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RESIN, A DESKTOP-COMPUTER PROGRAM FOR FINDING CUT-SETS

IEEE TRANSACTIONS ON RELIABILITY 1981年第5期30卷 407-410页

作者： MAGEE, D REFSUM, A QUEENS UNIV BELFAST DEPT ELECT ENGNBELFAST BT7 1NNANTRIMNORTH IRELAND

This paper describes an efficient algorithm for finding the minimal cut-sets for the output nodes of any network. The advantages over previously published algorithms are that it can be used on a desktop computer, and ... 详细信息

关键词： Resins logic arrays programmable logic arrays Computer networks Computer network reliability Reliability engineering Algorithm design and analysis Circuit testing logic circuits Frequency

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THE DESIGN OF A SEMI-CUSTOM INTEGRATED-CIRCUIT FOR THE SLAC SLC TIMING CONTROL-SYSTEM

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IEEE TRANSACTIONS ON NUCLEAR SCIENCE 1985年第1期32卷 87-88页

作者： LINSTADT, E Stanford Linear Accelerator Center Stanford CA USA

A semi-custom (gate array) integrated circuit has been designed for use in the SLAC Linear Collider timing and control system. The design process and SLAC's experiences during the phases of the design cycle are described. Issues concerning the partitioning of the design into semi-custom and standard components are discussed. Functional descriptions of the semi-custom integrated circuit and the timing module in which it is used are given.

关键词： Timing Control systems programmable logic arrays CAMAC Costs Resistors Packaging Libraries Process design Delay effects

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ELECTROMAGNETIC LAUNCHER CONTROL USING FINITE STATE MACHINES

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IEEE TRANSACTIONS ON MAGNETICS 1993年第1期29卷 954-957页

作者： GAY, JM CORNETTE, JB HEYSE, MW Wright Laboratory (WL/MNSH) FL USA

This paper shows the continued viability of sequential Finite State Machines (FSMs), as a means to control the sequencing of Electromagnetic Launcher (EML) systems. While computer controlled sequencing is an attractive alternative, FSMs are easy to design, inexpensive and reliable. Several FSM controllers are currently in use for the long duration EML experiments at the Hypervelocity Research Facility, Eglin Air Force Base, Florida. This paper discusses basic system design, with reference to design procedure and systems interfacing. Flexibility, and the fail-safe nature of the FSM (i.e., system interrupt capability) are also discussed. Where requirements include repeatability, reliability, ease of operation, relative tow cost, and flexibility, the FSM is presented as a reasonable alternative to more expensive computer based systems.

关键词： Electromagnetic launching Automata Control systems Decoding logic devices programmable logic arrays Counting circuits Electromagnetic forces Force control Hardware

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Protein regions important for plasminogen activation and inactivation of α₂-antiplasmin in the surface protease Pla of Yersinia pestis

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MOLECULAR MICROBIOLOGY 2001年第5期40卷 1097-1111页

作者： Kukkonen, M Lähteenmäki, K Suomalainen, M Kalkkinen, N Emödy, L Lång, H Korhonen, TK Univ Helsinki Dept Biosci Div Gen Microbiol FIN-00014 Helsinki Finland Univ Helsinki Inst Biotechnol FIN-00014 Helsinki Finland Univ Med Sch Dept Microbiol Pecs Hungary

The plasminogen activator, surface protease Pla, of the plague bacterium Yersinia pestis is an important virulence factor that enables the spread of Y. pestis from subcutaneous sites into circulation. Pla-expressing Y. pestis and recombinant Escherichia coli formed active plasmin in the presence of the major human plasmin inhibitor, alpha (2)-antiplasmin, and the bacteria were found to inactivate alpha (2)-antiplasmin. In contrast, only poor plasminogen activation and no cleavage of alpha (2)-antiplasmin was observed with recombinant bacteria expressing the homologous gene ompT from E. coli. A beta -barrel topology model for Pla and OmpT predicted 10 transmembrane beta -strands and five surface-exposed loops L1-L5. Hybrid Pla-OmpT proteins were created by substituting each of the loops between Pla and OmpT. Analysis of the hybrid molecules suggested a critical role of L3 and L4 in the substrate specificity of Pla towards plasminogen and alpha (2)-antiplasmin. Substitution analysis at 25 surface-located residues showed the importance of the conserved residues H101, H208, D84, D86, D206 and S99 for the proteolytic activity of Pla-expressing recombinant E. coli. The mature alpha -Pla of 292 amino acids was processed into beta -Pla by an autoprocessing cleavage at residue K262, and residues important for the self-recognition of Pla were identified. Prevention of autoprocessing of Pla, however, had no detectable effect on plasminogen activation or cleavage of alpha (2)-antiplasmin. Cleavage of alpha (2)-antiplasmin and plasminogen activation were influenced by residue R211 in L4 as well as by unidentified residues in L3. OmpT, which is not associated with invasive bacterial disease, was converted into a Pla-like protease by deleting residues D214 and P215, by substituting residue K217 for R217 in L4 of OmpT and also by substituting the entire L3 with that from Pla. This simple modification of the surface loops and the substrate specificity of OmpT exemplifies the evoluti

