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Eutectogels: Recent Advances and Emerging Biological Applications

ADVANCED functionAL MATERIALS 2025年

作者： Hu, Yi Yang, Wenhui Zhan, Jiamian Pu, Chunyi Zhong, Linfang Hou, Honghao Southern Med Univ Affiliated Hosp 5 Guangzhou 510900 Guangdong Peoples R China Southern Med Univ Sch Basic Med Sci Guangdong Prov Key Lab Construct & Detect Tissue E Guangzhou 510515 Peoples R China

Eutectogels, a family of emerging materials, integrate the characteristics of deep eutectic solvents (DES) and gels, presenting unique application potential in biomedical engineering. However, the latest progress of eutectogels and their applications in the biomedical field remain to be summarized and refined. This review first introduces the composition of eutectogels and their unique properties generated by the interaction between DES and the gel matrix. Subsequently, the classifications and advantages of eutectogels are comprehensively discussed according to their cross-linked preparation methods, including physical, chemical, and multiple cross-linked. By analyzing the properties of eutectogels, such as mechanical performance, thermal properties, conductivity, injectability, and their structure-function relationships, the application potential of eutectogels is overviewed. Then, the eutectogel's application prospects in biomedical engineering are elaborated in detail, including their application in drug delivery to improve drug stability and precise control release, enhancing curative effects and reducing side effects. Also, the functional utilization in tissue engineering, biosensing, bioadhesives, and related biomedical domains are comprehensively explored. Finally, existing challenges and prospective research directions of eutectogels are delineated.

关键词： bioadhesives biomedical engineering biosensing eutectogels structure-function relationships

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Skin's New Shield: Food-Derived Bioactive Peptides in Combating Photoaging-An Investigation Into Inhibitory Mechanisms and structure-Activity relationships

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JOURNAL OF FOOD BIOCHEMISTRY 2025年第1期2025卷

作者： Liu, Ruijia He, Lijuan Chen, Linfeng Zhang, Yihao Zhang, Yinxiao An, Jiulong Li, He Liu, Xinqi Beijing Technol & Business Univ Minist Educ Key Lab Geriatr Nutr & Hlth Beijing 100048 Peoples R China Beijing Technol & Business Univ Natl Soybean Proc Ind Technol Innovat Ctr Beijing 100048 Peoples R China Guangzhou Han Lan Tu Biotechnol Co Ltd Guangzhou Peoples R China

In recent years, skin health has become one of the leading causes of nonfatal disease burden due to the significance of the skin in the body and the ubiquitous presence of ultraviolet radiation that negatively affects skin conditions and causes skin photoaging. Bioactive peptides (BAP) have received much attention for their antiphotoaging activity in skin because they are natural, safe, and functional. Previous studies have demonstrated that specific amino acids or sequences, as well as some characteristic amino acids, are key to the antiphotoaging effects of BAP. Nevertheless, their inhibitory mechanisms and the association between their structures and abilities are not comprehensively documented. This paper summarizes the mechanisms of antiphotoaging peptides derived from different food processing by-products from the literature over the past 4 years, focusing on the structure-activity relationship based on the inhibitory mechanisms and amino acid compositions of BAP. In addition, the current challenges in obtaining and researching BAP are discussed, and future approaches are proposed. This review provides a theoretical basis for discovering more possible food-borne antiphotoaging peptides and exploring the correlation between the structures and effects of antiphotoaging peptides.

