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synaptic functions and a memristive mechanism on Pt/AlOx/HfOx/TiN bilayer-structure memristors

JOURNAL OF PHYSICS D-APPLIED PHYSICS 2020年第3期53卷 035302-035302页

作者： Liu, Chang Wang, Lai-Guo Cao, Yan-Qiang Wu, Ming-Ze Xia, Yi-Dong Wu, Di Li, Ai-Dong Nanjing Univ Collaborat Innovat Ctr Adv Microstruct Jiangsu Key Lab Artificial Funct MatColl Engn & Mat Sci & Engn DeptNatl Lab Solid State Microstr Nanjing 210093 Jiangsu Peoples R China Anqing Normal Univ Key Lab Funct Coordinat Cpds Anhui Higher Educ In AnHui Prov Key Lab Optoelect & Magnetism Funct Ma Anqing 246011 Peoples R China

In this paper, Pt/AlOx/HfOx/TiN bilayer-structure memristors were fabricated by atomic layer deposition. Some essential synaptic biological functions are achieved in such a single inorganic electronic synapse using analog resistive switching behavior. With the aid of x-ray photoelectron spectroscopy (XPS), the non-uniform distribution of oxygen vacancies in the Pt/AlOx/HfOx/TiN memristor has been confirmed. The oxygen-deficient HfOx layer has much more oxygen vacancies than the AlOx layer. In the Pt/AlOx/HfOx/TiN device, the formation/rupture of the nanoscale conductive filaments of oxygen vacancies probably occurs in the AlOx layer. The thickness of the filaments can be altered with the amplitude and width of the stimulating pulses. With the conductive filaments becoming narrower to a quantum wire, quantum conductance has been observed during the bipolar reset process of Pt/AlOx/HfOx/TiN. A memristive switching mechanism of a bilayer metal oxide synaptic device has been proposed to explain synaptic plasticity based on the oxygen vacancies migration/diffusion model.

关键词： memristor synaptic functions atomic layer deposition memristive mechanism quantum conductance

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Cordycepin and Nano-cordycepin-biotin ameliorate cognitive impairments via improving hippocampal synaptic functions in Parkinson's mice

Cordycepin and Nano-cordycepin-biotin ameliorate cognitive i...

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2019中国生理学会学术年会暨张锡钧基金第十五届全国青年优秀生理学学术论文交流会及第十三届全国青年生理学工作者学术会议

作者： Li Liu Ying-Jie Shang Zi-Fan Mai Zhao-Hui Chen Bao-Yan Wu 李楚华 School of Life Science South China Normal University College of Biophotonics South China Normal University

Background Parkinson's disease(PD) is a progressive neurodegenerative disorder that results from the loss of dopaminergic neurons in substantia nigra(SN).Abnormal aggregation of alpha-synuclein(α-syn) causes the dopaminergic neurons degeneration, further decreases the expression of tyrosine hydroxylase(TH) in *** changes of α-syn and TH are considered to be the two major representative pathological features of *** is well known that motor disorders are a group of classic symptoms of PD ***, PD also presents with various non-motor *** example, cognitive dysfunction, one of the non-motor symptoms of PD, could be observed in the early stage of *** is worth to be noted that most research focuses on motor dysfunction in PD, and few reports pay attention to cognitive impairments of ***, an active constituent from Chinese herbs Cordyceps militaris, has been shown to improve learning and memory and to protect against memory deficiencies induced by neurotoxic *** the current study, the first purpose is to investigate whether cordycepin ameliorates cognitive impairments induced by ***,previous studies have showed that cordycepin is easily degraded by adenosine deaminase(ADA) to inactive compounds in *** recent years, nano-drugs have attracted extensive attention, especially in the application of neurodegenerative diseases due to their advantages of drug delivery efficiency and drug-controlled *** that the limitations of the metabolic characteristics of cordycepin,the second purpose of this study is to synthesize a new nano-drug namely nano-cordycepin-biotin and to investigate whether it reduces the learning and memory impairments of PD *** 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine(MPTP) was used to establish an in vivo(30 mg/kg, once a day for 8 days, intraperitoneal injection) PD model in mice and an in vitro(25 μM MPTP, perfusion for 15 min) PD model in hippocampal slices of ***

