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long noncoding rnas in human reproductive processes and diseases

MOLECULAR REPRODUCTION AND DEVELOPMENT 2024年第1期91卷 e23728页

作者： Zhang, Le Sun, Hailong Chen, Xiujuan Inner Mongolia Med Univ Ctr Reprod Med Affiliated Hosp Hohhot 010050 Inner Mongolia Peoples R China

Infertility has become a global disease burden. Although assisted reproductive technologies are widely used, the assisted reproduction birth rate is no more than 30% worldwide. Therefore, understanding the mechanisms of reproduction can provide new strategies to improve live birth rates and clinical outcomes of enhanced implantation. long noncoding rnas (lncrnas) have been reported to exert regulatory roles in various biological processes and diseases in many species. In this review, we especially focus on the role of lncrnas in human reproduction. We summarize the function and mechanisms of lncrnas in processes vital to reproduction, such as spermatogenesis and maturation, sperm motility and morphology, follicle development and maturation, embryo development and implantation. Then, we highlight the importance and diverse potential of lncrnas as good diagnostic molecular biomarkers and therapeutic targets for infertility treatment.

关键词： human reproduction long noncoding rnas potential biomarkers potential therapeutic targets reproductive diseases

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long noncoding rnas in Human Stemness and Differentiation

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TRENDS IN CELL BIOLOGY 2021年第7期31卷 542-555页

作者： Azad, Fatemeh Mirzadeh Polignano, Isabelle Laurence Proserpio, Valentina Oliviero, Salvatore Univ Turin Dept Life Sci & Syst Biol Turin Italy Italian Inst Genom Med IIGM Fdn Turin Italy FPO IRCCS Candiolo Canc Inst Turin Italy

There is increasing evidence that long noncoding rnas (lncrnas) are among the main regulatory factors of stem cell maintenance and differentiation. They act through various mechanisms and interactions with proteins, DNA, and RNA. This heterogeneity in function increases the capabilities of the lncRNome toolkit but also makes it difficult to predict the function of novel lncrnas or even rely on biological information produced in animal models. As lncrnas are species-and tissue-specific, the recent technical advances in self-renewal and differentiation of human embryonic stem cells (ESCs) make these cells the ideal system to identify key regulatory lncrnas and study their molecular functions. Here we provide an overview of the functional versatility of lncRNA mechanistic heterogeneity in regulating pluripotency maintenance and human differentiation.

关键词： long noncoding rnas human pluripotent stem cells neuroectoderm mesoderm endoderm

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long noncoding rnas in mesenchymal stromal/stem cells osteogenic differentiation:Implications in osteoarthritis pathogenesis

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World Journal of Stem Cells 2022年第6期14卷 429-434页

作者： Daniel Quintero Hugo C Rodriguez Anish G Potty Dimitrios Kouroupis Ashim Gupta Department of Orthopaedics Division of Sports MedicineUniversity of MiamiMiller School of MedicineMiamiFL 33136United States Holy Cross Orthopedic Institute:Fort Lauderdale Practice Oakland ParkFL 33334United States South Texas Orthopedic Research Institute LaredoTX 78045 United States Diabetes Research Institute Cell Transplant CenterUniversity of MiamiMiller School of MedicineMiamiFL 33136United States BioIntegrate LawrencevilleGA 30043United States Future Biologics LawrencevilleGA 30043United States

This letter focuses on a recently published article that provided an exceptional description of the effect of epigenetic modifications on gene expression patterns related to skeletal system ***,it discusses a novel modality of epigenetic regulation,the long noncoding rnas(lncrnas),and provides evidence of their involvement in mesenchymal stromal/stem cells osteo-/adipogenic differentiation *** focus on lncrnas,there is an emerging cross talk between lncrnas and mirnas interaction as a novel mechanism in the regulation of the function of the musculoskeletal system,by controlling bone homeostasis and bone regeneration,as well as the osteogenic differentiation of stem ***,we touched on some examples to demonstrate this *** addition,we believe there is still much to discover from the effects of lncrnas on progenitor and non-progenitor cell *** incorporated data from other published articles to review lncrnas in normal progenitor cell osteogenic differentiation,determined lncrnas involved in osteoarthritis pathogenesis in progenitor cells,and provided a review of lncrnas in non-progenitor cells that are differentially regulated in *** conclusion,we really enjoyed reading this article and with this information we hope to further our understanding of lncrnas and mesenchymal stromal/stem cells regulation.