关键词： antiphotoaging mechanisms bioactive peptides food proteins photoaging mechanisms structure-function relationships

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The Right Tool for the Job: A Review of Insect Mouthparts as a Tool Kit for Biomimetic Studies

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BIOMIMETICS 2025年第4期10卷 196-196页

作者： Lehnert, Matthew S. Myers, Kendall O. Reiter, Kristen E. Kent State Univ Stark Dept Biol Sci North Canton OH 44720 USA Cuyahoga Community Coll Biol Dept Highland Hills OH 44122 USA

Few traits exhibit a more diverse collection of exemplary structure-function relationships than the mouthparts of insects. The global dominance of insects is attributed to their diverse food sources, which are matched by an array of morphological and chemical adaptations: a 'tool kit' for biomimicry. This review provides an overview of insect mouthparts that have contributed to biomimetics, including information about morphology and functionality in relation to particular feeding mechanisms. Themes in the groups of insects employed for particular biomimetic studies, including their lineages and feeding strategies, are identified along with suggestions for future studies, which together underscore the importance and promise of the development of novel engineered devices inspired by the unique 'tools' of insect mouthparts.

关键词： mandibulate mouthparts haustellate mouthparts insect morphology feeding mechanisms structure-function relationships

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Physicochemical, Structural, and functional Properties of Fructans from Single-Clove Garlic and Multiclove Garlic: A Comparison

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2024年第14期72卷 7818-7831页

作者： Qiu, Zhichang Li, Lingyu Du, Hengjun Chen, Huiyun Chen, Gang Zheng, Zhenjia Xiao, Hang Univ Massachusetts Dept Food Sci Amherst MA 01003 USA Shandong Agr Univ Key Lab Food Nutr & Hlth Univ Shandong Coll Food Sci & Engn Tai An 271018 Shandong Peoples R China Ningbo Acad Agr Sci Inst Agr Proc Res Ningbo 315040 Zhejiang Peoples R China Zhejiang Agr & Forest Univ Coll Food & Hlth Hangzhou 311300 Zhejiang Peoples R China

This study aimed to compare the structural features and functional properties of polysaccharides from single-clove garlic (SGPs) and multiclove garlic (MGPs) and to establish their structure-function relationships. Both SGPs and MGPs were identified as fructans consisting mainly of -> 1)-beta-d-Fruf (2 -> and -> 6)-beta-d-Fruf (2 -> residues but differed in average molecular weights (6.76 and 5.40 kDa, respectively). They shared similar thermodynamic properties, X-ray diffraction patterns, and high gastrointestinal digestive stability. These two purified fructans could dose-dependently scavenge free radicals, reduce oxidized metals, and effectively alleviate metronidazole-induced oxidative stress and CuSO4-induced inflammation in zebrafish via inhibiting the overexpression of inflammation-related proteins and cytokines. SGPs showed lower free radical scavenging activity in vitro than MGPs but higher antioxidant and anti-inflammatory activities in vivo. Taken together, the molecular weight was the main structural difference between the two garlic fructans of different varieties, which is a potential reason for their differences in biological activities.

关键词： fructans garlic variety structural features biological activities structure-function relationships

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Comment on "Comparing proteins by their internal dynamics: Exploring structure-function relationships beyond static structural alignments" by C. Micheletti

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PHYSICS OF LIFE REVIEWS 2013年第1期10卷 33-34页

作者： Lesk, Arthur M. Penn State Univ Dept Biochem & Mol Biol University Pk PA 16802 USA Penn State Univ Huck Inst Genom Prote & Bioinformat University Pk PA 16802 USA

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A Soluble Expression Construct of the Isolated Catalytic Domain of Plasmodium falciparum ATP4 Exhibits ATPase Activity Independent of a γ-Phosphate Receiving Aspartate

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MOLECULAR MICROBIOLOGY 2025年第0期 2025 Mar 17页

作者： Beyer, Timo Caliebe, Jesko Kahler, Lara Beitz, Eric Christian Albrechts Univ Kiel Dept Pharmaceut & Med Chem Kiel Germany

