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检索条件"主题词=Txnip"
545 条 记 录,以下是21-30 订阅
排序:
Silencing hnRNPD inhibits gastric cancer growth by increasing txnip-mediated oxidative stress
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Discover Oncology 2025年 第1期16卷 1-12页
作者: Zou, Xuan Li, Jin Zhou, Junshuo Ren, Qiulei Wang, Kelong Wang, Xiaoyan Reproductive Medicine Center Suizhou Hospital Hubei University of Medicine Hubei Suizhou 441300 China Gynaecology Ward 2 Suizhou Hospital Hubei University of Medicine Hubei Suizhou 441300 China Institute of Basic Medical Sciences Hubei University of Medicine Hubei Shiyan 442000 China Department of Clinical Oncology Taihe Hospital Hubei University of Medicine Hubei Shiyan 442000 China
Background: RNA-binding proteins (RBPs) are essential for controlling gene expression, and their dysregulation is a key factor in tumor development and progression. Heterogeneous nuclear ribonucleoprotein D (hnRNPD), ... 详细信息
来源: 评论
Mechanistic insights into the protective potential of ambrisentan against L-arginine induced acute pancreatitis and multiorgan damage (role of NRF2/HO-1 and txnip/NLRP3 pathways)
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Biomedicine and Pharmacotherapy 2025年 187卷 118119-118119页
作者: Almutary, Khaled H. Zaghloul, Marwa S. Nader, Manar A. Elsheakh, Ahmed R. Department of Pharmacology and Toxicology Faculty of Pharmacy Mansoura University Mansoura 35516 Egypt Majmaah University P.O.Box 66 Majmaah 11952 Saudi Arabia Department of Pharmacology and Toxicology Faculty of Pharmacy Mansoura National University Gamasa 7731168 Egypt Future Studies and Risks Management & National Committee of Drugs Academy of Scientific Research Ministry of Higher Education Elsayeda Zeinab Egypt
Acute pancreatitis (AP) is an abrupt inflammation of the pancreatic tissue. The severity of AP varies from mild and self-limiting to severe, potentially fatal, and can affect several organ systems. The most severe typ... 详细信息
来源: 评论
Emodin delays rheumatoid arthritis progression by inhibiting the ROS/txnip/NLRP3 signaling pathway
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International Immunopharmacology 2025年 158卷 114861页
作者: Zhou, Linlan Liu, Jun Yang, Kang Cai, Chunlei Cheng, LianYing Du, Dehao He, Haohua Hua, Xinyu Rong, Xiaofeng Department of Combination of Chinese and Western Medicine The First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases Chongqing 400016 China Department of Rehabilitation Medicine of Jiangbei Campus The First Affiliated Hospital of Army Medical University Chongqing 401315 China Jiangbei District Hospital of Traditional Chinese Medicine No. 35 Village 1 Jianxin East Road Jiangbei District Chongqing 400020 China College of Traditional Chinese Medicine Chongqing Medical University Chongqing 400016 China
Rheumatoid arthritis (RA) is a chronic autoimmune disorder affecting small joints of the hands, feet, and ankles, causing synovitis, pannus formation, and vasculitis. RA can lead to joint destruction and multi-system ... 详细信息
来源: 评论
Ginsenoside Rg1 attenuates T2DM-induced renal damage and fibrosis by inhibiting TRPC6-ChREBP-txnip signaling
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Journal of Ethnopharmacology 2025年 348卷 119863页
作者: Zhang, Hui Liang, Haoyu Fan, Lei Zhu, Xing Ji, Pengmin Su, Yong Li, Weiping Li, Weizu Department of Pharmacology School of Basic Medical Sciences Key Laboratory of Anti-inflammatory and Immunopharmacology Ministry of Education Anhui Medical University Hefei 230032 China Department of Pharmacy The First Affiliated Hospital of Anhui Medical University Hefei 230032 China
Ethnopharmacological relevance: As a traditional Chinese medicine, ginseng has many benefits, including regulating blood sugar, blood pressure and so on. Ginsenoside Rg1 is the main active component of ginseng and has... 详细信息
来源: 评论
M2 macrophage derived exosomal miR-20a-5p ameliorates trophoblast pyroptosis and placental injuries in obstetric antiphospholipid syndrome via the txnip/NLRP3 axis
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Life Sciences 2025年 370卷 123561页
作者: Zhang, Hongyuan Jiang, Ning Xu, Mingyang Jing, Die Dong, Tingting Liu, Qian Lv, Qingfeng Huo, Ruiheng Chen, Pengzheng Li, Lei Wang, Xietong Department of Obstetrics and Gynecology Shandong Provincial Hospital Shandong University Shandong Jinan 250021 China Department of Obstetrics and Gynecology Shandong Provincial Hospital Affiliated to Shandong First Medical University Shandong Jinan 250021 China The Laboratory of Medical Science and Technology Innovation Center (Institute of Translational Medicine) Shandong First Medical University (Shandong Academy of Medical Sciences) of China Shandong Jinan 250117 China Department of Obstetrics and Gynecology Feixian County People's Hospital Shandong Linyi 273400 China The Affiliated Taian City Central Hospital of Qingdao University Shandong Taian 271000 China
