咨询与建议

限定检索结果

文献类型

  • 100 篇 期刊文献
  • 1 篇 会议

馆藏范围

  • 101 篇 电子文献
  • 0 种 纸本馆藏

日期分布

学科分类号

  • 6 篇 理学
    • 6 篇 生物学
  • 6 篇 工学
    • 3 篇 计算机科学与技术...
    • 2 篇 电气工程
    • 2 篇 生物工程
    • 1 篇 化学工程与技术
    • 1 篇 环境科学与工程(可...
    • 1 篇 软件工程
  • 2 篇 农学
  • 1 篇 医学
    • 1 篇 基础医学(可授医学...
    • 1 篇 药学(可授医学、理...

主题

  • 101 篇 computational bi...
  • 19 篇 bioinformatics
  • 16 篇 cancer
  • 12 篇 biocomputational...
  • 12 篇 biological scien...
  • 11 篇 transcriptomics
  • 11 篇 immunology
  • 9 篇 genomic analysis
  • 6 篇 molecular biolog...
  • 6 篇 neuroscience
  • 5 篇 cell biology
  • 5 篇 machine learning
  • 5 篇 cancer systems b...
  • 5 篇 association anal...
  • 4 篇 health sciences
  • 4 篇 mathematical bio...
  • 4 篇 physiology
  • 4 篇 health informati...
  • 4 篇 genetics
  • 3 篇 neural networks

机构

  • 4 篇 univ chinese aca...
  • 2 篇 univ montreal de...
  • 2 篇 chinese acad sci...
  • 2 篇 harvard med sch ...
  • 2 篇 univ montreal de...
  • 1 篇 univ cambridge d...
  • 1 篇 indian inst sci ...
  • 1 篇 sichuan univ nhc...
  • 1 篇 natl ctr cardiov...
  • 1 篇 riken lab med sc...
  • 1 篇 duke univ med ct...
  • 1 篇 helmholtz ctr in...
  • 1 篇 univ cambridge c...
  • 1 篇 chinese acad sci...
  • 1 篇 univ sherbrooke ...
  • 1 篇 daffodil int uni...
  • 1 篇 univ munster eur...
  • 1 篇 univ milan ctr c...
  • 1 篇 univ milan ctr c...
  • 1 篇 brown univ brown...

作者

  • 3 篇 you zhu-hong
  • 2 篇 guo zhen-hao
  • 2 篇 liu nan
  • 2 篇 yi hai-cheng
  • 2 篇 hussin julie g.
  • 2 篇 paul bikash kuma...
  • 2 篇 wu di
  • 2 篇 poujol raphael
  • 2 篇 liu rui
  • 2 篇 wang fei
  • 2 篇 ahmed kawsar
  • 2 篇 layton anita t.
  • 1 篇 simmons alan j.
  • 1 篇 li dean
  • 1 篇 hildebrand willi...
  • 1 篇 ganopoulou maria
  • 1 篇 supakar tinku
  • 1 篇 gao fan
  • 1 篇 jiang xiaoyi
  • 1 篇 ysebaert loïc

