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A review of biosensor technology and algorithms for glucose monitoring

JOURNAL OF DIABETES AND ITS COMPLICATIONS 2021年第8期35卷 107929-107929页

作者： Zhang, Yaguang Sun, Jingxue Liu, Liansheng Qiao, Hong Harbin Med Univ Affiliated Hosp 2 Harbin 150086 Heilongjiang Peoples R China Harbin Inst Technol Sch Elect & Informat Engn Harbin 150080 Peoples R China

Diabetes mellitus (DM) has become a serious illness in the whole world. Until now, there is no effective cure for patients with DM. It is well known that the glucose level is one key factor to determine the progress of DM. It is also an important reference to carry out the accurate and timely treatment for patients with DM. In this article, the related biosensors technology that can be utilized to identify and predict glucose level are reviewed in detail, including the algorithms that can help to achieve numerical value of glucose level. Firstly, the biosensor technol-ogy based on the physiological fluids are illustrated, including blood, sweat, interstitial fluid, ocular fluid, and other available fluids. Secondly, the algorithms for achieving numerical value of glucose level are investigated, in-cluding the physiological model-based method and the machine learning-based method. Finally, the future de-velopment trend and challenges of glucose level monitoring are given and the conclusions are drawn. (c) 2021 Elsevier Inc. All rights reserved.

关键词： Glucose monitoring biosensor technology Algorithms for glucose analysis Diabetes mellitus

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The guided-mode resonance biosensor: Principles, technology, and implementation 10

The guided-mode resonance biosensor: Principles, technology,...

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Conference on Frontiers in Biological Detection - From Nanosensors to Systems X

作者： Magnusson, Robert Lee, Kyu J. Hemmati, Hafez Ko, Yeong Hwan Wenner, Brett R. Allen, Jeffery W. Allen, Monica S. Gimlin, Susanne Weidanz, Debra Wawro Univ Texas Arlington Dept Elect Engn Arlington TX 76019 USA Air Force Res Lab Sensors Directorate Wright Patterson AFB OH 45433 USA Air Force Res Lab Munit Directorate Eglin AFB FL 32542 USA Resonant Sensors Inc Arlington TX 76010 USA

ISBN: (数字)9781510615069

ISBN: (纸本)9781510615069

The guided-mode resonance (GMR) sensor operates with quasi-guided modes induced in periodic films The resonance is enabled by 1D or 2D nanopatterns that are expeditiously fabricated. Optical sensors are needed in many fields including medical diagnostics, chemical analyses, and environmental monitoring. Inducing resonance in multiple modes enables extraction of complete bioreaction information including the biolayer thickness, biolayer refractive index, and any change in the refractive index in the background buffer solution. Thus, we refer to this version of the GMR sensor as the complete biosensor. We address the fundamentals, state of technological development, and implementation of this basic sensor modality.

关键词： guided-mode resonance effect guided-mode resonance sensor photonic-crystal sensor leaky-mode resonance resonant waveguide gratings metamaterials biosensor technology chemical sensor environmental sensor

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Acetylcholinesterase-immobilized cellulose membrane biosensors designed by covalent bonding for indirect visual colorimetric detection of chlorpyrifos

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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 2025年 336卷 126005页

作者： Li, Yuan Ding, Yinying Zhao, Jifeixue Luo, Xiaogang Wuhan Inst Technol Sch Chem Engn & Pharm Key Lab Novel Biomass based Environm & Mat Petr & 206 Guanggu 1st Rd Wuhan 430205 Hubei Province Peoples R China

In this work, Acetylcholinesterase (AChE)-immobilized cellulose membrane biosensors (CBS) with the capability of indirectly detecting chlorpyrifos (CPF) were successfully developed by covalent bonding AChE to the modified cellulose membrane surface. In the presence of active AChE, thiocholine (TCh) was produced by hydrolyzing acetylthiocholine (ATCh) and reacted with 5,5 '-dithiobis-(2-nitrobenzoic acid) (DTNB) to produce yellow chromophore thionitrobenzoic acid (TNB-). CPF can interrupt the process above by inhibitory attacking at the active serine (ser) site. The change of color intensity was shown to enable quantitative and qualitative detection of CPF. The structures and properties of membranes were characterized by scanning electron microscopy (SEM), energy spectrometry (EDS), Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS), etc. Experiments proved that CBS had high selectivity, long shelf life, and wide detection limits for qualitative and semi-quantitative detection of CPF, and its limit of detection (LOD) was 5 nmol/L over a linear range of 15-120 nmol/L. The contrast experiment with a filter paper-based strip showed that the CBS had better detectability. The design of CBS offered an excellent strategy for the covalent immobilization of enzymes and visual colorimetric detection of CPF.

