Mining and analyzing potential attack paths in networks based on alarm information can provide references for accurate and effective network defense measures. However, current research lacks thorough extraction and in...
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ISBN:
(纸本)9798331532109;9798331532093
Mining and analyzing potential attack paths in networks based on alarm information can provide references for accurate and effective network defense measures. However, current research lacks thorough extraction and integration of deep features from alarm information. In this work, we propose APE-VD, an attack path extraction model based on VGAE and DBSCAN. It involves constructing network attack graphs based on host connectivity information and alarm types. Additionally, it creates temporal attack graphs by combining alarm data from different time slices with flow relationships. Using variationalautoencoders, the temporal attack graphs are reduced in dimensionality to obtain alarm flow features. DBSCAN clustering is utilized to mine outlier nodes. To enhance clustering accuracy and robustness, second-order temporal risk features are extracted based on outlier nodes as prior information. Further, variationalautoencoders and DBSCAN clustering are applied again. After filtering based on risk thresholds, forward and backward retrieval of nodes is conducted to derive attack paths. Simulation results on widely used log datasets demonstrate that APE-VD can efficiently uncover attack paths within limited computational complexity, aiding in reconstructing attack scenarios.
Diverse types of cells interact and communicate with each other to maintain tissue homeostasis and perform biological functions. Perturbations to these interactions can break the homeostasis of the tissue microenviron...
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Diverse types of cells interact and communicate with each other to maintain tissue homeostasis and perform biological functions. Perturbations to these interactions can break the homeostasis of the tissue microenvironment, leading to disease. Understanding intercellular communication changes in disease is critical for therapeutic development. Cell-cell communication networks (CCCNs) inferred from single-cell RNA sequencing data are highly variable and only capture a snapshot of the dynamic intercellular communication system. We develop a graphical generative model to compare CCCNs between disease and control samples to identify disease associated perturbations to intercellular communications. The distribution of CCCNs is learned using variational graph autoencoder (VGAE) in disease and control groups separately. Then a large number of graphs is generated to assess the significance of the difference between the two distributions using different graph distance measures. We demonstrate the advantage of this approach in improving the power of identifying disease associated perturbations to intercellular communications through both simulation studies and real scRNA-seq datasets.
Social recommendation has been an effective approach to solve the new user recommendation problem based on user -item interactions and user -user social relations. Although lots of research has been done, it is still ...
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Social recommendation has been an effective approach to solve the new user recommendation problem based on user -item interactions and user -user social relations. Although lots of research has been done, it is still an emergent and challenging issue to predict the behaviors of new users without any historical interaction. Firstly, the previous methods fail to consider social structures and social semantics when looking for potential social neighbors for new users, resulting in inconsistent preferences of these neighbors. Secondly, existing methods employ deterministic modeling way to represent and aggregate neighbors, limiting the diversity and robustness of new user representations. Therefore, we present a novel new user preference uncertainty modeling framework, named Disentangled -feature and Composite -prior VAE(DC-VAE), to predict the behaviors of new users without any interaction. Concretely, a length -adaptive similarity metric considering the length of user behaviors and social relationships is designed for all users to choose more analogous neighbors, especially more effective for new users due to the metric incorporating the social structures and social semantics. Then the Neighbor -based Disentangled Features module is proposed to disentangle different types of neighbor characteristics and model more diversified new user representations. Next, unlike traditional Gaussian prior constraint, the Neighbor -based Composite prior module is proposed to fuse the priors of neighbors and obtain more expressive and robust new user representations. Finally, we theoretically prove the advantages of composite prior and disentangled features. Extensive experiments on three datasets demonstrate that our model DC-VAE is remarkably superior to other baselines.
With the rapid development of graphvariational Bayes theory, some representative community detection methods have been proposed. Although these methods are well designed, they are limited by the inherent constraints ...
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With the rapid development of graphvariational Bayes theory, some representative community detection methods have been proposed. Although these methods are well designed, they are limited by the inherent constraints of static networks. Therefore, how to re-examine the information in static networks from a new perspective becomes a challenge. To this end, in this paper, we propose EG-VGAE and its variant EGC-VGAE, going beyond the constraints of static networks from a new perspective. Specifically, we first demonstrate that the evolution relations on static networks can be simulated reasonably. And then, our EG-VGAE method combines evolution information with static network information to realize a fine-grained propagation of local low -frequency signals to global low -frequency signals, thereby improving the accuracy of community assignment for each node. Building on this progress, our method EGC-VGAE imposes the smoothness constraint on adjacent slices, significantly enhancing the sensitivity of the method to evolution information and mitigating the impact of network noise. The comprehensive experimental results on real static networks well validate that our methods outperform state-of-the-art methods in most cases. The code is available at https://***/GDM-SCNU/EG-VGAE.
Long noncoding RNAs (lncRNAs) participate in various biological processes and have close linkages with diseases. In vivo and in vitro experiments have validated many associations between lncRNAs and diseases. However,...
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Long noncoding RNAs (lncRNAs) participate in various biological processes and have close linkages with diseases. In vivo and in vitro experiments have validated many associations between lncRNAs and diseases. However, biological experiments are time-consuming and expensive. Here, we introduce LDA-VGHB, an lncRNA-disease association (LDA) identification framework, by incorporating feature extraction based on singular value decomposition and variational graph autoencoder and LDA classification based on heterogeneous Newton boosting machine. LDA-VGHB was compared with four classical LDA prediction methods (i.e. SDLDA, LDNFSGB, IPCARF and LDASR) and four popular boosting models (XGBoost, AdaBoost, CatBoost and LightGBM) under 5-fold cross-validations on lncRNAs, diseases, lncRNA-disease pairs and independent lncRNAs and independent diseases, respectively. It greatly outperformed the other methods with its prominent performance under four different cross-validations on the lncRNADisease and MNDR databases. We further investigated potential lncRNAs for lung cancer, breast cancer, colorectal cancer and kidney neoplasms and inferred the top 20 lncRNAs associated with them among all their unobserved lncRNAs. The results showed that most of the predicted top 20 lncRNAs have been verified by biomedical experiments provided by the Lnc2Cancer 3.0, lncRNADisease v2.0 and RNADisease databases as well as publications. We found that HAR1A, KCNQ1DN, ZFAT-AS1 and HAR1B could associate with lung cancer, breast cancer, colorectal cancer and kidney neoplasms, respectively. The results need further biological experimental validation. We foresee that LDA-VGHB was capable of identifying possible lncRNAs for complex diseases. LDA-VGHB is publicly available at https://***/plhhnu/LDA-VGHB.
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