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Dual Recognition Strategy-Based Transistor sensor array for Ultrasensitive and Multi-Target Detection of Antibiotics

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ADVANCED FUNCTIONAL MATERIALS 2025年第3期35卷

作者： Tao, Tian Wei, Xiaojie Ye, Ziwei Zong, Boyang Li, Qiuju Mao, Shun Tongji Univ Shanghai East Hosp Biomed Multidisciplinary Innovat Res Inst Coll Environm Sci & EngnState Key Lab Pollut Cont 1239 Siping Rd Shanghai 200092 Peoples R China Shanghai Inst Pollut Control & Ecol Secur Shanghai 200092 Peoples R China

Multi-target detection is a notable development direction in the field of analytical methods, boasting significant potential for breakthroughs in complex sample detection. Herein, an extended gate field-effect transistor (EGFET) sensor array for ultrasensitive and multi-target detection of antibiotics is developed. To enhance the recognition ability for diverse antibiotics, a dual-recognition strategy based on tailor-made molecularly imprinted polymer (MIP) and aptamer is adopted to fabricate the extended gate electrode (sensing electrode). The dual-recognition strategy-based EGFET exhibits superior sensitivity, selectivity, and stability compared to single recognition probes due to the synergistic effect of the affinities of MIP and specific aptamer. The developed sensor array can detect three types of antibiotics, including ampicillin, amoxicillin, and kanamycin, at the same time with record-low detection limit (fM level) and a detection range spanning six orders of magnitude. The practical detection of antibiotics in various samples (tap water, river water, milk, honey, and artificial urine) further validates the feasibility of the sensor array in practical applications. The key advantages of flexibility, high sensitivity and selectivity, and multifunctionality demonstrate the high potential of EGFET sensor array for simultaneous detection of multiple target molecules.

关键词： antibiotics extended gate field-effect transistor MIP-aptamer hybrid multi-target detection sensor array

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One-component dual-mode sensor array for identification and quantification of biothiols

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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 2025年 329卷 125555页

作者： Ning, Yuanna Wang, Yongbo Wang, Shaojie Wang, Wencai Shaanxi Univ Sci & Technol Sch Biol & Pharmaceut Sci Xian 710021 Peoples R China Shanxi Univ Xinghuacun Coll Sch Life Sci Taiyuan 030006 Peoples R China

Biothiol analysis is significant to health assessment and early detection of potential diseases. Considering practical requirements, simple and rapid identification and determination of biothiols are still a great challenge due to the similar structures. Fortunately, the recently emerging colorimetric sensor array technique makes such a task possible. Herein, one-component dual-mode sensor array consisting of carbon dots (CDs) and Ag nanoparticles (AgNPs) system was designed for identification and quantification of biothiols. The identification principle is based on the inner filter effect (IFE) and different binding constants. Due to the IFE between CDs and AgNPs, the fluorescence of CDs was quenched, but recovered again after addition of biothiols because of the binding of biothiols with AgNPs. Significantly, the fluorescence recovered in varying degree due to the different binding constants of biothiols to AgNPs. Meanwhile, the absorbance of the system decreased and the color of the solution deepened. Therefore, the CDs-AgNPs system with fluorescence and absorbance response was used as the single sensing unit and generated the cross-responsive signal for different biothiols. The sensor array achieved 100 % accuracy in identifying biothiols and biothiol mixtures. Moreover, the rapid quantification of biothiols in serum samples was also achieved by RGB-based smartphone colorimetry. The way to construct one component sensor array with dual mode signal outputs tremendously saves cost and time, providing a powerful tool for the identification of different biothiols. In addition, the rapid quantification of biothiols in serum samples based on RGB-based smartphone colorimetry demonstrated its powerful application prospects in disease diagnosis.