关键词： Parkinson's disease cognitive impairments cordycepin Nano-cordycepin-biotin synaptic functions

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Plasticity of parylene memristors: Compact phenomenological model and synaptic properties

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CHAOS SOLITONS & FRACTALS 2025年 190卷

作者： Yuklyaevskikh, Georgii A. Shvetsov, Boris S. V. Emelyanov, Andrey Kulagin, Vsevolod A. V. Rylkov, Vladimir Demin, Vyacheslav A. Natl Res Ctr Kurchatov Inst Moscow 123182 Russia Lomonosov Moscow State Univ Moscow 119991 Russia Natl Res Univ Moscow Inst Phys & Technol Moscow 141701 Russia

Memristive devices have proven themselves as synaptic elements with rich internal dynamics and stochasticity for bio-inspired neuromorphic computing systems. Memristors based on parylene are of special interest due to their promising memristive properties, biocompatibility and ease of production. However, their synaptic behavior has not yet been fully demonstrated. In addition, the previously proposed model of resistive switching (RS) of these memristors was of a qualitative character and therefore important switching nuances turned out to be hidden. In this paper, a phenomenological model of resistive switching in parylene memristors is developed, based on the electromigration of metal cations from the top electrode, taking into account the stochastic nature of the RS process and conductivity of the parylene gap between the filament and the electrode, which determines various resistive states (plasticity) of the structures. The model is confirmed by a good correspondence between the calculated and measured current-voltage characteristics of the memristors. We also demonstrate various forms of bio-inspired plasticity of the structures, such as paired pulse facilitation/depression, long-term potentiation/depression and spike timing/amplitude/width/rate dependent plasticity. In the case of rate-based plasticity it resembles the theoretically and experimentally thoroughly studied BCM plasticity rule. The results obtained show the possibility of using such structures in the development of next-generation neuromorphic computing systems with promising calculating and learning capabilities.

关键词： Memristor Resistive switching Parylene Compact model synaptic functions BCM plasticity rule

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Ganoderic acid A ameliorates depressive-like behaviors in CSDS mice: Insights from proteomic profiling and molecular mechanisms

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JOURNAL OF AFFECTIVE DISORDERS 2024年 358卷 270-282页

作者： Xu, Jin-jie Kan, Wei-jing Wang, Tian-yi Li, Lei Zhang, Yi Ge, Zi-yu Xu, Ji-yi Yin, Zi-jia Feng, Yuan Wang, Gang Du, Jing Capital Med Univ Beijing Anding Hosp Natl Clin Res Ctr Mental Disorders Beijing 100088 Peoples R China Capital Med Univ Beijing Anding Hosp Beijing Key Lab Mental Disorders Beijing 100088 Peoples R China Capital Med Univ Adv Innovat Ctr Human Brain Protect Beijing 100069 Peoples R China Harbin Med Univ Daqing Campus Harbin 163319 Heilongjiang Peoples R China

