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UDCA,a novel strategy for preventing SARS-CoV-2 infection via FXR-mediated ACE2 downregulation

生物化学与生物物理学报（英文版） 2023年第5期55卷 885-887页

作者： Mengjiao Chen Rongrong Zhu Min Zhang Institute of Cardiovascular Disease Key Laboratory for Arteriosclerology of Hunan ProvinceHunan International Scientific and Technological Cooperation Base of Arteriosclerotic DiseaseDepartment of Bioinformatics and Medical Big DataHengyang Medical SchoolUniversity of South ChinaHengyang 421001China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in the current outbreak of coronavirus disease 2019(COVID-19)in humans,causing worldwide health issues[1].The periodic and unexpected consequences have made SARS-CoV-2 a severe threat to human beings,forcing researchers to explore the underlying mechanisms of *** converting enzyme 2(ACE2),a cell surface protein,acts as a specific functional receptor for SARS-CoV-2,as well as the earlier SARS-CoV,leading to viral entry into host cells[2].

关键词： "> UDCA a novel strategy for preventing SARS-CoV-2 infection via FXR-mediated ACE2 downregulation .MathJax_Hover_Frame {border-radius: .25em -webkit-border-radius: .25em -moz-border-radius: .25em -khtml-border-radius: .25em box-shadow: 0px 0px 15px #83A -webkit-box-shadow: 0px 0px 15px #83A -moz-box-shadow: 0px 0px 15px #83A -khtml-box-shadow: 0px 0px 15px #83A border: 1px solid #A6D ! important display: inline-block position: absolute} .MathJax_Menu_Button .MathJax_Hover_Arrow {position: absolute cursor: pointer display: inline-block border: 2px solid #AAA border-radius: 4px -webkit-border-radius: 4px -moz-border-radius: 4px -khtml-border-radius: 4px font-family: 'Courier New' Courier font-size: 9px color: #F0F0F0} .MathJax_Menu_Button .MathJax_Hover_Arrow span {display: block background-color: #AAA border: 1px solid border-radius: 3px line-height: 0 padding: 4px} .MathJax_Hover_Arrow:hover {color: white!important border: 2px solid #CCC!important} .MathJax_Hover_Arrow:hover span {background-color: #CCC!important} #MathJax_About {position: fixed left: 50% width: auto text-align: center border: 3px outset padding: 1em 2em background-color: #DDDDDD color: black cursor: default font-family: message-box font-size: 120% font-style: normal text-indent: 0 text-transform: none line-height: normal letter-spacing: normal word-spacing: normal word-wrap: normal white-space: nowrap float: none z-index: 201 border-radius: 15px -webkit-border-radius: 15px -moz-border-radius: 15px -khtml-border-radius: 15px box-shadow: 0px 10px 20px #808080 -webkit-box-shadow: 0px 10px 20px #808080 -moz-box-shadow: 0px 10px 20px #808080 -khtml-box-shadow: 0px 10px 20px #808080 filter: progid:DXImageTransform.Microsoft.dropshadow(OffX=2 OffY=2 Color='gray' Positive='true')} #MathJax_About.MathJax_MousePost {outline: none} .MathJax_Menu {position: absolute background-color: white color: black width: auto padding: 2px border: 1px solid #CCCCCC margin: 0 cursor: default font: menu text-align: left text-indent: 0 text-transform: none line-height: nor

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Assessment of the alleviating effects of salidroside on myocardial function and perfusion impairment in rats with sepsis

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生物化学与生物物理学报（英文版） 2023年第5期55卷 882-884页

作者： Wenjuan Qin Wenrong Shi Ruimeng Tian Yanna Wang Jia Feng Yifei Zhou Shanshan Dong Jing Cheng Caiyun Zhang Guilin Lu Department of Ultrasonography the First Affiliated HospitalShihezi UniversityShihezi 832008China

Sepsis is a systemic inflammatory response syndrome caused by infection that affects millions of people each year and carries a high risk of *** has become a global public health problem[1].Sepsis mediates mitochondrial dysfunction,inhibits myocardial function,and directly causes impaired myocardial *** septic cardiac dysfunction occurs,the mortality rate of patients with sepsis increases significantly[2].