Aim: Obstetric antiphospholipid syndrome (OAPS) is a pregnancy-related complication characterized by trophoblast pyroptosis and placental injury induced by antiphospholipid antibodies (aPLs). M2-polarized macrophage-d... 详细信息
来源: 评论
Palmitic acid enhances the sensitivity of ferroptosis via endoplasmic reticulum stress mediated the ATF4/txnip Axis in polycystic ovary syndrome
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Phytomedicine 2025年 142卷 156777页
作者: Zhang, Xumin Liu, Jianrong Bai, Chunmei Fan, Yanxin Song, Haixia Huang, Ziwei Li, Yang Luo, Ting The Fifth Clinical Medical College of Shanxi Medical University 29 Shuangtaisi street Shanxi Taiyuan 030012 China Department of reproductive Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University 29 Shuangtaisi street Shanxi Taiyuan 030012 China Department of Orthopedics Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University 29 Shuangtasi Street Shanxi Taiyuan 030012 China
Background: Palmitic acid (PA), the most prevalent saturated fatty acid in humans, is closely associated with ovarian dysfunction. Elevated PA levels in the follicular fluid of patients with polycystic ovary syndrome ... 详细信息
来源: 评论
Thioredoxin-1 inhibits NLRP3-mediated pyroptosis by regulating txnip in models of Alzheimer’s disease
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Scientific Reports 2025年 第1期15卷 1-14页
作者: Jia, Jinjing Sheng, Zixuan Zhang, Yuqian Guo, Lunxi Chen, Zhuo’er Zhu, Dongsheng Zeng, Xiansi Liu, Hongjun Research Center of Neuroscience Jiaxing University Medical College Jiaxing 314001 China Department of Physiology Jiaxing University Medical College Jiaxing 314001 China Department of Neurology The Affiliated Hospital of Jiaxing University Jiaxing 314000 China Department of Biochemistry and Molecular Biology Jiaxing University Medical College Jiaxing 314001 China Judicial Expertise Center Jiaxing University Jiaxing 314001 China Department of Neurology Zhejiang Xin’an International Hospital affiliated to Jiaxing University Jiaxing 314000 China Research Center of Neuroscience Department of Biochemistry Jiaxing University Medical College Jiaxing 314001 China
Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by memory loss. Our recent study has demonstrated that thioredoxin-1 (Trx-1) could protect neurons via repressing NLRP1‑mediated neu... 详细信息
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txnip-mediated nuclear factor-κB signaling pathway and intracellular shifting of txnip in uric acid-induced NLRP3 inflammasome
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2019年 第4期511卷 725-731页
作者: Kim, Seong-Kyu Choe, Jung-Yoon Park, Ki-Yeon Catholic Univ Daegu Dept Internal Med Div Rheumatol Sch Med Daegu South Africa Catholic Univ Daegu Arthrit & Autoimmun Res Ctr Daegu South Africa
Objective: The aim of this study was to assess the role of thioredoxin-interacting protein (txnip) in nuclear factor-kappa B (NF-kappa B) signaling and the interaction between txnip and NOD-like receptor protein 3 (NL... 详细信息
来源: 评论
txnip regulates germinal center generation by suppressing BCL-6 expression
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IMMUNOLOGY LETTERS 2010年 第2期129卷 78-84页
作者: Shao, Yan Kim, Sang Yong Shin, Daesung Kim, Mi Sun Suh, Hyun-Woo Piao, Zheng-Hao Jeong, Mira Lee, Suk Hyung Yoon, Suk Ran Lim, Byung Ho Kim, Woo-Ho Ahn, Jeong Keun Choi, Inpyo Korea Res Inst Biosci & Biotechnol Cell Therapy Res Ctr Taejon 305333 South Korea BHK Inc Res Inst Cell Therapy Seoul 135832 South Korea Korea Adv Inst Sci & Technol Dept Biol Sci Taejon 305701 South Korea Seoul Natl Univ Coll Med Dept Pathol Seoul 110406 South Korea Chungnam Natl Univ Dept Microbiol Sch Biosci & Biotechnol Taejon 305764 South Korea
The detailed mechanism driving the germinal center (GC) reaction to B cell lymphomagenesis has not been clarified. Thioredoxin interacting protein (txnip), also known as vitamin D3 up-regulated protein 1 which is an i... 详细信息
来源: 评论
txnip potentiates Redd1-induced mTOR suppression through stabilization of Redd1
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ONCOGENE 2011年 第35期30卷 3792-3801页
作者: Jin, H-O Seo, S-K Kim, Y-S Woo, S-H Lee, K-H Yi, J-Y Lee, S-J Choe, T-B Lee, J-H An, S. Hong, S-I Park, I-C Korea Inst Radiol & Med Sci Div Radiat Canc Res Seoul 139706 South Korea Korea Inst Radiol & Med Sci Lab Modulat Radiobiol Responses Seoul 139706 South Korea Hanyang Univ Dept Chem Lab Mol Biochem Seoul 133791 South Korea Konkuk Univ Dept Microbiol Engn Seoul South Korea
The mammalian target of rapamycin (mTOR) is a highly conserved serine-threonine kinase activated in response to growth factors and nutrients. Because of frequent dysregulation of the mTOR signaling pathway in diverse ... 详细信息
来源: 评论