Objective: Ganoderic Acid A (GAA), a primary bioactive component in Ganoderma, has demonstrated ameliorative effects on depressive-like behaviors in a Chronic Social Defeat Stress (CSDS) mouse model. This study aims to elucidate the underlying molecular mechanisms through proteomic analysis. Methods: C57BL/6 J mice were allocated into control (CON), chronic social defeat stress (CSDS), GAA, and imipramine (IMI) groups. Post-depression induction via CSDS, the GAA and IMI groups received respective treatments of GAA (2.5 mg/kg) and imipramine (10 mg/kg) for five days. Behavioral assessments utilized standardized tests. Proteins from the prefrontal cortex were analyzed using LC-MS, with further examination via bioinformatics and PRM for differential expression. Western blot analysis confirmed protein expression levels. Results: Chronic social defeat stress (CSDS) induced depressive-like behaviors in mice, which were significantly alleviated by GAA treatment, comparably to imipramine (IMI). Proteomic analysis identified distinct proteins in control (305), GAA-treated (949), and IMI-treated (289) groups. Enrichment in mitochondrial and synaptic proteins was evident from GO and PPI analyses. PRM analysis revealed significant expression changes in proteins crucial for mitochondrial and synaptic functions (namely, Naa30, Bnip1, Tubgcp4, Atxn3, Carmil1, Nup37, Apoh, Mrpl42, Tprkb, Acbd5, Dcx, Erbb4, Ppp1r2, Fam3c, Rnf112, and Cep41). Western blot validation in the prefrontal cortex showed increased levels of Mrpl42, Dcx, Fam3c, Ppp1r2, Rnf112, and Naa30 following GAA treatment. Conclusion: GAA exhibits potential antidepressant properties, with its action potentially tied to the modulation of synaptic functions and mitochondrial activities.

关键词： Ganoderic acid A Chronic social defeat stress Proteomic profiling Mitochondrial activities synaptic functions

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CsPbBr3 QDs Employed as Gate to Fabricate an Artificial Photosynapse

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ACS APPLIED ELECTRONIC MATERIALS 2023年第9期5卷 4996-5004页

作者： Peng, Yubo Jin, Xudong Zeng, Pingjun Zhao, Min Gao, Zhipeng Ji, Jian-long Li, Xiaona Chen, Weiyi Taiyuan Univ Technol Coll Biomed Engn Taiyuan 030024 Peoples R China Taiyuan Univ Technol Key Lab Interface Sci Engn Adv Mat Minist Educ Taiyuan 030024 Peoples R China Taiyuan Univ Technol Coll Elect Informat & Opt Engn Taiyuan 030024 Peoples R China

Recently, artificial photosynapses have attracted much attention from researchers because they have the ability to perceive, process, and remember information about the external environment, which can greatly improve the efficiency of visual information processing. This work prepared the artificial optical synaptic transistors based on organic electrochemical transistors (OECTs) and CsPbBr3 quantum dots (QDs) synthesized at room temperature. The fabricated device here could successfully imitate the visual functions by mimicking the important synaptic features such as excitatory postsynaptic currents, paired-pulse facilitation, spiking-rate-dependent plasticity, spiking-number-dependent plasticity, and short-term memory to long-term memory transition. Employing the device, we also simulated the capabilities of the human visual system of light adaptation, image recognition, and preprocessing. The investigations in this work indicated that CsPbBr3 QDs have a high potential application in fabricating artificial photosynapses of the type of OECTs to imitate human vision due to the simpler fabrication process.

关键词： imitating vision learning and forgetting synaptic functions perovskite nanocrystals PEDOT:PSS

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Multiple Switching Modes of NiOx Memristors for Memory-Driven Multifunctional Device Applications

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ACS APPLIED ELECTRONIC MATERIALS 2022年第7期4卷 3739-3748页

作者： Park, Young Ran Cho, Haein Wang, Gunuk Korea Univ KIST Grad Sch Converging Sci & Technol Seoul 02841 South Korea Korea Univ Dept Integrat Energy Engn Seoul 02841 South Korea Korea Inst Sci & Technol Ctr Neuromorph Engn Seoul 02792 South Korea

