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检索条件"主题词=computational bioinformatics"
101 条 记 录,以下是21-30 订阅
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Bayesian multivariate genetic analysis improves translational insights
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ISCIENCE 2023年 第10期26卷 107854页
作者: Urbut, Sarah M. Koyama, Satoshi Hornsby, Whitney Bhukar, Rohan Kheterpal, Sumeet Truong, Buu Selvaraj, Margaret S. Neale, Benjamin O'Donnell, Christopher J. Peloso, Gina M. Natarajan, Pradeep Massachusetts Gen Hosp Cardiovasc Res Ctr Boston MA 02114 USA Broad Inst Program Med & Populat Genet Cambridge MA 02142 USA Harvard Med Sch Dept Med Boston MA 02115 USA Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA VA Boston Healthcare Syst Dept Vet Affairs Boston MA 02130 USA Boston Univ Sch Publ Hlth Dept Biostat Boston MA 02218 USA
While lipid traits are known essential mediators of cardiovascular disease, few approaches have taken advantage of their shared genetic effects. We apply a Bayesian multivariate size estimator, mash, to GWAS of four l... 详细信息
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Radiomics and deep learning models to differentiate lung adenosquamous carcinoma: A multicenter trial
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ISCIENCE 2023年 第9期26卷 107634页
作者: Chu, Xianjing Niu, Lishui Yang, Xianghui He, Shiqi Li, Aixin Chen, Liu Liang, Zhan Jing, Di Zhou, Rongrong Cent South Univ Xiangya Hosp Dept Oncol Changsha 410008 Peoples R China Changsha Cent Hosp Dept Oncol Changsha 410004 Peoples R China Univ British Columbia Dept Comp Sci 2329 West Mall Vancouver BC Canada Univ South Affiliated Hosp 1 Hengyang Med Sch Dept Radiotherapy Hengyang 421001 Peoples R China Cent South Univ Xiangya Hosp Xiangya Lung Canc Ctr Changsha 410008 Peoples R China Cent South Univ Xiangya Hosp Natl Clin Res Ctr Geriatr Disorders Changsha 410008 Peoples R China
Adenosquamous carcinoma (ASC) is frequently misdiagnosed or overlooked in clinical practice due to its dual histological components and potential transformation from either adenocarcinoma (ADC) or squamous cell carcin... 详细信息
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Gene presence/absence variation in Mytilus galloprovincialis and its implications in gene expression and adaptation
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ISCIENCE 2023年 第10期26卷 107827页
作者: Saco, Amaro Rey-Campos, Magali Gallardo-Escarate, Cristian Gerdol, Marco Novoa, Beatriz Figueras, Antonio Spanish Natl Res Council Inst Marine Res Vigo Spain Univ Concepcion Ctr Aquaculture Res Concepcion Chile Univ Trieste Dept Life Sci Trieste Italy
Presence/absence variation (PAV) is a well-known phenomenon in prokaryotes that was described for the first time in bivalves in 2020 in Mytilus galloprovincialis. The objective of the present study was to further our ... 详细信息
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Multi-scale spatial modeling of immune cell distributions enables survival prediction in primary central nervous system lymphoma
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ISCIENCE 2023年 第8期26卷 107331页
作者: Roemer, Margaretha G. M. van de Brug, Tim Bosch, Erik Berry, Daniella Hijmering, Nathalie Stathi, Phylicia Weijers, Karin Doorduijn, Jeannette Bromberg, Jacoline van de Wiel, Mark Ylstra, Bauke de Jong, Daphne Kim, Yongsoo Vrije Univ Amsterdam Canc Ctr Amsterdam Dept Pathol Amsterdam UMC Amsterdam Netherlands Vrije Univ Amsterdam Amsterdam Publ Hlth Res Inst Dept Epidemiol & Data Sci Amsterdam UMC Amsterdam Netherlands Vrije Univ Amsterdam Dept Math Amsterdam Netherlands Univ Amsterdam Dept Pathol HOVON Pathol Facil & Biobank HOP Med Ctr Amsterdam Netherlands Univ Med Ctr Rotterdam Erasmus MC Canc Inst Dept Hematol Rotterdam Netherlands Univ Med Ctr Rotterdam Erasmus MC Canc Inst Brain Tumor Ctr Dept Neurooncol Rotterdam Netherlands
To understand the clinical significance of the tumor microenvironment (TME), it is essential to study the interactions between malignant and non-malignant cells in clinical specimens. Here, we established a computatio... 详细信息
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Quantitative analysis of disease-related metabolic dysregulation of human microbiota
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ISCIENCE 2023年 第1期26卷 105868页
作者: Fumagalli, Maria Rita Saro, Stella Maria Tajana, Matteo Zapperi, Stefano Porta, Caterina A. M. La Univ Milan Ctr Complex & Biosyst Dept Environm Sci & Policy Via Celoria 26 I-20133 Milan Italy CNR Ist Biofis Via Marini 6 I-16149 Genoa Italy Univ Milan Ctr Complex & Biosyst Dept Phys Via Celoria 16 I-20133 Milan Italy CNR Ist Chim Mat Condensata & Tecnol Energia Via R Cozzi 53 I-20125 Milan Italy
The metabolic activity of all the micro-organism composing the human micro -biome interacts with the host metabolism contributing to human health and disease in a way that is not fully understood. Here, we introduce S... 详细信息
