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检索条件"主题词=Noncoding Sequence"
24 条 记 录,以下是1-10 订阅
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noncoding sequences Near Duplicated Genes Evolve Rapidly
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GENOME BIOLOGY AND EVOLUTION 2010年 第0期2卷 518-533页
作者: Kostka, Dennis Hahn, Matthew W. Pollard, Katherine S. Univ Calif San Francisco Gladstone Inst Gladstone Inst Cardiovasc Dis San Francisco CA 94143 USA Indiana Univ Dept Biol Bloomington IN 47405 USA Indiana Univ Sch Informat & Comp Bloomington IN 47405 USA Univ Calif San Francisco Inst Human Genet San Francisco CA 94143 USA Univ Calif San Francisco Div Biostat San Francisco CA 94143 USA
Gene expression divergence and chromosomal rearrangements have been put forward as major contributors to phenotypic differences between closely related species. It has also been established that duplicated genes show ... 详细信息
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Selective constraint on noncoding regions of hominid genomes
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PLOS COMPUTATIONAL BIOLOGY 2005年 第7期1卷 593-598页
作者: Bush, Eliot C. Lahn, Bruce T. Univ Chicago Howard Hughes Med Inst Dept Human Genet Chicago IL 60637 USA
An important challenge for human evolutionary biology is to understand the genetic basis of human-chimpanzee differences. One influential idea holds that such differences depend, to a large extent, on adaptive changes... 详细信息
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Evolution of the dystrophin muscular promoter and 5′ flanking region in primates
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JOURNAL OF MOLECULAR EVOLUTION 1998年 第2期46卷 168-179页
作者: Fracasso, C Patarnello, T Univ Padua Dept Biol I-35121 Padua Italy
About 1.6 kb of the noncoding region upstream of the muscular dystrophin gene was sequenced in human and other primates. The alignment showed the existence of many stretches of conserved sequences among the compared s... 详细信息
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RNA expression in a cartilaginous fish cell line reveals ancient 3′ noncoding regions highly conserved in vertebrates
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007年 第4期104卷 1224-1229页
作者: Forest, David Nishikawa, Ryuhei Kobayashi, Hiroshi Parton, Angela Bayne, Christopher J. Barnes, David W. Mt Desert Isl Biol Lab Salsbury Cove ME 04672 USA
We have established a cartilaginous fish cell line [Squalus acanthias embryo cell line (SAE)], a mesenchymal stem cell line derived from the embryo of an elasmobranch, the spiny dogfish shark S. acanthias. Elasmobranc... 详细信息
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Phylogeny of South African Gnaphalieae (Asteraceae) based on two noncoding chloroplast sequences
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AMERICAN JOURNAL OF BOTANY 2000年 第2期87卷 259-272页
作者: Bayer, RJ Puttock, CF Kelchner, SA CSIRO Ctr Plant Biodivers Res Australian Natl Herbarium Canberra ACT Australia Australian Natl Univ Div Bot & Zool Canberra ACT Australia
The Gnaphalieae are a group of sunflowers that have their greatest diversity in South America, Southern Africa, and Australia. The objective of this study was to reconstruct a phylogeny of the South African Gnaphaliea... 详细信息
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GENERATION OF HIGH SPECIFICITY OF EFFECT THROUGH LOW-SPECIFICITY BINDING OF PROTEINS TO DNA
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FEBS LETTERS 1988年 第2期231卷 291-298页
作者: ZUCKERKANDL, E VILLET, R USDA ARS BELTSVILLE AGR RES CTRBELTSVILLE AGR RES CTR WNPABLDG 055BELTSVILLEMD 20705
It is proposed that proteins can bind with relatively low-affinity and specificity to multiple sites, defined as sequence motifs, on polynucleotide chains, and that such binding can collectively be turned into high-af... 详细信息
