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5th International Conference on Transportation Engineering, ICTE 2015

作者： Li, Yuan Yuan, Jiehong Song, Lijun Mei, Guiming Zhang, Kunlun Lin, Zejin Department of Traffic and Transportation Engineering College of Basic Education National University of Defense Technology Changsha China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle Engineering Hunan University Changsha Hunan China State Key Laboratory of Traction Power Southwest Jiaotong University Chengdu China

ISBN: (数字)9780784479384

ISBN: (纸本)9780784479384

The objective of this paper is to develop a new computational method of friction power loss of the spiral bevel gears transmission system of the helicopter tail reducer. At first, the velocity and force of the meshing point were analyzed during meshing process. Then a computational model of friction power loss for spiral bevel gear was established based on the principle of meshing and tribology theory, considering the effects of actual contact ratio and time-variant factors. This model considered the effects of actual contact ratio and time-variant factors including mesh point relative sliding velocity of mesh point, normal load, friction coefficient, etc. © ASCE.

关键词： computational method Friction power loss Spiral bevel gears spiral bevel gears computational methods power loss point of engagement contact ratio friction power BEVEL GEAR engaging

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computational method for the fifth-order KdV equation

Computational method for the fifth-order KdV equation

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2010 Second ETP/IITA World Congress in Applied Computing, Computer Science, and Computer Engineering(ACC 2010)

作者： Jin-Ming ZUO, Yao-Ming ZHANG, Rui ZHANG (School of Science, Shandong University of Technology, Zibo, 255049, P. R. China)

A new computational method is proposed for the solution of the fifth-order KdV equation. An important advantage to be gained from the method is unconditionally stable. Numerical results portraying a single line-soliton solution and the interaction of two-line solitions are reported for the fifth-order KdV equation. they show that the method has good stability and accuracy.

关键词： computational method fifth-order KdV equation solition wave stability analysis phase error

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A computational method for evaluating the damage in a solder joint of an electronic package subjected to thermal loads

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ENGINEERING COMPUTATIONS 2014年第3期31卷 467-489页

作者： Johansson, Jonas Belov, Ilja Johnson, Erland Leisner, Peter Saab AB Elect Def Syst Jonkoping Sweden Jonkoping Univ Sch Engn Dept Mech Engn Jonkoping Sweden SP Tech Res Inst Sweden Dept Struct & Solid Mech Boras Sweden SP Tech Res Inst Sweden Dept Elect Boras Sweden

Purpose - The purpose of this paper is to introduce a novel computational method to evaluate damage accumulation in a solder joint of an electronic package, when exposed to operating temperature environment. A procedure to implement the method is suggested, and a discussion of the method and its possible applications is provided in the paper. Design/methodology/approach - methodologically, interpolated response surfaces based on specially designed finite element (FE) simulation runs, are employed to compute a damage metric at regular time intervals of an operating temperature profile. The developed method has been evaluated on a finite-element model of a lead-free PBGA256 package, and accumulated creep strain energy density has been chosen as damage metric. Findings - The method has proven to be two orders of magnitude more computationally efficient compared to FE simulation. A general agreement within 3 percent has been found between the results predicted with the new method, and FE simulations when tested on a number of temperature profiles from an avionic application. The solder joint temperature ranges between +25 and +75 degrees C. Practical implications - The method can be implemented as part of reliability assessment of electronic packages in the design phase. Originality/value - The method enables increased accuracy in thermal fatigue life prediction of solder joints. Combined with other failure mechanisms, it may contribute to the accuracy of reliability assessment of electronic packages.

关键词： computational method Thermal fatigue Finite element analysis Electronic package Lead-free solder Operating temperature environment

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Application of computational method in Designing a Unit Cell of Bone Tissue Engineering Scaffold: A Review

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POLYMERS 2021年第10期13卷 1584-1584页

作者： Mustafa, Nur Syahirah Akhmal, Nor Hasrul Izman, Sudin Ab Talib, Mat Hussin Shaiful, Ashrul Ishak Mohamad Omar, Mohd Nazri Bin Yahaya, Nor Zaiazmin Illias, Suhaimi Univ Teknol Malaysia Fac Engn Sch Mech Engn Johor Baharu 81310 Johor Malaysia Univ Malaysia Perlis Fac Mech Engn Technol Arau 02600 Malaysia