关键词： Cellulose membrane Enzyme inhibition and colorimetric assay biosensor technology Detection of organophosphorus pesticides

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Multiplex aptamer cluster detection platform and systems toxicology study for 17(3-estradiol, bisphenol A, and diethylstilbestrol

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FOOD CHEMISTRY 2025年第Pt 3期463卷 141395页

作者： Li, Ning Ren, Chenxi Hu, Qin Wang, Bo Yang, Zhenquan Xiao, Lixia Guan, Tianzhu Yangzhou Univ Sch Food Sci & Engn Yangzhou 225127 Peoples R China Yangzhou Univ Yangzhou Engn Res Ctr Food Intelligent Packaging & Yangzhou 225127 Peoples R China

Intake of 17 beta-estradiol (E2), bisphenol A (BPA), and diethylstilbestrol (DES) from food can contribute to endocrine disorders. Therefore, developing a sensitive method for the simultaneous detection of E2, BPA, and DES and understanding their combined effects on endocrine disruption are crucial. We developed a fluorescence aptasensing platform utilizing DNase I-assisted cyclic enzymatic signal amplification in conjunction with an aptamer/graphene oxide complex. Using PEG 20000 as a surface-blocking agent, the aptasensor achieved ultralow detection limits of 2.643, 0.3039, and 0.6996 for E2, BPA, and DES, respectively. The sensor demonstrated accurate detection in plastic bottled water at spiked levels of 10 and 100 ng/mL. Systems toxicology revealed 30 potential targets for mixture-induced endocrine disruption. Molecular docking showed binding affinities of E2, BPA, and DES for ESR1 of -9.94, -8.29, and -8.98 kcal/mol, respectively. These results highlight the effectiveness of the aptasensor and provide valuable insights into endocrine disruption mechanisms.

关键词： Fluorescence aptasensor Signal amplification Molecular docking biosensor technology Endocrine-disrupting chemicals

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Immunosensors in food, health, environment, and agriculture: a review

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ENVIRONMENTAL CHEMISTRY LETTERS 2024年第5期22卷 2573-2605页

作者： Kumar, Harsh Dhalaria, Rajni Guleria, Shivani Cimler, Richard Prerna, Prerna Dhanjal, Daljeet Singh Chopra, Chirag Sethi, Nidhi Pathera, Ashok Kumar Kala, Deepak Kimta, Neetika Kaur, Talwinder Valko, Marian Manickam, Sivakumar Alomar, Suliman Y. Kumar, Dinesh Kuca, Kamil Univ Hradec Kralove Fac Sci Ctr Adv Technol Rokitanskeho 62 Hradec Kralove 50003 Czech Republic Shoolini Univ Biotechnol & Management Sci Sch Biol & Environm Sci Solan 173229 India Thapar Inst Engn & Technol Ctr Relevance & Excellence Agro & Ind Biotechnol Dept Biotechnol Patiala 147001 India Thapar Inst Engn & Technol Dept Biotechnol Patiala 147001 India Lovely Profess Univ Sch Bioengn & Biosci Phagwara 144411 India Guru Nanak Dev Univ Dept Pharmaceut Sci Amritsar 143005 India Amity Univ Amity Inst Food Technol Noida 201313 India Inst High Pressure Phys CENETRA Terahertz Lab Warsaw Poland Guru Nanak Dev Univ Dept Microbiol Amritsar 143005 India Slovak Univ Technol Bratislava Fac Chem & Food Technol Bratislava 81237 Slovakia Univ Teknol Brunei Fac Engn Petr & Chem Engn BE-1410 Bandar Seri Begawan Brunei King Saud Univ Coll Sci Zool Dept Riyadh 11451 Saudi Arabia Shoolini Univ Biotechnol & Management Sci Sch Bioengn & Food Technol Solan 173229 India Univ Hosp Hradec Kralove Biomed Res Ctr Hradec Kralove Czech Republic Univ Hradec Kralove Fac Sci Dept Chem Hradec Kralove 50003 Czech Republic

The increasing pollution of ecosystems by both biological and non-biological contaminants has recently fostered the rapid development of biosensors, thus opening a new investigation area in analytical sciences. Here, we review the applications of immunosensors in food safety, human health, environmental sciences, water pollution, and agriculture. We present the analysis of cancer markers, pathogens, antigens, antibiotics, pesticides, toxins, allergens, hormones, and phytohormones. Immunosensors comprise electrochemical, microgravimetric, optical, and thermometric immunosensors. Immunosensors have advantages such as enhanced sensitivity, selectivity, speed, and cost-effectiveness. In particular, antibody-based biosensors have outperformed traditional methods in identifying and analysing various compounds. Immunosensors are able to detect compounds at nanomolar to picomolar levels.

