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  • 26 篇 英文
检索条件"主题词=long-noncoding RNA"
26 条 记 录,以下是11-20 订阅
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Imprinted lncrna KCNQ1OT1 regulates CDKN1C expression through promoter binding and chromatin folding in pigs
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GENE 2024年 923卷 148590页
作者: Zhou, Yongfeng Yu, Hao Zhang, Daoyu Wang, Zhengzhu Li, Qi An, Xinglan Zhang, Sheng Li, Ziyi Jilin Univ Hosp 1 Key Lab Organ Regenerat & Transplantat Minist Educ Changchun 130021 Peoples R China Jilin Univ Coll Anim Sci Changchun Peoples R China First Hosp Jilin Univ Genet Diag Ctr Changchun Peoples R China Shenzhen Univ South China Hosp Shenzhen Peoples R China
long noncoding rnas (lncrnas) are implicated in a number of regulatory functions in eukaryotic genomes. In humans, KCNQ1OT1 is a 91 kb imprinted lncrna that inhibits multiple surrounding genes in cis. Among them, CDKN... 详细信息
来源: 评论
Effects of myo-inositol on regulating glucose and lipid metabolism and alternative splicing events coexpressed with lncrnas in the liver tissues of diabetic mice
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HELIYON 2024年 第11期10卷 e32460页
作者: Li, Jin'e Huang, Qiulan Nie, Qin Luo, Yunfei Zeng, Haixia Zhang, Yuying He, Xiaoju Liu, Jianping Nanchang Univ Affiliated Hosp 2 Jiangxi Med Coll Dept Endocrinol & Metab Nanchang 330006 Jiangxi Peoples R China Inst Study Endocrinol & Metab Jiangxi Prov Nanchang 330006 Jiangxi Peoples R China Nanchang Univ Affiliated Hosp 2 Jiangxi Med Coll Dept Obstet & Gynecol Nanchang 330006 Jiangxi Peoples R China Wuhan Univ Zhongnan Hosp Wuhan 430071 Hubei Peoples R China 1 Minde Rd Nanchang 330000 Jiangxi Peoples R China
Objective: Recent studies have shown that gene alternative splicing (AS) and long noncoding rnas (lncrnas) are involved in diabetes mellitus (DM) and its complications. Currently, myo-inositol (MI) is considered as ef... 详细信息
来源: 评论
FIMICS: A panel of long noncoding rnas for cardiovascular conditions
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HELIYON 2023年 第1期9卷 e13087页
作者: Firat, Huseyin Zhang, Lu Baksi, Shounak Leszek, Przemyslaw Schordan, Eric Ounzain, Samir Kottwitz, Jan Patriki, Dimitri Heidecker, Bettina Luscher, Thomas F. Pedrazzini, Thierry Devaux, Yvan Luxembourg Inst Hlth Cardiovasc Res Unit Strassen Luxembourg Inst Cardiol Heart Failure & Transplantol Dept Warsaw Poland Firalis SA Huningue France HAYA Therapeut Lausanne Vaud Switzerland Kantonsspital St Gallen Div Anesthesiol Intens Care Rescue & Pain Med CH-9007 St Gallen Switzerland Univ Hosp Zurich Dept Cardiol Raemistr 100 CH-8091 Zurich Switzerland Charite Univ Med Berlin Berlin Germany Imperial Coll London Royal Brompton & Harefield Hosp GSTT London England Kings Coll London London England Univ Zurich Ctr Mol Cardiol Zurich Switzerland Univ Lausanne Dept Cardiovasc Med Expt Cardiol Unit Med Sch Lausanne Switzerland
Cardiovascular disorders such as heart failure are leading causes of mortality. Patient stratifica-tion via identification of novel biomarkers could improve management of cardiovascular diseases of complex etiologies.... 详细信息
来源: 评论
Distinct gene expression patterns of SOX2 and SOX2OT variants in different types of brain tumours
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JOUrnaL OF GENETICS 2023年 第1期102卷 25-25页
作者: Fouani, Youssef Gholipour, Akram Oveisee, Maziar Shahryari, Alireza Saberi, Hooshang Mowla, Seyed Javad Malakootian, Mahshid Tarbiat Modares Univ Fac Biol Sci Dept Mol Genet Tehran *** Iran Iran Univ Med Sci Cardiogenet Res Ctr Rajaie Cardiovasc Med & Res Ctr Tehran *** Iran Bam Univ Med Sci Sch Med Bam *** Iran Univ Tehran Med Sci Dept Neurosurg Tehran *** Iran Univ Tehran Med Sci Brain & Spinal Cord Injuries Repair Res Ctr Tehran *** Iran
Numerous investigations have been recently published on the dysregulated expression of long-noncoding rnas (lncrnas) in various cancer types, emphasizing that abnormal lncrna expression is a major contributor to tumou... 详细信息
来源: 评论
Deciphering the role of non-coding rnas SNHG18, HOXA11-AS, MEG3, and MDC1-AS1 in glioma patients: A combined experimental and computational study
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GENE REPORTS 2024年 36卷
