Machine learning (ML) methods based on histopathology slides are increasingly used for cancer diagnosis and treatment. Analyses with specialized experimental stains, such as spatial proteomics, are often limited to ti...
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ISBN:
(纸本)9798350313345;9798350313338
Machine learning (ML) methods based on histopathology slides are increasingly used for cancer diagnosis and treatment. Analyses with specialized experimental stains, such as spatial proteomics, are often limited to tissue microarrays (TMAs) rather than whole slide images due to the cost of data generation. While different approaches for selecting tissue to include in a TMA exist, the impact of the sampling protocol on downstream ML-model performance is underexplored. Here, we present a general-purpose framework to evaluate ML performance of synthetic TMA datasets. We compare the performance of 16 synthetic TMA breast carcinoma datasets for predicting patient overall survival, immunohistochemistry subtype, and mutation status. We deduce several common design principles that are broadly applicable across TMA applications. Finally, we conduct a case study into principled and task-specific TMA sampling procedures in budget-constrained scenarios.
This paper presents a method for synthesizing a free-labeled Petri net with inhibitor arcs (inhibitor net) from its generated finite language. Inhibitor arcs extend the modeling power of Petri nets to the Turing machi...
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ISBN:
(纸本)9798350358513;9798350358520
This paper presents a method for synthesizing a free-labeled Petri net with inhibitor arcs (inhibitor net) from its generated finite language. Inhibitor arcs extend the modeling power of Petri nets to the Turing machine level, offering significant benefits for modeling physical systems such as parallel machine systems in manufacturing. However, inhibitor arcs modify the enabling conditions, complicating the synthesis problem and rendering previous methods inapplicable. To address this challenge, we introduce novel logical conditions to manage the altered enabling conditions and formulate the synthesis problem as an integer linear programming problem. Experimental results demonstrate the effectiveness of the proposed method.
linear codes related to applications in Galois Geometry often require a certain divisibility of the occurring weights. In this paper we present an algorithmic framework for the classification of linear codes over fini...
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ISBN:
(纸本)9783031645280;9783031645297
linear codes related to applications in Galois Geometry often require a certain divisibility of the occurring weights. In this paper we present an algorithmic framework for the classification of linear codes over finite fields with restricted sets of weights. The underlying algorithms are based on lattice point enumeration and integer linear programming. We present new enumeration and non-existence results for projective two-weight codes, divisible codes, and additive F-4-codes.
This paper investigates a new lane reservation problem with task merging that consists of optimally determining which lanes in a transportation network have to be reserved and designing reserved lane-based routes in t...
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This paper investigates a new lane reservation problem with task merging that consists of optimally determining which lanes in a transportation network have to be reserved and designing reserved lane-based routes in the network for time-crucial transport tasks. Part of the tasks whose destinations are geographically close is merged to reduce the number of vehicles and transport costs. Reserved lanes can reduce the travel time of task vehicles passing through them, while they will generate negative impact on normal traffic, such as traffic delay to the vehicles on adjacent non-reserved lanes. The objective is to minimize the total negative impact of all reserved lanes. For this problem, two new integer linear programming (ILP) models are first developed. The complexity of the problem is proved to be NP-hard. Since commercial solver (like CPLEX) is time-consuming for solving it when the problem size increases, a fast and effective improved differential evolution algorithm (IDEA) is developed based on explored problem properties. Extensive experimental results for a real-life case and benchmark instances of up to 500 nodes in the network and 30 transport tasks show the favorable performance of the IDEA, as compared to CPLEX, differential evolution algorithm and genetic algorithm. Management insights are also drawn to support practical decision-making.
We focus on robotic sensor networks (RSNs), wherein mobile data collectors or robots are dispatched into the sensor field to collect data from the sensor nodes, and study a new algorithmic problem called battery-const...
