Regarding sugar and salt crystallization with large single crystals,the agglomerate thermodynamics and geometric morphologies,not the dynamics,dominate the particlesizedistribution(PSD).To consider this issue,a PSD ...
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Regarding sugar and salt crystallization with large single crystals,the agglomerate thermodynamics and geometric morphologies,not the dynamics,dominate the particlesizedistribution(PSD).To consider this issue,a PSD design model is proposed for limited large crystal *** this model,the agglomeration thermodynamic criticality is determined by estimating the adhesion and dispersion forces between single *** geometric agglomerate morphologies are described by corresponding single crystal units stacking with *** seed well-controlled of population,the key parameters of PSD(D01,D50 and D99)are precisely *** erythritol,the model design accuracies are 92%–99%in the 1.2 L and 10 L crystallizers,indicating that it can design PSD at various crystallization *** the general research attention to microcrystal agglomeration kinetics(mostly active pharmaceutical ingredients),this model effectively guides the sugar and salt PSD design with limited large crystal agglomeration.
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