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检索条件"主题词=Txnip"
545 条 记 录,以下是111-120 订阅
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txnip contributes to induction of pro-inflammatory phenotype and caspase-3 activation in astrocytes during Alzheimer's diseases
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REDOX BIOLOGY 2023年 63卷 102735页
作者: Kim, Junhyung Lim, Jaejoon Yoo, Ik Dong Park, Samel Moon, Jong-Seok Soonchunhyang Univ Soonchunhyang Inst Med bio Sci SIMS Dept Integrated Biomed Sci Cheonan 31151 Chungcheongnam South Korea CHA Univ Bundang CHA Med Ctr Dept Neurosurg Yatap dong 59 Seongnam 13496 South Korea Soonchunhyang Univ Hosp Cheonan Dept Nucl Med Cheonan 31151 Chungcheongnam South Korea Soonchunhyang Univ Hosp Cheonan Dept Internal Med Cheonan 31151 Chungcheongnam South Korea Soonchunhyang Univ Soonchunhyang Inst Med bio Sci SIMS Dept Integrated Biomed Sci Cheonan Chungcheongnam South Korea
Neuroinflammation and oxidative stress have been implicated in the pathogenesis of Alzheimer's disease (AD). Neuroinflammation and oxidative stress are associated with neuronal death in AD. Astrocytes are linked t... 详细信息
来源: 评论
Notoginsenoside R1 Protects against Diabetic Nephropathy through txnip-NLRP3 Signaling Pathway
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Clinical Complementary Medicine and Pharmacology 2023年 第4期3卷 34-48页
作者: Chunting Zhang Renyikun Yuan Siyuan Li Guodong Huang Kaili Sun Jiaping Pan Qiuxia Liu Xiang Gao Zhijing Wang Tongyu Li Shilong Lu Jianzhen Lv Liting Huang Hongwei Gao College of Pharmacy Guangxi University of Chinese MedicineNanning 530200GuangxiChina Guangxi Engineering Technology Research Center of Advantage Chinese Development Nanning 530200GuangxiChina Guangxi International Zhuang Medicine Hospital Nanning 530200GuangxiChina The First Affiliated Hospital of Guangxi University of Chinese Medicine Nanning 530200GuangxiChina Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine Nanning 530001GuangxiChina
Background:Diabetic nephropathy(DN)is a microvascular complication of diabetes mellitus(DM).DN results from many factors,including changes in glomerular hemodynamics,oxidative stress and inflammation,and in-terstitial... 详细信息
来源: 评论
Long non-coding RNA NEAT1 promotes lipopolysaccharide-induced injury in human tubule epithelial cells by regulating miR-93-5p/txnip axis
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MEDICAL MICROBIOLOGY AND IMMUNOLOGY 2021年 第2-3期210卷 121-132页
作者: Yang, Jing Wu, Lin Liu, Shanshou Hu, Xiaomin Wang, Qianmei Fang, Liying Xijing Hosp Dept Emergency Xian Shaanxi Peoples R China Fourth Peoples Hosp Shaanxi Prov Dept Resp & Crit Care Med 512 Xianning East Rd Xian 710043 Shaanxi Peoples R China
Many long non-coding RNAs (lncRNAs) have been found to play crucial roles in sepsis-induced acute kidney injury (AKI), including lncRNA nuclear-enriched abundant transcript 1 (NEAT1). We aimed to further elucidate the... 详细信息
来源: 评论
Upregulation of txnip contributes to granulosa cell dysfunction in polycystic ovary syndrome via activation of the NLRP3 inflammasome
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MOLECULAR AND CELLULAR ENDOCRINOLOGY 2023年 561卷 111824页
作者: Wang, Ying Yang, Jiyu Wang, Yu Chen, Yao Wang, Yiran Kuang, Hongying Feng, Xiaoling Heilongjiang Univ Chinese Med Affiliated Hosp 1 Dept Gynecol 2 Harbin Peoples R China Heilongjiang Univ Chinese Med Grad Sch Harbin Peoples R China Heilongjiang Univ Chinese Med Sch Pharm Harbin Peoples R China
Polycystic ovary syndrome (PCOS) is a complex endocrine disease. Thioredoxin-interacting protein (txnip) promotes oxidative stress and triggers inflammation. Herein, we investigated the role and potential mechanism of... 详细信息
来源: 评论
硫氧还原蛋白互作蛋白txnip在胚胎干细胞中抑制早期胚胎基因表达
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南开大学学报(自然科学版) 2024年 第3期57卷 26-29,34页
作者: 李晓敏 周莎 吕鑫屹 南开大学药物化学生物学全国重点实验室 天津300350
胚胎干细胞是一种具有高发育潜能的多能干细胞.虽然胚胎干细胞中有极少量细胞高表达2细胞早期胚胎相关基因,但是这些2细胞基因却在大部分胚胎干细胞中被沉默.2细胞胚胎相关基因被哪些因子所沉默仍不完全清楚.发现硫氧还原蛋白互作蛋白Tx... 详细信息
来源: 评论
Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to txnip depletion and AMPK activation in breast cancer cells
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CANCER & METABOLISM 2021年 第1期9卷 5页
作者: Almouhanna, Fadi Blagojevic, Biljana Can, Suzan Ghanem, Ali Woelfl, Stefan Heidelberg Univ Inst Pharm & Mol Biotechnol Neuenheimer Feld 364 D-69120 Heidelberg Germany