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A personalized stepwise dynamic predictive algorithm of the time to first treatment in chronic lymphocytic leukemia
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ISCIENCE 2023年 第9期26卷 107591页
作者: Moysiadis, Theodoros Koparanis, Dimitris Liapis, Konstantinos Ganopoulou, Maria Vrachiolias, George Katakis, Ioannis Moyssiadis, Chronis Vizirianakis, Ioannis S. Angelis, Lefteris Fokianos, Konstantinos Kotsianidis, Ioannis Democritus Univ Univ Hosp Alexandroupolis Dept Hematol Thrace Med Sch Alexandroupolis 68100 Greece Aristotle Univ Thessaloniki Sch Informat Thessaloniki 54124 Greece Univ Nicosia Sch Sci & Engn Dept Comp Sci CY-2417 Nicosia Cyprus Aristotle Univ Thessaloniki Sch Math Thessaloniki 54124 Greece Aristotle Univ Thessaloniki Sch Pharm Thessaloniki 54124 Greece Univ Nicosia Sch Life & Hlth Sci Dept Life Sci CY-2417 Nicosia Cyprus Univ Cyprus Dept Math & Stat CY-1678 Nicosia Cyprus
Personalized prediction is ideal in chronic lymphocytic leukemia (CLL). Although refined models have been developed, stratifying patients in risk groups, it is required to accommodate time-dependent information of pat... 详细信息
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Systematic analysis reveals a pan-cancer SNHG family signature predicting prognosis and immunotherapy response
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ISCIENCE 2023年 第10期26卷 108055页
作者: Zheng, Haotian Wang, Guanghui Wang, Yadong Liu, Jichang Ma, Guoyuan Du, Jiajun Shandong Univ Shandong Prov Hosp Inst Oncol Jinan Peoples R China Shandong First Med Univ Shandong Prov Hosp Dept Thorac Surg Jinan Peoples R China Shandong Univ Shandong Prov Hosp Dept Thorac Surg Jinan Peoples R China
Small nucleolar RNA host genes (SNHGs) are a special family of long non-coding RNAs (lncRNAs), which not only function in a way similar to other lncRNAs but also influence the intracellular level of small nucleolar RN... 详细信息
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Understanding locomotion in trilobites by means of three-dimensional models
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ISCIENCE 2023年 第9期26卷 107512页
作者: Esteve, Jorge Rubio, Pedro UCM Fac CC Geol Dept Geodinam Estratig & Paleontol Area Paleontol Jose Antonio Novais 12 Madrid 28040 Spain Burashi SL Avda Ma Zambrano 24-6B Zaragoza 50018 Spain
Trilobites were one of the first animals on Earth to leave their imprints on the sea floor. Such imprints represent behavioral traces related to feeding or protection, in both cases implying different types of locomot... 详细信息
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Whole-genome DNA methylation and DNA methylation-based biomarkers in lung squamous cell carcinoma
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ISCIENCE 2023年 第7期26卷 107013页
作者: Cai, Qidong He, Boxue Tu, Guangxu Peng, Weilin Shi, Shuai Qian, Banglun Liang, Qingchun Peng, Shaoliang Tao, Yongguang Wang, Xiang Cent South Univ Xiangya Hosp 2 Dept Thorac Surg Changsha 410011 Peoples R China Cent South Univ Xiangya Hosp 2 Hunan Key Lab Early Diag & Precise Treatment Lung Changsha 410011 Peoples R China Cent South Univ Xiangya Hosp 2 Dept Pathol Changsha 410011 Peoples R China Hunan Univ Coll Comp Sci & Elect Engn Changsha 410082 Peoples R China Natl Univ Def Technol Sch Comp Sci Changsha 410073 Peoples R China Peng Cheng Lab Shenzhen 518000 Peoples R China Cent South Univ Xiangya Hosp Dept Pathol Key Lab Carcinogenesis & Canc Invas Changsha 410078 Hunan Peoples R China Cent South Univ Canc Res Inst NHC Key Lab Carcinogenesis Changsha 410078 Hunan Peoples R China Cent South Univ Sch Basic Med Changsha 410078 Hunan Peoples R China
Exploring early detection methods through comprehensive evaluation of DNA methylation for lung squamous cell carcinoma (LUSC) patients is of great significance. By using different machine learning algorithms for featu... 详细信息
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An artificial bee bare-bone hunger games search for global optimization and high-dimensional feature selection
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ISCIENCE 2023年 第5期26卷 106679页
作者: Chen, Zhiqing Xuan, Ping Heidari, Ali Asghar Liu, Lei Wu, Chengwen Chen, Huiling Escorcia-Gutierrez, Jose Mansour, Romany F. Wenzhou Polytech Sch Intelligent Mfg Wenzhou 325035 Peoples R China Shantou Univ Sch Engn Dept Comp Sci Shantou 515063 Peoples R China Wenzhou Univ Key Lab Intelligent Informat Safety & Emergency Zh Wenzhou 325035 Peoples R China Sichuan Univ Coll Comp Sci Chengdu 610065 Sichuan Peoples R China Univ Costa Dept Computat Sci & Elect CUC Barranquilla 080002 Colombia New Valley Univ Fac Sci Dept Math El Kharga 72511 Egypt
The domains of contemporary medicine and biology have generated substantial high-dimensional genetic data. Identifying representative genes and decreasing the dimensionality of the data can be challenging. The goal of... 详细信息
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