关键词： Biothiols sensor array Carbon dots Ag nanoparticles Dual mode

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Paper-based colorimetric sensor array integrated with smartphone APP for the identification of tea polyphenol and Longjing tea

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BIOsensorS & BIOELECTRONICS 2025年 278卷 117391页

作者： Yang, Xiaoyu Bi, Zhichun Li, Jie Wang, Le Huang, Hui Li, Yongxin Jilin Univ Coll New Energy & Environm Minist Educ Key Lab Groundwater Resources & EnvironmKey Lab W Changchun 130021 Peoples R China Jilin Univ Coll Food Sci & Engn Changchun 130025 Peoples R China Liaoning Police Coll Dalian 116036 Peoples R China

West Lake Longjing tea is among the top ten renowned teas in China. However, consumers often struggle to accurately identify genuine West Lake Longjing tea through visual inspection, leading to widespread counterfeiting and fraud in the market. The aim of this work is to develop a real-time detection tool for consumers, including a visual color-changing test paper and an accompanying mobile phone recognition application. The mobile application has been developed for the purpose of facilitating rapid identification of the provenance of Longjing tea. Firstly, we used the polyphenol oxidase-like activity and the peroxidase-like activity of nanozymes to construct the sensor array, and found that tea polyphenols and Longjing tea had different responses to the sensor array. Then combined with LDA and HCA algorithms, the identification of tea polyphenols and the differentiation of Longjing production area were realized. The results showed that as low as 1 mu M of seven tea polyphenols could be efficiently recognized, and Longjing green tea from six production regions could be differentiated from West Lake Longjing adulterated with different proportions of other production regions. In addition, we developed a paper-based sensor array and a smartphone APP to distinguish multiple concentrations of tea polyphenols and Longjing from different production areas by recognizing the color difference of the paper. The construction of this sensor array and the development of smartphone APP can be successfully applied to the source identification and the adulteration of Longjing tea.

关键词： sensor array Nanozyme Longjing tea Smartphone APP

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Light-responsive bifunctional crosslinker enables facile preparation of antifouling sensor array for immunodetection of viral antigens

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sensorS AND ACTUATORS B-CHEMICAL 2025年 422卷

作者： Sun, Shijie Chen, Yancao Xu, Ruili Shang, Jinhui Li, Huiwen Xiong, Bin Zhang, Xiao-Bing Hunan Univ Coll Chem & Chem Engn State Key Lab Chemo Biosensing & Chemometr Changsha 410082 Peoples R China GRG Metrol & Test Hunan Co Ltd Changsha 410003 Peoples R China

To achieve reliable detection of viral antigens, it is critical to develop of antifouling sensor arrays. Herein, we introduce a robust strategy for facile design and construction of hydrogel-based antifouling sensor arrays with a light-responsive bifunctional crosslinker. Upon UV light irradiation, the capture antibodies and blocking agents can be chemically conjugated onto the hydrogel interface to generate antifouling sensor arrays with desirable protein patterns with the aid of a hole-array mask. We demonstrated the antifouling sensor arrays for the quantitative detection of SARS-CoV-2 spike protein with satisfying sensitivity and high signal-to-background ratio. We further confirmed the prepared multiplexed sensor arrays for the detection of multiple viral proteins simultaneously in complex environments. Moreover, we achieved the quantitative detection of synthetic viruslike particles and SARS-CoV-2 pseudoviruses with satisfying detection performances. All these evidences suggested that the hydrogel-based antifouling sensor arrays holds great potential for quantitative analysis of viral antigens and virus particles in real applications.