关键词： Antibodies biosensor technology Immobilization Nanomaterials Immunosensor applications Nanotechnology

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Nanosensing doxorubicin: a new frontier in medicinal chemistry

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MEDICINAL CHEMISTRY RESEARCH 2025年第6期34卷 1253-1268页

作者： Karzad, Nazila Rastmanesh, Samad Shaterian, Elham Shaterian, Hamed Mobed, Ahmad Tabriz Univ Med Sci Alzahra Hosp Dept Obstet & Gynecol Tabriz Iran Tabriz Univ Med Sci Sch Pharm Dept Pharmaceut & Nanotechnol Tabriz Iran Islamic Azad Univ Tabriz Branch Fac Med Sci Tabriz Iran Social Determinants Hlth Res Ctr Hlth Management & Safety Promot Tabriz Iran

The advent of nanosensing technologies marks a significant advancement in medicinal chemistry, particularly in the detection and monitoring of therapeutic agents such as doxorubicin. This review aims to elucidate the development of cutting-edge biosensor technologies specifically tailored for the sensitive and selective detection of doxorubicin, a cornerstone chemotherapeutic agent. We critically analyze various recently developed nanosensors, including electrochemical sensors and optical sensors, highlighting their distinct mechanisms, advantages, and limitations. Unlike previous literature, this review synthesizes current research findings to provide a comprehensive overview of how these innovative nanosensing platforms can enhance drug monitoring, improve therapeutic outcomes, and support personalized medicine approaches. By addressing the existing challenges in doxorubicin detection, our findings underscore the transformative potential of integrating nanotechnology with biosensing applications, ultimately contributing to more effective cancer treatment strategies.

关键词： Nanosensing Doxorubicin biosensor technology Medicinal chemistry Nanomaterials Chemotherapy monitoring

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A brief review on novel biomarkers identified and advanced biosensing technologies developed for rapid diagnosis of Japanese Encephalitis Virus

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PROCEEDINGS OF THE INDIAN NATIONAL SCIENCE ACADEMY 2022年第4期88卷 617-625页

作者： Roberts, Akanksha Gandhi, Sonu DBT Natl Inst Anim Biotechnol NIAB Hyderabad 500032 Telangana India DBT Reg Ctr Biotechnol RCB Faridabad 121001 Haryana India

Advanced biosensor technology research is imperative for the management of infectious disease outbreaks such as Japanese Encephalitis (JE), a zoonotic disease caused by the flavivirus JE virus (JEV) which is transmitted to humans (dead-end hosts) from the amplification host, pigs, via mosquitoes. To avoid future pandemic scenarios, proactive research rather than responsive research in the field of diagnostics is a requirement for development of rapid, sensitive and specific screening detection methods. In this mini-review, we have critically compared and evaluated the different types of biomarkers (antigen, antibody, nucleic acid) identified for JEV diagnostics and their specific roles in the manifestation of the infection which may be potentially used for therapeutics and drug development as no treatment is available for JE. Furthermore, different biosensors developed for the detection of JEV biomarkers have been discussed in detail to give an overview of the working principles (electrochemical, optical, etc.), fabrication components (signal amplifier, bioreceptor, etc.), detection limits and response times. This review provides a compact compiled base on available JEV diagnostic research work being currently carried out along with their limitations, future prospective, and major challenges faced. This will enable future development of rapid point-of-care diagnostic screening methods for JEV infection management, which may help reduce number of fatalities.

关键词： Japanese Encephalitis Virus Biomarkers Point of care Diagnostics biosensor technology

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Recent advancementsin urea biosensors for biomedical applications

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IET NANOBIOtechnology 2021年第4期15卷 358-379页

作者： Singh, Saravjeet Sharma, Minakshi Singh, Geeta Deenbandhu Chhotu Ram Univ Sci & Technol Dept Biomed Engn Murthal Sonepat India Maharshi Dayanand Univ Dept Zool Rohtak Haryana India

The quick progress in health care technology as a recurrent measurement of biochemical factors such as blood components leads to advance development and growth in biosensor technology necessary for effectual patient concern. The review wok of authors present a concise information and brief discussion on the development made in the progress of potentiometric, field effect transistor, graphene, electrochemical, optical, polymeric, nanoparticles and nanocomposites based urea biosensors in the past two decades. The work of authors is also centred on different procedures/methods for detection of urea by using amperometric, potentiometric, conductometric and optical processes, where graphene, polymer etc. are utilised as an immobilised material for the fabrication of biosensors. Further, a comparative revision has been accomplished on various procedures of urea analysis using different materials-based biosensors, and it discloses that electrochemical and potentiometric biosensor is the most promise one among all, in terms of rapid response time, extensive shelf life and resourceful design.

