Military operations represent a complex involvement of various types of forces, requiring as far as possible their flawless alignment during the maneuver to meet the objectives of the operation. In order to use the fo...
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ISBN:
(纸本)9783030982607;9783030982591
Military operations represent a complex involvement of various types of forces, requiring as far as possible their flawless alignment during the maneuver to meet the objectives of the operation. In order to use the forces effectively, it is necessary to successfully carry out the planning process of the task force to create an operational order and to be able to effectively command and control subordinate units during the conduct of the operation based on the development of the situation in the combat zone. The article describes the algorithm development of individual steps of the decision-making process of the brigade combat team staff officer of the engineer specialization when designing the mobility and counter-mobility support of task force during the planning of the operation. The proposed individual steps of the decision-making process were designed based on the analysis of documents related to the engineer support of the troops and the authors' own experience from practical exercises and exercises on simulators. Each step of the algorithm requires input data from the user, based on which it adds values to the designed engineer modular elements. The output and the main benefit of the algorithm are the values of modular elements and engineer-based recommendations for their use. Based on the algorithm, software was programmed to support the decision-making process of the engineer officer, leading to a reduction in the probability of human error during the planning process given the different levels of knowledge.
Introduction Dupilumab is a human monoclonal antibody that targets both IL-4 and IL-13 signaling. It is currently indicated for the treatment of asthma, moderate-to-severe atopic dermatitis, and chronic rhinosinusitis...
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Introduction Dupilumab is a human monoclonal antibody that targets both IL-4 and IL-13 signaling. It is currently indicated for the treatment of asthma, moderate-to-severe atopic dermatitis, and chronic rhinosinusitis with nasal polyps (CRSwNP). Eosinophilia has been reported as a potential adverse event in treated patients. Areas covered A selective search on PubMed and Medline up to January 2022 was performed, by focusing on dupilumab-induced hypereosinophilia described in clinical trials, real-life studies, and case reports. The possible mechanisms underlying dupilumab-induced hypereosinophilia and the eosinophil-related morbidity have also been explored. Expert opinion Dealing with dupilumab-induced hypereosinophilia represents a clinical challenge for clinicians managing patients on dupilumab therapy. An algorithm for the practical management of dupilumab-induced hypereosinophilia has been proposed, in order to properly investigate potential eosinophil-related morbidity and avoid unnecessary drug discontinuation.
The World Health Organization(WHO)has set the goal of eliminating hepatitis as a threat to public health by *** mother-to-child transmission(MTCT)of hepatitis B virus(HBV)is not only the key to eliminating viral hepat...
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The World Health Organization(WHO)has set the goal of eliminating hepatitis as a threat to public health by *** mother-to-child transmission(MTCT)of hepatitis B virus(HBV)is not only the key to eliminating viral hepatitis,but also a hot issue in the field of hepatitis B prevention and *** standardize the clinical management of preventing MTCT of HBV and achieve zero HBV infection among infants,the Chinese Foundation for Hepatitis Prevention and Control organized experts to compile a management algorithm for prevention of MTCT of HBV based on the latest research progress and guidelines,including 10 steps of pregnancy management and postpartum follow-up,among which screening,antiviral treatment,and infant immunization are its core components.
BACKGROUND CONTEXT: With improvements in surgical techniques and perioperative management, transfusion rates after spine surgery have decreased over time. Given this trend, routine preoperative ABO/Rh type and antibod...