关键词： Light-responsive bifunctional crosslinker Antifouling sensor sensor array Immunodetection Viral antigen

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A dual-mode transparent flexible pressure sensor array for tactile sensing visualization

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CHEMICAL ENGINEERING JOURNAL 2025年 510卷

作者： Fang, Chenyu Zhao, Leilei Su, Wenwen Qin, Binyu Poechmueller, Peter Shandong Univ Sch Integrated Circuits Jinan 250101 Peoples R China Qingdao Univ Sch Pharm Qingdao 266071 Peoples R China

Flexible pressure sensors exhibit significant potential for applications in robotics, smart medical devices, and human-computer interaction;however, achieving transparency, high sensitivity, and multimodal perception simultaneously presents numerous challenges. In this study, we present a dual-mode transparent flexible pressure sensor array (DPSA) based on triboelectric and capacitive sensing principles. The sensor utilizes radio-frequency magnetron sputtering to deposit ITO films onto a flexible PET substrate, combined with a bilayer hemispherical PDMS elastomer to create a sandwich structure with high spatial resolution. This design enhances the sensor's sensitivity and multimodal sensing capabilities by leveraging the change in contact area between the hemispherical PDMS array and the transparent electrodes. Utilizing a custom data acquisition system, the DPSA can monitor multi-touch and sliding trajectories in real time across a wide pressure range. In capacitive mode, the DPSA exhibits a sensitivity of 1.36 kPa-1 and a response time of 3.9 ms at low pressure ranges;in triboelectric mode, it achieves a sensitivity of 0.25 kPa-1 and a minimum detection limit of 0.3 Pa across higher pressure ranges. Experimental results demonstrate that the DPSA exhibits excellent performance in tactile sensing and external force detection, highlighting its significant potential for future applications in intelligent tactile systems and wireless human-machine interfaces.

关键词： Triboelectric nanogenerator Dual mode Pressure sensitivity sensor array Tactile sensing

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pH-regulated CQDs@Eu/GMP ICP sensor array and its fingerprinting on 96-well plates: Toward point-of-use/specific identification and quantitation of six tetracyclines in animal farm wastewater, milks and milk-derivative products

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FOOD CHEMISTRY 2025年 468卷 142349页

作者： Gao, Ming Bian, Chang Wang, Junxia Liu, Yu Li, Zhenghao Zhao, Yutao Wang, Xuedong Suzhou Univ Sci & Technol Sch Environm Sci & Engn Suzhou 215009 Peoples R China Suzhou Shijing Technol Co Ltd No 58 Jinrui Rd Suzhou 215137 Peoples R China Suzhou Univ Sci & Technol Sch Environm Sci & Engn Suzhou Natl Joint Lab Green & Low Carbon Wastewate Suzhou 215009 Peoples R China

Herein, a "lab-on-an-AIE@Ln/ICP" sensor array was constructed by employing aggregation-induced emission carbon quantum dots (AIE-CQDs) as the guest and Eu/GMP ICP as the host. Based on the antenna effect (AE) and reductive photo-induced electron transfer (r-PET) between CQDs@Eu/GMP ICPs and tetracyclines (TCs), the asconstructed sensor produced satisfactorily dual-emitting fluorescence. By combining pH regulation with principal component analysis (PCA), the underlying fingerprinting patterns realized the specific identification and quantitation of six TCs in animal farm wastewater, milks and milk-derivative products. Through the aggregationinduced quenching of CQDs@Eu/GMP ICPs on test strips, the discernible fluorescence alterations were successfully utilized for developing smartphone-based visual assay. To sum up, the prominent novelty of this study lies in that based on the comprehensive principles of AE and r-PET along with combination of pH-adjustment and PCA, the pioneered sensor assay achieves specifically identifying and sensing individual TCs for their rapid and on-site detection in animal-derived matrices.

关键词： Lanthanide infinite coordination polymer sensor array Principal component analysis Tetracycline antibiotics Smartphone-based visual assay

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A signal energy approach of acoustic source localization in plate structures using a discrete sensor array

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ULTRASONICS 2025年 148卷 107555页

作者： Ma, Chenning Cui, Zhiwen Liu, Jinxia Kundu, Tribikram Jilin Univ Coll Phys Dept Acoust & Microwave Phys Changchun 130012 Jilin Peoples R China Jilin Univ Chongqing Res Inst Chongqing 401120 Peoples R China Chinese Acad Sci Inst Acoust State Key Lab Acoust Beijing 100190 Peoples R China Univ Arizona Dept Civil & Architectural Engn & Mech Tucson AZ 85721 USA Univ Arizona Aerosp & Mech Engn Dept Mat Sci & Engn Dept Tucson AZ 85721 USA

