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Lncrna81246 regulates resistance against tea leaf spot by interrupting the miR164d-mediated degradation of NAC1

PLANT JOUrnaL 2025年第1期121卷 e17173页

作者： Guo, Di Li, Dongxue Liu, Fenghua Ma, Yue Zhou, Jing-Jiang Sheth, Sujitraj Song, Baoan Chen, Zhuo Guizhou Univ State Key Lab Green Pesticide Key Lab Green Pesticide & Agr Bioengn Minist Educ Guiyang 550025 Guizhou Peoples R China Guizhou Univ Coll Tea Sci Guiyang 550025 Guizhou Peoples R China Guizhou Univ Coll Agr Guiyang 550025 Guizhou Peoples R China Univ Cambridge Med Res Council Mitochondrial Biol Unit Cambridge CB2 0XY England

Non-coding rnas play crucial roles in plant responses to viral stresses. However, their molecular mechanisms in tea leaf spot responses remain unclear. In this study, using Camellia sinensis, we identified lncrna81246 as a long non-coding rna that localizes to both the nucleus and cytoplasm. It functions as a competitive endogenous rna, thereby disrupting CsNAC1 (encoding NAC domain-containing protein 1) degradation mediated by miR164d. Silencing lncrna81246 increased the resistance of tea plants to presistanceathogens, whereas transient lncrna81246-overexpression plants showed decreased resistance to pathogens. Co-expression assays in Nicotiana benthamiana revealed that lncrna81246 affects the miR164d-CsNAC1 regulatory module. Transient miR164d-overexpression and silencing assays demonstrated its positive regulation of tea plant resistance. Specifically, silencing its target, CsNAC1,enhanced disease resistance, whereas transient overexpression reduced plant resistance. Yeast one-hybrid, dual-luciferase, and RT-qPCR assay results suggested that CsNAC1 alters the expression of CsEXLB1, whereas AsODN and tobacco transient overexpression assays showed that CsEXLB1 negatively regulated tea plant resistance. Thus, our research demonstrated that lncrna81246 acts as a mediator to interfere with the miR164d-CsNAC1 regulatory module involved in the disease resistance of tea plants.

关键词： noncoding rna cerna CsNAC1 tea leaf spot disease resistance miR164 long noncoding rna microrna

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noncoding rnas: A Story of Networks and Long-Distance Relationships

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JOUrnaL OF MOLECULAR BIOLOGY 2013年第19期425卷 3577-3581页

作者： Ostankovitch, Marina Pyle, Anna Marie Journal Mol Biol Cambridge MA 02139 USA Yale Univ Dept Mol Cellular & Dev Biol New Haven CT 06520 USA Yale Univ Dept Chem New Haven CT 06520 USA

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noncoding rnas in development and teratology, with focus on effects of cannabis, cocaine, nicotine, and ethanol

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BIRTH DEFECTS RESEARCH 2019年第17期111卷 1308-1319页

作者： Pinson, Marisa R. Miranda, Rajesh C. Texas A&M Hlth Sci Ctr Dept Neurosci & Expt Therapeut 8447 Riverside Pkwy Suite 1005 MREB Bryan TX 77807 USA

Completion of the Human Genome Project has led to the identification of a large number of transcription start sites that are not paired with protein-coding genes, supporting the growing recognition of the abundance of encoded nonprotein-coding rnas (ncrnas) and their importance for speciation and species-specific development. Present in both plants and animals, ncrnas vary in size, function, primary sequence, and secondary structure. While micrornas (mirnas) are the best known, there are a number of other ncrnas (long[er] nonprotein-coding rna, pseudogenes, circular rnas, and so on) that have been shown to play an important role in the development either directly or via networks of proteins and other ncrnas, including modulating the impact of mirnas. Furthermore, these ncrnas and their developmental regulatory networks are sensitive to teratogens such as ethanol, cannabis, cocaine, and nicotine. A better understanding of the developmental role of ncrnas and their capacity to mediate teratogenesis is a necessary step in efforts to minimize the long-term consequences of developmental exposures to drugs-of-abuse. Moreover, with increasing awareness of the prevalence of polydrug use, experimental models will need to incorporate more complex drug exposure paradigms into meaningful assessments of developmental ncrna function.

