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检索条件"主题词=computational bioinformatics"
101 条 记 录,以下是71-80 订阅
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Non-linear Deep Neural Network for Rapid and Accurate Prediction of Phenotypic Responses to Kinase Inhibitors
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ISCIENCE 2020年 第5期23卷 101129-101129页
作者: Vijay, Siddharth Gujral, Taranjit S. Fred Hutchinson Canc Res Ctr Div Human Biol 1124 Columbia St Seattle WA 98104 USA Univ Washington Dept Pharmacol Seattle WA 98195 USA
Protein kinase inhibitors are one of the most successful targeted therapies to date. Despite this progress, additional kinase inhibitors are needed to expand the target space as well as overcome drug resistance that h... 详细信息
来源: 评论
Functional Connectivity Fingerprints at Rest Are Similar across Youths and Adults and Vary with Genetic Similarity
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ISCIENCE 2020年 第1期23卷 100801-100801页
作者: Demeter, Damion, V Engelhardt, Laura E. Mallett, Remington Gordon, Evan M. Nugiel, Tehila Harden, K. Paige Tucker-Drob, Elliot M. Lewis-Peacock, Jarrod A. Church, Jessica A. Univ Texas Austin Dept Psychol Austin TX 78712 USA Univ Texas Austin Populat Res Ctr Austin TX 78712 USA Univ Texas Austin Biomed Imaging Ctr Austin TX 78712 USA VISN 17 Ctr Excellence Res Returning War Vet Waco TX 76711 USA Univ Texas Dallas Ctr Vital Longev Sch Behav & Brain Sci Dallas TX 75235 USA Baylor Univ Dept Psychol & Neurosci Waco TX 76789 USA
Distinguishing individuals from brain connectivity, and studying the genetic influences on that identification across different ages, improves our basic understanding of functional brain network organization. We appli... 详细信息
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Modularization of grid cells constrained by the pyramidal patch lattice
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ISCIENCE 2021年 第4期24卷 102301页
作者: Wang, Tao Yang, Fan Wang, Ziqun Zhang, Bing Wang, Wei Liu, Feng Nanjing Univ Collaborat Innovat Ctr Adv Microstruct Dept Phys Natl Lab Solid State Microstruct Nanjing 210093 Peoples R China Nanjing Univ Med Sch Drum Tower Hosp Dept Radiol Nanjing 210008 Peoples R China Nanjing Univ Inst Brain Sci Nanjing 210023 Peoples R China
Grid cells provide a metric representation of self-location. They are organized into modules, showing discretized scales of grid spacing, but the underlying mechanism remains elusive. In this modeling study, we propos... 详细信息
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Machine learning workflows identify a microRNA signature of insulin transcription in human tissues
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ISCIENCE 2021年 第4期24卷 102379页
作者: Wong, Wilson K. M. Joglekar, Mugdha, V Saini, Vijit Jiang, Guozhi Dong, Charlotte X. Chaitarvornkit, Alissa Maciag, Grzegorz J. Gerace, Dario Farr, Ryan J. Satoor, Sarang N. Sahu, Subhshri Sharangdhar, Tejaswini Ahmed, Asma S. Chew, Yi Vee Liuwantara, David Heng, Benjamin Lim, Chai K. Hunter, Julie Januszewski, Andrzej S. Sorensen, Anja E. Akil, Ammira S. A. Gamble, Jennifer R. Loudovaris, Thomas Kay, Thomas W. Thomas, Helen E. O'Connell, Philip J. Guillemin, Gilles J. Martin, David Simpson, Ann M. Hawthorne, Wayne J. Dalgaard, Louise T. Ma, Ronald C. W. Hardikar, Anandwardhan A. Western Sydney Univ Sch Med Diabet & Islet Biol Grp Narellan Rd & Gilchrist Dr Campbelltown NSW 2560 Australia Univ Sydney Fac Med & Hlth Diabet & Islet Biol Grp 92-94 Parramatta Rd Camperdown NSW 2050 Australia Univ Technol Sydney Sch Life Sci 15 Broadway Ultimo NSW 2007 Australia Univ Technol Sydney Ctr Hlth Technol 15 Broadway Ultimo NSW 2007 Australia Chinese Univ Hong Kong Prince Wales Hosp Dept Med & Therapeut Hong Kong Peoples R China Chinese Univ Hong Kong Prince Wales Hosp Hong Kong Inst Diabet & Obes Hong Kong Peoples R China Chinese Univ Hong Kong Prince Wales Hosp Li Ka Shing Inst Hlth Sci Hong Kong Peoples R China Roskilde Univ Dept Sci & Environm Univ Vej 1 DK-4000 Roskilde Denmark Univ Sydney Ctr Transplant & Renal Res Westmead Inst Med Res 176 Hawkesbury Rd Westmead NSW 2145 Australia Macquarie Univ Fac Med Hlth & Human Sci Sydney NSW 2019 Australia Univ Sydney Med Sch Centenary Inst Ctr EndotheliumVasc Biol Program Locked Bag 6 Newtown NSW 2042 Australia Univ Sydney NHMRC Clin Trials Ctr 92-94 Parramatta Rd Camperdown NSW 2050 Australia Sidra Med Dept Human Genet Precis Med Program POB 26999 Doha Qatar St Vincents Inst 9 Princes St Fitzroy Vic Australia Univ Melbourne Dept Med 9 Princes St Fitzroy Vic Australia Strathfield Hosp Upper GI Surg 2-3 Everton Rd Strathfield NSW 2135 Australia
Dicer knockout mouse models demonstrated a key role for microRNAs in pancreatic beta-cell function. Studies to identify specific microRNA( s) associated with human (pro-)endocrine gene expression are needed. We profil... 详细信息
