different classes of ncrnas in the developing mouse lens and will be monumental in elucidating processes essential for the development of the ocular lens and the maintenance of its transparency. (C) 2016 Elsevier Ltd. All rights reserved.

关键词： non-coding rna rna-Seq Developing mouse lens Transcriptome

来源：评论

学校读者我要写书评

暂无评论

non-coding rna influences in dementia

引用

non-coding rna Research 2018年第4期3卷 188-194页

作者： Ayers, Duncan Scerri, Charles Centre for Molecular Medicine and Biobanking University of Malta Msida MSD 2080 Malta Faculty of Biology Medicine and Health Sciences The University of Manchester Manchester M13 9PL United Kingdom Dept. of Pathology Faculty of Medicine and Surgery University of Malta Msida MSD 2080 Malta

Dementia is a complex clinical syndrome characterised by progressive decline in cognitive function. It usually presents itself as impairment in memory, loss of judgement, abstract thinking and other disturbances that are severe enough to interfere with activities of daily living. It has long been considered as one of the major challenges at present posing an ever-increasing demand on global health and social care systems. Of all the different forms of dementia, Alzheimer's disease (AD) is the most common. The term non-coding rna (ncrna) refers to rna sequences which do not have the ability to be translated into proteins and therefore mainly fall within the realm of the recently acknowledged ‘dark matter’ of the genome. This genomic dark matter encompasses a whole spectrum of differing ncrna families such as micrornas (mirnas), long non-coding rnas (lncrnas), PIWI-interacting rnas (pirnas), transfer rnas (trnas), small nuclear rnas (snornas) and circular rnas (circrnas), to name but a few. Consequently, due to the widespread influences of mirnas and lncrnas across all disease pathways, it is of critical importance for researchers in the field of dementia to focus their attention on possible ncrna-induced pathogeneses, with the ultimate goal of identifying novel diagnostic procedures and drug targets, together with the development of novel therapies to control such a devastating mental condition in the patient population. © 2018

关键词： Dementia lncrna microrna mirna ncrna non-coding rna

来源：评论

学校读者我要写书评

暂无评论

non-coding rna A bridge between small rna and DNA

引用

rna BIOLOGY 2009年第2期6卷 138-140页

作者： Kurth, Henriette M. Mochizuki, Kazufumi Austrian Acad Sci Inst Mol Biotechnol IMBA A-1030 Vienna Austria

Small rnas are not only involved in post-transcriptional gene silencing in the cytoplasm, but also modulate activities of the nuclear genome. Although silencing of mrnas involves rna-rna base-pairing, it remains unclear whether the rnai machinery responsible for chromatin or DNA modification interacts with DNA or rna. The identification of an rna helicase required for chromatin-Argonaute protein interaction as well as the presence of Argonaute-associated long non-coding transcripts in Tetrahymena suggest the presence of rna-rna interactions prior to small rna-induced heterochromatin formation in ciliates.

关键词： non-coding rna small rna DNA elimination Tetrahymena Argonaute

来源：评论

学校读者我要写书评

暂无评论

non-coding rna: It's Not Junk (vol 62, pg 1107, 2017)

引用

DIGESTIVE DISEASES AND SCIENCES 2017年第11期62卷 3260-3260页

作者： Boland, C. R. UCSD Sch Med GI Div Gilman Dr San Diego CA 92093 USA

来源：评论

学校读者我要写书评

暂无评论

non-coding rna Analysis Using the Rfam Database

引用

Current Protocols in Bioinformatics 2018年第1期62卷 e51-e51页

作者： Kalvari, Ioanna Nawrocki, Eric P. Argasinska, Joanna Quinones-Olvera, Natalia Finn, Robert D. Bateman, Alex Petrov, Anton I. European Molecular Biology Laboratory European Bioinformatics Institute Wellcome Genome Campus Hinxton Cambridge United Kingdom National Center for Biotechnology Information National Institutes of Health Department of Health and Human Services Bethesda MD United States Systems Biology Graduate Program Harvard University Cambridge MA United States

Rfam is a database of non-coding rna families in which each family is represented by a multiple sequence alignment, a consensus secondary structure, and a covariance model. Using a combination of manual and literature-based curation and a custom software pipeline, Rfam converts descriptions of rna families found in the scientific literature into computational models that can be used to annotate rnas belonging to those families in any DNA or rna sequence. Valuable research outputs that are often locked up in figures and supplementary information files are encapsulated in Rfam entries and made accessible through the Rfam Web site. The data produced by Rfam have a broad application, from genome annotation to providing training sets for algorithm development. This article gives an overview of how to search and navigate the Rfam Web site, and how to annotate sequences with rna families. The Rfam database is freely available at http://***. © 2018 by John Wiley & Sons, Inc. Copyright © 2018 John Wiley & Sons, Inc.