关键词： drugs of abuse embryo fetus microrna noncoding rna polydrug use transcriptome

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noncoding rnas as Promising Diagnostic Biomarkers and Therapeutic Targets in Intestinal Fibrosis of Crohn's Disease: The Path From Bench to Bedside

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INFLAMMATORY BOWEL DISEASES 2021年第7期27卷 971-982页

作者： Zhou, Long-Yuan Lin, Si-Nan Rieder, Florian Chen, Min-Hu Zhang, Sheng-Hong Mao, Ren Sun Yat Sen Univ Affiliated Hosp 1 Dept Gastroenterol 58 Zhongshan Rd 2nd Guangzhou 510080 Peoples R China Cleveland Clin Digest Dis & Surg Inst Dept Gastroenterol Hepatol & Nutr Cleveland OH 44106 USA

Fibrosis is a major pathway to organ injury and failure, accounting for more than one-third of deaths worldwide. Intestinal fibrosis causes irreversible and serious clinical complications, such as strictures and obstruction, secondary to a complex pathogenesis. Under the stimulation of profibrotic soluble factors, excessive activation of mesenchymal cells causes extracellular matrix deposition via canonical transforming growth factor-beta/Smads signaling or other pathways (eg, epithelial-to-mesenchymal transition and endothelial-to-mesenchymal transition) in intestinal fibrogenesis. In recent studies, the importance of noncoding rnas (ncrnas) stands out in fibrotic diseases in that ncrnas exhibit a remarkable variety of biological functions in modulating the aforementioned fibrogenic responses. In this review, we summarize the role of ncrnas, including the emerging long ncrnas and circular rnas, in intestinal fibrogenesis. Notably, the translational potential of ncrnas as diagnostic biomarkers and therapeutic targets in the management of intestinal fibrosis is discussed based on clinical trials from fibrotic diseases in other organs. The main points of this review include the following: Characteristics of ncrnas and mechanisms of intestinal fibrogenesis Wide participation of ncrnas (especially the emerging long ncrnas and circular rnas) in intestinal fibrosis, including transforming growth factor-beta signaling, epithelial-to-mesenchymal transition/endothelial-to-mesenchymal transition, and extracellular matrix remodeling Translational potential of ncrnas in the diagnosis and treatment of intestinal fibrosis based on clinical trials from fibrotic diseases in other organs

关键词： intestinal fibrosis Crohn's disease noncoding rna extracellular matrix

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noncoding rnas: Potential players in the self-renewal of mammalian spermatogonial stem cells

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MOLECULAR REPRODUCTION AND DEVELOPMENT 2018年第8-9期85卷 720-728页

作者： Bie, Beibei Wang, Ya Li, Liang Fang, Huanle Liu, Libing Sun, Jin Xian Peihua Univ Med Sch Dept Pharm Xian Shaanxi Peoples R China Xi An Jiao Tong Univ Affiliated Hosp 2 Natl & Local Joint Engn Res Ctr Biodiag & Biother 157 West 5th Rd Xian 710004 Shaanxi Peoples R China

Spermatogonial stem cells (SSCs), a unique population of male germ cells with self-renewal ability, are the foundation for maintenance of spermatogenesis throughout the life of the male. Although many regulatory molecules essential for SSC self-renewal have been identified, the fundamental mechanism underlying how SSCs acquire and maintain their self-renewal activity remains largely to be elucidated. In recent years, many types of noncoding rnas (ncrnas) have been suggested to regulate the SSC self-renewal through multiple ways, indicating ncrnas play crucial roles in SSC self-renewal. In this paper, we mainly focus on four types of ncrnas including microrna, long ncrna, piwi-interacting rna, as well as circular rnas, and reviewed their potential roles in SSC self-renewal that discovered recently to help us gain a better understanding of molecular mechanisms by which ncrnas perform their function in regulating SSC self-renewal.

