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检索条件"主题词=constraint-based modeling"
178 条 记 录,以下是1-10 订阅
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Examining organic acid production potential and growth-coupled strategies in Issatchenkia orientalis using constraint-based modeling
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BIOTECHNOLOGY PROGRESS 2022年 第5期38卷 e3276-e3276页
作者: Suthers, Patrick F. Maranas, Costas D. Penn State Univ Dept Chem Engn University Pk PA 16802 USA Penn State Univ Ctr Adv Bioenergy & Bioprod Innovat University Pk PA 16802 USA
Growth-coupling product formation can facilitate strain stability by aligning industrial objectives with biological fitness. Organic acids make up many building block chemicals that can be produced from sugars obtaina... 详细信息
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Regulatory dynamic enzyme-cost flux balance analysis: A unifying framework for constraint-based modeling
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JOURNAL OF THEORETICAL BIOLOGY 2020年 501卷 110317-110317页
作者: Liu, Lin Bockmayr, Alexander Free Univ Berlin Dept Math & Comp Sci Arnimallee 6 D-14195 Berlin Germany
Integrated modeling of metabolism and gene regulation continues to be a major challenge in computational biology. While there exist approaches like regulatory flux balance analysis (rFBA), dynamic flux balance analysi... 详细信息
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constraint-based modeling in microbial food biotechnology
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BIOCHEMICAL SOCIETY TRANSACTIONS 2018年 第2期46卷 249-260页
作者: Rau, Martin H. Zeidan, Ahmad A. Chr Hansen AS Discovery R&D Microbial Platform DK-2970 Horsholm Denmark
Genome-scale metabolic network reconstruction offers a means to leverage the value of the exponentially growing genomics data and integrate it with other biological knowledge in a structured format. constraint-based m... 详细信息
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A mathematical framework for yield (vs. rate) optimization in constraint-based modeling and applications in metabolic engineering
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METABOLIC ENGINEERING 2018年 47卷 153-169页
作者: Klamt, Steffen Mueller, Stefan Regensburger, Georg Zanghellini, Juergen Max Planck Inst Dynam Complex Tech Syst Magdeburg Germany Univ Vienna Fac Math Vienna Austria Johannes Kepler Univ Linz Inst Algebra Linz Austria Univ Nat Resources & Life Sci Dept Biotechnol Vienna Austria Austrian Ctr Ind Biotechnol Vienna Austria
Background: The optimization of metabolic rates (as linear objective functions) represents the methodical core of flux-balance analysis techniques which have become a standard tool for the study of genome-scale metabo... 详细信息
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constraint-based Student modeling in Probability Story Problems with Scaffolding Techniques
INTERNATIONAL JOURNAL OF EMERGING TECHNOLOGIES IN LEARNING
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INTERNATIONAL JOURNAL OF EMERGING TECHNOLOGIES IN LEARNING 2018年 第1期13卷 178-205页
作者: Khodeir, Nabila Wanas, Nayer Elazhary, Hanan Elect Res Inst Dept Informat Cairo Egypt Elect Res Inst Informat Giza Egypt King Abdulaziz Univ Fac Comp & Informat Technol Dept Comp Sci Jeddah Saudi Arabia
constraint-based student modeling (CBM) is an important technique employed in intelligent tutoring systems to model student knowledge to provide relevant assistance. This paper introduces the Math Story Problem Tutor ... 详细信息
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constraint-based modeling of Heterologous Pathways: Application and Experimental Demonstration for Overproduction of Fatty Acids in Escherichia coli
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BIOTECHNOLOGY AND BIOENGINEERING 2014年 第10期111卷 2056-2066页
作者: Ip, Kuhn Donoghue, Neil Kim, Min Kyung Lun, Desmond S. Univ S Australia Phen & Bioinformat Res Ctr Sch Informat Technol & Math Sci Mawson Lakes SA 5095 Australia Univ S Australia Australian Ctr Plant Funct Genom Mawson Lakes SA 5095 Australia Rutgers State Univ Ctr Computat & Integrat Biol Camden NJ 08102 USA Rutgers State Univ Dept Comp Sci Camden NJ 08102 USA
constraint-based modeling has been shown, in many instances, to be useful for metabolic engineering by allowing the prediction of the metabolic phenotype resulting from genetic manipulations. But the basic premise of ... 详细信息
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Flux Variability Analysis: Application to Developing Oilseed Rape Embryos Using Toolboxes for constraint-based modeling
Flux Variability Analysis: Application to Developing Oilseed...
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作者: Jordan O. Hay Jörg Schwender
Flux variability analysis enables comprehensive exploration of alternate optimal routes in a metabolic network. This method is especially useful with models such as bna572 for the developing oilseed rape embryo which ... 详细信息
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Toward a modeling, optimization, and predictive control framework for fed-batch metabolic cybergenetics
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BIOTECHNOLOGY AND BIOENGINEERING 2024年 第1期121卷 366-379页
作者: Espinel-Rios, Sebastian Morabito, Bruno Pohlodek, Johannes Bettenbrock, Katja Klamt, Steffen Findeisen, Rolf Max Planck Inst Dynam Complex Tech Syst Anal & Redesign Biol Networks Magdeburg Germany Yokogawa Insil Biotechnol GmbH Stuttgart Germany Tech Univ Darmstadt Control & Cyber Phys Syst Lab Darmstadt Germany
Biotechnology offers many opportunities for the sustainable manufacturing of valuable products. The toolbox to optimize bioprocesses includes extracellular process elements such as the bioreactor design and mode of op... 详细信息
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Adjusting for false discoveries in constraint-based differential metabolic flux analysis
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JOURNAL OF BIOMEDICAL INFORMATICS 2024年 150卷 104597页
作者: Galuzzi, Bruno G. Milazzo, Luca Damiani, Chiara Univ Milano Bicocca Dept Biotechnol & Biosci Piazza Ateneo Nuovo 1 I-20126 Milan Italy Univ Milano Bicocca Dept Informat Syst & Commun Piazza Ateneo Nuovo 1 I-20126 Milan Italy Inst Mol Bioimaging & Physiol IBFM I-20054 Segrate Italy ISBE IT SYSBIO Ctr Syst Biol Milan Italy
One of the critical steps to characterize metabolic alterations in multifactorial diseases, as well as their heterogeneity across different patients, is the identification of reactions that exhibit significantly diffe... 详细信息
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Prediction and integration of metabolite-protein interactions with genome-scale metabolic models
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METABOLIC ENGINEERING 2024年 82卷 216-224页
作者: Habibpour, Mahdis Razaghi-Moghadam, Zahra Nikoloski, Zoran Max Planck Inst Mol Plant Physiol Syst Biol & Math Modeling Grp D-14476 Potsdam Germany Univ Potsdam Inst Biochem & Biol Bioinformat Dept D-14476 Potsdam Germany
Metabolites, as small molecules, can act not only as substrates to enzymes, but also as effectors of activity of proteins with different functions, thereby affecting various cellular processes. While several experimen... 详细信息
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