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BACKGROUND CONTEXT: With improvements in surgical techniques and perioperative management, transfusion rates after spine surgery have decreased over time. Given this trend, routine preoperative ABO/Rh type and antibody screen (T&S) laboratory testing may not be warranted in all patients undergoing spine surgery. PURPOSE: The aim of the current study is to evaluate risk factors for intra/postoperative transfusion in patients undergoing a variety of spine procedures and to develop an algorithm for selectively ordering preoperative T&S testing in appropriate patients. STUDY DESIGN/SETTING: This is a single institution, retrospective observational study of patients undergoing emergent or elective spine surgery. External validation of the algorithm was performed on a national sample of patients undergoing spine surgery from the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) national database. PATIENT SAMPLE: A total of 5,947 surgeries from January 1, 2016 to December 31, 2019 at a single institution, and 166,113 surgeries from the 2016 to 2018 ACS-NSQIP database. OUTCOME MEASURES: The primary outcome measure was performance of intraoperative or postoperative transfusion. METHODS: Using the institutional sample, univariate statistics (chi-square tests, fisher's exact test, 2-sided independent sample tests) were performed to compare demographics, comorbidities, and surgical details (case type, number of levels treated, etc.) between patients who did and did not require intra- or postoperative transfusion. Transfusion rates were calculated and compared across procedure types. Multivariate logistic regression was performed to identify independent predictors of transfusion and the model's accuracy was evaluated using the area under the curve (AUC) of the receiver operating characteristics (ROC) curve. A risk-based algorithm suggesting no preoperative T&S in low transfusion risk procedures, routine preoperative T&S in high-risk procedure
The article addresses the void in developing analytical methods concerning to design urban configurations that could reduce fire risks, and, thus, could help in achieving sustainable goals. A novel algorithm is develo...
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The article addresses the void in developing analytical methods concerning to design urban configurations that could reduce fire risks, and, thus, could help in achieving sustainable goals. A novel algorithm is developed to generate alternative Urban Built Form (UBF) models that could be less susceptible to fire compared to the existing built-form. Fire susceptibility of a generated UBF is predicted using a developed linear regression model. The algorithm considers existing regulations to derive rules and develop scenarios that might be effective in building fire-resilient cities. The outcomes of the simulations showed a significant decrease in the fire susceptibility of the southern region of Mumbai city. Moreover, for a certain simulated scenario the predicted UBF could accommodate twice the current population while being less susceptible than the existing UBF. The proposed techniques and methods can act as a decision-making tool in taking pre-emptive planning measures to develop fire resilient cities.
Objective Tumor registries in integrated healthcare systems (IHCS) have high precision for identifying incident cancer but often miss recently diagnosed cancers or those diagnosed outside of the IHCS. We developed an ...
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Objective Tumor registries in integrated healthcare systems (IHCS) have high precision for identifying incident cancer but often miss recently diagnosed cancers or those diagnosed outside of the IHCS. We developed an algorithm using the electronic medical record (EMR) to identify people with a history of cancer not captured in the tumor registry to identify adults, aged 40-65 years, with no history of cancer. Materials and Methods The algorithm was developed at Kaiser Permanente Colorado, and then applied to 7 other IHCS. We included tumor registry data, diagnosis and procedure codes, chemotherapy files, oncology encounters, and revenue data to develop the algorithm. Each IHCS adapted the algorithm to their EMR data and calculated sensitivity and specificity to evaluate the algorithm's performance after iterative chart review. Results We included data from over 1.26 million eligible people across 8 IHCS;55 601 (4.4%) were in a tumor registry, and 44848 (3.5%) had a reported cancer not captured in a registry. The common attributes of the final algorithm at each site were diagnosis and procedure codes. The sensitivity of the algorithm at each IHCS was 90.65%-100%, and the specificity was 87.91%-100%. Discussion Relying only on tumor registry data would miss nearly half of the identified cancers. Our algorithm was robust and required only minor modifications to adapt to other EMR systems. Conclusion This algorithm can identify cancer cases regardless of when the diagnosis occurred and may be useful for a variety of research applications or quality improvement projects around cancer care.
Energy consumption is a critical variable in a world increasingly concerned about environmental sustainability. Therefore, it is necessary to have procedures that facilitate its measurement. This article presents a su...
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ISBN:
(数字)9781728167152
ISBN:
(纸本)9781728167152
Energy consumption is a critical variable in a world increasingly concerned about environmental sustainability. Therefore, it is necessary to have procedures that facilitate its measurement. This article presents a summary of the aspects to be considered when planning to monitor energy consumption in a CNC milling process. The synthesis is presented in the form of an algorithm and a set of guiding criteria. The algorithm has been examined evaluating the detailed consumption in a milling of cavities.