关键词： Antiplasmin Plasminogen Plasminogen Activators Recombinant Proteins Serine Endopeptidases 抗纤维蛋白溶酶纤维蛋白溶酶原纤溶酶原激活剂 Proteases Serine Endopeptidases Substrate Specificity Plasminogen Recombinant Proteins Amino Acid Motifs Antiplasmins programmable logic arrays Layer 3 (network layer) Escherichia coli Cytokinesis Virulence Factors plasminogen activation Yersinia pestis Plasminogen Activators

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A 3.6-NS ECL FIELD programmable ARRAY logic DEVICE

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IEEE JOURNAL OF SOLID-STATE CIRCUITS 1985年第5期20卷 1036-1042页

作者： MILLHOLLAN, MS SUNG, C National Semiconductor Santa Clara CA USA

A 10-kH and 100K ECL compatible field programmable array logic IC with 3.6-ns propagation delay and 1.0-W power dissipation has been developed. The device is organized as 12 inputs, 64 product terms, four outputs, and four bidirectional I/Os. The device also features the ability to complement the output by programming the polarity. To facilitate field programming and testing, an on-chip PLA causes the device to emulate a TTL compatible 2048/spl times/1-bit PROM, and the PLA is also used to control the device in test modes of operations to enhance the testability. The excellent speed-power performance has been realized by use of an oxide-isolated dual-layer metal process and an optimized circuit design.

关键词： programmable logic arrays logic devices Propagation delay PROM logic design logic functions Fuses logic circuits Power dissipation Testing

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Biocompatibility of New Drug-eluting Biodegradable Urethral Stent Materials

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UROLOGY 2010年第1期75卷 229-234页

作者： Kotsar, Andres Nieminen, Riina Isotalo, Taina Mikkonen, Joonas Uurto, Ilkka Kellomaki, Minna Talja, Martti Moilanen, Eeva Tammela, Teuvo L. J. Tampere Univ Hosp Dept Urol Tampere 33521 Finland Tampere Univ Hosp Dept Vasc Surg Tampere 33521 Finland Univ Tampere Sch Med Immunopharmacol Res Grp FIN-33101 Tampere Finland Paijat Hame Cent Hosp Dept Surg Lahti Finland Tampere Univ Technol Inst Biomed Engn FIN-33101 Tampere Finland

OBJECTIVES To investigate the effects of biodegradable stent material (poly-96L/4D-lactic acid [PLA]) on the production of cytokines and other inflammatory mediators in vitro and the biocompatibility of new drug-eluting biodegradable urethral stent materials in vivo. Indomethacin, dexamethasone, and simvastatin were used in the materials. METHODS The effects of the biodegradable stent material on cytokines and other inflammatory mediators were measured using the Human Cytokine Antibody Array and enzyme-linked immunosorbent assay in THP-1 cells, with bacterial lipopolysaccharide as a positive control. To assess the biocompatibility of the stent materials, we used muscle implantation. Biodegradable stent materials without drug-eluting properties and silicone and latex were used as controls. The measurements were done at 3 weeks and 3 months. RESULTS The PLA stent material induced production of inflammatory mediators, especially interleukin-8, tumor necrosis factor-alpha, and transforming growth factor-beta, in vitro. The increase in the production of these mediators with the PLA stent material was smaller than in the cells treated with lipopolysaccharide. In vivo, the effects of the biodegradable materials did not differ at 3 weeks, although, at 3 months, dexamethasone had induced more tissue reactions than had the other materials. At 3 months, fibrosis and chronic inflammatory changes were decreased in the biodegradable material groups compared with the positive control. CONCLUSIONS PLA stent material increased the production of cytokines and other inflammatory mediators less than did positive controls in vitro. The in vivo biocompatibility of the drug-eluting biodegradable materials was better than that of the positive controls. Drug-eluting biodegradable urethral stents could potentially offer a new treatment modality in the future. UROLOGY 75: 229-234, 2010. (C) 2010 Elsevier Inc.

关键词： biodegradable materials urethral stent programmable logic arrays Mediator Complex full control BIODEGRADABLE Cytokines biodegradability biomaterial compatibility Stents Production

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Accelerating Reactive Compatibilization of PE/PLA Blends by an Interfacially Localized Catalyst

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ACS MACRO LETTERS 2015年第1期4卷 30-33页

作者： Thurber, Christopher M. Xu, Yuewen Myers, Jason C. Lodge, Timothy P. Macosko, Christopher W. Univ Minnesota Dept Chem Engn & Mat Sci Minneapolis MN 55414 USA Univ Minnesota Dept Chem Minneapolis MN 55414 USA Oak Ridge Natl Lab Oak Ridge TN 37831 USA Univ Minnesota Characterizat Facil Minneapolis MN 55455 USA

We show catalyst localized at the interface can compatibilize polyethylene (PE) and polylactide (PLA) blends. Telechelic hydroxyl functional PE was synthesized by ring opening metathesis polymerization, which reacted with PLA in melt mixing (shown by adhesion and droplet size reduction). Lewis acid tin catalysts were examined as interfacial reaction promoters, with the goal of interfacial localization. Stannous octoate was shown to localize at the interface by transmission electron microscopy with energy dispersive X-ray spectroscopy and improved dispersion of PLA in PE as compared to uncatalyzed materials and a nonlocalized tin chloride dihydrate.