In the field of engineering structural health monitoring, acoustic source localization (ASL) is a common method to monitor early damage. Most of the existing ASL techniques have high requirements for accurate acquisition of time of arrival, and require complex iterative algorithms or signal processing techniques, which are not conducive to real-time monitoring. In this paper, a signal energy approach of acoustic source localization in plate structures using a discrete sensor array is proposed. The proposed method overcomes the above problems by simply using the amplitude of the recorded signal to calculate the energy and does not need to know the mechanical properties of the material in advance. Thus, it should be useful for real-time and efficient prediction of acoustic source. Numerical simulations and experiments are carried out on aluminum and composite plates to demonstrate the feasibility and application potential of the proposed method. The proposed method demonstrates good accuracy and holds significant potential for wide-ranging applications in the health monitoring of plate structures.

关键词： Acoustic emission Source localization Plate structure Signal-energy approach Lamb waves sensor array

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A novel quantum dot-based ratiometric fluorescence sensor array: For reducing substances detection and Baijiu quality discrimination

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ANALYTICA CHIMICA ACTA 2025年 1347卷 343785页

作者： Xia, Xuhui Zhao, Peng Zheng, Jia Li, Xuheng Zeng, Xin Men, Dianhui Luo, Yiyao Hou, Changjun Huo, Danqun Chongqing Univ Key Lab Biol Sci & Technol Minist Educ Bioengn Coll Chongqing 400044 Peoples R China Sichuan Univ Sci & Engn Coll Bioengn Key Lab Sichuan Prov Liquor Making Biol Technol & Applicat 188 Univ Town Yi Bin 644000 Peoples R China Wuliangye Grp Co Ltd Strong Flavor Baijiu Solid State Fermentat Key Lab Yibin 644007 Peoples R China

Background: Discriminating the quality of baijiu is critical for fostering the growth of the China baijiu market and safeguarding customers' rights. However, establishing a small-scale and rapid baijiu discriminating sensor assay still remains a challenge. Results: Here, we first introduced ratiometric fluorescence sensor array for the detection of reducing substances in baijiu to achieve baijiu discrimination. A ratiometric fluorescence sensor array is built using 2,3-diaminophenazine (oxidized-state OPD, oxOPD) to quench three distinct fluorescence signals of quantum dots while reducing interference from background signals. The reducing chemicals in baijiu can react with Ag+, weakening the quenching effect and changing the ratio. The discriminating of 12 types of organic small molecules which were presented in baijiu was achieved with 97.2 % accuracy by using machine learning classification methods. Meanwhile, 0.1 mu M limit of detection (LOD) for ascorbic acid shows that our methods have the potential to quantitative detect reducing substances. In real sample detection, our methods can discriminate 10 distinct qualities of baijiu with 100 % accuracy. We also encoded the fingerprints of different varieties of baijiu for quality control and information reading. Significance and novelty: Overall, our easy but robust sensing array not only overcomes the problem of background signal interference but also gives an ideal way for discriminating different qualities of baijiu, food and other areas.

关键词： Quantum dots Rtiometric fluorescence sensor array Baijiu discriminating

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A Dual Fluorescence Turn-On sensor array Formed by Poly(para-aryleneethynylene) and Aggregation-Induced Emission Fluorophores for Sensitive Multiplexed Bacterial Recognition

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2024年第16期63卷 e202318483-e202318483页

作者： Yu, Yang Ni, Weiwei Hu, Qin Li, Huihai Zhang, Yi Gao, Xu Zhou, Lingjia Zhang, Shuming Ma, Shuoyang Zhang, Yanliang Huang, Hui Li, Fei Han, Jinsong China Pharmaceut Univ Coll Engn Natl R&D Ctr Chinese Herbal Med Proc Dept Food Qual & SafetyState Key Lab Nat Med Nanjing 210009 Peoples R China Chongqing Med Univ Affiliated Hosp 2 Dept Lab Med Chongqing 400010 Peoples R China Nanjing Univ Chinese Med Nanjing Hosp Chinese Med Nanjing Res Ctr Infect Dis Integrated Tradit Chine Nanjing 210022 Peoples R China