Accurate detection and precise timing of transient events such as X-ray photons, gamma-ray burst, coronal mass ejections (CMEs), ground-level enhancements (GLEs) and Forbush decreases (FDs) frequently raise issues tha...
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Accurate detection and precise timing of transient events such as X-ray photons, gamma-ray burst, coronal mass ejections (CMEs), ground-level enhancements (GLEs) and Forbush decreases (FDs) frequently raise issues that remain on the cutting edge of research in astrophysics. In an attempt to automate FD event selection, a combination of Fast Fourier transform as well as FD detection algorithms implemented in the statistical computing software R was developed and recently used to calculate the magnitude and FD event timing. The R-FD code implemented in the present study includes several different calculations. Some subroutines detect both small and large transient intensity reductions (minima/pits) as well as increases (maxima/peaks) in cosmic ray (CR) data. Others calculate event amplitude, timing and cataloguing of the events identified. As the current work focuses on reductions in CR flux (FDs), the subroutine that identifies increases was disabled. Totals of 229 FDs at Magadan neutron monitor (NM), 230 (Oulu NM) and 224 (Inuvick NM) were identified with daily averaged data, while 4032 (Magadan), 4144 (Oulu) and 4055 (Inuvick) were detected with hourly averages. FDs identified as simultaneous at the three stations totaled 99 for the daily and 261 for the hourly CR averages respectively.
Background: The dual marker algorithm Risk of Ovarian Malignancy algorithm (ROMA) has been widely used in the clinic for the identification of equivocal pelvic masses in ovarian carcinoma. To obtain higher diagnostic ...
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Background: The dual marker algorithm Risk of Ovarian Malignancy algorithm (ROMA) has been widely used in the clinic for the identification of equivocal pelvic masses in ovarian carcinoma. To obtain higher diagnostic efficiency, we created a new diagnostic index, Risk of Ovarian Malignancy Index (ROMI), by combing thymidine kinase 1 (TK1), HE4 and CA125.& nbsp;Methods: 335 patients with pelvic masses on imaging and 46 healthy controls were enrolled. Serum TK1 was analyzed before further study. ROMI and ROMA were evaluated for diagnostic efficiency.& nbsp;Results: The level of TK1 was elevated in malignant ovarian tumors compared to benign masses (p < 0.001) and healthy controls (p < 0.001). TK1 expression was positively correlated with stage, intrapelvic metastasis, lymphatic metastasis and distant metastasis (all p values < 0.001). The area under the receiver operating characteristic curve (AUC) of ROMI was higher than that of ROMA for both pre-and postmenopausal women. ROMI had better sensitivity, specificity, accuracy, and positive and negative predictive values than ROMA in diagnosis of all-stage or stage I + II ovarian carcinoma for both pre-and postmenopausal women.& nbsp;Conclusions: TK1 is a potential biomarker in detection of ovarian carcinoma. ROMI shows better diagnostic performance than ROMA in distinguishing malignant ovarian tumors from benign masses.
A method of detecting chemical oxygen demand(COD) of water based on ultraviolet(UV) absorption spectra is proposed. The modeling and analysis of the standard samples and the actual water samples are carried out respec...
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A method of detecting chemical oxygen demand(COD) of water based on ultraviolet(UV) absorption spectra is proposed. The modeling and analysis of the standard samples and the actual water samples are carried out respectively. For the standard solution samples, the univariate linear models based on single wavelengths and the partial least square(PLS) model based on synergy interval partial least square(Si PLS) and moving window partial least square(MWPLS) are established. For the actual water samples, different pre-processing methods are used. Si PLS and MWPLS are used to select the characteristic bands. The least squares support vector machine algorithm optimized by particle swarm optimization(PSO-LSSVM) algorithm is used to establish the prediction model, and the prediction results of various models are compared. The results show that the optimal model is PSO-LSSVM which uses Si PLS to select the characteristic bands of the first derivative spectra(preprocessing method). The determination coefficient of the prediction set is 0.963 1, and the root mean square error of prediction(RMSEP) is 2.225 4 mg/L. PSO-LSSVM algorithm has good prediction performance for the analysis of COD in actual water samples by UV spectra. This paper provides a new design idea for the research and development of water quality detection optical sensor.
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