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检索条件"主题词=computational bioinformatics"
101 条 记 录,以下是51-60 订阅
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Atherosclerotic plaque vulnerability quantification system for clinical and biological interpretability
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ISCIENCE 2023年 第9期26卷 107587页
作者: Zhang, Ge Cui, Xiaolin Qin, Zhen Wang, Zeyu Lu, Yongzheng Xu, Yanyan Xu, Shuai Tang, Laiyi Zhang, Li Liu, Gangqiong Wang, Xiaofang Zhang, Jinying Tang, Junnan Zhengzhou Univ Affiliated Hosp 1 Dept Orthoped Zhengzhou 450052 Henan Peoples R China Henan Prov Key Lab Cardiac Injury & Repair Zhengzhou 450052 Henan Peoples R China Henan Prov Clin Res Ctr Cardiovasc Dis Zhengzhou 450052 Henan Peoples R China Chinese Univ Hong Kong Shenzhen Sch Med Shenzhen 518172 Peoples R China
Acute myocardial infarction dominates coronary artery disease mortality. Identifying bio-signatures for pla-que destabilization and rupture is important for preventing the transition from coronary stability to insta-b... 详细信息
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Visualizing gene expression changes in time, space, and single cells with expressyouRcell
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ISCIENCE 2023年 第6期26卷
作者: Paganin, Martina Tebaldi, Toma Lauria, Fabio Viero, Gabriella Inst Biophys CNR Unit Trento Trento Italy Yale Univ Sch Med Yale Comprehens Canc Ctr New Haven CT USA Univ Trento Dept CIBIO Trento Italy
The last decade has witnessed massive advancements in high-throughput techniques capable of producing increasingly complex gene expression datasets across time and space and at the resolution of single cells. Yet, the... 详细信息
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An interpretable machine learning pipeline based on transcriptomics predicts phenotypes of lupus patients
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ISCIENCE 2023年 第10期26卷 108042页
作者: Leventhal, Emily L. Daamen, Andrea R. Grammer, Amrie C. Lipsky, Peter E. AMPEL BioSolut LLC Charlottesville VA 22902 USA RILITE Res Inst Charlottesville VA 22902 USA
Machine learning (ML) has the potential to identify subsets of patients with distinct phenotypes from gene expression data. However, phenotype prediction using ML has often relied on identifying important genes withou... 详细信息
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Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis
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ISCIENCE 2022年 第2期25卷 103822页
作者: Garcia-Mendivil, Laura Perez-Zabalza, Maria Mountris, Konstantinos Duwe, Sam Smisdom, Nick Perez, Marta Lujan, Lluis Wolfs, Esther Driesen, Ronald B. Maria Vallejo-Gil, Jose Carlos Fresneda-Roldan, Pedro Fananas-Mastral, Javier Vazquez-Sancho, Manuel Matamala-Adell, Marta Fernando Sorribas-Berjon, Juan Andre Bellido-Morales, Javier Javier Mancebon-Sierra, Francisco Sebastian Vaca-Nunez, Alexander Ballester-Cuenca, Carlos Olivan-Viguera, Aida Diez, Emiliano Ordovas, Laura Pueyo, Esther Univ Zaragoza Aragon Inst Engn Res Biomed Signal Interpretat & Computat Simulat Grp Zaragoza 50018 Spain IIS Aragon BSICoS Zaragoza 50018 Spain Hasselt Univ Adv Opt Microscopy Ctr Biomed Res Inst B-3500 Diepenbeek Belgium Hasselt Univ Biomed Res Inst B-3500 Diepenbeek Belgium Univ Zaragoza Dept Anat Embryol & Anim Genet Zaragoza 50013 Spain Univ Zaragoza Inst Univ Invest Mixto Agroalimentario Aragon IA2 Zaragoza 50013 Spain Univ Zaragoza Dept Anim Pathol Zaragoza 50013 Spain Univ Hosp Miguel Servet Dept Cardiovasc Surg Zaragoza 50009 Spain Biomed Res Networking Ctr Bioengn Biomat & Nanome Zaragoza 50018 Spain Consejo Nacl Invest Cient & Tecn Inst Expt Med & Biol Cuyo IMBECU RA-5500 Mendoza Argentina ARAID Fdn Zaragoza 50018 Spain
Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and ... 详细信息
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Polyvalent guide RNAs for CRISPR antivirals
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ISCIENCE 2022年 第11期25卷 105333页
作者: Bagchi, Rammyani Tinker-Kulberg, Rachel Salehin, Mohammad Supakar, Tinku Chamberlain, Sydney Ligaba-Osena, Ayalew Josephs, Eric A. Univ N Carolina Dept Nanosci Greensboro NC 27401 USA Univ N Carolina Dept Biol Greensboro NC 27401 USA
CRISPR effector Cas13 recognizes and degrades RNA molecules that are complementary to its guide RNA (gRNA) and possesses potential as an antiviral biotechnology because it can degrade viralmRNAandRNAgenomes. Because m... 详细信息
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Predicting miRNA-disease association through combining miRNA function and network topological similarities based on MINE
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ISCIENCE 2022年 第11期25卷 105299页
作者: Cao, Buwen Li, Renfa Xiao, Sainan Deng, Shuguang Zhou, Xiangjun Zhou, Lang Hunan City Univ Coll Informat & Elect Engn Yiyang 413000 Peoples R China Hunan Univ Coll Comp Sci & Elect Engn Key Lab Embedded & Cyber Phys Syst Changsha 410082 Peoples R China
Predicting associations between microRNAs (miRNAs) and diseases from the viewpoint of function modules has become increasingly popular However, existing methods obtained the relations between diseases and miRNAs only ... 详细信息
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Deep learning model of somatic hypermutation reveals importance of sequence context beyond hotspot targeting
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ISCIENCE 2022年 第1期25卷 103668页
作者: Tang, Catherine Krantsevich, Artem MacCarthy, Thomas SUNY Stony Brook Dept Appl Math & Stat Stony Brook NY 11794 USA SUNY Stony Brook Laufer Ctr Phys & Quantitat Biol Stony Brook NY 11794 USA Merck & Co Inc Exploratory Sci Ctr Cambridge MA USA
B cells undergo somatic hypermutation (SHM) of the Immunoglobulin (Ig) variable region to generate high-affinity antibodies. SHM relies on the activity of activation-induced deaminase (AID), which mutates C>U prefe... 详细信息
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Synchrony of biomarker variability indicates a critical transition: Application to mortality prediction in hemodialysis
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ISCIENCE 2022年 第6期25卷 104385页
作者: Cohen, Alan A. Leung, Diana L. Legault, Veronique Gravel, Dominique Blanchet, F. Guillaume Cote, Anne-Marie Fulop, Tamas Lee, Juhong Dufour, Frederik Liu, Mingxin Nakazato, Yuichi Univ Sherbrooke PRIMUS Res Grp Dept Family Med Sherbrooke PQ J1H 5N4 Canada Res Ctr Aging Sherbrooke PQ J1H 4C4 Canada Ctr Hosp Univ Sherbrooke Res Ctr Sherbrooke PQ J1H 5N4 Canada Univ Sherbrooke Dept Biol Sherbrooke PQ J1K 2R1 Canada Univ Sherbrooke Dept Math Sherbrooke PQ J1K 2R1 Canada Univ Sherbrooke Dept Sci Sante Communautaires Sherbrooke PQ J1H 5N4 Canada Univ Sherbrooke Dept Med Nephrol Div Sherbrooke PQ J1H 5N4 Canada Univ Sherbrooke Dept Med Geriatr Div Sherbrooke PQ J1H 5N4 Canada Ctr Hosp Univ Sherbrooke InfoCtr Ctr Integth Univ Sante & Serv Sociaux Estrie Sherbrooke PQ J1H 5N4 Canada Hakuyukai Med Corp Yuai Nisshin Clin Div Nephrol Kita Ku 2-1914-6 Nisshin Cho Saitama Saitama 3310823 Japan Yale Univ Dept Pathol New Haven CT 06519 USA
