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A basic program FOR DETERMINATION OF NUMERICAL DENSITY OF CYTOPLASMIC COMPARTMENTS .2. ANALYSIS OF ELLIPSOIDS AND CYLINDRICAL PARTICLES

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COMPUTERS IN BIOLOGY AND MEDICINE 1986年第4期16卷 273-277页

作者： DEPAZ, P BARRIO, JP RENAUPIQUERAS, J UNIV LEON FAC BIOLDEPT CIENCIAS FISIOLLEONSPAIN INST INVEST CITOL CAJA AHORROS VALENCIASPAIN

A basic program is presented to obtain the numerical density, shape coefficient (β) and k factor for the size distribution of a series of diameters measured from E.M. micrographs. Also its minimal sample size can be ... 详细信息

关键词： Numerical density k factor β coefficient Minimal sample size Ellipsoids Cylinders basic program

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CONFREG - A basic program FOR CALCULATING AND PLOTTING CONFIDENCE-REGIONS BASED ON CORRELATIONAL ANALYSES

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COMPUTER METHODS AND programS IN BIOMEDICINE 1989年第1期29卷 37-42页

作者： ITURRIAGA, R ALCAYAGA, J ZAPATA, P Laboratory of Neurobiology Catholic University of Chile Santiago 1 Chile

Many observations encountered in biological and medical research are randomly distributed in bivariate scales, and thus not susceptible to simple regression analyses. Since such data are depicted by ellipses in scatter diagrams, a computer program to calculate the confidence regions for the means or the total data of bivariate samples was written in basic for correlational analyses. The program, based on the principal axes algorithm, plots the calculated confidence regions as an elliptic area, using the fitted equations for its major and minor axes. The program displays the sample parameters required to perform comparisons between different groups of experimental conditions.

关键词： Correlational analyses Principal axis Confidence region basic program Ellipse plotting Microcomputer

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THE ASSESSMENT OF BIOEQUIVALENCE IN A 2-PERIOD CROSS-OVER DESIGN - DEVELOPMENT OF A SIMPLE basic program

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COMPUTER METHODS AND programS IN BIOMEDICINE 1991年第2期35卷 151-153页

作者： MEINEKE, I DEMEY, C SMITH KLINE DAUELSBERG GMBH SK&F INST APPL CLIN PHARMACOLGOTTINGENGERMANY

The complete algorithms needed in the calculation of confidence intervals on the basis of observations from a two-way cross-over bioequivalence trial are described. They do not contain assumptions as to the expected sampling distribution or possible period effects. The algorithms were used in a basic program, which was developed subsequently. Its validity is demonstrated here with a set of literature data. The program is available from the authors upon request.

关键词： NONPARAMETRIC CONFIDENCE INTERVAL basic program BIOEQUIVALENCE

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STEREOLOGICAL PARAMETERS FROM THE ANALYSIS OF THE CELL MICROGRAPHS EITHER BY MANUAL POINT-COUNTING METHODS OR BY USING A SEMI-AUTOMATIC SYSTEM - A basic program FOR ZX-SPECTRUM PERSONAL-COMPUTER

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COMPUTERS IN BIOLOGY AND MEDICINE 1985年第3期15卷 153-158页

作者： DEPAZ, P BARRIO, JP UNIV LEON FAC BIOLDEPT C FISIOLLEONSPAIN

A basic program is presented which calculates stereological parameters from the data obtained by the analysis of cell micrographs, either by manual point-counting or semi-automatic analysis methods.

关键词： Stereological parameters Point-counting methods Semi-automatic system basic program

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A basic program FOR DERIVING LINEAR-REGRESSION FORMULAS FOR INTRAOCULAR-LENS POWER PREDICTION

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JOURNAL OF CATARACT AND REFRACTIVE SURGERY 1986年第2期12卷 188-194页

作者： MURPHY, CG MURPHY, GE Athens Alabama

We present an original basic program written specifically for the ophthalmologist that allows calculation of linear regression formulas for prediction of emmetropic lens power from the surgeon's own data. The program features ongoing data storage, options for analyzing specific ranges (such as longer axial lengths), and calculation of residuals. The program is user-friendly and may be used with minimal computer knowledge. The authors will copy the program at no charge on a user's initialized diskette.

关键词： basic program intraocular lens regression formula

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A program IN basic FOR CALCULATION OF TISSUE ION FLUX RATES, RATE CONSTANTS, AND CELLULAR ION CONTENTS AND CONCENTRATIONS FOR A 3 COMPARTMENTAL SERIAL MODEL

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COMPUTERS IN BIOLOGY AND MEDICINE 1986年第3期16卷 187-194页

作者： MACCHIA, DD ASTERITA, MF INDIANA UNIV SCH MED NW CTR MED EDUC DEPT PHYSIOL GARY IN 46408 USA

A basic program is presented to calculate tissue ion flux rates, rate constants, and cellular ion contents and concentrations from ion flux curves. For the purpose of this program, the biological tissue will be treated as a three compartmental series model. The program requires that eight experimentally determined variables be entered for each ion species to be analyzed: the experimental slope and intercept variables for each phase of the flux curve, the wet and dry tissue weights, the known or estimated value of extracellular space and the measured or known value of the cellular surface to volume ratio of the particular tissue being studied. All other required input data are obtained from the literature or experimental protocol and may be treated as constants. This program was designed for the in vitro determination of ion exchange in skeletal muscle but may be used with little or no modification for flux measurements in other tissues.