ABSTRACT: Multiple building components with a variety of switching capabilities are required to implement memory-driven parallel computing architecture and multifunctional device applications. In this regard, there is a high demand for implementing multiple switching modes based on only one active material in a simple device form. In this study, we demonstrated the ability of a solution-processable two-terminal Ag (or Al)/NiOx/ ITO memristor that exhibits triple-switching characteristics depending on the different voltage regimes. Notably, the device exhibits an analog bipolar switching behavior under a low programming voltage (<= 1.0 V), enabling essential synaptic functions, as well as a high recognition accuracy of 87.42% in a single-layer neural network. After the electroforming process to form the oxygen vacancy-based conductive filament in the NiOx layer, the device concurrently exhibited digital bipolar switching and unipolar threshold switching behaviors at different voltage regimes without compliance current. These three switching characteristics are related to the transition of dominant switching mechanisms depending on the operating scheme, which is investigated using various material and chemical characterization techniques during switching, including cross-sectional scanning transmission electron microscopy, atomic force microscopy, ultraviolet photoelectron spectroscopy, and X-ray photoelectron spectroscopy.

关键词： NiO x memristor analog bipolar switching digital bipolar switching unipolar threshold switching synaptic functions

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Liquid-Solid Combination Memristors with Switchable Resistance

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ADVANCED ELECTRONIC MATERIALS 2024年第11期10卷

作者： Duan, Libing Han, Xue Pei, Ruochen Peng, Qianwen Guo, Shenghui Li, Yangyang Geng, Wangchang Northwestern Polytech Univ MOE Key Lab Mat Phys & Chem Extraordinary Condit Xian 710072 Peoples R China Northwestern Polytech Univ Sch Phys Sci & Technol Xian 710072 Peoples R China Northwestern Polytech Univ Sch Chem & Chem Engn Xian 710072 Peoples R China

Here a reconfigurable memristor is demonstrated by connecting ZnO film to a fluidic channel. The memristive characteristics are successfully demonstrated with an electrolyte solution. The benefit of using a microfluidic channel is that the memristive characteristics can be adjusted by changing the electrolyte solution in real-time. The neuromorphic functions such as long-term plasticity, Spiking-Rate-Dependent Plasticity (SRDP), and behavior associated with "learning experiences"are demostrated in the devices. The capability of real-time manipulating of memristive characteristics enables diverse manipulations on memristive characteristics of the devices, by doping of different concentrated and type of ions in the ZnO film. The electrolyte solution will open new possibilities for resistance switch manipulations, for the next generation neuromorphic computing. New memristor! A reconfigurable memristor by connecting ZnO film to a fluidic channel. This provides a new device structure capable of achieving resistance changes and synaptic behavior, thereby offering a model for memristor research. image

关键词： dynamic control memristor solution synaptic functions ZnO film

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Sophisticated Conductance Control and Multiple Synapse functions in TiO2-Based Multistack-Layer Crossbar Array Memristor for High-Performance Neuromorphic Systems

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ADVANCED FUNCTIONAL MATERIALS 2024年第51期34卷

作者： So, Hyojin Ji, Hyeonseung Kim, Sungjun Kim, Sungjoon Dongguk Univ Div Elect & Elect Engn Seoul 04620 South Korea Korea Univ Dept AI Semicond Engn Sejong 30019 South Korea

In this study, oxygen-rich TiOy and TiOx layers are intentionally designed to have different oxygen compositions, functioning as an overshoot suppression layer (OSL) and oxygen reservoirs. Furthermore, by natural oxidation reactions occurring between the TiOy/TiOx/Al2O3 switching layer and the Pt/Al top electrode, an additional AlOy layer can be induced to act as an additional OSL. The proposed annealing process accelerates the oxidation reaction of AlOy/TiOy OSLs, thereby enhancing the self-compliance feature of devices. Moreover, the ultrathin AlN serves as an oxygen barrier layer (OBL) that inhibits the movement of oxygen ions at the interface between the Al2O3 layer and the Pt/Ti bottom electrode. The optimized devices are tested by DC sweep and pulses for neuromorphic computing systems. To realize biological synapse characteristics, several key synaptic memory plasticities are proposed. Finally, a 24 x 24 crossbar array based on the 0T-1R structure, incorporating optimized AlOy/TiOy OSLs and OBL via the annealing process, is characterized. During the electroforming step, all specified target cells (marked with the letters "ESDL") achieved self-compliance at low current levels without experiencing hard-breakdown failures or interference among neighboring cells. The successful array performance is demonstrated by the accurate tuning of target weights.

