咨询与建议

限定检索结果

文献类型

  • 100 篇 期刊文献
  • 1 篇 会议

馆藏范围

  • 101 篇 电子文献
  • 0 种 纸本馆藏

日期分布

学科分类号

  • 6 篇 理学
    • 6 篇 生物学
  • 6 篇 工学
    • 3 篇 计算机科学与技术...
    • 2 篇 电气工程
    • 2 篇 生物工程
    • 1 篇 化学工程与技术
    • 1 篇 环境科学与工程(可...
    • 1 篇 软件工程
  • 2 篇 农学
  • 1 篇 医学
    • 1 篇 基础医学(可授医学...
    • 1 篇 药学(可授医学、理...

主题

  • 101 篇 computational bi...
  • 19 篇 bioinformatics
  • 16 篇 cancer
  • 12 篇 biocomputational...
  • 12 篇 biological scien...
  • 11 篇 transcriptomics
  • 11 篇 immunology
  • 9 篇 genomic analysis
  • 6 篇 molecular biolog...
  • 6 篇 neuroscience
  • 5 篇 cell biology
  • 5 篇 machine learning
  • 5 篇 cancer systems b...
  • 5 篇 association anal...
  • 4 篇 health sciences
  • 4 篇 mathematical bio...
  • 4 篇 physiology
  • 4 篇 health informati...
  • 4 篇 genetics
  • 3 篇 neural networks

机构

  • 4 篇 univ chinese aca...
  • 2 篇 univ montreal de...
  • 2 篇 chinese acad sci...
  • 2 篇 harvard med sch ...
  • 2 篇 univ montreal de...
  • 1 篇 univ cambridge d...
  • 1 篇 indian inst sci ...
  • 1 篇 sichuan univ nhc...
  • 1 篇 natl ctr cardiov...
  • 1 篇 riken lab med sc...
  • 1 篇 duke univ med ct...
  • 1 篇 helmholtz ctr in...
  • 1 篇 univ cambridge c...
  • 1 篇 chinese acad sci...
  • 1 篇 univ sherbrooke ...
  • 1 篇 daffodil int uni...
  • 1 篇 univ munster eur...
  • 1 篇 univ milan ctr c...
  • 1 篇 univ milan ctr c...
  • 1 篇 brown univ brown...

作者

  • 3 篇 you zhu-hong
  • 2 篇 guo zhen-hao
  • 2 篇 liu nan
  • 2 篇 yi hai-cheng
  • 2 篇 hussin julie g.
  • 2 篇 paul bikash kuma...
  • 2 篇 wu di
  • 2 篇 poujol raphael
  • 2 篇 liu rui
  • 2 篇 wang fei
  • 2 篇 ahmed kawsar
  • 2 篇 layton anita t.
  • 1 篇 simmons alan j.
  • 1 篇 li dean
  • 1 篇 hildebrand willi...
  • 1 篇 ganopoulou maria
  • 1 篇 supakar tinku
  • 1 篇 gao fan
  • 1 篇 jiang xiaoyi
  • 1 篇 ysebaert loïc