关键词： noncoding rna self-renewal spermatogonial stem cell

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noncoding rnas: potential regulators in cardioncology

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AMERICAN JOUrnaL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2019年第1期316卷 H160-H168页

作者： Chatterjee, Shambhabi Gupta, Shashi Kumar Baer, Christian Thum, Thomas Hannover Med Sch Inst Mol & Translat Therapeut Strategies D-30625 Hannover Germany Hannover Med Sch REBIRTH Excellence Cluster Hannover Germany Imperial Coll London Natl Heart & Lung Inst London England

Cancer is the leading cause of morbidity and mortality in the United States and globally. Owing to improved early diagnosis and advances in oncological therapeutic options, the number of cancer survivors has steadily increased. Such efficient cancer therapies have also lead to alarming increase in cardiovascular complications in a significant proportion of cancer survivors, due to adverse cardiovascular effects such as cardiotoxicity, cardiac atrophy, and myocarditis. This has emerged as a notable concern in healthcare and given rise to the new field of cardioncology, which aims at understanding the processes that occur in the two distinct disorders and how they interact to influence the progression of each other. A key player in both cancer and heart failure is the genome, which is predominantly transcribed to noncoding rnas (ncrnas). Since the emergence of ncrnas as master regulators of gene expression, several reports have shown the relevance of ncrnas in cancer and cardiovascular disorders. However, the knowledge is quite limited regarding the relevance of ncrnas in cardioncology. The objective of this review is to summarize the current knowledge of ncrnas in the context of cardioncology. Furthermore, the therapeutic strategies as well as the prospective translational applications of these ncrna molecules to the clinics are also discussed.

关键词： biomarker cardiotoxicity doxorubicin heart failure noncoding rna

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noncoding rnas endogenously rule the cancerous regulatory realm while proteins govern the normal

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COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOUrnaL 2022年 20卷 1935-1945页

作者： Wang, Anyou Univ Calif Riverside Inst Integrat Genome Biol Riverside CA 92521 USA

Cancers evolve from normal tissues and share an endogenous regulatory realm distinctive from that of normal human tissues. Unearthing such an endogenous realm faces challenges due to heterogeneous biology data. This study computes petabyte level data and reveals the endogenous regulatory networks of normal and cancers and then unearths the most important endogenous regulators for normal and cancerous realm. In normal, proteins dominate the entire realm and trans-regulate their targets across chromosomes and ribosomal proteins serve as the most important drivers. However, in cancerous realm, noncoding rnas dominate the whole realm and pseudogenes work as the most important regulators that cis-regulate their neighbors, in which they primarily regulate their targets within 1 million base pairs but they rarely regulate their cognates with complementary sequences as thought. Therefore, two distinctive mechanisms rule the normal and cancerous realm separately, in which noncoding rnas endogenously regulate cancers, instead of proteins as currently conceptualized. This establishes a fundamental avenue to understand the basis of cancerous and normal physiology. (c) 2022 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： noncoding rna Cancer Regulatory network Systems Endogenous FINET Big data Pseudogene

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noncoding rnas versus Protein Biomarkers in Cardiovascular Disease

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TRENDS IN MOLECULAR MEDICINE 2020年第6期26卷 583-596页

作者： Schulte, Christian Barwari, Temo Joshi, Abhishek Zeller, Tanja Mayr, Manuel Kings Coll London Kings British Heart Fdn Ctr 125 Coldharbour Lane London SE5 9NU England Univ Heart & Vasc Ctr Hamburg Clin Cardiol Hamburg Germany German Ctr Cardiovasc Res DZHK Partner Site Hamburg Hamburg Germany St Bartholomews Hosp Barts Heart Ctr London England

The development of more sensitive protein biomarker assays results in continuous improvements in detectability, extending the range of clinical applications to the detection of subclinical cardiovascular disease (CVD). However, these efforts have not yet led to improvements in risk assessment compared with existing risk scores. noncoding rnas (ncrnas) have been assessed as biomarkers, and mirnas have attracted most attention. More recently, other ncrna classes have been identified, including long noncoding rnas (lncrnas) and circular rnas (circrnas). Here, we compare emerging ncrna biomarkers in the cardiovascular field with protein biomarkers for their potential in clinical application, focusing on myocardial injury.