关键词： cross-point array neuromorphic systems resistive switching self-compliance synaptic functions

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A Physically Transient Self-Rectifying and Analogue Switching Memristor Synapse

IEEE ELECTRON DEVICE LETTERS

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IEEE ELECTRON DEVICE LETTERS 2021年第11期42卷 1599-1602页

作者： Lv, Jiaxin Wang, Saisai Li, Fanfan Liang, Qi Yang, Mei Ma, Xiaohua Wang, Hong Hao, Yue Xidian Univ Sch Adv Mat & Nanotechnol Key Lab Wide Band Gap Semicond Technol Xian 710071 Peoples R China Xidian Univ Sch Microelect Key Lab Wide Band Gap Semicond Technol Xian 710071 Peoples R China

A physical transient memristor synapse with self-rectifying and analogue switching behaviors based on Mo/MgO/AZO (Al2O3 2 wt %, ZnO 98 wt %)/W is presented. By modulating thickness of MgO layer, the device with 5 nm MgO insulator layer shows stable resistive switching memory with a rectification ratio up to 10(2), and precise tuning synaptic functions. Meanwhile, the formation of Schottky barrier and oxygen vacancy conductive filament is proposed to further explain self-rectifying and analogue switching behaviors. Additionally, the electrical characteristics of the Mo/MgO/AZO/W devices degraded after being immersed in deionized water (DI) for 3 min, which demonstrated the physically transient features successfully. The physical transient self-rectifying memristors have great potential for applications in secure neuromorphic computing systems, and bio-integrated electronics.

关键词： Physically transient self-rectifying analogue switching synaptic functions

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Spectrum-dependent photonic synapses based on 2D imine polymers for power-efficient neuromorphic computing

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InfoMat 2021年第8期3卷 904-916页

作者： Junyao Zhang Qianqian Shi Ruizhi Wang Xuan Zhang Li Li Jianhua Zhang Li Tian Lize Xiong Jia Huang Interdisciplinary Materials Research Center School of Materials Science and EngineeringShanghai Institute of Intelligent Science and TechnologyTongji UniversityShanghaiPeople's Republic of China Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People's Hospital Affiliated to Tongji UniversityShanghaiPeople's Republic of China Key Laboratory of Advanced Display and System Application Ministry of EducationShanghai UniversityShanghaiPeople's Republic of China

2D polymers(2DPs)have attracted increasing interests in sensors,catalysis,and gas storage ***,2DPs with unique band structure and tunable photophysical properties also have immense potential for application in photonic neuromorphic ***,photonic synaptic transistors based on 2DPs as the light-tunable charge-trapping medium are developed for the first *** resulted organic transistors can successfully emulate common synaptic functions,including excitatory postsynaptic current,pair-pulse facilitation,the transition of short-term memory to long-term memory,and dynamic *** from the high photosensitivity of the 2DP,the devices can be operated under a low operating voltage of0.1 V,and achieve an ultralow energy consumption of~0.29 pJ per *** addition,the heterostructure formed between the 2DP and organic semiconductor enables spectrum-dependent synaptic responses,which facilitates the simulation of visual learning and memory processes in distinct emotional *** underlying mechanism of spectrum-dependent synaptic-like behaviors is systematically validated with in situ atomic force microscopy based electrical *** spectrum-enabled tunability of synaptic behaviors further promotes the realization of optical logic functions and associative *** work inspires the new application of 2DPs in photonic synapses for future neuromorphic computing.

关键词： 2D polymers neuromorphic computing photonic synapses synaptic functions

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