关键词： basic program Flux measurements Ion contents Ion concentration

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CALCIUM - A program IN basic FOR CALCULATING THE COMPOSITION OF SOLUTIONS WITH SPECIFIED FREE CONCENTRATIONS OF CALCIUM, MAGNESIUM AND OTHER DIVALENT-CATIONS

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COMPUTERS IN BIOLOGY AND MEDICINE 1988年第5期18卷 351-366页

作者： CHANG, D HSIEH, PS DAWSON, DC UNIV MICHIGAN SCH MED DEPT PHYSIOL 6811 MED SCI 2 BOX 0622 ANN ARBOR MI 48109 USA UNIV MICHIGAN CELLULAR & MOLEC BIOL PROGRAM ANN ARBOR MI 48109 USA

A basic program is presented which facilitates the formulation of biologically relevant chemical solutions containing specified free concentrations of as many as three divalent metal cations (Ca2+, Mg2+ and the choice of a third divalent cation) at any pH in the presence of as many as three ligands (EGTA, ATP and GTP). The program uses the law of mass action and the absolute stability (association) constants found in the literature to calculate the total concentration of divalent metal cation needed to achieve a desired free concentration. The user enters the pH, the concentrations of the ligands used and the desired free concentrations of the divalent cations. This program was developed for use in a wide range of biological applications, particularly the rapid design of solutions which mimic certain aspects of intracellular fluid.

关键词： basic program Free divalent metal cation concentration Calcium Magnesium EGTA ATP GTP Multi-metal/multi-ligand equilibrium

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REPLI - A program IN basic FOR DETERMINATION OF APPROXIMATE SAMPLE-SIZE

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INTERNATIONAL JOURNAL OF BIO-MEDICAL COMPUTING 1991年第3-4期27卷 193-200页

作者： LUTTKE, A Arnimstrasse 2 5000 Koln 30 F.R.G.

REPLI, a program written in elementary basic, calculates the approximate sample size, which is required to detect a desired difference between any two group means in an experiment with n groups for a given probability and at three significance levels of the means difference. A prior knowledge of the variability of data in the groups is expected in order to base the estimate on a rational footing. If this knowledge does not exist, an educated guess and/or several trials with different assumptions on the most likely variability can be used. The a priori estimate preventss that sample sizes are completely out of a reasonable range. Since the program is applicable for experimental settings where several groups need be investigated, it is particularly interesting to users of ANOVA and/or comparable non-parametric tests.

关键词： ANOVA A PRIORI TEST basic program APPROXIMATE SAMPLE SIZE ESTIMATE SIMULATION

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A STRUCTURED program IN basic FOR THE ANALYSIS OF PERIPHERAL-NERVE MORPHOMETRY

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JOURNAL OF NEUROSCIENCE METHODS 1982年第1-2期5卷 103-120页

作者： PULLEN, AH INST NEUROL SOBELL DEPT NEUROPHYSIOL QUEEN SQ HOUSE QUEEN SQ LONDON WC1N 3BG ENGLAND

The basic program developed for use on a MSI 6800 microprocessor analyzes cross-sectional measurements of fiber (D) and axon (d) caliber made on electron micrographs of suitable magnification. Data input routines cover measurements of area and diameter, made manually or presented as fully computed values printed out by a M.O.P. Separate sub-routines input digitized data from a digitizer tablet coupled to the microprocessor. Myelin sheath thickness (2M) (D-d), or area and g (d/D) are derived. The 2 analytical programs provide either frequency distributions, with associated statistics for each parameter, or analyses of the relationships (D:D), (d:2M) and (D:g). The highly structured nature of the program permits it to be edited or extended according to the project. The main program controls the overall flow of analysis;discrete subprograms inserted into the main program perform the data input, parameter derivations, data checks and analyses. This system offers maximum flexibility and is suitable for most morphometric investigations involving animal peripheral nerves.

关键词： microprocessor microcomputer peripheral nerve morphometry basic program

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A USEFUL program IN basic FOR AXONAL MORPHOMETRY WITH INTRODUCTION OF NEW CYTOSKELETAL PARAMETERS

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JOURNAL OF NEUROSCIENCE METHODS 1991年第3期39卷 271-289页

作者： FERNANDEZ, E CUENCA, N DEJUAN, J UNIV ALICANTE FAC MEDINST NEUROSCIE-03080 ALICANTESPAIN

Interest in the structure of axons and quantification of their components has been growing over the last years. However, the existing literature contains few reports of available computer programmes to facilitate such studies. This paper presents a fully comprehensive basic programme for the morphometric analysis of electron micrographs of cross-sectional nerve fibres. From drawings of fibre and axonal contours and dots of the microtubules and neurofilaments, the programme calculates the following parameters: area, diameter and form factor of the fibres and axons, number and density of microtubules and neurofilaments, proportion between microtubules and neurofilaments (R-proportion), myelin thickness and the diameter of the axon relative to its sheath (g-ratio). The programme also introduces three new parameters to analyse the degree of uniformity of microtubule and neurofilament distribution: distances between microtubules and between neurofilaments, equilateral index and cytoskeletal intermingling index. The programme is written in Microsoft basic Interpreter for Apple Macintosh (Microsoft Corporation) but can be used on other computers. Although the programme has been tested on adult rat optic nerve fibres, it can be used for different projects concerning axonal morphometry.

关键词： MORPHOMETRY basic program OPTIC NERVE NERVE FIBERS MICROTUBULES NEUROFILAMENTS

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