The design of a scaffold of bone tissue engineering plays an important role in ensuring cell viability and cell growth. Therefore, it is a necessity to produce an ideal scaffold by predicting and simulating the properties of the scaffold. Hence, the computational method should be adopted since it has a huge potential to be used in the implementation of the scaffold of bone tissue engineering. To explore the field of computational method in the area of bone tissue engineering, this paper provides an overview of the usage of a computational method in designing a unit cell of bone tissue engineering scaffold. In order to design a unit cell of the scaffold, we discussed two categories of unit cells that can be used to design a feasible scaffold, which are non-parametric and parametric designs. These designs were later described and being categorised into multiple types according to their characteristics, such as circular structures and Triply Periodic Minimal Surface (TPMS) structures. The advantages and disadvantages of these designs were discussed. Moreover, this paper also represents some software that was used in simulating and designing the bone tissue scaffold. The challenges and future work recommendations had also been included in this paper.

关键词： numerical analysis computational method tissue engineering scaffold design mechanical strength simulation software

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Design of potential RNAi (miRNA and siRNA) molecules for Middle East respiratory syndrome coronavirus (MERS-CoV) gene silencing by computational method

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Interdisciplinary sciences, computational life sciences 2014年 2014 Nov 6页

作者： Suza Mohammad Nur Md Anayet Hasan Mohammad Al Amin Mehjabeen Hossain Tahmina Sharmin Department of Genetic Engineering and Biotechnology Faculty of Biological Sciences University of Chittagong Chittagong 4331 Bangladesh.

The Middle East respiratory syndrome coronavirus (MERS-CoV) is a virus that manifests itself in viral infection with fever, cough, shortness of breath, renal failure and severe acute pneumonia, which often result in a fatal outcome. MERS-CoV has been shown to spread between people who are in close contact. Transmission from infected patients to healthcare personnel has also been observed and is irredeemable with present technology. Genetic studies on MERS-CoV have shown that ORF 1ab encodes replicase polyproteins and play a foremost role in viral infection. Therefore, ORF 1ab replicase polyprotein may be used as suitable target for disease control. Viral activity can be controlled by RNA interference (RNAi) technology, a leading method for post transcriptional gene silencing in a sequence specific manner. However, there is a genetic inconsistency in different viral isolates; it is a great challenge to design potential RNAi (miRNA and siRNA) molecules which can silence the respective target genes rather than any other viral gene simultaneously. In current study four effective miRNA and five siRNA molecules for silencing of nine different strains of MERS-CoV were rationally designed and corroborated using computational methods, which might lead to knockdown the activity of virus. siRNA and miRNA molecules were predicted against ORF1ab gene of different strains of MERS-CoV as effective candidate using computational methods. Thus, this method may provide an insight for the chemical synthesis of antiviral RNA molecule for the treatment of MERS-CoV, at genomic level.

关键词： MERS-CoV RNAi antiviral gene silencing computational method

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A computational method for solving a class of singular boundary value problems arising in science and engineering

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Egyptian Journal of Basic and Applied Sciences 2016年第4期3卷 383-391页

作者： Pandy Pirabaharan R. David Chandrakumar Department of Mathematics Anna University University College of Engineering Dindigul 624 622 Tamilnadu India Department of Mathematics Vickram College of Engineering Sivaganga District Tamilnadu India

This note deals with a new computational method for solving a class of singular boundary value problems. The method is based upon Bernstein Polynomials. The properties of Bernstein Polynomials, together with Bernstein operational matrix for differentiation formula, are presented and utilized to reduce the given singular boundary value problems to the set of algebraic equations. The proposed method is applied to solve some test problems with the comparison between the computational solutions and the exact solutions. The results indicate that the proposed algorithm provides high reliability and good accuracy.

