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检索条件"主题词=Txnip"
545 条 记 录,以下是71-80 订阅
排序:
txnip deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease
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RENAL FAILURE 2024年 第1期46卷 2338933页
作者: Du, Yunxia Wu, Ming Song, Shan Bian, Yawei Shi, Yonghong Hebei Med Univ Dept Pathol Shijiazhuang Peoples R China Hebei Key Lab Kidney Dis Shijiazhuang Peoples R China Hebei Med Univ Inst Med & Hlth Sci Ctr Metab Dis & Canc Res Shijiazhuang Peoples R China Hebei Med Univ Dept Pathol Shijiazhuang 050017 Peoples R China
Thioredoxin-interacting protein (txnip) is an important regulatory protein for thioredoxin (TRX) that elicits the generation of reactive oxygen species (ROS) by inhibiting the redox function of TRX. Abundant evidence ... 详细信息
来源: 评论
Disrupting CISD2 function in cancer cells primarily impacts mitochondrial labile iron levels and triggers txnip expression
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FREE RADICAL BIOLOGY AND MEDICINE 2021年 176卷 92-104页
作者: Karmi, Ola Sohn, Yang-Sung Zandalinas, Sara, I Rowland, Linda King, Skylar D. Nechushtai, Rachel Mittler, Ron Univ Missouri Sch Med Dept Surg Christopher S Bond Life Sci Ctr 1201 Rollins St Columbia MO 65201 USA Hebrew Univ Jerusalem Alexander Silberman Inst Life Sci Edmond J Safra Campus Givat Ram IL-91904 Jerusalem Israel Univ Missouri Coll Agr Food & Nat Resources Div Plant Sci & Interdisciplinary Plant Grp Christopher S Bond Life Sci Ctr 1201 Rollins St Columbia MO 65201 USA
The CISD2 (NAF-1) protein plays a key role in regulating cellular homeostasis, aging, cancer and neurodegenerative diseases. It was found to control different calcium, reactive oxygen species (ROS), and iron signaling... 详细信息
来源: 评论
The Effect of Verapamil on txnip Gene Expression, GLP1R mRNA, FBS, HbA1c, and Lipid Profile in T2DM Patients Receiving Metformin and Sitagliptin
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DIABETES THERAPY 2021年 第10期12卷 2701-2713页
作者: Malayeri, Alireza Zakerkish, Mehrnoosh Ramesh, Farrokh Galehdari, Hamid Hemmati, Ali Asghar Angali, Kambiz A. Ahvaz Jundishapur Univ Med Sci Sch Pharm Dept Pharmacol Ahvaz Iran Ahvaz Jundishapur Univ Med Sci Hlth Res Inst Dept Internal Med Diabet Res Ctr Ahvaz Iran Shahid Chamran Univ Ahvaz Dept Genet Fac Sci Ahvaz Iran Ahvaz Jundishapur Univ Med Sci Sch Pharm Med Plant Res Ctr Ahvaz Iran Ahvaz Jundishapur Univ Med Sci Sch Hlth Dept Biostat & Epidemiol Ahvaz Iran
Introduction: Type 2 diabetes mellitus (T2DM) is the most common type of diabetes. A decrease in the number of pancreatic beta cells is a pathological sign of diabetes, and to date there is no drug treatment that targ... 详细信息
来源: 评论
Chronic intermittent hypoxia-induced mitochondrial dysfunction mediates endothelial injury via the txnip/NLRP3/IL-1? signaling pathway
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FREE RADICAL BIOLOGY AND MEDICINE 2021年 165卷 401-410页
作者: Yan, Ya Ru Zhang, Liu Lin, Ying Ni Sun, Xian Wen Ding, Yong Jie Li, Ning Li, Hong Peng Li, Shi Qi Zhou, Jian Ping Li, Qing Yun Shanghai Jiao Tong Univ Ruijin Hosp Dept Resp & Crit Care Med Sch Med Shanghai 200025 Peoples R China Shanghai Jiao Tong Univ Inst Resp Dis Sch Med Shanghai 200025 Peoples R China
Oxidative stress and inflammation induced by chronic intermittent hypoxia (CIH) are trigger factors of cardiovascular diseases in patients with obstructive sleep apnea (OSA). This study aimed to investigate the role o... 详细信息
来源: 评论
Effect of Sleeve Gastrectomy on Plasma Thioredoxin-Interacting Protein (txnip)
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OBESITY SURGERY 2021年 第11期31卷 4829-4835页
作者: Chu, Yuxiao Widjaja, Jason Hong, Jian Dolo, Ponnie Robertlee Zhu, Xiaocheng Yao, Libin Xuzhou Med Univ Affiliated Hosp Dept Gastrointestinal Surg Xuzhou 221002 Jiangsu Peoples R China
Purpose The mechanism in which bariatric surgery induces diabetes remission is still poorly understood. This study proposes Thioredoxin-interacting protein (txnip) as a possible factor for the anti-diabetic mechanism ... 详细信息
