检索结果-内蒙古大学图书馆

Pacemaker implantation after transcatheter aortic valve replacement: A perspective from deployment and sizing

INTERNATIONAL JOURNAL OF CARDIOLOGY 2016年 222卷 654-655页

作者： Xiong, Tian-Yuan Feng, Yuan Chen, Mao Sichuan Univ West China Hosp Dept Cardiol 37 Guoxue Alley Chengdu 610041 Peoples R China

来源：评论

学校读者我要写书评

暂无评论

A Simple and Portable Algorithm for Identifying Atrial Fibrillation in the Electronic Medical Record

引用

AMERICAN JOURNAL OF CARDIOLOGY 2016年第2期117卷 221-225页

作者： Khurshid, Shaan Keaney, John Ellinor, Patrick T. Lubitz, Steven A. Massachusetts Gen Hosp Dept Med Boston MA 02114 USA Massachusetts Gen Hosp Cardiovasc Res Ctr Boston MA 02114 USA Massachusetts Gen Hosp Dept Cardiol Cardiac Arrhythmia Serv Boston MA 02114 USA

Atrial fibrillation (AF) is common and increases stroke risk and mortality. Many knowledge gaps remain with respect to practice patterns and outcomes. Electronic medical records (EMRs) may serve as powerful research tools if AF status can be properly ascertained. We sought to develop an algorithm for identifying subjects with and without AF in the EMR and compare it to previous methods. Using a hospital network EMR (n = 5,737,846), we randomly selected 8,200 subjects seen at a large academic medical center in January 2014 to derive and validate 7 AF classification schemas (4 cases and 3 controls) to construct a composite AF algorithm. In an independent sample of 172,138 subjects, we compared this algorithm against published AF classification methods. In total, we performed manual adjudication of AF in 700 subjects. Three AF schemas (AF1, AF2, and AF4) achieved positive predictive value (PPV) >0.9. Two control schemas achieved PPV>0.9 (control 1 and control 3). A combination algorithm AF1, AF2, and AF4 (PPV 88%;8.2% classified) outperformed published classification methods including >1 outpatient International Statistical Classification of Diseases, Ninth Revision code or 1 outpatient code with an electrocardiogram demonstrating AF (PPV 82%;5.9% classified), =1 inpatient International Statistical Classification of Diseases, Ninth Revision code or electrocardiogram demonstrating AF (PPV 88%;6.1% classified), or the intersection of these (PPV 84%;7.4% classified). When applied simultaneously, the case and control algorithms classified 98.4% of the cohort with zero disagreement. In conclusion, we derived a parsimonious and portable algorithm to identify subjects with and without AF with high sensitivity. If broadly applied, this algorithm can provide optimal power for EMR-based AF research. Copyright (C) 2016 Elsevier Inc. All rights reserved.

关键词： air feed equipment Electronic Health Records Research Tools algorithms AF-4 Protein p-phenyl vinyl AF-2 Academic Medical Centers Classification Methods computer algorithms

来源：评论

学校读者我要写书评

暂无评论

Control-oriented modelling of gas-liquid cylindrical cyclones

Control-oriented modelling of gas-liquid cylindrical cyclone...

引用

American Control Conference

作者： Torstein Thode Kristoffersen Christian Holden Sigurd Skogestad Olav Egeland Department of Mechanical and Industrial Engineering Norwegian University of Science and Technology (NTNU) Department of Chemical Engineering Norwegian University of Science and Technology (NTNU)

ISBN: (纸本)9781509045839

Compact separators are increasingly used for subsea separation of hydrocarbons, because of their low weight and low cost. A problem is their small volume, which makes them very sensitive to flow variations. This can degrade separation performance, which in turn can cause operational problems and economic loss. Improved control can increase robustness and therefore, the focus of this paper is to derive a control-oriented model based on first principles to enable the development of robust control algorithms. The derived model is controlled by a PI feedback control algorithm and tuned using the SIMC tuning rules. The model is qualitatively verified in simulations, and the behaviour confirmed with reported observations from experimental work and field applications from literature.

关键词： Underweight cyclones Hydrocarbons tuning Cylindrical Turning focus FOCUSING Standing Orders simulating Separators Modeling Object oriented modeling computer algorithms economic losses

来源：评论

学校读者我要写书评

暂无评论

gkmSVM: an R package for gapped-kmer SVM

引用

BIOINFORMATICS 2016年第14期32卷 2205-2207页

作者： Ghandi, Mahmoud Mohammad-Noori, Morteza Ghareghani, Narges Lee, Dongwon Garraway, Levi Beer, Michael A. Broad Inst MIT & Harvard Cambridge MA 02142 USA Univ Tehran Coll Sci Sch Math Stat & Comp Sci Tehran Iran Univ Tehran Coll Engn Dept Engn Sci Tehran Iran Inst Res Fundamental Sci IPM Tehran Iran Johns Hopkins Univ McKusick Nathans Inst Genet Med Baltimore MD USA Harvard Univ Sch Med Dana Farber Canc Inst 44 Binney St Boston MA 02115 USA Johns Hopkins Univ Dept Biomed Engn Baltimore MD USA