语言

  • 101 篇 英文
检索条件"主题词=computational bioinformatics"
101 条 记 录,以下是31-40 订阅
排序:
Application of a deep learning algorithm in the detection of hip fractures
收藏 引用
ISCIENCE 2023年 第8期26卷 107350页
作者: Gao, Yan Soh, Nicholas Yock Teck Liu, Nan Lim, Gilbert Ting, Daniel Cheng, Lionel Tim-Ee Min, Kang Liew, Charlene Oh, Hong Choon Tan, Jin Rong Venkataraman, Narayan Goh, Siang Hiong Yan, Yet Yen Singapore Hlth Serv SingHlth Changi Gen Hosp Hlth Serv Res Singapore Singapore Singapore Hlth Serv SingHlth Changi Gen Hosp Dept Diagnost Radiol Singapore Singapore Duke NUS Med Sch Ctr Quantitat Med Singapore Singapore Singapore Hlth Serv SingHlth Duke NUS Med Sch Singapore Singapore Singapore Gen Hosp Dept Diagnost Radiol Singapore Singapore Duke NUS Med Sch Radiol Sci ACP Singapore Singapore Singapore Hlth Serv SingHlth Changi Gen Hosp Dept Med Informat Singapore Singapore Singapore Hlth Serv SingHlth Changi Gen Hosp Dept Emergency Med Singapore Singapore
This paper describes the development of a deep learning model for prediction of hip fractures on pelvic radiographs (X-rays). Developed using over 40,000 pelvic radiographs from a single institution, the model demonst... 详细信息
来源: 评论
Gene-metabolite annotation with shortest reactional distance enhances metabolite genome-wide association studies results
收藏 引用
ISCIENCE 2023年 第12期26卷 108473页
作者: Baron, Cantin Cherkaoui, Sarah Therrien-Laperriere, Sandra Ilboudo, Yann Poujol, Raphael Mehanna, Pamela Garrett, Melanie E. Telen, Marilyn J. Ashley-Koch, Allison E. Bartolucci, Pablo Rioux, John D. Lettre, Guillaume Rosiers, Christine Des Ruiz, Matthieu Hussin, Julie G. Univ Montreal Dept Biochim & Med Mol Montreal PQ Canada Montreal Heart Inst Montreal PQ Canada Univ Childrens Hosp Zurich Univ Zurich Childrens Res Ctr Div Oncol Zurich Switzerland Univ Paris Saclay Gustave Roussy Canc Ctr Dept Pediat & Adolescent Oncol Villejuif France Duke Mol Inst Duke Med Ctr Durham NC USA Duke Univ Med Ctr Dept Med Div Hematol Durham NC USA Univ Paris Est Creteil Hop Univ Henri Mondor Sickle Cell Referral Ctr AP HPUMGGR Creteil France Univ Paris Est Creteil Lab Excellence LABEX IMRB Creteil France Univ Montreal Dept Med Montreal PQ Canada Univ Montreal Dept Nutr Montreal PQ Canada
Metabolite genome-wide association studies (mGWAS) have advanced our understanding of the genetic control of metabolite levels. However, interpreting these associations remains challenging due to a lack of tools to an... 详细信息
来源: 评论
Prediction of postpartum prediabetes by machine learning methods in women with gestational diabetes mellitus
收藏 引用
ISCIENCE 2023年 第10期26卷 107846页
作者: Parkhi, Durga Periyathambi, Nishanthi Ghebremichael-Weldeselassie, Yonas Patel, Vinod Sukumar, Nithya Siddharthan, Rahul Narlikar, Leelavati Saravanan, Ponnusamy Univ Warwick Div Hlth Sci Populat Evidence & Technol Coventry England George Eliot Hosp Dept Diabet Endocrinol & Metab Nuneaton England Open Univ Sch Math & Stat Milton Keynes England Inst Math Sci Dept Computat Biol Chennai India Indian Inst Sci Educ & Res Dept Data Sci Pune India
Early onset of type 2 diabetes and cardiovascular disease are common complications for women diagnosed with gestational diabetes. Prediabetes refers to a condition in which blood glucose levels are higher than normal,... 详细信息
来源: 评论
A multi-center performance assessment for automated histopathological classification and grading of glioma using whole slide images
收藏 引用
ISCIENCE 2023年 第11期26卷 108041页
