The study of myogenesis in the embryo is a rapidly expanding field. In this context, the consequences of mutating different members of the MyoD family together with an increasing number of observations that point to t...
详细信息
The study of myogenesis in the embryo is a rapidly expanding field. In this context, the consequences of mutating different members of the MyoD family together with an increasing number of observations that point to the importance of the MEF2 or RSRF family as myogenic regulators, and the identification of Pax-3 as a marker of early myogenic cells, have advanced our understanding of the molecular embryology of skeletal muscle. Novel cardiac regulatory factors such as Nkx-2.5 and GATA-4, in addition to MEF2 isoforms, are also beginning to be identified. At the molecular level, crystallographic studies have led to a structural model of the actinomyosin complex and also to information about how MyoD contacts DNA.
Skeletal muscle differentiation entails the coupling of muscle-specific gene expression to terminal withdrawal from the cell cycle. Several models have recently been proposed which attempt to explain how regulated exp...
详细信息
Skeletal muscle differentiation entails the coupling of muscle-specific gene expression to terminal withdrawal from the cell cycle. Several models have recently been proposed which attempt to explain how regulated expression and function of myogenic transcription factors ensures that proliferation and differentiation of skeletal muscle cells are mutually exclusive processes.
Specific DNA binding by eukaryotic transcription factors is conferred by several types of sequence motif. These domains have been extensively studied with regard to their precise interaction with DNA and the basis of ...
详细信息
Specific DNA binding by eukaryotic transcription factors is conferred by several types of sequence motif. These domains have been extensively studied with regard to their precise interaction with DNA and the basis of sequence specificity. Evidence is accumulating that DNA-binding domains serve functions in addition to binding DNA: they are also targets of viral and cellular regulatory proteins.
During the past year, targeted mutagenesis in mice has begun to clarify the roles of individual members of the MyoD family of myogenic regulators in vertebrate development. In this review, we discuss these studies bot...
详细信息
During the past year, targeted mutagenesis in mice has begun to clarify the roles of individual members of the MyoD family of myogenic regulators in vertebrate development. In this review, we discuss these studies both in the context of tissue interactions necessary to induce skeletal muscle precursor cells during embryogenesis and the molecular circuitry that regulates the terminal differentiation of these cells.
Recent work indicates that the Drosophila nervous system develops in a progressive process of cell fate specification. Expression of specific proneural genes in clusters of cells (the proneural clusters) in the cellul...
详细信息
Analysis of de novo gene activation in multinucleated heterokaryons has shown that the differentiated state, although stable, is not irreversible, and can be reprogrammed in the presence of appropriate combinations of...
详细信息
Analysis of de novo gene activation in multinucleated heterokaryons has shown that the differentiated state, although stable, is not irreversible, and can be reprogrammed in the presence of appropriate combinations of trans-acting regulatory molecules. These properties have been exploited to design strategies for identifying novel regulators of cellular differentiation.
Sex determination and sexually dimorphic differentiation in Drosophila involve multiple regulatory mechanisms, including alternative splicing, transcriptional control, subcellular compartmentalization, and intercellul...
详细信息
Sex determination and sexually dimorphic differentiation in Drosophila involve multiple regulatory mechanisms, including alternative splicing, transcriptional control, subcellular compartmentalization, and intercellular signal transduction. Regulatory interactions occur throughout the development of the fly, some requiring the continuous function of the genes involved, and others being temporally limited, but having permanent consequences. The control of sexual differentiation in Drosophila is, for the most part, subject to the continuous active control of numerous regulatory proteins operating at many levels.
During the past year, our understanding of the cellular and molecular processes involved in the generation and control of circadian rhythms has advanced significantly. Progress has been made at the level of the circad...
详细信息
During the past year, our understanding of the cellular and molecular processes involved in the generation and control of circadian rhythms has advanced significantly. Progress has been made at the level of the circadian pacemaker mechanism itself, the input pathways that regulate the pacemaker, and the mechanisms by which the pacemaker regulates its various outputs. A common theme underlying all three of these processes is the involvement of transcriptional and translational control. This review is an updated and extended version of a review first published in Current Opinion in Neurobiology 1991, 1:556-561.
暂无评论