We present a new R package for training gapped-kmer SVM classifiers for DNA and protein sequences. We describe an improved algorithm for kernel matrix calculation that speeds run time by about 2 to 5-fold over our original gkmSVM algorithm. This package supports several sequence kernels, including: gkmSVM, kmer-SVM, mismatch kernel and wildcard kernel. Availability and Implementation: gkmSVM package is freely available through the Comprehensive R Archive Network (CRAN), for Linux, Mac OS and Windows platforms. The C++ implementation is available at ***/gkmsvm

关键词： AMINO acid sequence DNA sequencing KERNEL functions computer algorithms BIOLOGICAL systems

来源：评论

学校读者我要写书评

暂无评论

Comparison of Li-ion battery degradation models for system design and control algorithm development

Comparison of Li-ion battery degradation models for system d...

引用

American Control Conference

作者： Xing Jin Ashish P. Vora Vaidehi Hoshing Tridib Saha Gregory M. Shaver Oleg Wasynczuk Subbarao Varigonda Department of Mechanical Engineering Purdue University Department of Electrical and Computer Engineering Purdue University Cummins Inc.

ISBN: (纸本)9781509045839

Within electrified vehicle powertrains, lithium-ion battery performance degrades with aging and usage, resulting in a loss in both energy and power capacity. As a result, models used for system design and control algorithm development would ideally capture the impact of those efforts on battery capacity degradation, be computationally efficient, and simple enough to be used for algorithm development. This paper provides an assessment of the state-of-the-art in lithium-ion battery degradation models, including accuracy, computational complexity, and amenability to control algorithm development. Various aging and degradation models have been studied in the literature, including physically-based electrochemical models, semi-empirical models, and empirical models. Some of these models have been validated with experimental data;however, comparisons of pre-existing degradation models across multiple experimental data sets have not been previously published. Three degradation models, a 1-d electrochemical model (AutoLion ST, or ALST), a semi-empirical model (from the National Renewable Energy Laboratory) and an empirical model (published in the literature), are compared against three published experimental data sets for a 2.3-Ah commercial graphite/LiFePO_4 cell. The results show that the physically-based model is best able to capture results across all three representative data sets with an error less than 10 %, but is 24× slower than the empirical model, and 4000× slower than the semi-empirical model, making it unsuitable for powertrain system design and model-based algorithm development. Despite being computationally efficient, the semi-empirical and empirical models, when used under conditions that lie outside the calibration data set, exhibit up to 60% error in capacity loss prediction. Such models require expensive experimental data collection to recalibrate for every new application. Thus, in the author's opinion, there exists a need for a physically-based model tha

关键词： computer algorithms lithium ion battery empirical models NATIONAL RENEWABLE ENERGY LABORATORY MODEL MAKING System design power capacity Experimental data Dataset deterioration

来源：评论

学校读者我要写书评

暂无评论

ASAFE: ancestry-specific allele frequency estimation

引用

BIOINFORMATICS 2016年第14期32卷 2227-2229页

作者： Zhang, Qian S. Browning, Brian L. Browning, Sharon R. Univ Washington Dept Med Seattle WA USA Univ Washington Dept Biostat Seattle WA 98195 USA Univ Washington Dept Med Div Med Genet Seattle WA 98195 USA

In a genome-wide association study (GWAS) of an admixed population, such as Hispanic Americans, ancestry-specific allele frequencies can inform the design of a replication GWAS. We derive an EM algorithm to estimate ancestry-specific allele frequencies for a bi-allelic marker given genotypes and local ancestries on a 3-way admixed population, when the phase of each admixed individual's genotype relative to the pair of local ancestries is unknown. We call our algorithm Ancestry Specific Allele Frequency Estimation (ASAFE). We demonstrate that ASAFE has low error on simulated data.

关键词： GENOMES ALLELES computer algorithms GENOTYPE

来源：评论

学校读者我要写书评

暂无评论

BISQUE: locus- and variant-specific conversion of genomic, transcriptomic and proteomic database identifiers

引用

BIOINFORMATICS 2016年第10期32卷 1598-1600页

作者： Meyer, Michael J. Geske, Philip Yu, Haiyuan Cornell Univ Dept Biol Stat & Computat Biol Ithaca NY 14853 USA Cornell Univ Weill Inst Cell & Mol Biol Ithaca NY 14853 USA Triinst Training Program Computat Biol & Med New York NY 10065 USA

Biological sequence databases are integral to efforts to characterize and understand biological molecules and share biological data. However, when analyzing these data, scientists are often left holding disparate biological currency-molecular identifiers from different databases. For downstream applications that require converting the identifiers themselves, there are many resources available, but analyzing associated loci and variants can be cumbersome if data is not given in a form amenable to particular analyses. Here we present BISQUE, a web server and customizable command-line tool for converting molecular identifiers and their contained loci and variants between different database conventions. BISQUE uses a graph traversal algorithm to generalize the conversion process for residues in the human genome, genes, transcripts and proteins, allowing for conversion across classes of molecules and in all directions through an intuitive web interface and a URL-based web service.