语言

  • 101 篇 英文
检索条件"主题词=computational bioinformatics"
101 条 记 录,以下是21-30 订阅
排序:
Panera: An innovative framework for surmounting uncertainty in microbial community modeling using pan-genera metabolic models
收藏 引用
ISCIENCE 2024年 第7期27卷 110358页
作者: Palanikumar, Indumathi Sinha, Himanshu Raman, Karthik Indian Inst Technol IIT Madras Bhupat Jyoti Mehta Sch Biosci Dept Biotechnol Chennai 600036 India IIT Madras Ctr Integrat Biol & Syst Med IBSE Chennai 600036 India IIT Madras Robert Bosch Ctr Data Sci & Artificial Intelligen Chennai 600036 India IIT Madras Wadhwani Sch Data Sci & AI Dept Data Sci & AI Chennai 600036 Tamil Nadu India
Utilization of 16S rRNA data in constraint-based modeling to characterize microbial communities confronts a major hurdle of lack of species-level resolution, impeding the construction of community models. We introduce... 详细信息
来源: 评论
Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis
收藏 引用
ISCIENCE 2022年 第2期25卷 103822页
作者: Garcia-Mendivil, Laura Perez-Zabalza, Maria Mountris, Konstantinos Duwe, Sam Smisdom, Nick Perez, Marta Lujan, Lluis Wolfs, Esther Driesen, Ronald B. Maria Vallejo-Gil, Jose Carlos Fresneda-Roldan, Pedro Fananas-Mastral, Javier Vazquez-Sancho, Manuel Matamala-Adell, Marta Fernando Sorribas-Berjon, Juan Andre Bellido-Morales, Javier Javier Mancebon-Sierra, Francisco Sebastian Vaca-Nunez, Alexander Ballester-Cuenca, Carlos Olivan-Viguera, Aida Diez, Emiliano Ordovas, Laura Pueyo, Esther Univ Zaragoza Aragon Inst Engn Res Biomed Signal Interpretat & Computat Simulat Grp Zaragoza 50018 Spain IIS Aragon BSICoS Zaragoza 50018 Spain Hasselt Univ Adv Opt Microscopy Ctr Biomed Res Inst B-3500 Diepenbeek Belgium Hasselt Univ Biomed Res Inst B-3500 Diepenbeek Belgium Univ Zaragoza Dept Anat Embryol & Anim Genet Zaragoza 50013 Spain Univ Zaragoza Inst Univ Invest Mixto Agroalimentario Aragon IA2 Zaragoza 50013 Spain Univ Zaragoza Dept Anim Pathol Zaragoza 50013 Spain Univ Hosp Miguel Servet Dept Cardiovasc Surg Zaragoza 50009 Spain Biomed Res Networking Ctr Bioengn Biomat & Nanome Zaragoza 50018 Spain Consejo Nacl Invest Cient & Tecn Inst Expt Med & Biol Cuyo IMBECU RA-5500 Mendoza Argentina ARAID Fdn Zaragoza 50018 Spain
Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and ... 详细信息
来源: 评论
Machine learning workflows identify a microRNA signature of insulin transcription in human tissues
收藏 引用
ISCIENCE 2021年 第4期24卷 102379页
作者: Wong, Wilson K. M. Joglekar, Mugdha, V Saini, Vijit Jiang, Guozhi Dong, Charlotte X. Chaitarvornkit, Alissa Maciag, Grzegorz J. Gerace, Dario Farr, Ryan J. Satoor, Sarang N. Sahu, Subhshri Sharangdhar, Tejaswini Ahmed, Asma S. Chew, Yi Vee Liuwantara, David Heng, Benjamin Lim, Chai K. Hunter, Julie Januszewski, Andrzej S. Sorensen, Anja E. Akil, Ammira S. A. Gamble, Jennifer R. Loudovaris, Thomas Kay, Thomas W. Thomas, Helen E. O'Connell, Philip J. Guillemin, Gilles J. Martin, David Simpson, Ann M. Hawthorne, Wayne J. Dalgaard, Louise T. Ma, Ronald C. W. Hardikar, Anandwardhan A. Western Sydney Univ Sch Med Diabet & Islet Biol Grp Narellan Rd & Gilchrist Dr Campbelltown NSW 2560 Australia Univ Sydney Fac Med & Hlth Diabet & Islet Biol Grp 92-94 Parramatta Rd Camperdown NSW 2050 Australia Univ Technol Sydney Sch Life Sci 15 Broadway Ultimo NSW 2007 Australia Univ Technol Sydney Ctr Hlth Technol 15 Broadway Ultimo NSW 2007 Australia Chinese Univ Hong Kong Prince Wales Hosp Dept Med & Therapeut Hong Kong Peoples R China Chinese Univ Hong Kong Prince Wales Hosp Hong Kong Inst Diabet & Obes Hong Kong Peoples R China Chinese Univ Hong Kong Prince Wales Hosp Li Ka Shing Inst Hlth Sci