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检索条件"主题词=Programming language"
1117 条 记 录,以下是211-220 订阅
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PELDOR Measurements on Nitroxide-Labeled Oligonucleotides
PELDOR Measurements on Nitroxide-Labeled Oligonucleotides
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作者: Tobias Hett Olav Schiemann
In the past decades, pulsed dipolar electron paramagnetic resonance spectroscopy (PDS) has emerged as a powerful tool in biophysical chemistry to study the structure, dynamics, and function of biomolecules like oligon... 详细信息
来源: 评论
Data Sharing and Reuse: A Method by the AIRR Community
Data Sharing and Reuse: A Method by the AIRR Community
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作者: Brian D. Corrie Scott Christley Christian E. Busse Lindsay G. Cowell Kira C. Neller Florian Rubelt Nicholas Schwab
High-throughput sequencingHigh-throughput sequencing of adaptive immune receptor repertoires (AIRR, i.e., IGImmunoglobulin (IG) and TRT cell receptor (TR)) has revolutionized the ability to study the adaptive immune r... 详细信息
来源: 评论
Analysis of mRNA Dynamics Using RNA Sequencing Data
Analysis of mRNA Dynamics Using RNA Sequencing Data
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作者: Rached Alkallas Hamed S. Najafabadi
The RNA abundance of each gene is determined by its rates of transcription and RNA decay. Biochemical experiments that measure these rates, including transcription inhibition and metabolic labelling, are challenging t... 详细信息
来源: 评论
High-Throughput DNA FISH (hiFISH)
High-Throughput DNA FISH (hiFISH)
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作者: Elizabeth Finn Tom Misteli Gianluca Pegoraro
High-throughput DNA fluorescence in situ hybridization (hiFISH) combines multicolor combinatorial DNA FISH staining with automated image acquisition and analysis to visualize and localize tens to hundreds of genomic l... 详细信息
来源: 评论
Investigating Histone Modification Dynamics by Mechanistic Computational Modeling
Investigating Histone Modification Dynamics by Mechanistic C...
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作者: Govind Menon Martin Howard
The maintenance of transcriptional states regulated by histone modifications and controlled switching between these states are fundamental concepts in our understanding of nucleosome-mediated epigenetic memory. Any ap... 详细信息
来源: 评论
Computational Study on the Dynamics of Mycobacterium Tuberculosis RNA Polymerase Assembly
Computational Study on the Dynamics of Mycobacterium Tubercu...
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作者: Sneha Bheemireddy Narayanaswamy Srinivasan
Gene regulation is an intricate phenomenon involving precise function of many macromolecular complexes. Molecular basis of this phenomenon is highly complex and cannot be fully understood using a single technique. Com... 详细信息
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High-Throughput Profiling of Metabolic Phenotypes Using High-Resolution GC-MS
High-Throughput Profiling of Metabolic Phenotypes Using High...
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作者: Nishikant Wase Nathan Abshire Toshihiro Obata
Metabolite profiling provides insights into the metabolic signatures, which themselves are considered as phonotypes closely related to the agronomic and phenotypic traits such as yield, nutritional values, stress resi... 详细信息
来源: 评论
Locus-Specific DNA Methylation Profiling of Human LINE-1 Retrotransposons
Locus-Specific DNA Methylation Profiling of Human LINE-1 Ret...
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作者: Francisco J. Sanchez-Luque Marie-Jeanne H. Kempen Geoffrey J. Faulkner
Long Interspersed Element 1 (LINE-1 or L1) retrotransposons are the only active and autonomous mobile genetic elements present in the human genome. They are responsible for insertional mutagenesis traced to the germli... 详细信息
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StarMap: a user-friendly workflow for Rosetta-driven molecular structure refinement
StarMap: a user-friendly workflow for Rosetta-driven molecul...
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作者: Wolfgang Lugmayr Vadim Kotov Nikolaus Goessweiner-Mohr Jiri Wald Frank DiMaio Thomas C. Marlovits
Cryogenic electron microscopy (cryo-EM) data represent density maps of macromolecular systems at atomic or near-atomic resolution. However, building and refining 3D atomic models by using data from cryo-EM maps is not... 详细信息
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Searching thousands of genomes to classify somatic and novel structural variants using STIX
Searching thousands of genomes to classify somatic and novel...
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作者: Murad Chowdhury Brent S. Pedersen Fritz J. Sedlazeck Aaron R. Quinlan Ryan M. Layer
Structural variants are associated with cancers and developmental disorders, but challenges with estimating population frequency remain a barrier to prioritizing mutations over inherited variants. In particular, varia... 详细信息
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