关键词： genome annotation Infernal non-coding rna Rfam rna family

来源：评论

学校读者我要写书评

暂无评论

non-coding rna in C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia: A perfect storm of dysfunction

引用

non-coding rna Research 2018年第4期3卷 178-187页

作者： Douglas, Andrew G.L. Wessex Clinical Genetics Service University Hospital Southampton NHS Foundation Trust Southampton United Kingdom Human Development and Health Faculty of Medicine University of Southampton Southampton United Kingdom

A hexanucleotide repeat expansion in the first intron/promoter region of C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both sense and antisense transcripts exist at the C9orf72 locus but the function of the antisense lncrna is unknown. rna toxicity of the transcribed repeat expansion has been implicated in the pathogenesis of C9orf72-related ALS/FTD, not only through direct sequestration of important rna binding proteins but also indirectly through non-ATG dependent translation into dipeptide repeats. Formation of rna/DNA hybrid R-loops may also play a key role in the pathogenesis of this condition and this mechanism could provide a link between the repeat expansion, DNA damage, repeat instability and deficiency of rna binding proteins. non-coding C9orf72 antisense transcripts could also act to epigenetically regulate gene expression at the locus. The potential effects of such non-coding rnas should be considered in the design of antisense oligonucleotide therapeutics for C9orf72-related ALS/FTD. Furthermore, the mechanisms of rna dysregulation exemplified by C9orf72-related disease may help illustrate more broadly how a “perfect storm” of dysfunction occurs in ALS/FTD and how targeting these factors could lead to corrective or preventative therapies. © 2018

关键词： ALS Amyotrophic lateral sclerosis C9orf72 Frontotemporal dementia FTD non-coding rna

来源：评论

学校读者我要写书评

暂无评论

SCancerrna:Expression at the Single-cell Level and Interaction Resource of non-coding rna Biomarkers for Cancers

引用

Genomics, Proteomics & Bioinformatics 2024年第3期22卷 125-131页

作者： Hongzhe Guo Liyuan Zhang Xinran Cui Liang Cheng Tianyi Zhao Yadong Wang Faculty of Computing Harbin Institute of TechnologyHarbin 150001China College of Bioinformatics Science and Technology Harbin Medical UniversityHarbin 150001China School of Medicine and Health Harbin Institute of TechnologyHarbin 150001China

non-coding rnas(ncrnas)participate in multiple biological processes associated with cancers as tumor suppressors or oncogenic *** to their high stability in plasma,urine,and many other fluids,ncrnas have the potential to serve as key biomarkers for early diagnosis and screening of *** cancer progression,tumor heterogeneity plays a crucial role,and it is particularly important to understand the gene expression patterns of individual *** the development of single-cell rna sequencing(scrna-seq)technologies,uncovering gene expression in different cell types for human cancers has become feasible by profiling transcriptomes at the cellular ***,a well-organized and comprehensive online resource that provides access to the expression of genes corresponding to ncrna biomarkers in different cell types at the single-cell level is not available ***,we developed the SCancerrna database to summarize experimentally supported data on long ncrna,microrna,PIWI-interacting rna,small nucleolar rna,and circular rna biomarkers,as well as data on their differential expression at the cellular ***,we collected biological functions and clinical applications of biomarkers to facilitate the application of ncrna biomarkers to cancer diagnosis,as well as the monitoring of progression and targeted *** also allows users to explore interaction networks of different types of ncrnas,and build computational models in the *** is freely accessible at http://***/BioMarker.