关键词： long noncoding rnas Epigenetics Mesenchymal stromal/stem cells Degenerative bone diseases Osteoarthritis Osteoporosis

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long noncoding rnas in neurodevelopment and Parkinson’s disease

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Animal Models and Experimental Medicine 2019年第4期2卷 239-251页

作者： Ying Lyu Lin Bai Chuan Qin Institute of Medical Laboratory Animal Science Chinese Academy of Medical Sciences & Comparative Medical Center Peking Union Medical College

long noncoding rnas(lnc rnas) are RNA molecules comprising more than 200 nucleotides, which are not translated into proteins. Many studies have shown that lnc rnas are involved in regulating a variety of biological processes, including immune, cancer, stress, development and differentiation at the transcriptional, epigenetic or post-transcriptional levels. Here, we review the role of lnc rnas in the process of neurodevelopment, neural differentiation, synaptic function, and pathogenesis of Parkinson’s disease(PD). These pathomechanisms include protein misfolding and aggregation, disordered protein degradation, mitochondrial dysfunction, oxidative stress, autophagy, apoptosis, and neuroinflammation. This information will provide the basis of lnc RNA-based disease diagnosis and drug treatment for PD.

关键词： long noncoding rnas neural development neural differentiation Parkinson's disease synapses

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long noncoding rnas in peripheral blood mononuclear cells of hypertensive patients with heart failure with preserved ejection fraction in relation to their functional capacity

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HELLENIC JOURNAL OF CARDIOLOGY 2021年第6期62卷 473-476页

作者： Kontaraki, Joanna E. Marketou, Maria E. Kochiadakis, George E. Patrianakos, Alexandros Maragkoudakis, Spyros Plevritaki, Anthi Papadaki, Sofia Alevizaki, Afroditi Theodosaki, Ourania Parthenakis, Fragiskos I. Univ Crete Sch Med Mol Cardiol Lab Iraklion NE Greece Heraklion Univ Hosp Dept Cardiol POB 1352 Iraklion NE Greece

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long noncoding rnas and cancer, an overview

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STEROIDS 2018年 133卷 93-95页

作者： Camacho, Cristel V. Choudhari, Ramesh Gadad, Shrikanth S. Texas Tech Univ Hlth Sci Ctr Paul L Foster Sch Med Ctr Emphasis CancDept Biomed Sci El Paso TX 79905 USA Univ Texas Southwestern Med Ctr Dallas Cecil H & Ida Green Ctr Reprod Biol Sci Lab Signaling & Gene Regulat Dallas TX 75390 USA Univ Texas Southwestern Med Ctr Dallas Dept Obstet & Gynecol Div Basic Reprod Biol Res Dallas TX 75390 USA

long noncoding rnas (lncrnas) are implicated in several biological processes, including but not limited to cardiovascular physiology, reproduction, differentiation, metabolism, DNA repair, and inflammation. Under normal physiological conditions, expression of Incrnas is tissue-specific and tightly regulated. In contrast, prevalent cancer types exhibit aberrant expression of lncrnas. In this context, lncrnas can drive cancer cell characteristics by controlling gene expression programs related to tumor suppressive and oncogenic functions. Hence, they can be excellent biomarkers and targets for therapeutic intervention in cancers. Understanding the molecular mechanisms by which lncrnas drive cancer progression will improve our understanding of the etiology of cancer and suggest new ways to treat this disease. This review will provide a perspective on the role of lncrnas in cancer initiation and progression.

关键词： long noncoding rnas Cancer

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long noncoding rnas CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage

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AMERICAN JOURNAL OF HUMAN GENETICS 2017年第2期101卷 255-266页

作者： Betts, Joshua A. Marjaneh, Mahdi Moradi Al-Ejeh, Fares Lim, Yi Chieh Shi, Wei Sivakumaran, Haran Tropee, Romain Patch, Ann-Marie Clark, Michael B. Bartonicek, Nenad Wiegmans, Adrian P. Hillman, Kristine M. Kaufmann, Susanne Bain, Amanda L. Gloss, Brian S. Crawford, Joanna Kazakoff, Stephen Wani, Shivangi Wen, Shu W. Day, Bryan Moller, Andreas Cloonan, Nicole Pearson, John Brown, Melissa A. Mercer, Timothy R. Waddell, Nicola Khanna, Kum Kum Dray, Eloise Dinger, Marcel E. Edwards, Stacey L. French, Juliet D. QIMR Berghofer Med Res Inst Canc Div Brisbane Qld 4006 Australia Univ Queensland Sch Chem & Mol Biosci Brisbane Qld 4072 Australia Queensland Univ Technol Translat Res Inst Brisbane Qld 4102 Australia Univ Oxford Dept Psychiat Warneford Hosp Oxford OX1 2JD England Garvan Inst Med Res Sydney NSW 2010 Australia Univ New South Wales Fac Med St Vincents Clin Sch Sydney NSW 2052 Australia Univ Queensland Inst Mol Biosci Brisbane Qld 4072 Australia Queensland Univ Technol Inst Hlth & Biomed Innovat Brisbane Qld 4059 Australia

Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a distal enhancer that regulates CCND1. Here, we report that, in addition to regulating CCND1, this enhancer regulates two estrogen-regulated long noncoding rnas, CUPID1 and CUPID2. We provide evidence that the risk-associated SNPs are associated with reduced chromatin looping between the enhancer and the CUPID1 and CUPID2 bidirectional promoter. We further show that CUPID1 and CUPID2 are predominantly expressed in hormone-receptor-positive breast tumors and play a role in modulating pathway choice for the repair of double-strand breaks. These data reveal a mechanism for the involvement of this region in breast cancer.