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Deep intronic NIPBL de novo mutations and differential diagnoses revealed by whole genome and RNA sequencing in Cornelia de Lange syndrome patients
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HUMAN MUTATION 2022年 第12期43卷 1882-1897页
作者: Coursimault, Juliette Cassinari, Kevin Lecoquierre, Francois Quenez, Olivier Coutant, Sophie Derambure, Celine Vezain, Myriam Drouot, Nathalie Vera, Gabriella Schaefer, Elise Philippe, Anais Doray, Berenice Lambert, Laetitia Ghoumid, Jamal Smol, Thomas Rama, Melanie Legendre, Marine Lacombe, Didier Fergelot, Patricia Olaso, Robert Boland, Anne Deleuze, Jean-Francois Goldenberg, Alice Saugier-Veber, Pascale Nicolas, Gael Normandie Univ UNIROUEN Inserm U1245 F-76000 Rouen France CHU Rouen Dept Genet F-76000 Rouen France Reference Ctr Dev Disorders FHU G4 Genom F-76000 Rouen France Hop Univ Strasbourg Inst Genet Med Alsace IGMA Serv Genet Med Strasbourg France Ctr Hosp Univ Felix Guyon Serv Genet Med Bellepierre St Denis France CHRU Nancy Serv Genet Clin F-54000 Nancy France UMR INSERM U 1256 N GERE F-54000 Nancy France Univ Lille CHU Lille ULR7364 RADEME Clin Genet Guy Fontaine F-59000 Lille France Univ Lille FHU G4 Genom F-59000 Lille France Univ Lille CHU Lille ULR7364 RADEME Inst Genet Med F-59000 Lille France CHU Lille Inst Genet Med Lille France CHU Bordeaux Serv Genet Med Bordeaux France Univ Bordeaux INSERM U1211 Bordeaux France CHU Bordeaux Genet Med Bordeaux France Univ Paris Saclay CEA Ctr Natl Rech Genom Humaine CNRGH F-91057 Evry France
Cornelia de Lange syndrome (CdLS;MIM# 122470) is a rare developmental disorder. Pathogenic variants in 5 genes explain approximately 50% cases, leaving the other 50% unsolved. We performed whole genome sequencing (WGS... 详细信息
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A series of ENU-induced single-base substitutions in a long-range cis-element altering Sonic hedgehog expression in the developing mouse limb bud
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GENOMICS 2007年 第2期89卷 207-214页
作者: Masuya, Hiroshi Sezutsu, Hideki Sakuraba, Yoshiyuki Sagai, Tomoko Hosoya, Masaki Kaneda, Hideki Miura, Ikuo Kobayashi, Kimio Sumiyama, Kenta Shimizu, Aya Nagano, Junko Yokoyama, Haruka Kaneko, Satoko Sakurai, Noriko Okagaki, Yuka Noda, Tetsuo Wakana, Shigeharu Gondo, Yoichi Shiroishi, Toshihiko RIKEN Mouse Funct Genom Res Grp GSC Tsukuba Ibaraki 3050074 Japan RIKEN Populat & Quantitat Genom Team GSC Tsurumi Ku Yokohama Kanagawa 2300045 Japan Natl Inst Genet Mammalian Genet Lab Mishima Shizuoka 4118540 Japan Natl Inst Genet Div Populat Genet Mishima Shizuoka 4118540 Japan
Mammal-fish-conserved-sequence 1 (MFCS1) is a highly conserved sequence that acts as a limb-specific cis-acting regulator of Sonic hedgehog (Shh) expression, residing 1 Mb away from the Shh coding sequence in mouse. U... 详细信息
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Computational prediction of transcription-factor binding site locations
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Genome Biology 2004年 第1期5卷 1-11页
作者: Bulyk, Martha L. Division of Genetics Department of Medicine Brigham and Women's Hospital Boston MA 02115 77 Avenue Louis Pasteur United States
Identifying genomic locations of transcription-factor binding sites, particularly in higher eukaryotic genomes, has been an enormous challenge. Various experimental and computational approaches have been used to detec... 详细信息
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Chimp genome released
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Genome Biology 2003年 第1期4卷 1-3页
作者: Russo, Eugene
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