The sodium/proton-exchanging ATPase of Plasmodium falciparum malaria parasites, PfATP4, is an emerging drug target. Inhibition results in detrimental cell swelling due to cytosolic accumulation of sodium and alkalization. PfATP4 is a sodium-releasing type II P-type ATPase restricted to apicomplexan parasites. Experimental data on structure-function relationships of the isolated protein are absent. Here, we produced and purified the soluble catalytic domain of PfATP4 and evaluated kinetic properties by in vitro phosphate colorimetry. The protein exhibited Mg2+-dependent ATPase activity at the same order of magnitude as the native cellular PfATP4 and was insensitive to the presence of sodium. AlphaFold 3-based structure and ATP/Mg2+ interaction predictions identified key residues of the nucleotide binding domain (Lys619, Lys652, Arg703). Replacement of the lysines by methionine decreased the enzymatic activity to one quarter. Individual mutation of the putative Mg2+-coordinating Asp865 of the phosphorylation domain was tolerated, while a joint replacement with Asp869 decreased ATPase again to one quarter. Mutation of the putative gamma-phosphate receiving Asp451 maintained the rate of Pi release. Our data attribute typical functional roles for P-type ATPases to the basic and acidic residues of the soluble PfATP4 catalytic domain and show that its ATP hydrolysis is independent of phosphorylation of Asp451.

关键词： ATPase malaria proton sodium structure-function relationships

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Strategies for the design of analogs of auranofin endowed with anticancer potential

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EXPERT OPINION ON DRUG DISCOVERY 2024年第7期19卷 855-867页

作者： Vitali, Valentina Massai, Lara Messori, Luigi Univ Florence Dept Chem Ugo Schiff Lab Met Med MetMed Via Lastruccia 3 I-50019 Sesto Fiorentino Italy

IntroductionAuranofin (AF) is a well-established, FDA-approved, antiarthritic gold drug that is currently being reevaluated for a variety of therapeutic indications through drug repurposing. AF has shown great promise as a potential anticancer agent and has been approved for a few clinical trials in cancer. The renewed interest in AF has led to extensive research into the design, preparation and biological evaluation of auranofin analogs, which may have an even better pharmacological profile than the parent *** coveredThis article reviews the strategies for chemical modification of the AF scaffold. Several auranofin analogs have been prepared and characterized for medical application in the field of cancer treatment over the last 20 years. Some emerging structure-function relationships are proposed and *** opinionThe chemical modification of the AF scaffold has been the subject of intense activity in recent years and this strategy has led to the preparation and evaluation of several AF analogs. The case of iodauranofin is a particularly promising example. The availability of homogeneous biological data for a group of AF derivatives allows some initial structure-function relationships to be proposed, which may inspire the design and synthesis of new and better AF analogs for cancer treatment.

关键词： Anticancer therapy chemical modification drug design gold drugs structure-function relationships

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Asymmetry between the dorsal and ventral digging valves of the female locust: function and mechanics

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BMC BIOLOGY 2024年第1期22卷 129页

作者： Gershon, Shmuel Bar-On, Benny Sonnenreich, Shai Ayali, Amir Pinchasik, Bat-El Tel Aviv Univ Fac Engn Sch Mech Engn IL-6997801 Tel Aviv Israel Ben Gurion Univ Negev Dept Mech Engn IL-84105 Beer Sheva Israel Tel Aviv Univ Fac Life Sci Sch Zool IL-6997801 Tel Aviv Israel Tel Aviv Univ Sagol Sch Neurosci IL-6997801 Tel Aviv Israel Tel Aviv Univ Ctr Phys & Chem Living Syst IL-69978 Tel Aviv Israel

Background The female locust is equipped with unique digging tools, namely two pairs of valves-a dorsal and a ventral-utilized for excavating an underground hole in which she lays her eggs. This apparatus ensures that the eggs are protected from potential predators and provides optimal conditions for successful hatching. The dorsal and the ventral valves are assigned distinct roles in the digging process. Specifically, the ventral valves primarily function as anchors during propagation, while the dorsal valves displace soil and shape the underground *** In this study, we investigated the noticeable asymmetry and distinct shapes of the valves, using a geometrical model and a finite element method. Our analysis revealed that although the two pairs of valves share morphological similarities, they exhibit different 3D characteristics in terms of absolute size and structure. We introduced a structural characteristic, the skew of the valve cross-section, to quantify the differences between the two pairs of valves. Our findings indicate that these structural variations do not significantly contribute to the valves' load-bearing capabilities under external *** The evolutionary development of the form of the female locust digging valves is more aligned with fitting their respective functions rather than solely responding to biomechanical support needs. By understanding the intricate features of these locust valves, and using our geometrical model, valuable insights can be obtained for creating more efficient and specialized tools for various digging applications.