Hong Kong Peoples R China Roskilde Univ Dept Sci & Environm Univ Vej 1 DK-4000 Roskilde Denmark Univ Sydney Ctr Transplant & Renal Res Westmead Inst Med Res 176 Hawkesbury Rd Westmead NSW 2145 Australia Macquarie Univ Fac Med Hlth & Human Sci Sydney NSW 2019 Australia Univ Sydney Med Sch Centenary Inst Ctr EndotheliumVasc Biol Program Locked Bag 6 Newtown NSW 2042 Australia Univ Sydney NHMRC Clin Trials Ctr 92-94 Parramatta Rd Camperdown NSW 2050 Australia Sidra Med Dept Human Genet Precis Med Program POB 26999 Doha Qatar St Vincents Inst 9 Princes St Fitzroy Vic Australia Univ Melbourne Dept Med 9 Princes St Fitzroy Vic Australia Strathfield Hosp Upper GI Surg 2-3 Everton Rd Strathfield NSW 2135 Australia
Dicer knockout mouse models demonstrated a key role for microRNAs in pancreatic beta-cell function. Studies to identify specific microRNA( s) associated with human (pro-)endocrine gene expression are needed. We profil... 详细信息
来源: 评论
Bayesian multivariate genetic analysis improves translational insights
收藏 引用
ISCIENCE 2023年 第10期26卷 107854页
作者: Urbut, Sarah M. Koyama, Satoshi Hornsby, Whitney Bhukar, Rohan Kheterpal, Sumeet Truong, Buu Selvaraj, Margaret S. Neale, Benjamin O'Donnell, Christopher J. Peloso, Gina M. Natarajan, Pradeep Massachusetts Gen Hosp Cardiovasc Res Ctr Boston MA 02114 USA Broad Inst Program Med & Populat Genet Cambridge MA 02142 USA Harvard Med Sch Dept Med Boston MA 02115 USA Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA VA Boston Healthcare Syst Dept Vet Affairs Boston MA 02130 USA Boston Univ Sch Publ Hlth Dept Biostat Boston MA 02218 USA
While lipid traits are known essential mediators of cardiovascular disease, few approaches have taken advantage of their shared genetic effects. We apply a Bayesian multivariate size estimator, mash, to GWAS of four l... 详细信息
来源: 评论
Radiomics and deep learning models to differentiate lung adenosquamous carcinoma: A multicenter trial
收藏 引用
ISCIENCE 2023年 第9期26卷 107634页
作者: Chu, Xianjing Niu, Lishui Yang, Xianghui He, Shiqi Li, Aixin Chen, Liu Liang, Zhan Jing, Di Zhou, Rongrong Cent South Univ Xiangya Hosp Dept Oncol Changsha 410008 Peoples R China Changsha Cent Hosp Dept Oncol Changsha 410004 Peoples R China Univ British Columbia Dept Comp Sci 2329 West Mall Vancouver BC Canada Univ South Affiliated Hosp 1 Hengyang Med Sch Dept Radiotherapy Hengyang 421001 Peoples R China Cent South Univ Xiangya Hosp Xiangya Lung Canc Ctr Changsha 410008 Peoples R China Cent South Univ Xiangya Hosp Natl Clin Res Ctr Geriatr Disorders Changsha 410008 Peoples R China
Adenosquamous carcinoma (ASC) is frequently misdiagnosed or overlooked in clinical practice due to its dual histological components and potential transformation from either adenocarcinoma (ADC) or squamous cell carcin... 详细信息
来源: 评论
Gene presence/absence variation in Mytilus galloprovincialis and its implications in gene expression and adaptation
收藏 引用
ISCIENCE 2023年 第10期26卷 107827页
作者: Saco, Amaro Rey-Campos, Magali Gallardo-Escarate, Cristian Gerdol, Marco Novoa, Beatriz Figueras, Antonio Spanish Natl Res Council Inst Marine Res Vigo Spain Univ Concepcion Ctr Aquaculture Res Concepcion Chile Univ Trieste Dept Life Sci Trieste Italy
Presence/absence variation (PAV) is a well-known phenomenon in prokaryotes that was described for the first time in bivalves in 2020 in Mytilus galloprovincialis. The objective of the present study was to further our ... 详细信息
来源: 评论
Multi-scale spatial modeling of immune cell distributions enables survival prediction in primary central nervous system lymphoma
收藏 引用
ISCIENCE 2023年 第8期26卷 107331页