作者: Jin, Lei Sun, Tianyang Liu, Xi Cao, Zehong Liu, Yan Chen, Hong Ma, Yixin Zhang, Jun Zou, Yaping Liu, Yingchao Shi, Feng Shen, Dinggang Wu, Jinsong Fudan Univ Huashan Hosp Neurol Surg Dept Glioma Surg Div Shanghai 200040 Peoples R China Fudan Univ Huashan Hosp Natl Ctr Neurol Disorders Shanghai 200040 Peoples R China Shanghai United Imaging Intelligence Co Ltd Dept Res & Dev Shanghai 200030 Peoples R China Fudan Univ Huashan Hosp Dept Pathol Shanghai 200040 Peoples R China Wuhan Zhongji Biotechnol Co Ltd Wuhan 430206 Peoples R China Shandong First Med Univ Prov Hosp Dept Neurosurg Jinan 250021 Shandong Peoples R China ShanghaiTech Univ Sch Biomed Engn Shanghai 201210 Peoples R China Shanghai Clin Res & Trial Ctr Shanghai 201210 Peoples R China
Accurate pathological classification and grading of gliomas is crucial in clinical diagnosis and treatment. The application of deep learning techniques holds promise for automated histological pathology diagnosis. In ... 详细信息
来源: 评论
Selection for immune evasion in SARS-CoV-2 revealed by high-resolution epitope mapping and sequence analysis
收藏 引用
ISCIENCE 2023年 第8期26卷 107394页
作者: N'Guessan, Arnaud Kailasam, Senthilkumar Mostefai, Fatima Poujol, Raphael Grenier, Jean-Christophe Ismailova, Nailya Contini, Paola De Palma, Raffaele Haber, Carsten Stadler, Volker Bourque, Guillaume Hussin, Julie G. Shapiro, B. Jesse Fritz, Jorg H. Piccirillo, Ciriaco A. McGill Univ Dept Microbiol & Immunol Montreal PQ Canada McGill Univ McGill Genome Ctr Montreal PQ Canada Canadian Ctr Computat Genom Montreal PQ Canada McGill Univ Dept Human Genet Montreal PQ Canada Montreal Heart Inst Res Ctr Montreal PQ Canada Univ Montreal Dept Biochim & Med Mol Montreal PQ Canada Univ Genoa Dept Internal Med Genoa Italy PEPperPRINT GmbH Heidelberg Germany Univ Montreal Dept Med Montreal PQ Canada McGill Univ McGill Univ Res Ctr Complex Traits MRCCT Montreal PQ Canada McGill Infect Dis & Immun Global Hlth Program Res Inst Hlth Ctr Montreal PQ Canada McGill Univ Dahdaleh Inst Med DIgM Montreal PQ Canada
Here, we exploit a deep serological profiling strategy coupled with an integrated, computational framework for the analysis of SARS-CoV-2 humoral immune responses. Applying a high-density peptide array (HDPA) spanning... 详细信息
来源: 评论
Genetic overlap for ten cardiovascular diseases: A comprehensive gene-centric pleiotropic association analysis and Mendelian randomization study
收藏 引用
ISCIENCE 2023年 第11期26卷 108150页
作者: Liu, Zeye Xu, Jing Tan, Jiangshan Li, Xiaofei Zhang, Fengwen Ouyang, Wenbin Wang, Shouzheng Huang, Yuan Li, Shoujun Pan, Xiangbin Natl Ctr Cardiovasc Dis Dept Struct Heart Dis Beijing 100037 Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Fuwai Hosp Beijing 100037 Peoples R China Natl Hlth Commiss Key Lab Cardiovasc Regenerat Med Beijing 100037 Peoples R China Chinese Acad Med Sci Key Lab Innovat Cardiovasc Devices Beijing 100037 Peoples R China Chinese Acad Med Sci Fuwai Hosp Natl Clin Res Ctr Cardiovasc Dis Beijing 100037 Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Natl Ctr Cardiovasc Dis Fuwai Hosp State Key Lab Cardiovasc Dis Beijing Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Key Lab Pulm Vasc Med Natl Clin Res Ctr Cardiovasc Dis State Key Lab Cardiovasc DisFuwai HospNatl Ctr C Beijing 100037 Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Fuwai Hosp Dept Cardiol Beijing Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Fuwai Hosp Pediat Cardiac Surg Ctr State Key Lab Cardiovasc DisNatl Ctr Cardiovasc D Beijing Peoples R China