关键词： Biomechanics Digging Finite element method structure-function relationships Geometry

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Mechanisms of action of coffee bioactive compounds - a key to unveil the coffee paradox

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CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION 2023年第28期64卷 10164页

作者： Machado, Fernanda Coimbra, Manuel A. A. del Castillo, Maria Dolores Coreta-Gomes, Filipe Univ Aveiro Chem Dept LAQV REQUIMTE Aveiro Portugal CSIC UAM Inst Invest Ciencias Alimentac Madrid Spain Univ Coimbra Inst Mol Sci CQC IMS Coimbra Chem Ctr Dept Chem Coimbra Portugal

The knowledge of the relationship between the chemical structure of food components with their mechanisms of action is crucial for the understanding of diet health benefits. This review relates the chemical variability present in coffee beverages with the mechanisms involved in key physiological events, supporting coffee as a polyvalent functional food. Coffee intake has been related with several health-promoting properties such as neuroprotective (caffeine, chlorogenic acids and melanoidins), anti-inflammatory (caffeine, chlorogenic acids, melanoidins, diterpenes), microbiota modulation (polysaccharides, melanoidins, chlorogenic acids), immunostimulatory (polysaccharides), antidiabetic (trigonelline, chlorogenic acids), antihypertensive (chlorogenic acids) and hypocholesterolemic (polysaccharides, chlorogenic acids, lipids). Nevertheless, caffeine and diterpenes are coffee components with ambivalent effects on health. Additionally, a large range of potentially harmful compounds, including acrylamide, hydroxymethylfurfural, furan, and advanced glycation end products, are formed during the roasting of coffee and are present in the beverages. However, coffee beverages are part of the daily human dietary healthy habits, configuring a coffee paradox.

关键词： Coffee brew health benefits structure-function relationships Maillard reaction products melanoidins polysaccharides chlorogenic acids caffeine trigonelline lipids diterpenes

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Emerging spinel ferrite catalysts for driving CO2 hydrogenation to high-value chemicals

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MATTER 2023年第5期6卷 1404-1434页

作者： Orege, Joshua Iseoluwa Kifle, Ghebretensae Aron Yu, Yang Wei, Jian Ge, Qingjie Sun, Jian Chinese Acad Sci Dalian Inst Chem Phys Dalian Natl Lab Clean Energy Dalian 116023 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Shanghai Univ Inst Environm Pollut & Hlth Sch Environm & Chem Engn Shanghai 200444 Peoples R China

Spinel ferrite catalysts (SFCs) have demonstrated significant benefits as excellent materials for the sustainable production of highvalue chemicals from CO2 hydrogenation thanks to their flexible structure, tunable composition, and thermal stability. They can promote the activation, adsorption, and reactivity of CO2 with high conversion efficiencies and stable performances. These have triggered the exponentially growing attention they have received in the last few years. Here, current developments in catalytic CO2 hydrogenation to olefins, alcohols, aromatics, and other liquid hydrocarbons are discussed in terms of fabrication, modification strategies, and structure-performance relationships under various categories of SFCs, namely Fe3O4 (magnetite)-based, transition-metal-based, alkaline-earth metal-based, and Al-based SFCs. Furthermore, the review reveals key performance-influencing factors and provides insights into selectivity control mechanisms during the SFC-promoted CO2 hydrogenation reaction. In the end, current underlying challenges and recommendations to motivate further design of more high-performance SFCs with long lifespans for CO2 hydrogenation are provided.

关键词： spinel ferrite CO2 hydrogenation functional catalysts structural modification high-value chemicals heterogeneous catalysis structure-function relationships modification fabrication

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