作者: Roemer, Margaretha G. M. van de Brug, Tim Bosch, Erik Berry, Daniella Hijmering, Nathalie Stathi, Phylicia Weijers, Karin Doorduijn, Jeannette Bromberg, Jacoline van de Wiel, Mark Ylstra, Bauke de Jong, Daphne Kim, Yongsoo Vrije Univ Amsterdam Canc Ctr Amsterdam Dept Pathol Amsterdam UMC Amsterdam Netherlands Vrije Univ Amsterdam Amsterdam Publ Hlth Res Inst Dept Epidemiol & Data Sci Amsterdam UMC Amsterdam Netherlands Vrije Univ Amsterdam Dept Math Amsterdam Netherlands Univ Amsterdam Dept Pathol HOVON Pathol Facil & Biobank HOP Med Ctr Amsterdam Netherlands Univ Med Ctr Rotterdam Erasmus MC Canc Inst Dept Hematol Rotterdam Netherlands Univ Med Ctr Rotterdam Erasmus MC Canc Inst Brain Tumor Ctr Dept Neurooncol Rotterdam Netherlands
To understand the clinical significance of the tumor microenvironment (TME), it is essential to study the interactions between malignant and non-malignant cells in clinical specimens. Here, we established a computatio... 详细信息
来源: 评论
Characterization of mechanisms positioning costimulatory complexes in immune synapses
收藏 引用
ISCIENCE 2021年 第10期24卷 103100页
作者: Siokis, Anastasios Robert, Philippe A. Demetriou, Philippos Kvalvaag, Audun Valvo, Salvatore Mayya, Viveka Dustin, Michael L. Meyer-Hermann, Michael Helmholtz Ctr Infect Res Dept Syst Immunol D-38106 Braunschweig Germany Helmholtz Ctr Infect Res Braunschweig Integrated Ctr Syst Biol D-38106 Braunschweig Germany Tech Univ Carolo Wilhelmina Braunschweig Inst Biochem Biotechnol & Bioinformat D-38106 Braunschweig Germany Univ Oxford Nuffield Dept Orthopaed Rheumatol & Musculoskelet Kennedy Inst Rheumatol Oxford OX3 7FY England Oslo Univ Hosp Inst Canc Res Dept Mol Cell Biol N-0379 Oslo Norway Univ Oslo Dept Immunol N-0372 Oslo Norway
Small immunoglobulin superfamily (sIGSF) adhesion complexes form a corolla of microdomains around an integrin ring and secretory core during immunological synapse (IS) formation. The corolla recruits and retains major... 详细信息
来源: 评论
Assessment of circulating proteins in thyroid cancer: Proteome-wide Mendelian randomization and colocalization
收藏 引用
ISCIENCE 2024年 第6期27卷 109961页
作者: Fan, Qinghua Wen, Shifeng Zhang, Yi Feng, Xiuming Zheng, Wanting Liang, Xiaolin Lin, Yutong Zhao, Shimei Xie, Kaisheng Jiang, Hancheng Tang, Haifeng Zeng, Xiangtai Guo, You Wang, Fei Yang, Xiaobo Guangxi Med Univ Sch Publ Hlth Nanning 530000 Guangxi Peoples R China Guangxi Univ Sci & Technol Affiliated Hosp 2 Guangxi Key Lab Precise Prevent & Treatment Thyroi Liuzhou 545000 Guangxi Peoples R China Zhengzhou Univ Affiliated Hosp 1 Zhengzhou 450000 Henan Peoples R China Guangxi Univ Sci & Technol Affiliated Hosp 2 Liuzhou 545000 Guangxi Peoples R China Liuzhou Workers Hosp Liuzhou 545000 Guangxi Peoples R China Second Peoples Hosp Yulin Yulin 537000 Guangxi Peoples R China Gannan Med Univ Affiliated Hosp 1 Ganzhou 341000 Jiangxi Peoples R China
The causality between circulating proteins and thyroid cancer (TC) remains unclear. We employed five large-scale circulating proteomic genome-wide association studies (GWASs) with up to 100,000 participants and a TC m... 详细信息
来源: 评论
Automated design of CRISPR prime editors for 56,000 human pathogenic variants
收藏 引用
ISCIENCE 2021年 第11期24卷 103380页
作者: Morris, John A. Rahman, Jahan A. Guo, Xinyi Sanjana, Neville E. New York Genome Ctr New York NY 10013 USA NYU Dept Biol New York NY 10003 USA
Prime editors (PEs) are clustered regularly interspaced short palindromic repeats (CRISPR)-based genome engineering tools that can introduce precise base-pair edits. We developed an automated pipeline to correct (ther... 详细信息
来源: 评论