来源: 评论
W2476 represses txnip transcription via dephosphorylation of FOXO1 at Ser319
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CHEMICAL BIOLOGY & DRUG DESIGN 2021年 第5期97卷 1089-1099页
作者: Zhong, Li Liu, Qing Liu, Qiaofeng Zhang, Shikai Cao, Yongbing Yang, Dehua Wang, Ming-Wei Chinese Acad Sci Natl Ctr Drug Screening CAS Key Lab Receptor Res Shanghai Inst Mat Med Shanghai 201203 Peoples R China Univ Chinese Acad Sci Beijing Peoples R China Fudan Univ Sch Pharm Shanghai Peoples R China Shanghai Univ Tradit Chinese Med Shanghai TCM Integrated Hosp Shanghai Peoples R China
Thioredoxin-interacting protein (txnip) overexpression is implicated in the pathogenesis of type 2 diabetes. Previous studies have shown that a small molecule compound (W2476) was able to improve beta-cell dysfunction... 详细信息
来源: 评论
miR-125b enhances metastasis and progression of cancer via the txnip and HIF1α pathway in pancreatic cancer
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CANCER BIOMARKERS 2021年 第1期31卷 27-38页
作者: Wang, Pengli Zheng, Dan Qi, Hongyang Gao, Qi Xinxiang Cent Hosp Dept Gastroenterol 56 Jinsui Ave Xinxiang 453000 Henan Peoples R China Xinxiang Cent Hosp Dept Endocrinol Xinxiang Henan Peoples R China
BACKGROUND: MicroRNAs (miRNAs) play potential role in the development of various types of cancer conditions including pancreatic cancer (PC) targeting several cellular processes. Present study was aimed to evaluate fu... 详细信息
来源: 评论
Intestinal metabolite UroB alleviates cerebral ischemia/reperfusion injury by promoting competition between TRIM65 and txnip for binding to NLRP3 inflammasome in response to neuroinflammation (vol 1870, 167056, 2024)
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2024年 第7期1870卷 167056页
作者: Luo, Jing Luo, Yujia Chen, Jialei Gao, Yu Tan, Junyi Yang, Yongkang Yang, Changhong Jiang, Ning Luo, Yong Chongqing Med Univ Affiliated Hosp 1 Dept Neurol Chongqing Peoples R China Chongqing Med Univ Dept Pathol Chongqing Peoples R China Chongqing Med Univ Mol Med Diagnost & Testing Ctr Chongqing Peoples R China Chongqing Med Univ Affiliated Hosp 1 Dept Pathol Chongqing Peoples R China Chongqing Med Univ Affiliated Hosp 1 Dept Orthoped Chongqing Peoples R China Chongqing Med Univ Coll Basic Med Sci Mol Med & Canc Res Ctr Chongqing Peoples R China Chengdu Univ Clin Med Coll Dept Clin Med Chengdu Peoples R China Chongqing Med Univ Dept Bioinformat Chongqing Peoples R China
Our previous research suggests that targeting NLRP3 inflammasomes holds promise for mitigating cerebral ischemia/reperfusion injury. The gut metabolite Urolithin B (UroB) has been shown to inhibit the neuroinflammatio... 详细信息
来源: 评论
A novel link between melatonin and circ_0005753/PTBP1/txnip regulatory network in the modulation of osteogenic potential in mesenchymal stem cells
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CHEMICAL BIOLOGY & DRUG DESIGN 2024年 第1期103卷 e14380页
作者: Tu, Wei Zhu, Shuying Li, Fan Xu, Chengyun Tu, Weiping Chen, Yanxia Nanchang Univ Endocrine Dept Affiliated Hosp 2 Nanchang Jiangxi Peoples R China Nanchang Univ Affiliated Hosp 2 Dept Nephrol Nanchang Jiangxi Peoples R China Nanchang Univ Dept Nephrol Affiliated Hosp 2 1 Minde Rd Nanchang 330006 Jiangxi Peoples R China
Labeled with pluripotent potential, the transplantation of bone marrow mesenchymal stem cells (BMSCs) is considered as a promising strategy for treating osteoporosis (OP). Melatonin (MEL) has been investigated to be a... 详细信息
来源: 评论
Ranolazine ameliorates T1DM-induced testicular dysfunction in rats;role of NF-κB/txnip/GSDMD-N/IL-18/Beclin-1 κ B/txnip/GSDMD-N/IL-18/Beclin-1 signaling pathway
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EUROPEAN JOURNAL OF PHARMACOLOGY 2024年 977卷 176744页
作者: Samaha, Mahmoud M. Nour, Omnia A. Mansoura Univ Fac Pharm Dept Pharmacol & Toxicol Mansoura 35516 Egypt
Approximately 90% of diabetic males have varying degrees of testicular dysfunction. The current study investigates the possible beneficial consequences of ranolazine against T1DM-induced testicular dysfunction in rats... 详细信息
来源: 评论