作者: Mohammadian, Kamal Moradi, Arash Shabani, Mansoureh Kazemi, Somayeh Ganji, Shahla Mohammad Hamadan Univ Med Sci Dept Radiat Oncol Hamadan Iran Hamadan Univ Med Sci Canc Res Ctr Hamadan Iran Natl Inst Genet Engn & Biotechnol Med Biotechnol Inst Dept Mol Med Tehran Iran Islamic Azad Univ Sci & Res Branch Tehran Iran Islamic Azad Univ Tehran Med Sci Branch Tehran Iran
Background: Gliomas are brain tumours categorised into low-grade (I and II) and high-grade (III and IV). Unfortunately, patients with high-grade gliomas have a poor prognosis, which is why researchers are working to i... 详细信息
来源: 评论
Effect of simulated microgravity and ionizing radiation on expression profiles of mirna, lncrna, and mrna in human lymphoblastoid cells
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LIFE SCIENCES IN SPACE RESEARCH 2020年 24卷 1-8页
作者: Fu Hanjiang Su Fei Zhu Jie Zheng Xiaofei Ge Changhui Beijing Inst Radiat Med Dept Expt Hematol & Biochem 27 Taiping Rd Beijing 100850 Peoples R China
In space, multiple unique environmental factors, particularly microgravity and space radiation, pose a constant threat to astronaut health. Micrornas (mirnas) and long noncoding rnas (lncrnas) are functional rnas that... 详细信息
来源: 评论
Identification of male infertility-related long non-coding rnas and their functions based on a competing endogenous rna network
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JOUrnaL OF INTErnaTIONAL MEDICAL RESEARCH 2020年 第10期48卷 300060520961277-300060520961277页
作者: Zhou, Zuo Wang, Bing Hosp Zibo City Dept Obstet Maternal & Child Hlth Zibo Shandong Peoples R China Hosp Zibo City Ctr Reprod Med Maternal & Child Hlth 11 Xingyuan East Rd Zibo Shandong Peoples R China
Objective To identify male infertility-related long non-coding (lnc)rnas and an lncrna-related competing endogenous (ce)rna network. Methods Expression data including 13 normospermic and eight teratozoospermic samples... 详细信息
来源: 评论
SENCR stabilizes vascular endothelial cell adherens junctions through interaction with CKAP4
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2019年 第2期116卷 546-555页
作者: Lyu, Qing Xu, Suowen Lyu, Yuyan Choi, Mihyun Christie, Christine K. Slivano, Orazio J. Rahman, Arshad Jin, Zheng-Gen long, Xiaochun Xu, Yawei Miano, Joseph M. Univ Rochester Sch Med & Dent Aab Cardiovasc Res Inst Rochester NY 14642 USA Tongji Univ Sch Med Shanghai Peoples Hosp 2 Dept Cardiol Shanghai 200072 Peoples R China Albany Med Coll Dept Mol & Cellular Physiol Albany NY 12208 USA Univ Rochester Sch Med & Dent Dept Pediat Rochester NY 14642 USA
SENCR is a human-specific, vascular cell-enriched long-noncoding rna (lncrna) that regulates vascular smooth muscle cell and endothelial cell (EC) phenotypes. The underlying mechanisms of action of SENCR in these and ... 详细信息
来源: 评论
Epigenetic Components of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Uncover Potential Transposable Element Activation
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CLINICAL THERAPEUTICS 2019年 第4期41卷 675-698页
作者: Almenar-Perez, Eloy Ovejero, Tamara Sanchez-Fito, Teresa Espejo, Jose A. Nathanson, Lubov Oltra, Elisa Univ Catolica Valencia San Vicente Martir Escuela Doctorado Valencia Spain Univ Catolica Valencia San Vicente Martir Sch Med Valencia 46001 Spain Univ Catolica Valencia San Vicente Martir Sch Expt Sci Valencia Spain Nova Southeastern Univ Kiran C Patel Coll Osteopath Med Ft Lauderdale FL 33314 USA Nova Southeastern Univ Inst Neuro Immune Med Ft Lauderdale FL 33314 USA Ctr Invest Principe Felipe Unidad Mixta CIPF UCV Valencia Spain
Purpose: Studies to determine epigenetic changes associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remain scarce;however, current evidence clearly shows that methylation patterns of genomic D... 详细信息
来源: 评论
Expanding the horizon of EV-rnas: Lncrnas in EVs as biomarkers for disease pathways
Extracellular vesicle
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Extracellular vesicle 2023年 2卷 100025页
作者: Michail Spanos Priyanka Gokulnath Emeli Chatterjee Guoping Li Dimitrios Varrias Saumya Das Cardiovascular Research Center Massachusetts General Hospital and Harvard Medical School Boston MA USA. Albert Einstein College of Medicine/Jacobi Medical Center The Bronx NY USA.
Extracellular vesicles (EVs) are membrane-bound nanoparticles with different types of cargo released by cells and postulated to mediate functions such as intercellular communications. Recent studies have shown that lo... 详细信息
来源: 评论