关键词： biomarkers troponin myosin-binding protein C noncoding rna mirna long noncoding rna circular rna

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noncoding rnas and Stroke

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NEUROSCIENTIST 2019年第1期25卷 22-26页

作者： Zhang, Xuejing Hamblin, Milton H. Yin, Ke-Jie Univ Pittsburgh Pittsburgh Inst Brain Disorders & Recovery Dept Neurol Sch Med S514 BST200 Lothrop St Pittsburgh PA 15213 USA Tulane Univ Sch Med Dept Pharmacol New Orleans LA 70112 USA

Over many years, extensive efforts have focused on the development and improvement of diagnostic and therapeutic strategies to reduce stroke-associated neurovascular damage, such as blood-brain barrier dysfunction, brain edema, parenchymal inflammation, and neural cell death. However, the only clinically applied pharmacological therapy to date for the treatment of acute ischemic stroke is thrombolysis. Because of the short therapeutic window of current thrombolytic therapy and the activation of various pathophysiological signaling cascades triggered after ischemic stroke, the development of new therapies is urgently required. noncoding rnas (ncrnas) are defined as untranslated regulatory rna molecules. Although ncrnas with biological roles have been known for almost 60 years, they have within the past decade emerged as key mediators of posttranscriptional gene expression/function in pathological aspects of ischemic stroke. With properties of relative stability, specificity, and reproducibility, ncrnas are considered to be promising as biomarkers and better candidates than proteins and genes for early recognition of the onset of disease. In this update, we summarized the current knowledge for three groups of ncrnas in stroke, focusing on the role of long noncoding rnas and circular rnas as biomarkers for stroke and as targets for regulating large sets of genes in related pathways after ischemic stroke.

关键词： noncoding rna stroke microrna long-noncoding rna circular rna

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noncoding rnas: Stress, Glucocorticoids, and Posttraumatic Stress Disorder

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BIOLOGICAL PSYCHIATRY 2018年第10期83卷 849-865页

作者： Daskalakis, Nikolaos P. Provost, Allison C. Hunter, Richard G. Guffanti, Guia Harvard Med Sch McLean Hosp Dept Psychiat Belmont MA USA Cohen Vet Biosci Inc Cambridge MA USA Univ Massachusetts Dept Psychol Boston MA 02125 USA

Posttraumatic stress disorder (PTSD) is a pathologic response to trauma that impacts similar to 8% of the population and is highly comorbid with other disorders, such as traumatic brain injury. PTSD affects multiple biological systems throughout the body, including the hypothalamic-pituitary-adrenal axis, cortical function, and the immune system, and while the study of the biological underpinnings of PTSD and related disorders are numerous, the roles of non-coding rnas (ncrnas) are just emerging. Moreover, deep sequencing has revealed that ncrnas represent most of the transcribed mammalian genome. Here, we present developing evidence that ncrnas are involved in critical aspects of PTSD pathophysiology. In that regard, we summarize the roles of three classes of ncrnas in PTSD and related disorders: micrornas, long-noncoding rnas, and retrotransposons. This review evaluates findings from both animal and human studies with a special focus on the role of ncrnas in hypothalamic-pituitary-adrenal axis abnormalities and glucocorticoid dysfunction in PTSD and traumatic brain injury. We conclude that ncrnas may prove to be useful biomarkers to facilitate personalized medicines for trauma-related brain disorders.

关键词： Glucocorticoids Long-noncoding rna Microrna noncoding rna PTSD Retrotransposons Stress TBI

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