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检索条件"主题词=computational bioinformatics"
101 条 记 录,以下是1-10 订阅
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Analyzing the protein-protein interaction network and the topological properties of prostate cancer and allied diseases: A computational bioinformatics approach
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GENE REPORTS 2020年 21卷
作者: Puspo, Nadira Akter Akter, Laboni Siddique, Sinthia Paul, Bikash Kumar Ahmed, Kawsar Bhuiyan, Touhid Islam, Md Kabirul Daffodil Int Univ Dept Software Engn Dhaka Bangladesh Mawlana Bhashani Sci & Technol Univ MBSTU Dept Informat & Commun Technol ICT Santosh 1902 Tangail Bangladesh Mawlana Bhashani Sci & Technol Univ MBSTU Grp Biophotomatix Santosh 1902 Tangail Bangladesh Daffodil Int Univ Dept Multimedia & Creat Technol Dhaka Bangladesh
Background and objectives: Some of cancer diseases are related to each other by their metabolic structures. Literature reviews show that Prostate Cancer (PC), Breast Cancer (BC), Bladder Cancer (BDC) and Colorectal Ca... 详细信息
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bioinformatics Perspective of Drug Repurposing
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CURRENT bioinformatics 2024年 第4期19卷 295-315页
作者: Patel, Binita Gelat, Brijesh Soni, Mehul Rathaur, Pooja Johar, S. R. Kaid Gujarat Univ Sch Sci Dept Life Sci Ahmadabad 380009 Gujarat India Gujarat Univ Sch Sci Dept Zool BMTC HG & WBC Ahmadabad 380009 Gujarat India Gujarat Univ Sch Sci Dept Bioinformat Ahmadabad 380009 Gujarat India
Different diseases can be treated with various therapeutic agents. Drug discovery aims to find potential molecules for existing and emerging diseases. However, factors, such as increasing development cost, generic com... 详细信息
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In silico designing and characterization of outer membrane protein K (OmpK) from Vibrio anguillarum and its expression in Nicotiana tabacum for the development of a plant-based vaccine against fish vibriosis
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JOURNAL OF BIOTECHNOLOGY 2024年 380卷 51-63页
作者: Malik, Muhammad Suleman Elahi, Iqra Sameeullah, Muhammad Ijaz, Fatima Batool, Neelam Khalid, Fatima Gurel, Ekrem Saba, Kiran Waheed, Mohammad Tahir Quaid I Azam Univ Fac Biol Sci Dept Biochem Islamabad Pakistan Bolu Abant Izzet Baysal Univ Fac Agr Dept Field Crops TR-14030 Bolu Turkiye Bolu Abant Izzet Baysal Univ Ctr Innovat Food Technol Dev Applicat & Res TR-14030 Bolu Turkiye Bolu Abant Izzet Baysal Univ Fac Sci & Literature Dept Biol TR-14030 Bolu Turkiye Shaheed Benazir Bhutto Women Univ Fac Life Sci Dept Biochem Peshawar Pakistan
Vibriosis is caused by Vibrio anguillarum in various species of aquaculture. A novel, secure, and stable vaccine is needed to eradicate vibriosis. Here, for reverse vaccinology and plant -based expression, the outer m... 详细信息
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Molecular simulations reveal intricate coupling between agonist-bound R-adrenergic receptors and G protein
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ISCIENCE 2025年 第2期28卷 111741页
作者: Han, Yanxiao Dawson, John R. D. Demarco, Kevin R. Rouen, Kyle C. Ngo, Khoa Bekker, Slava Yarov-Yarovoy, Vladimir Clancy, Colleen E. Xiang, Yang K. Ahn, Surl-Hee Vorobyov, Igor Univ Calif Davis Dept Physiol & Membrane Biol Davis CA 95616 USA Univ Calif Davis Biophys Grad Grp Davis CA 95616 USA Amer River Coll Sacramento CA 95841 USA Univ Calif Davis Dept Anesthesiol & Pain Med Davis CA 95616 USA Univ Calif Davis Ctr Precis Med & Data Sci Davis CA 95616 USA Univ Calif Davis Dept Pharmacol Davis CA 95616 USA VA Northern Calif Hlth Care Syst Mather CA 95655 USA Univ Calif Davis Dept Chem Engn Davis CA 95616 USA
G protein-coupled receptors (GPCRs) and G proteins transmit signals from hormones and neurotransmitters across cell membranes, initiating downstream signaling and modulating cellular behavior. Using advanced computer ... 详细信息
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Improving genome-scale metabolic models of incomplete genomes with deep learning
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ISCIENCE 2024年 第12期27卷 111349页
作者: Boer, Meine D. Melkonian, Chrats Zafeiropoulos, Haris Haas, Andreas F. Garza, Daniel R. Dutilh, Bas E. Univ Utrecht Theoret Biol & Bioinformat NL-3584 CH Utrecht Netherlands NIOZ Royal Netherlands Inst Sea Res Dept Marine Microbiol & Biogeochem POB 59 NL-1790 AB Den Burg Netherlands Wageningen Univ & Res Bioinformat Grp Wageningen Netherlands Katholieke Univ Leuven Rega Inst Med Res Dept Microbiol Immunol & Transplantat Lab Mol Bacteriol B-3000 Leuven Belgium Univ Paris Saclay INRAE PROSE F-92761 Antony France Friedrich Schiller Univ Jena Inst Biodivers Fac Biol Sci Cluster Excellence Balance Microverse D-07743 Jena Germany
Deciphering microbial metabolism is essential for understanding ecosystem functions. Genome-scale metabolic models (GSMMs) predict metabolic traits from genomic data, but constructing GSMMs for uncultured bacteria is ... 详细信息