关键词： biomedical equipment Microsensors and nanosensors potentiometric biosensor nanocomposites field effect transistor health care Micromechanical and nanomechanical devices and systems nanoparticles Chemical sensors blood components biosensor technology materials-based biosensors optical processes enzymes urea biosensors blood Biomedical measurement and imaging recurrent measurement electrochemical biosensor potentiometric processes reviews Reviews and tutorial papers amperometric processes Sensing and detecting devices urea analysis organic compounds polymers biochemistry Patient diagnostic methods and instrumentation biochemical factors health care technology chemical sensors biomedical applications graphene biosensors conductometric processes resource letters biosensors nanosensors

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Biomolecules for early detection of biofilms through point-of-use devices

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MICROCHEMICAL JOURNAL 2024年 207卷

作者： Bazsefidpar, Shayesteh Saweres-Arguelles, Clara Gutierrez, Gemma Matos, Maria Calero, Victor Serrano-Pertierra, Esther Garcia, Pilar Blanco-Lopez, Maria del Carmen Univ Oviedo Dept Phys & Analyt Chem Oviedo 33006 Spain Univ Oviedo Dept Chem Engn & Environm Technol Oviedo 33006 Spain Univ Oviedo Biotechnol Inst Asturias Oviedo 33006 Spain Univ Oviedo Dept Biochem & Mol Biol Oviedo 33006 Spain CSIC Dairy Res Inst Asturias IPLA Paseo Rio Linares S-N Villaviciosa 33300 Asturias Spain Hlth Res Inst Asturias ISPA Oviedo Spain

Biofilms are communities of microorganisms that attach to biotic and abiotic surfaces. They cause infections and industrial contaminations that carry along serious health issues and great economic loss. The secreted extracellular polymeric substances enhance biofilm tolerance to antibiotics, biocides and host defenses. Therefore, there is an urgent need to develop new strategies for detecting and monitoring microbial biofilms in the early stages of formation. biosensor technology can provide rapid detection, high selectivity and sensitivity using small, portable, simple, and low-cost devices. The selection of an appropriate molecular target involved in a regulatory network during different stages of biofilm formation determines the type of information the biosensor provides. This comprehensive review discusses the biomolecules that contribute to the formation of biofilms, with a particular emphasis on those involved in the initial stages, and their potential as specific targets for the early detection of these microbial structures. Additionally, we provide a critical analysis of the current state of biosensors for detecting biofilms, including recent work with rapid test based on lateral flow immunoassays (LFIA). The information analyzed in this review could guide the development of innovative biosensors or chemical sensors to detect the early formation of biofilms, contributing to the fight against antimicrobial resistance.

关键词： Biofilm detection biosensor technology Biomolecules Lateral flow immunoassay

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Efficient Microfluidic Screening Method Using a Fluorescent Immunosensor for Recombinant Protein Secretions

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SMALL 2023年第34期19卷 2207943-2207943页

作者： Ito, Yoshihiro Sasaki, Ryuichi Asari, Sayaka Yasuda, Takanobu Ueda, Hiroshi Kitaguchi, Tetsuya Tokyo Inst Technol Grad Sch Life Sci & Technol Yokohama Kanagawa 2268503 Japan Ajinomoto Co Inc Res Inst Biosci Prod & Fine Chem Kawasaki Kanagawa 2108681 Japan Inst Innovat Res Tokyo Inst Technol Lab Chem & Life Sci Yokohama Kanagawa 2268503 Japan

Microbial secretory protein expression is widely used for biopharmaceutical protein production. However, establishing genetically modified industrial strains that secrete large amounts of a protein of interest is time-consuming. In this study, a simple and versatile high-throughput screening method for protein-secreting bacterial strains is developed. Different genotype variants induced by mutagens are encapsulated in microemulsions and cultured to secrete proteins inside the emulsions. The secreted protein of interest is detected as a fluorescence signal by the fluorescent immunosensor quenchbody (Q-body), and a cell sorter is used to select emulsions containing improved protein-secreting strains based on the fluorescence intensity. The concept of the screening method is demonstrated by culturing Corynebacterium glutamicum in emulsions and detecting the secreted proteins. Finally, productive strains of fibroblast growth factor 9 (FGF9) are screened, and the FGF9 secretion increased threefold compared to that of parent strain. This screening method can be applied to a wide range of proteins by fusing a small detection tag. This is a highly simple process that requires only the addition of a Q-body to the medium and does not require the addition of any substrates or chemical treatments. Furthermore, this method shortens the development period of industrial strains for biopharmaceutical protein production.

关键词： biosensor technology droplet microfluidics high throughput screening microorganism engineering protein production

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