关键词： "> Assessment of the alleviating effects of salidroside on myocardial function and perfusion impairment in rats with sepsis .MathJax_Hover_Frame {border-radius: .25em -webkit-border-radius: .25em -moz-border-radius: .25em -khtml-border-radius: .25em box-shadow: 0px 0px 15px #83A -webkit-box-shadow: 0px 0px 15px #83A -moz-box-shadow: 0px 0px 15px #83A -khtml-box-shadow: 0px 0px 15px #83A border: 1px solid #A6D ! important display: inline-block position: absolute} .MathJax_Menu_Button .MathJax_Hover_Arrow {position: absolute cursor: pointer display: inline-block border: 2px solid #AAA border-radius: 4px -webkit-border-radius: 4px -moz-border-radius: 4px -khtml-border-radius: 4px font-family: 'Courier New' Courier font-size: 9px color: #F0F0F0} .MathJax_Menu_Button .MathJax_Hover_Arrow span {display: block background-color: #AAA border: 1px solid border-radius: 3px line-height: 0 padding: 4px} .MathJax_Hover_Arrow:hover {color: white!important border: 2px solid #CCC!important} .MathJax_Hover_Arrow:hover span {background-color: #CCC!important} #MathJax_About {position: fixed left: 50% width: auto text-align: center border: 3px outset padding: 1em 2em background-color: #DDDDDD color: black cursor: default font-family: message-box font-size: 120% font-style: normal text-indent: 0 text-transform: none line-height: normal letter-spacing: normal word-spacing: normal word-wrap: normal white-space: nowrap float: none z-index: 201 border-radius: 15px -webkit-border-radius: 15px -moz-border-radius: 15px -khtml-border-radius: 15px box-shadow: 0px 10px 20px #808080 -webkit-box-shadow: 0px 10px 20px #808080 -moz-box-shadow: 0px 10px 20px #808080 -khtml-box-shadow: 0px 10px 20px #808080 filter: progid:DXImageTransform.Microsoft.dropshadow(OffX=2 OffY=2 Color='gray' Positive='true')} #MathJax_About.MathJax_MousePost {outline: none} .MathJax_Menu {position: absolute background-color: white color: black width: auto padding: 2px border: 1px solid #CCCCCC margin: 0 cursor: default font: menu text-align: left text-indent: 0 text-transf

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Ultraviolet nanosecond laser ablation of polyimide with thermal and nonthermal effects near threshold fluence (vol 34, 032004, 2022)

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JOURNAL OF LASER APPLICATIONS 2022年第3期34卷 032004-032004页

作者： Han, ChangSoon Zahid, Muhammad Aleem Lee, Byungwoo Oh, Jae-Yong Kim, Youngkuk Yi, Junsin Jeonnam Technopark Stiftung Laser Adv Syst Industrializat Ctr Jangseong Gun Jeollanam Do South Korea Sungkyunkwan Univ Interdisciplinary Program Photovolta Syst Engn Suwon Gyeonggi Do South Korea Sungkyunkwan Univ Dept Elect & Comp Engn Suwon 16419 Gyeonggi Do South Korea

Typically, a 355 nm laser is not sufficient for inducing photochemical ablation and leads to photothermal effects such as melting and recasting. Consequently, most previous studies on the irradiation of polyimide (PI) with such lasers have focused on temperature distribution on the surface and variations in the absorption properties of PI depending on the temperature and time. Herein, the authors demonstrate ablation without thermal effects on the surface of PI using a 355 nm pulse nanosecond laser near the threshold fluence. For ablation without thermal effects, the ablated and nonablated areas can be clearly distinguished in the area exposed to the laser. The interface between these areas, that is, the ablation shape, became wider with increasing laser fluence, even when the spot size remained unchanged; also, the shape of the ablated area was related to the laser intensity distribution. Ablation with thermal effects began to appear in the nonablated areas at higher laser fluence. This study shows that PI, which is physically stable and relatively inexpensive, can be used to develop cation exchange membranes, which can be applied to organic flow cells as well as microbial fuel cells.

关键词： UV nanosecond laser polyimide thermal effect photochemical ablation"> Ultraviolet nanosecond laser ablation of polyimide with thermal and nonthermal effects near threshold fluence: Journal of Laser Applications: Vol 34 No 3 .MathJax_Hover_Frame {border-radius: .25em -webkit-border-radius: .25em -moz-border-radius: .25em -khtml-border-radius: .25em box-shadow: 0px 0px 15px #83A -webkit-box-shadow: 0px 0px 15px #83A -moz-box-shadow: 0px 0px 15px #83A -khtml-box-shadow: 0px 0px 15px #83A border: 1px solid #A6D ! important display: inline-block position: absolute} .MathJax_Menu_Button .MathJax_Hover_Arrow {position: absolute cursor: pointer display: inline-block border: 2px solid #AAA border-radius: 4px -webkit-border-radius: 4px -moz-border-radius: 4px -khtml-border-radius: 4px font-family: 'Courier New' Courier font-size: 9px color: #F0F0F0} .MathJax_Menu_Button .MathJax_Hover_Arrow span {display: block background-color: #AAA border: 1px solid border-radius: 3px line-height: 0 padding: 4px} .MathJax_Hover_Arrow:hover {color: white!important border: 2px solid #CCC!important} .MathJax_Hover_Arrow:hover span {background-color: #CCC!important} #MathJax_About {position: fixed left: 50% width: auto text-align: center border: 3px outset padding: 1em 2em background-color: #DDDDDD color: black cursor: default font-family: message-box font-size: 120% font-style: normal text-indent: 0 text-transform: none line-height: normal letter-spacing: normal word-spacing: normal word-wrap: normal white-space: nowrap float: none z-index: 201 border-radius: 15px -webkit-border-radius: 15px -moz-border-radius: 15px -khtml-border-radius: 15px box-shadow: 0px 10px 20px #808080 -webkit-box-shadow: 0px 10px 20px #808080 -moz-box-shadow: 0px 10px 20px #808080 -khtml-box-shadow: 0px 10px 20px #808080} #MathJax_About.MathJax_MousePost {outline: none} .MathJax_Menu {position: absolute background-color: white color: black width: auto padding: 2px border: 1px solid #CCCCCC margin: 0 cursor: default font: menu text-align: left text-indent: 0 text-tra

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