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ISBN:
(纸本)9798350363999;9798350364002
We focus on robotic sensor networks (RSNs), wherein mobile data collectors or robots are dispatched into the sensor field to collect data from the sensor nodes, and study a new algorithmic problem called battery-constrained data collection in RSNs (BC-DCR). Given an RSN of sensor nodes with varying numbers of sensory data packets to be collected and a robot with limited battery power, the goal of the BC-DCR is to dispatch the robot into the sensor field to collect the maximum number of data packets before it runs out of battery power and returns to the depot for recharging. Although extensive research has been conducted to achieve various performance objectives of data collection in RSNs, not much work has focused on the robot's limited battery power. It is critical to consider the robot's limited battery power to optimize the data-collecting performance of a large-scale RSN. We show that at the core of the BC-DCR is a new variation of the classic traveling salesman problem called the Budget-Constrained Traveling Salesman Problem (BC-TSP), which has not been adequately solved. We design an integer linear programming (ILP)-based optimal algorithm and a time-efficient iterative greedy algorithm to solve the BC-TSP. Via extensive simulations using real measurements of battery power and mobility models of robots, we show that a) our algorithms outperform the existing work by collecting 29.1% more packets with the same battery power of the robots and b) our BC-TSP-based approach achieves 32.02% more network lifetime of the RSN compared to the existing approach.
Complex linear infrastructure projects have a unique characteristic that the construction site moves as the project progresses, necessitating that off-site manufacturing should be mobile. A mobile prefabrication facto...
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One important feature of every augmentative and alternative communication (AAC) application is the image view layout (IVL) in a user interface (VI) container, whose size is bound by the device's screen size. The I...
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To meet stringent performance requirements, communication networks are becoming increasingly programmable and flexible, supporting fast and frequent adjustments. However, reconfiguring networks in a dependable and tra...
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ISBN:
(纸本)9798350383515;9798350383508
To meet stringent performance requirements, communication networks are becoming increasingly programmable and flexible, supporting fast and frequent adjustments. However, reconfiguring networks in a dependable and transiently consistent manner is known to be algorithmically challenging. This paper revisits the fundamental problem of how to update the routes in a network in a (transiently) loop-free manner, considering both the Strong Loop-Freedom (SLF) and the Relaxed Loop-Freedom (RLF) property. We present two fast algorithms to solve the SLF and RLF problem variants exactly, to optimality. Our algorithms are based on a parameterized integerlinear program which would be intractable to solve directly by a classic solver. Our main technical contribution is a lazy cycle breaking strategy which, by adding constraints lazily, improves performance dramatically, and outperforms the state-of-the-art exact algorithms by an order of magnitude on realistic medium-sized networks. We further explore approximate algorithms and show that while a relaxation approach is relatively slow, with a local search approach short update schedules can be found, outperforming the state-of-the-art heuristics. On the theoretical front, we also provide an approximation lower bound for the update time of the state-of-the-art algorithm in the literature. As a contribution to the research community, we made all our code and implementations publicly available.
In this article we deal with the main critical issues of using electric vehicles in urban transport given the battery related limitations on driving range, and the network layout related limitations on the number of r...
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In this article we deal with the main critical issues of using electric vehicles in urban transport given the battery related limitations on driving range, and the network layout related limitations on the number of recharging stations. In this context, we seek the optimal routing plans together with the optimal locations of recharging stations for electric vehicle fleets through the Electric Vehicle Location Routing Problem with Intermediate Nodes (ELRP-IN) we propose. The ELRP-IN we formulate as a mathematical program considers the actual characteristics of battery discharging and recovering the braking energy. Energy consumption and recovery are determined through vehicle motion dynamics in conjunction with the 3-dimensional feature of the road geometry, passengers'/customers' demands on getting on and off, and the pre-defined speed profiles, where the graph corresponding to the road network is extended with the explicit consideration of intersections. By alternating the objectives adopted in the ELRP-IN formulation, we discuss through a number of numerical experiments involving real case instances the effects of both the objective functions and the parameters, including the consumption and the gain of energy, cost, traveled distance, and travel time, on the routing plans. Highlighting the finding that energy is not recovered in all the sections with descending grade, we reveal the direct effect of the elevation on the energy consumption, and hence on the location of a recharging station, where we discuss as well the limitation on energy recovery.
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