Critical transition theory suggests that complex systems should experience increased temporal variability just before abrupt state changes. We tested this hypothesis in 763 patients on long-term hemodialysis, using 11... 详细信息
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Quantitative landscapes reveal trajectories of cell-state transitions associated with drug resistance in melanoma
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ISCIENCE 2022年 第12期25卷 105499页
作者: Pillai, Maalavika Chen, Zihao Jolly, Mohit Kumar Li, Chunhe Indian Inst Sci Ctr Biosyst Sci & Engn Bangalore India Indian Inst Sci Undergrad Programme Bangalore India Fudan Univ Shanghai Ctr Math Sci Shanghai Peoples R China Fudan Univ Inst Sci & Technol Brain Inspired Intelligence Shanghai Peoples R China Fudan Univ Sch Math Sci Shanghai Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Shanghai Peoples R China
Drug resistance and tumor relapse in patients with melanoma is attributed to a combination of genetic and non-genetic mechanisms. Dedifferentiation, a common mechanism of non-genetic resistance in melanoma is characte... 详细信息
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Detecting time-evolving phenotypic components of adverse reactions against BNT162b2 SARS-CoV-2 vaccine via non-negative tensor factorization
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ISCIENCE 2022年 第10期25卷 105237页
作者: Ikeda, Kei Nakada, Taka-Aki Kageyama, Takahiro Tanaka, Shigeru Yoshida, Naoki Ishikawa, Tetsuo Goshima, Yuki Otaki, Natsuko Iwami, Shingo Shimamura, Teppei Taniguchi, Toshibumi Igari, Hidetoshi Hanaoka, Hideki Yokote, Koutaro Tsuyuzaki, Koki Nakajima, Hiroshi Kawakami, Eiryo Chiba Univ Grad Sch Med Dept Allergy & Clin Immunol Chiba 2608670 Japan Chiba Univ Grad Sch Med Dept Emergency & Crit Care Med Chiba 2608670 Japan Chiba Univ Grad Sch Med Artificial Intelligence Med Chiba 2608670 Japan RIKEN Informat R&D & Strategy Headquarters Adv Data Sci Project ADSP Yokohama Kanagawa 2300045 Japan Nagoya Univ Grad Sch Sci Div Biol Sci Interdisciplinary Biol Lab iBLab Nagoya Aichi 4648602 Japan Kyushu Univ Inst Math Ind Fukuoka 8190395 Japan Kyoto Univ Inst Adv Study Human Biol ASHBi Kyoto 6068501 Japan RIKEN Interdisciplinary Theoret & Math Sci Program iTHEM Wako Saitama 3510198 Japan Japanese Fdn Canc Res JFCR NEXT Ganken Program Tokyo 1358550 Japan Sci Groove Inc Fukuoka 8100041 Japan Nagoya Univ Grad Sch Med Div Syst Biol Nagoya Aichi 4668550 Japan Chiba Univ Chiba Univ Hosp Dept Infect Dis Chiba 2608670 Japan Chiba Univ Chiba Univ Hosp COVID Vaccine Ctr 19 Chiba 2608670 Japan Chiba Univ Chiba Univ Hosp Clin Res Ctr Chiba 2608670 Japan Chiba Univ Grad Sch Med Dept Endocrinol Hematol & Gerontol Chiba 2608670 Japan RIKEN Ctr Biosyst Dynam Res Lab Bioinformat Res Wako Saitama 3510198 Japan Chiba Univ Inst Adv Acad Res IAAR Chiba 2608670 Japan
Symptoms of adverse reactions to vaccines evolve over time, but traditional studies have focused only on the frequency and intensity of symptoms. Here, we attempt to extract the dynamic changes in vaccine adverse reac... 详细信息
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