关键词： computational method Bernstein operational matrices Nonlinear differential equations Singular boundary value problems

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QGRS-Conserve: a computational method for discovering evolutionarily conserved G-quadruplex motifs

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HUMAN GENOMICS 2014年第1期8卷 8-8页

作者： Frees, Scott Menendez, Camille Crum, Matt Bagga, Paramjeet S. Ramapo Coll Dept Comp Sci Mahwah NJ 08807 USA Ramapo Coll Dept Bioinformat Mahwah NJ 08807 USA

Background: Nucleic acids containing guanine tracts can form quadruplex structures via non-Watson-Crick base pairing. Formation of G-quadruplexes is associated with the regulation of important biological functions such as transcription, genetic instability, DNA repair, DNA replication, epigenetic mechanisms, regulation of translation, and alternative splicing. G-quadruplexes play important roles in human diseases and are being considered as targets for a variety of therapies. Identification of functional G-quadruplexes and the study of their overall distribution in genomes and transcriptomes is an important pursuit. Traditional computational methods map sequence motifs capable of forming G-quadruplexes but have difficulty in distinguishing motifs that occur by chance from ones which fold into G-quadruplexes. Results: We present Quadruplex forming 'G'-rich sequences (QGRS)-Conserve, a computational method for calculating motif conservation across exomes and supports filtering to provide researchers with more precise methods of studying G-quadruplex distribution patterns. Our method quantitatively evaluates conservation between quadruplexes found in homologous nucleotide sequences based on several motif structural characteristics. QGRS-Conserve also efficiently manages overlapping G-quadruplex sequences such that the resulting datasets can be analyzed effectively. Conclusions: We have applied QGRS-Conserve to identify a large number of G-quadruplex motifs in the human exome conserved across several mammalian and non-mammalian species. We have successfully identified multiple homologs of many previously published G-quadruplexes that play post-transcriptional regulatory roles in human genes. Preliminary large-scale analysis identified many homologous G-quadruplexes in the 5'- and 3'-untranslated regions of mammalian species. An expectedly smaller set of G-quadruplex motifs was found to be conserved across larger phylogenetic distances. QGRS-Conserve provides means to bu

关键词： G-quadruplex computational method Cis-regulatory motifs Evolutionary conservation

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computational method with variable cutoff radius in molecular dynamics simulation

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Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics 2006年第4期27卷 556-558页

作者： Cai, Zhi-Yong Zeng, Dan-Ling Liu, Juan-Fang College of Power Engineering Chongqing University Chongqing 400044 China

In molecular dynamics simulation, a fixed cutoff radius is usually chosen for the calculation, and the recommended value of it is scattering, thus it causes trouble of its selection and also influences the precision of the results. In the present paper, a new computational method with variable cutoff radius is suggested. An example for the simulation of a two phase system is provided to support such a suggestion.

关键词： computational method Molecular dynamics simulation Variable cutoff radius

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A computational method for Identifying Yeast Cell Cycle Transcription Factors

A Computational Method for Identifying Yeast Cell Cycle Tran...

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作者： Wei-Sheng Wu

The eukaryotic cell cycle is a complex process and is precisely regulated at many levels. Many genes specific to the cell cycle are regulated transcriptionally and are expressed just before they are needed. To understand the cell cycle process, it is important to identify the cell cycle transcription factors (TFs) that regulate the expression of cell cycle-regulated genes. Here, we describe a computational method to identify cell cycle TFs in yeast by integrating current ChIP-chip, mutant, transcription factor-binding site (TFBS), and cell cycle gene expression data. For each identified cell cycle TF, our method also assigned specific cell cycle phases in which the TF functions and identified the time lag for the TF to exert regulatory effects on its target genes. Moreover, our method can identify novel cell cycle-regulated genes as a by-product. less

关键词： Saccharomyces cerevisiae Algorithm Cell cycle Transcription factor computational method Dynamic model

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Discussion on the Teaching Reform Mode of computational method Course

Discussion on the Teaching Reform Mode of Computational Meth...

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2013年教育技术与管理科学国际会议

作者： Hao Hui Qiang Hongfu Li Xuerui Zhou Wei Wang Xueren Xi'an Research Institute of High technology Xi'an Research Inst. Of Hi-Tech

computational method course is one of professional basic courses in college of Engineering, which has strong theory and high teaching difficulty. The learning effect directly affects students' learning and research on the follow-up professional courses. By years of teaching experience and practice experience, specific reform methods had been carried out to improve the teaching effect to some extent from the aspects of the curriculum system, teaching methods and practice teaching system.

关键词： computational method Teaching Reform Heuristic Teaching Mathematical Modeling

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