Recent studies suggest that pleiotropic effects may explain the genetic architecture of cardiovascular diseases (CVDs). We conducted a comprehensive gene-centric pleiotropic association analysis for ten CVDs using gen... 详细信息
来源: 评论
Modeling breast cancer proliferation, drug synergies, and alternating therapies
收藏 引用
ISCIENCE 2023年 第5期26卷 106714页
作者: He, Wei Demas, Diane M. Shajahan-Haq, Ayesha N. Baumann, William T. Virginia Tech Program Genet Bioinformat & Computat Biol VT BIOTRANS Blacksburg VA 24061 USA Georgetown Univ Med Ctr Lombardi Comprehens Canc Ctr Dept Oncol Washington DC 20057 USA Virginia Tech Dept Elect & Comp Engn Blacksburg VA 24061 USA
Estrogen receptor positive (ER+) breast cancer is responsive to a number of tar-geted therapies used clinically. Unfortunately, the continuous application of tar-geted therapy often results in resistance, driving the ... 详细信息
来源: 评论
Intragenomic diversity of the V9 hypervariable domain in eukaryotes has little effect on metabarcoding
收藏 引用
ISCIENCE 2023年 第8期26卷 107291页
作者: Flegontova, Olga Lukes, Julius Horak, Ales Czech Acad Sci Inst Parasitol Biol Ctr Ceske Budejovice Czech Republic Univ Ostrava Fac Sci Dept Biol & Ecol Ostrava Czech Republic Univ South Bohemia Fac Sci Dept Mol Biol Ceske Budejovice Czech Republic
Metabarcoding revolutionized our understanding of diversity and ecology of microorganisms in different habitats. However, it is also associated with several inherent biases, one of which is associated with intragenomi... 详细信息
来源: 评论
A Kmer-based paired-end read de novo assembler and genotyper for canine MHC class I genotyping
收藏 引用
ISCIENCE 2023年 第2期26卷 105996页
作者: Feng, Yuan Hess, Paul R. Tompkins, Stephen M. Hildebrand, William H. Zhao, Shaying Univ Georgia Inst Bioinformat Dept Biochem & Mol Biol Athens GA 30602 USA North Carolina State Univ Coll Vet Med Dept Clin Sci Raleigh NC 27607 USA Univ Georgia Ctr Vaccines & Immunol UGA Athens GA 30602 USA Univ Oklahoma Hlth Sci Ctr Dept Microbiol & Immunol Oklahoma City OK 73104 USA
The major histocompatibility complex class I (MHC-I) genes are highly polymorphic. MHC-I genotyping is required for determining the peptide epitopes available to an individual's T-cell repertoire. Current genotypi... 详细信息
来源: 评论
Epitranscriptome analysis of NAD-capped RNA by spike-in-based normalization and prediction of chronological age
收藏 引用
ISCIENCE 2023年 第12期26卷 108558页
作者: Li, Dean Ge, Shuwe Liu, Yandong Pan, Miaomia Wang, Xueting Han, Guojing Zou, Sili Liu, Rui Niu, Kongyan Zhao, Chao Liu, Nan Qu, Lefeng Chinese Acad Sci Interdisciplinary Res Ctr Biol & Chem Shanghai Inst Organ Chem 100 Haike Ke Rd Shanghai 201210 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Naval Med Univ Chang Zheng Hosp Dept Vasc & Endovasc Surg Shanghai 200003 Peoples R China Fudan Univ Huashan Hosp Shanghai Med Coll Natl Clin Res Ctr Aging & MedSch Basic Med Sci 131 Dong An Rd Shanghai 200032 Peoples R China Metalife Biotechnol 1000 Zhen Chen Rd Shanghai 200444 Peoples R China Singlera Genom 500 Fu Rong Hua Rd Shanghai 201204 Peoples R China Shanghai Key Lab Aging Studies 100 Hai Ke Rd Shanghai 201210 Peoples R China
Nicotinamide adenine dinucleotide (NAD) can be used as an initiating nucleotide in RNA transcription to produce NAD-capped RNA (NAD-RNA). RNA modification by NAD that links metabolite with expressed transcript is a po... 详细信息
来源: 评论