BackgroundAerobic glycolysis, discovered by Otto Warburg, is a hallmark of cancer metabolism even though not yet fully understood. The low activity of the cancerous pyruvate kinase isozyme (M2) is thought to play an i... 详细信息
来源: 评论
High txnip expression accelerates the migration and invasion of the GDM placenta trophoblast
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BMC PREGNANCY AND CHILDBIRTH 2023年 第1期23卷 235-235页
作者: Sa, Rina Ma, Jing Yang, Jie Li, Dong Fang Du, Jie Jia, Jian Chao Li, Zhi Ying Huang, Na Lamusi, A. Sha, Rula Nai, Gal Hexig, Bayar Meng, Ji Qing Yu, Lan Inner Mongolia Peoples Hosp Dept Clin Med Res Ctr Hohhot 010010 Peoples R China Mongolia Matern & Child Hlth Care Hosp Dept Clin Lab Hohhot 010000 Peoples R China Inner Mongolia Peoples Hosp Dept Gynecol & Obstet Hohhot 010010 Peoples R China Inner Mongolia Int Mongolian Hosp Dept Ophthalmol Hohhot 010000 Peoples R China Inner Mongolia Peoples Hosp Dept Pharmacol Hohhot 010000 Peoples R China Inner Mongolia Univ Sch Life Sci Dept Genet Dev & Cell Biol Hohhot 010000 Peoples R China Inner Mongolia Univ Sch Life Sci State Key Lab Reprod Regulat & Breeding Grassland Hohhot 010000 Peoples R China Inner Mongolia Peoples Hosp Dept Endocrine & Metab Dis Hohhot 010010 Peoples R China
IntroductionOur previous study has proofed the glucose sensitive gene-thioredoxin-interacting protein (txnip) expression was up in the placenta of the patients with gestational diabetes mellitus (GDM), but the patholo... 详细信息
来源: 评论
DNMT1 regulates miR-20a/txnip-mediated pyroptosis of retinal pigment epithelial cells through DNA methylation
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MOLECULAR AND CELLULAR ENDOCRINOLOGY 2023年 第1期577卷 112012页
作者: Xi, Xiaoting Wang, Min Chen, Qianbo Ma, Jia Zhang, Junyan Li, Yan Kunming Med Univ Affiliated Hosp 1 Dept Ophthalmol Kunming 650032 Yunnan Peoples R China Fudan Univ Eye & ENT Hosp Dept Ophthalmol Shanghai 200031 Peoples R China Shanxi Bethune Hosp Shanxi Acad Med Sci Dept Clin Epidemiol & Evidence based Med Taiyuan 030032 Peoples R China Kunming Med Univ Affiliated Hosp 1 295 Xichang Rd Kunming 650032 Yunnan Peoples R China
Background: Pyroptosis of retinal pigment epithelium (RPE) cells is associated with the etiology of diabetic retinopathy (DR). In this study, we investigated the effect of DNMT1 on RPE cell pyroptosis by regulating mi... 详细信息
来源: 评论
1,8-Cineole ameliorates diabetic retinopathy by inhibiting retinal pigment epithelium ferroptosis via PPAR-?/txnip pathways
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BIOMEDICINE & PHARMACOTHERAPY 2023年 第1期164卷 114978-114978页
作者: Liu, Zhangnian Gan, Shiquan Fu, Lingyun Xu, Yini Wang, Shengquan Zhang, Guangqiong Pan, Di Tao, Ling Shen, Xiangchun Guizhou Med Univ State Key Lab Funct & Applicat Med Plants Guiyang Peoples R China Guizhou Med Univ High Efficacy Applicat Nat Med Resources Engn Ctr Dept Pharmacol Mat Med Guiyang Peoples R China Guizhou Med Univ Sch Pharmaceut Sci High Educ Key Lab Guizhou Prov Nat Med Pharmacol & Guiyang Peoples R China Guizhou Med Univ Union Key Lab Guiyang City Guizhou Med Univ Sch Pharmaceut Sci Key Lab Optimal Utilizat Nat Med Resources Guiyang Peoples R China Guizhou Med Univ Key Lab Endem & Ethn Dis Minist Educ Guiyang Peoples R China
1,8-Cineole, the main component of volatile oil in aromatic plants, has diverse pharmacological properties, including antioxidant, anti-inflammatory, and anti-cancer properties. Diabetic retinopathy (DR) is a common m... 详细信息
来源: 评论
Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/txnip/NLRP3 pathway
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INTERNATIONAL IMMUNOPHARMACOLOGY 2023年 114卷 109558页
作者: Jiang, Xiangfu Li, Yu Fu, Dongdong You, Tingyu Wu, Shuai Xin, Jiao Wen, Jiagen Huang, Yan Hu, Chengmu Anhui Med Univ Anhui Inst Innovat Drugs Sch Pharm Anhui Prov Key Lab Major Autoimmune Dis Hefei 230032 Peoples R China Anhui Med Univ Sch Pharm Inst Liver Dis Hefei 230032 Peoples R China Minist Educ Key Lab Antiinflammatory & Immune Med Hefei 230032 Peoples R China
The overuse of acetaminophen (APAP) may cause more severe hepatotoxicity in patients with non-alcoholic fatty liver disease (NAFLD). Caveolin-1 (CAV1), is an essential regulator of metabolic function, which can allevi... 详细信息
来源: 评论