关键词： non-coding rna Biomarker Cancer Single cell Interaction network

来源：评论

学校读者我要写书评

暂无评论

non-coding rna polymerases that silence transposable elements and reprogram gene expression in plants

引用

TRANSCRIPTION-AUSTIN 2020年第3-4期11卷 172-191页

作者： Rymen, Bart Ferrafiat, Laura Blevins, Todd Univ Strasbourg Inst Biol Mol Plantes Strasbourg France

Multisubunit rna polymerase (Pol) complexes are the core machinery for gene expression in eukaryotes. The enzymes Pol I, Pol II and Pol III transcribe distinct subsets of nuclear genes. This family of nuclear rna polymerases expanded in terrestrial plants by the duplication of Pol II subunit genes. Two Pol II-related enzymes, Pol IV and Pol V, are highly specialized in the production of regulatory, non-coding rnas. Pol IV and Pol V are the central players of rna-directed DNA methylation (RdDM), an rna interference pathway that represses transposable elements (TEs) and selected genes. Genetic and biochemical analyses of Pol IV/V subunits are now revealing how these enzymes evolved from ancestral Pol II to sustain non-coding rna biogenesis in silent chromatin. Intriguingly, Pol IV-RdDM regulates genes that influence flowering time, reproductive development, stress responses and plant-pathogen interactions. Pol IV target genes vary among closely related taxa, indicating that these regulatory circuits are often species-specific. Data from crops like maize, rice, tomato and Brassica rapa suggest that dynamic repositioning of TEs, accompanied by Pol IV targeting to TE-proximal genes, leads to the reprogramming of plant gene expression over short evolutionary timescales.

关键词： rna polymerase IV (Pol IV) non-coding rna rna-directed DNA Methylation transposable elements plant gene regulation

来源：评论

学校读者我要写书评

暂无评论

non-coding rna and drug resistance in head and neck cancer

引用

Cancer Drug Resistance 2024年第1期7卷 419-438页

作者： Yulong Zhang Yingming Peng Bingqin Lin Shuai Yang Feiqiang Deng Xuan Yang An Li Wanyi Xia Chenxi Gao Shaona Lei Wei Liao Qi Zeng Cancer Center The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000GuangdongChina Key Laboratory of Traditional Chinese Medicine for the Prevention and Treatment of Infectious Diseases Traditional Chinese Medicine Bureau of Guangdong Provincethe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000GuangdongChina Department of Radiotherapy and Minimally Invasive Surgery Cancer CenterThe Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000GuangdongChina Department of Otolaryngology and Head and Neck Surgery The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000GuangdongChina

Head and neck cancer(HNC)is ranked as the sixth most common malignant tumor,and the overall survival rate with current treatment options remains concerning,primarily due to drug resistance that develops following antitumor *** studies indicate that non-coding rnas play a crucial role in drug resistance among HNC *** article systematically reviews the current research landscape,explores novel targets and treatment strategies related to non-coding rnas and HNC resistance,raises some unresolved issues,and discusses five promising research directions in this field:ferroptosis,nanomedicine,exosomes,proteolysis-targeting chimeras(PROTACs),and artificial *** hope that our work will contribute to advancing research on overcoming HNC resistance through the regulation of non-coding rnas.

关键词： Head and neck cancer non-coding rna microrna long non-coding rna circular rna drug resistance

来源：评论

学校读者我要写书评

暂无评论

Prediction of small non-coding rna in bacterial genomes using support vector machines

引用

EXPERT SYSTEMS WITH APPLICATIONS 2010年第8期37卷 5549-5557页

作者： Chang, Tzu-Hao Wu, Li-Ching Lin, Jun-Hong Huang, Hsien-Da Liu, Baw-Jhiune Cheng, Kuang-Fu Horng, Jorng-Tzong Natl Cent Univ Dept Comp Sci & Informat Engn Chungli Taiwan Natl Cent Univ Inst Syst Biol & Bioinformat Chungli Taiwan Natl Chiao Tung Univ Inst Bioinformat Dept Biol Sci & Technol Hsinchu Taiwan Yuan Ze Univ Dept Comp Sci & Informat Engn Chungli Taiwan China Med Univ Grad Inst Stat Shenyang Peoples R China China Med Univ Dept Publ Hlth Shenyang Peoples R China China Med Univ Ctr Biostat Shenyang Peoples R China Asia Univ Dept Bioinformat Taichung Taiwan

Small non-coding rna genes have been shown to play important regulatory roles in a variety of cellular processes, but prediction of non-coding rna genes is a great challenge, using either an experimental or a computational approach, due to the characteristics of srnas, which are that srnas are small in size, are not translated into proteins and show variable stability. Most known srnas have been identified in Escherichia coli and have been shown to be conserved in closely related organisms. We have developed an integrative approach that searches highly conserved intergenic regions among related bacterial genomes for combinations of characteristics that have been extracted from known E. coli srna genes. Support vector machines (SVM) were then used with these characteristics to predict novel srna genes. (c) 2010 Elsevier Ltd. All rights reserved.

关键词： Expert systems Support vector machines Machine learning Bioinformatics non-coding rna

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：