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In silico studies reveal the anti-osteosarcoma targets and action mechanisms of resveratrol
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PROCESS BIOCHEMISTRY 2022年 第0期117卷 191-197页
作者: Li, Jun Wei, Wenxing Lai, Zongqiang Lai, Keng Po Guangxi Med Univ Pharmaceut Dept Affiliated Hosp 2 Nanning Peoples R China Guangxi Med Univ Clin Med Res Ctr Affiliated Hosp 2 166 Daxuedong Rd Nanning 530007 Guangxi Peoples R China
Previous reports have discovered the anticancer activity of resveratrol in preclinical experiments, especially towards osteosarcoma (OS). However, the comprehensive anti-OS mechanisms of resveratrol remain unexplored.... 详细信息
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ProteoMixture: A cell type deconvolution tool for bulk tissue proteomic data
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ISCIENCE 2024年 第3期27卷 109198页
作者: Teng, Pang-ning Schaaf, Joshua P. Abulez, Tamara Hood, Brian L. Wilson, Katlin N. Litzi, Tracy J. Mitchell, David Conrads, Kelly A. Hunt, Allison L. Olowu, Victoria Oliver, Julie Park, Fred S. Edwards, Marshe Chiang, Aichun Wilkerson, Matthew D. Raj-Kumar, Praveen-Kumar Tarney, Christopher M. Darcy, Kathleen M. Phippen, Neil T. Maxwell, G. Larry Conrads, Thomas P. Bateman, Nicholas W. Gynecol Canc Ctr Excellence Annandale VA 22003 USA Womens Hlth Integrated Res Ctr Annandale VA 22003 USA Henry M Jackson Fdn Adv Mil Med Inc Bethesda MD 20817 USA Inova Hlth Syst Womens Hlth Integrated Res Ctr Womens Serv Line Falls Church VA 22042 USA Uniformed Serv Univ Hlth Sci Ctr Mil Precis Hlth Dept Anat Physiol & Genet Bethesda MD 20814 USA Chan Soon Shiong Inst Mol Med Windber PA 15963 USA Uniformed Serv Univ Hlth Sci John P Murtha Canc Ctr Dept Surg Bethesda MD 20889 USA Walter Reed Natl Mil Med Ctr Bethesda MD 20889 USA
Numerous multi-omic investigations of cancer tissue have documented varying and poor pairwise transcript:protein quantitative correlations, and most deconvolution tools aiming to predict cell type proportions (cell ad... 详细信息
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Panera: An innovative framework for surmounting uncertainty in microbial community modeling using pan-genera metabolic models
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ISCIENCE 2024年 第7期27卷 110358页
作者: Palanikumar, Indumathi Sinha, Himanshu Raman, Karthik Indian Inst Technol IIT Madras Bhupat Jyoti Mehta Sch Biosci Dept Biotechnol Chennai 600036 India IIT Madras Ctr Integrat Biol & Syst Med IBSE Chennai 600036 India IIT Madras Robert Bosch Ctr Data Sci & Artificial Intelligen Chennai 600036 India IIT Madras Wadhwani Sch Data Sci & AI Dept Data Sci & AI Chennai 600036 Tamil Nadu India
Utilization of 16S rRNA data in constraint-based modeling to characterize microbial communities confronts a major hurdle of lack of species-level resolution, impeding the construction of community models. We introduce... 详细信息
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Assessment of circulating proteins in thyroid cancer: Proteome-wide Mendelian randomization and colocalization
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ISCIENCE 2024年 第6期27卷 109961页
作者: Fan, Qinghua Wen, Shifeng Zhang, Yi Feng, Xiuming Zheng, Wanting Liang, Xiaolin Lin, Yutong Zhao, Shimei Xie, Kaisheng Jiang, Hancheng Tang, Haifeng Zeng, Xiangtai Guo, You Wang, Fei Yang, Xiaobo Guangxi Med Univ Sch Publ Hlth Nanning 530000 Guangxi Peoples R China Guangxi Univ Sci & Technol Affiliated Hosp 2 Guangxi Key Lab Precise Prevent & Treatment Thyroi Liuzhou 545000 Guangxi Peoples R China Zhengzhou Univ Affiliated Hosp 1 Zhengzhou 450000 Henan Peoples R China Guangxi Univ Sci & Technol Affiliated Hosp 2 Liuzhou 545000 Guangxi Peoples R China Liuzhou Workers Hosp Liuzhou 545000 Guangxi Peoples R China Second Peoples Hosp Yulin Yulin 537000 Guangxi Peoples R China Gannan Med Univ Affiliated Hosp 1 Ganzhou 341000 Jiangxi Peoples R China
The causality between circulating proteins and thyroid cancer (TC) remains unclear. We employed five large-scale circulating proteomic genome-wide association studies (GWASs) with up to 100,000 participants and a TC m... 详细信息
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Safeguarding authenticity for mitigating the harms of generative AI: Issues, research agenda, and policies for detection, fact-checking, and ethical AI
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ISCIENCE 2024年 第2期27卷 108782页
作者: Hamed, Ahmed Abdeen Zachara-Szymanska, Malgorzata Wu, Xindong Sano Ctr Computat Med Network Med & AI Czarnowiejska 36 Bldg C5 PL-30072 Krakow Poland Jagiellonian Univ Fac Int & Polit Studies Wladys Lawa Reymonta 4 PL-30059 Krakow Poland Zhejiang Lab Res Ctr Knowledge Engn Kechuang Ave Hangzhou 311121 Zhejiang Peoples R China
As the influence of transformer-based approaches in general and generative artificial intelligence (AI) in particular continues to expand across various domains, concerns regarding authenticity and explainability are ... 详细信息
来源: 评论