关键词： MOLECULAR genetics RESEARCH HUMAN genome WEB servers computer algorithms GRAPH theory PYTHON (computer program language)

来源：评论

学校读者我要写书评

暂无评论

SAMFIRE: multi-locus variant calling for time-resolved sequence data

引用

BIOINFORMATICS 2016年第14期32卷 2208-2209页

作者： Illingworth, C. J. R. Univ Cambridge Dept Genet Cambridge CB2 3AS England Univ Cambridge Dept Genet Cambridge CB2 3AS England

An increasingly common method for studying evolution is the collection of time-resolved short-read sequence data. Such datasets allow for the direct observation of rapid evolutionary processes, as might occur in natural microbial populations and in evolutionary experiments. In many circumstances, evolutionary pressure acting upon single variants can cause genomic changes at multiple nearby loci. SAMFIRE is an open-access software package for processing and analyzing sequence reads from time-resolved data, calling important single-and multi-locus variants over time, identifying alleles potentially affected by selection, calculating linkage disequilibrium statistics, performing haplotype reconstruction and exploiting time-resolved information to estimate the extent of uncertainty in reported genomic data. Availability and Implementation: C++ code may be found at https://***/cjri/samfire/.

关键词： Microbial biotechnology Haplotypes Molecular genetics computer algorithms Gene expression

来源：评论

学校读者我要写书评

暂无评论

***: a quality control and analysis pipeline for droplet sequencing

引用

BIOINFORMATICS 2016年第14期32卷 2221-2223页

作者： Huo, Xiao Hu, Sheng'en Zhao, Chengchen Zhang, Yong Tongji Univ Shanghai Key Lab Signaling & Dis Res Sch Life Sci & Technol Shanghai 20092 Peoples R China

Motivation: Drop-seq has recently emerged as a powerful technology to analyze gene expression from thousands of individual cells simultaneously. Currently, Drop-seq technology requires refinement and quality control (QC) steps are critical for such data analysis. There is a strong need for a convenient and comprehensive approach to obtain dedicated QC and to determine the relationships between cells for ultra-high-dimensional datasets. Results: We developed Dr. seq, a QC and analysis pipeline for Drop-seq data. By applying this pipeline, Dr. seq provides four groups of QC measurements for given Drop-seq data, including reads level, bulk-cell level, individual-cell level and cell-clustering level QC. We assessed Dr. seq on simulated and published Drop-seq data. Both assessments exhibit reliable results. Overall, Dr. seq is a comprehensive QC and analysis pipeline designed for Drop-seq data that is easily extended to other droplet-based data types. Availability and Implementation: Dr. seq is freely available at: http://***/similar to zhanglab/drseq and https://***/tarela/drseq

关键词： GENE expression MOLECULAR genetics QUALITY control DATA analysis computer algorithms

来源：评论

学校读者我要写书评

暂无评论

Robust quantitative scratch assay

引用

BIOINFORMATICS 2016年第9期32卷 1439-1440页

作者： Vargas, Andrea Angeli, Marc Pastrello, Chiara McQuaid, Rosanne Li, Han Jurisicova, Andrea Jurisica, Igor Univ Toronto Dept Med Biophys Toronto ON Canada Univ Hlth Network Princess Margaret Canc Ctr Toronto ON Canada Univ Hlth Network Techna Toronto ON Canada Univ Toronto Dept Physiol Toronto ON Canada Lunenfeld Tanenbaum Res Inst Toronto ON Canada Univ Toronto Dept Obstet & Gynecol Toronto ON Canada Univ Toronto Dept Comp Sci Toronto ON Canada

The wound healing assay (or scratch assay) is a technique frequently used to quantify the dependence of cell motility-a central process in tissue repair and evolution of disease-subject to various treatments conditions. However processing the resulting data is a laborious task due its high throughput and variability across images. This Robust Quantitative Scratch Assay algorithm introduced statistical outputs where migration rates are estimated, cellular behaviour is distinguished and outliers are identified among groups of unique experimental conditions. Furthermore, the RQSA decreased measurement errors and increased accuracy in the wound boundary at comparable processing times compared to previously developedmethod (TScratch).

关键词： Wound healing Cell motility Cell physiology computer algorithms Errors

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：