关键词： programmable logic arrays MELT MIXING 2-ethylhexanoic acid tin(II) salt REACTIVE COMPATIBILISATION COMPATIBILISATION Catalysts acceleration ring opening metathesis polymerization Energy Dispersive X-Ray Spectroscopy Blends Polyethylenes

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Bridge to lung transplantation through a pulmonary artery to left atrial oxygenator circuit

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ANNALS OF THORACIC SURGERY 2008年第4期85卷 1202-1205页

作者： Schmid, Christof Philipp, Alois Hilker, Michael Arlt, Matthias Trabold, Benedikt Pfeiffer, Michael Schmid, Franz-Xaver Univ Hosp Regensburg Dept Cardiothorac Surg D-93053 Regensburg Germany Univ Hosp Regensburg Dept Anesthesiol D-93053 Regensburg Germany Univ Hosp Regensburg Div Pneumol D-93053 Regensburg Germany

Background. There is no mechanical device available to support patients with end-stage lung failure for weeks and months until appropriate donor organs for lung transplantation are available. Methods. In a 38-year-old female patient with primary pulmonary hypertension a paracorporeal artificial lung (PAL) system was placed parallel to the pulmonary circulation with connections to the pulmonary artery and to the left atrium. The key component of the PAL was a low-resistance membrane oxygenator. Results. After institution, the PAL had a blood flow of 3.5 L/min and created a PaO2/fraction of inspired oxygen ratio of 270, while the oxygenator was provided with oxygen 3L/min. The pulmonary artery pressure declined by almost 50%. The PAL worked well over 62 days until appropriate donor lungs were available. With resuming more physical activity, an increased flow through the native lung augmented the fraction of unsaturated blood arriving at the left atrium, which mandated increasing oxygen flow to the PAL. Conclusions. The data obtained with this case encourage further research into PAL systems, which may hopefully serve as a bridge to lung transplant device in appropriate patients in the future.

关键词： Adult Artificial Organs Atrial Function Left Female Follow-Up Studies 成年人人工器官心房功能左随访研究高血压肺性肺肺移植氧合器 SHCBP1 gene Left Atrium Adults Artificial Organs Pulmonary Circulation Atrial Function Prosthesis Oxygenators lung donor programmable logic arrays Pulmonary Artery LRIT1 gene oxygen ratio Lung Transplantation Follow-Up Studies

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A MONOLITHIC 64-BIT FLOATING-POINT COPROCESSOR

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IEEE JOURNAL OF SOLID-STATE CIRCUITS 1984年第4期19卷 538-539页

作者： TAKLA, N HECKER, M DATA GEN CORP WESTBOROMA

A double/single-precision floating-point processor using a titanium disilicide 3.5-/spl mu/m NMOS process achieves double-precision add/subtract, multiply, and divide in 2, 8, and 16 /spl mu/s respectively. The chip has about 35K devices and is about 400 mil on the side. The chip uses a single 5-V supply with TTL-compatible levels on all signals except for the clocks, which require 4.5 V for a logic high. Four input clocks are used to generate eight 50-ns intervals. A -2.5 V substrate bias generator is designed on the chip but uses a pin for an external capacitor. The processor, which is to be used in a desktop implementation of a minicomputer, executes the floating-point instruction set for the micro-Eclipse computer.

关键词： Coprocessors Clocks Registers Titanium MOS devices Hardware Propagation delay Switches programmable logic arrays Microcomputers

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THIN-MAGNETIC-FILM GENERAL-PURPOSE UNIFORM ARRAY BASED ON CONTROLLED DOMAIN MOTION

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IEEE TRANSACTIONS ON MAGNETICS 1973年第1期MAG9卷 36-38页

作者： VASILIEVA, NP MALYUTIN, VI CONTROL SCI INST MOSCOW USSR

Thin-film uniform arrays (UA's) are general purpose, easy to produce, and reliable even when implementing complex logic functions. The use of controlled domain motion in narrow channels of low coercive force, formed in a high-coercive-force film, may serve as the basis for the implementation of large uniform programmable logic arrays with memory which feature information storage immune to power supply failures, and the simplicity of logic and control implementation. In this paper, principles of UA design are considered. Attention is given to performing logic operations using the controllable movement of magnetic domains in thin films.

关键词： Motion control programmable logic arrays Force control programmable control Transistors logic arrays logic functions Coercive force Power supplies Magnetic domains

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