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检索条件"主题词=Programming language"
1117 条 记 录,以下是201-210 订阅
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Reconstruction of Genome-Scale Metabolic Model for
Reconstruction of Genome-Scale Metabolic Model for
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作者: Francisco Zorrilla Eduard J. Kerkhoven
Genome-scale metabolic models (GEMs) provide a useful framework for modeling the metabolism of microorganisms. While the applications of GEMs are wide and far reaching, the reconstruction and continuous curation of su... 详细信息
来源: 评论
Analysis of Transcriptomic Data Generated from Drug-Treated Cancer Cell Line
Analysis of Transcriptomic Data Generated from Drug-Treated ...
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作者: Swarnima Kushwaha Sudeshna Mukherjee Rajdeep Chowdhury Shibasish Chowdhury
Resistance to chemotherapy is one major obstacle in current cancer treatment. Therefore, understanding the molecular basis of the acquisition of resistance is vital for the design and development of appropriate cancer... 详细信息
来源: 评论
High-Throughput Screening Assay Profiling for Large Chemical Databases
High-Throughput Screening Assay Profiling for Large Chemical...
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作者: Daniel P. Russo Hao Zhu
High-throughput screening (HTS) techniques are increasingly being adopted by a variety of fields of toxicology. Notably, large-scale research efforts from government, industrial, and academic laboratories are screenin... 详细信息
来源: 评论
Using GenBank and SRA
Using GenBank and SRA
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作者: Eric W. Sayers Chris O’Sullivan Ilene Karsch-Mizrachi
GenBank® and the Sequence Read Archive (SRA) are comprehensive databases of publicly available DNA sequences. GenBank contains data for 480,000 named organisms, more than 176,000 within the embryophyta, obtained ... 详细信息
来源: 评论
Analysis of Molecular Dynamics Simulations of Protein Folding
Analysis of Molecular Dynamics Simulations of Protein Foldin...
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作者: Robert B. Best
Unbiased molecular dynamics simulations of proteins can now capture spontaneous folding events. This provides a wealth of data reflecting information on folding mechanism, but raises the challenge of interpreting it i... 详细信息
来源: 评论
Cell-Free Biosensors and AI Artificial intelligence (AI) Integration
Cell-Free Biosensors and AI Artificial intelligence (AI) Int...
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作者: Paul Soudier Léon Faure Maish Kushwaha Jean-Loup Faulon
Cell-free biosensors hold a great potential as alternatives for traditional analytical chemistry methods providing low-cost low-resource measurement of specific chemicals. However, their large-scale use is limited by ... 详细信息
来源: 评论
Agent-Based Modeling of Complex Molecular Systems
Agent-Based Modeling of Complex Molecular Systems
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作者: Mike Holcombe Eva Qwarnstrom
The seamless integration of laboratory experiments and detailed computational modeling provides an exciting route to uncovering many new insights into complex biological processes. In particular, the development of ag... 详细信息
来源: 评论
Modeling the Structure, Dynamics, and Transformations of Proteins with the UNRES Force Field
Modeling the Structure, Dynamics, and Transformations of Pro...
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作者: Adam K. Sieradzan Cezary Czaplewski Paweł Krupa Magdalena A. Mozolewska Agnieszka S. Karczyńska Agnieszka G. Lipska Emilia A. Lubecka Ewa Gołaś Tomasz Wirecki Mariusz Makowski Stanisław Ołdziej Adam Liwo
The physics-based united-residue (UNRES) model of proteins (*** ) has been designed to carry out large-scale simulations of protein folding. The force field has been derived and parameterized based on the... 详细信息
来源: 评论
High Spatial Resolution Luciferase Imaging of the
High Spatial Resolution Luciferase Imaging of the
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作者: Mark Greenwood Anthony J. Hall James C. Locke
The A. thaliana circadian clock is an example of a gene network that generates rich temporal and spatial dynamics. Bioluminescent imaging has proven a powerful method to help dissect the genetic mechanisms that genera... 详细信息
来源: 评论
All-optical interrogation of neural circuits in behaving mice
All-optical interrogation of neural circuits in behaving mic...
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作者: Lloyd E. Russell Henry W. Dalgleish Rebecca Nutbrown Oliver M. Gauld Dustin Herrmann Mehmet Fişek Adam M. Packer Michael Häusser
Recent advances combining two-photon calcium imaging and two-photon optogenetics with computer-generated holography now allow us to read and write the activity of large populations of neurons in vivo at cellular resol... 详细信息
来源: 评论