Bacterial infections have emerged as the leading causes of mortality and morbidity worldwide. Herein, we developed a dual-channel fluorescence "turn-on" sensor array, comprising six electrostatic complexes formed from one negatively charged poly(para-aryleneethynylene) (PPE) and six positively charged aggregation-induced emission (AIE) fluorophores. The 6-element array enabled the simultaneous identification of 20 bacteria (OD600=0.005) within 30s (99.0 % accuracy), demonstrating significant advantages over the array constituted by the 7 separate elements that constitute the complexes. Meanwhile, the array realized different mixing ratios and quantitative detection of prevalent bacteria associated with urinary tract infection (UTI). It also excelled in distinguishing six simulated bacteria samples in artificial urine. Remarkably, the limit of detection for E. coli and E. faecalis was notably low, at 0.000295 and 0.000329 (OD600), respectively. Finally, optimized by diverse machine learning algorithms, the designed array achieved 96.7 % accuracy in differentiating UTI clinical samples from healthy individuals using a random forest model, demonstrating the great potential for medical diagnostic applications.

关键词： sensor array Bacteria Identification Poly(para-aryleneethynylene) Aggregation-Induced Emission Machine Learning

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W-CeO2 nanospheres gas sensor array for accurate and selective H2S detection in exhaled breath

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CHEMICAL ENGINEERING JOURNAL 2024年 479卷

作者： Duan, Qiuyang Zhang, Wenjian Li, Long Ying, Binzhou Li, Tiankun Chen, Bingbing Li, Hua-Yao Liu, Huan Huazhong Univ Sci & Technol HUST Sch Integrated Circuits Wuhan Natl Lab Optoelect Opt Valley Lab 1037 Luoyu Rd Wuhan 430074 Hubei Peoples R China Shenzhen Huazhong Univ Sci Technol Res InstituteShenzhen Virtual Univ Pk Shenzhen 518000 Guangdong Peoples R China Wenzhou Adv Mfg Inst HUST Wenzhou Key Lab Optoelect Mat & Devices Applicat 1085 Meiquan Rd Wenzhou 325035 Zhejiang Peoples R China Nanjing Tech Univ Sch Energy Sci & Engn Nanjing 211816 Jiangsu Peoples R China

Hydrogen sulfide (H2S), an endogenous gas intricately linked with various physiological disorders, carries paramount importance for medical diagnostics. Despite its significance, rapid and precise H2S detection in the complex atmosphere of exhaled breath remains a formidable challenge. In this study, W-CeO2 core@shell nanospheres were synthesized employing a facile one-step hydrothermal method. Particularly, the 7 % W-CeO2 composite showcased exceptional gas sensing capabilities, characterized by a response of 18.4 and an effective detection threshold of 50 ppb at 225 degrees C with 80 % RH. The underlying gas-sensing mechanism was meticulously expounded. To enhance the discrimination of sensor responses towards diverse gases, a sensor array encompassing four distinct W-CeO2 sensors was meticulously devised. By synergizing this sensor array with an algorithmic approach, the discrimination accuracy for qualitative (100 %) and quantitative (89 %) classification of H2S, ethanol, and their mixtures within a high humidity range. Furthermore, the proposed sensor array's utility was extended to the design of an electronic nose system tailored for H2S detection in exhaled breath. This platform effectively evaluated its diagnostic efficacy for halitosis, evidencing its capability to discern exhaled breath samples from healthy exhaled samples and simulated halitosis exhaled samples accurately.

关键词： Exhaled breath CeO2 nanosphere sensor array Algorithm Electronic nose

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