关键词： 11q13 DNA repair GWAS breast cancer enhancer long noncoding rnas

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long noncoding rnas in the regulation of p53-mediated apoptosis in human cancers

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CELL BIOLOGY INTERNATIONAL 2021年第7期45卷 1364-1382页

作者： Chatterjee, Manjima Viswanathan, Pragasam Vellore Inst Technol Sch Bio Sci & Technol Vellore Tamil Nadu India

long noncoding rnas (lncrnas) are widely known for their regulatory function in transcriptional and posttranscriptional processes. The involvement of such non-protein-coding rnas in nuclear organization and chromatin remodeling is often associated with an increased risk of human malignancies. In cancer, lncrnas either promote cell survival or may act as a growth suppressor, thus conferring a key regulatory function other than their established role in fundamental cellular processes. Interestingly, lncrnas interfere with the stages of apoptosis and related pathways involving p53. Many of these molecules either regulate or are regulated by p53 while mounting oncogenic events. Consequently, they may confer both prosurvival or proapoptotic functions depending upon the tissue type. Since the mechanism of cell death is bypassed in many human cancers, it has emerged that the lncrnas are either overexpressed or knocked down to sensitize cells to apoptotic stimuli. Nonetheless, the abundant expression of lncrnas in tumor cells renders them suitable targets for anticancer therapies. Although the role of lncrnas in the p53 network and apoptosis has been independently defined, their interplay in activating p53-target genes during cell cycle arrest remains unexplored. Thus, we have specifically reviewed the possible involvement of lncrnas in the p53-mediated apoptosis of human cancer cells. In particular, we summarize the growing evidence from individual studies and analyze whether lncrnas are essential to facilitate apoptosis in a p53-dependent manner. This may lead to the identification of p53-associated lncrnas that are suitable therapeutic targets or diagnostic/prognostic markers.

关键词： apoptosis cancer cell signaling long noncoding rnas p53 network therapeutics

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long noncoding rnas and viral infections

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BIOMEDICINE-TAIWAN 2013年第1期3卷 34-42页

作者： Zhang, Quan Jeang, Kuan-Teh NIAID Mol Virol Sect Lab Mol Microbiol NIH Bethesda MD 20892 USA

In this review, we focus on the roles of long noncoding rnas (lncrnas), including cellular and viral lncrnas, in virus replication in infected cells. We survey the interactions and functions of several cellular lncrnas such as XIST, HOTAIR, NEAT1, BIC, and several virusencoded lncrnas. Copyright (C) 2013, China Medical University. Published by Elsevier Taiwan LLC. All rights reserved.

关键词： long noncoding rnas virus

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long noncoding rnas shape transcription in plants

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TRANSCRIPTION-AUSTIN 2020年第3-4期11卷 160-171页

作者： Lucero, Leandro Fonouni-Farde, Camille Crespi, Martin Ariel, Federico Univ Nacl Litoral Ctr Cient Tecnol CONICET Santa Fe Inst Agrobiotecnol Litoral CONICET Santa Fe Argentina Univ Paris Saclay Inst Plant Sci Paris Saclay IPS2 CNRS INRA Gif Sur Yvette France Univ Paris Batiment 630 Gif Sur Yvette France

The advent of novel high-throughput sequencing techniques has revealed that eukaryotic genomes are massively transcribed although only a small fraction of rnas exhibits protein-coding capacity. In the last years, long noncoding rnas (lncrnas) have emerged as regulators of eukaryotic gene expression in a wide range of molecular mechanisms. Plant lncrnas can be transcribed by alternative RNA polymerases, acting directly as long transcripts or can be processed into active small rnas. Several lncrnas have been recently shown to interact with chromatin, DNA or nuclear proteins to condition the epigenetic environment of target genes or modulate the activity of transcriptional complexes. In this review, we will summarize the recent discoveries about the actions of plant lncrnas in the regulation of gene expression at the transcriptional level.

关键词： long noncoding rnas circrnas inverted repeats MEDIATOR Polycomb PRC1 PRC2 Pol II transcription alternative splicing genome topology

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