来源: 评论
Characterization of mechanisms positioning costimulatory complexes in immune synapses
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ISCIENCE 2021年 第10期24卷 103100页
作者: Siokis, Anastasios Robert, Philippe A. Demetriou, Philippos Kvalvaag, Audun Valvo, Salvatore Mayya, Viveka Dustin, Michael L. Meyer-Hermann, Michael Helmholtz Ctr Infect Res Dept Syst Immunol D-38106 Braunschweig Germany Helmholtz Ctr Infect Res Braunschweig Integrated Ctr Syst Biol D-38106 Braunschweig Germany Tech Univ Carolo Wilhelmina Braunschweig Inst Biochem Biotechnol & Bioinformat D-38106 Braunschweig Germany Univ Oxford Nuffield Dept Orthopaed Rheumatol & Musculoskelet Kennedy Inst Rheumatol Oxford OX3 7FY England Oslo Univ Hosp Inst Canc Res Dept Mol Cell Biol N-0379 Oslo Norway Univ Oslo Dept Immunol N-0372 Oslo Norway
Small immunoglobulin superfamily (sIGSF) adhesion complexes form a corolla of microdomains around an integrin ring and secretory core during immunological synapse (IS) formation. The corolla recruits and retains major... 详细信息
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Automated design of CRISPR prime editors for 56,000 human pathogenic variants
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ISCIENCE 2021年 第11期24卷 103380页
作者: Morris, John A. Rahman, Jahan A. Guo, Xinyi Sanjana, Neville E. New York Genome Ctr New York NY 10013 USA NYU Dept Biol New York NY 10003 USA
Prime editors (PEs) are clustered regularly interspaced short palindromic repeats (CRISPR)-based genome engineering tools that can introduce precise base-pair edits. We developed an automated pipeline to correct (ther... 详细信息
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DANE-MDA: Predicting microRNA-disease associations via deep attributed network embedding
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ISCIENCE 2021年 第6期24卷 102455页
作者: Ji, Bo-Ya You, Zhu-Hong Wang, Yi Li, Zheng-Wei Wong, Leon Chinese Acad Sci Xinjiang Tech Inst Phys & Chem Urumqi 830011 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Xinjiang Lab Minor Speech & Language Informat Pro Urumqi 830011 Peoples R China China Univ Min & Technol Sch Comp Sci & Technol Xuzhou 221116 Jiangsu Peoples R China
Predicting the microRNA-disease associations by using computational methods is conductive to the efficiency of costly and laborious traditional bio-experiments. In this study, we propose a computational machine learni... 详细信息
来源: 评论
MicroRNA function can be reversed by altering target gene expression levels
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ISCIENCE 2021年 第9期24卷 103208页
作者: Svoronos, Alexander A. Campbell, Stuart G. Engelman, Donald M. Yale Univ Dept Biomed Engn New Haven CT 06520 USA Yale Univ Dept Mol Biophys & Biochem 266 Whitney AvePOB 208114 New Haven CT 06520 USA
Paradoxically, many microRNAs appear to exhibit entirely opposite functions when placed in different contexts. For example, miR-125b has been shown to be pro-apoptotic in some studies, but anti-apoptotic in others. To... 详细信息
来源: 评论
Prediction and identification of synergistic compound combinations against pancreatic cancer cells
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ISCIENCE 2021年 第9期24卷 103080页
作者: KalantarMotamedi, Yasaman Choi, Ran Joo Koh, Siang-Boon Bramhall, Jo L. Fan, Tai-Ping Bender, Andreas Univ Cambridge Ctr Mol Informat Dept Chem Lensfield Rd Cambridge CB2 1EW England Univ Cambridge Dept Pharmacol Tennis Court Rd Cambridge CB2 1PD England Univ Cambridge Canc Res UK Cambridge Inst Cambridge CB2 0RE England Yonsei Univ 50 Yonsei Ro Seoul South Korea
Resistance to current therapies is common for pancreatic cancer and hence novel treatment options are urgently needed. In this work, we developed and validated a computational method to select synergistic compound com... 详细信息
来源: 评论
Rapid methods for the evaluation of fluorescent reporters in tissue clearing and the segmentation of large vascular structures
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ISCIENCE 2021年 第6期24卷 102650页
作者: Kirschnick, Nils Drees, Dominik Redder, Esther Erapaneedi, Raghu da Graca, Abel Pereira Schafers, Michael Jiang, Xiaoyi Kiefer, Friedemann Univ Munster European Inst Mol Imaging Waldeyerstr 15 D-48149 Munster Germany Univ Munster Inst Comp Sci Einsteinstr 62 D-48149 Munster Germany Carl Zeiss Microscopy GmbH Zeiss Res Microscopy Solut Zeiss Microscopy Customer Ctr Europe Rudolf Eber Str 2 D-73447 Oberkochen Germany
Light sheet fluorescence microscopy (LSFM) of large tissue samples does not require mechanical sectioning and allows efficient visualization of spatially complex or rare structures. Therefore, LSFMhas become invaluabl... 详细信息
来源: 评论