Poroelastic nanodisks offer mechanical engineers enhanced control over material properties, enabling precise tuning of mechanical responses for advanced applications in sensors, actuators, and nano-mechanical systems....
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Poroelastic nanodisks offer mechanical engineers enhanced control over material properties, enabling precise tuning of mechanical responses for advanced applications in sensors, actuators, and nano-mechanical systems. This study presents a comprehensive analysis of thermally-affected multi-directional functionally graded sector annular nanodisks, focusing on their thermal-post buckling and nonlinear deflection behaviors. Utilizing a refined quasi-3D logarithmic theory (RQLT), the study incorporates the effects of Von-Karman nonlinearity to accurately capture the large deflection responses of these advanced nanostructures under thermal loading. The material properties of the nanodisks are graded in multiple directions, enhancing their ability to withstand thermal stresses and maintain structural integrity. To solve the complex governing equations derived from the RQLT, a nonlinear discrete-singular convolution (DSC) solution procedure is employed. This novel numerical technique allows for precise computation of the nonlinear deformation and stability characteristics of the nanodisks, providing insights into their behavior under various thermal conditions. The nonlinear DSC method's ability to handle singularities and discontinuities makes it particularly suitable for this type of advanced analysis. After obtaining the mathematics simulation data, a machine learning algorithm is used to test, train, and validate the results for future analysis of the mentioned problem with low computational cost. The results demonstrate the critical influence of thermal gradients and material gradation on the post-buckling and nonlinear deflection responses of sector annular nanodisks. The interplay between thermal effects and material properties highlights the necessity for incorporating multi-directional functionally graded materials in the design of high-performance nanostructures. This study's findings are pivotal for the development of next-generation nanodisks used in thermal en
This paper demonstrates a thorough examination of the bending behavior of sandwich concrete building structures that are reinforced with graphene nanoplatelets (GPLs). The analysis is confirmed using a machine learnin...
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This paper demonstrates a thorough examination of the bending behavior of sandwich concrete building structures that are reinforced with graphene nanoplatelets (GPLs). The analysis is confirmed using a machinelearning technique. Sandwich structures have notable benefits in terms of strength, longevity, and thermal insulation, making them well-suited for many building applications. Integrating GPLs into the concrete matrix improves the mechanical characteristics and performance of these structures, especially in terms of bending behavior. This study utilizes a machinelearning technique to verify the characterization of the temporary bending behavior of a concrete building structure reinforced with graphene nanoplatelets. The approach utilizes a dataset consisting of simulated bending data to create a prediction model that can reliably estimate the temporary bending response of the reinforced structure under different loading situations. The machine learning algorithm's effectiveness and dependability in optimizing the design and performance of graphene nanoplatelets reinforced sandwich concrete building structures are demonstrated through validation against simulated results. This provides engineers and designers with a powerful tool. This study enhances the comprehension and use of machinelearning approaches in analyzing and designing sophisticated structural materials and systems.
The measurement of the nonlinear dynamics of sandwich rotary sector plates is crucial for measurement engineers as it enables the precise analysis and understanding of the behavior of advanced composite structures und...
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The measurement of the nonlinear dynamics of sandwich rotary sector plates is crucial for measurement engineers as it enables the precise analysis and understanding of the behavior of advanced composite structures under dynamic conditions. These measurements help in identifying and mitigating potential issues related to vibration, stability, and fatigue, which are critical in industries like aerospace, automotive, and civil engineering. Accurate data on nonlinear dynamics aids in the optimization of design, enhancing performance, durability, and safety. Furthermore, it supports the development of predictive maintenance strategies, reducing downtime and operational costs, and contributing to the advancement of engineering materials and techniques. So, in the current work, for the first time, nonlinear dynamics of sandwich rotary sector plate via a mathematical modeling and machine learning algorithm is presented. First, due to a lack of information on the nonlinear dynamics of sandwich rotary sector plates, a dataset for training, testing, and validating the machine learning algorithm is presented. For this purpose, using Hamilton's principle, Von-Karman nonlinearity, and first-order shear deformation theory (FSDT), the nonlinear governing equations are obtained. Also, due to increasing stiffness and stability, an auxetic concrete foundation covers the sandwich structure. After that using the two-dimensional generalized differential quadrature method (GDQM) and Newmark's time integration method (NTIM), the nonlinear equations are solved. This research provides valuable insights for engineers in designing advanced composite structures with improved dynamic properties. The results also contribute to the broader understanding of nonlinear dynamic interactions in complex material systems, paving the way for innovative applications in various engineering fields.
Ultrasound-assisted solvent extraction (UASE) was appslied to extract phytoconstituents from Semecarpus anacardium L. The effective extraction parameters were optimized using the Response Surface Methodology (RSM) wit...
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Ultrasound-assisted solvent extraction (UASE) was appslied to extract phytoconstituents from Semecarpus anacardium L. The effective extraction parameters were optimized using the Response Surface Methodology (RSM) with Central Composite Face Centered design (CCFC), and the optimization parameters were validated through Adaptive Neuro-Fuzzy Inference System (ANFIS) and machinelearning (ML) algorithm models. The four independent parameters, i.e. ethanol concentration (X-1: 62-72% v/v), temperature (X-2: 38-48 degrees C), ultrasonic-exposure time (X-3: 12-24 min), and particle size (X-4: 2-5 mm) were optimized. The maximum yield of phytocompounds was achieved at X-1 = 67%, X-2 = 43 degrees C, X-3 = 18 min, and X-4 = 3.5 mm. The optimized yield of total phenolic, flavonoid, and antioxidant activity was considered when selecting process parameters. In this scenario, the optimized yields of total polyphenolic content (y(1) = 619.25 mg gallic acid equivalent (GAE)/g), total flavonoid content (y(2) = 151.24 mg Quercetin equivalents (QE)/g), free radical scavenging abilities (%DPPH*sc (y(3) = 66.41%), and %ABTS*sc (y(4) = 56.94%). The LC-MS peaks identify the presence of semecarpetin, butein, and amentoflavone, whereas GS-MS peaks represent seventeen gaseous components. Furthermore, the bioactive-rich optimized extract was nontoxic and supported the growth of macrophage- and epithelial cells in vitro. Conclusively, optimizing the UASE parameters enhanced the yield of bioactive compounds of S. anacardium L. [GRAPHICS]
Traditional human resource management systems face the problems of low efficiency and insufficient accuracy in data processing and decision support, while intelligent human resource management systems based on machine...
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Traditional human resource management systems face the problems of low efficiency and insufficient accuracy in data processing and decision support, while intelligent human resource management systems based on machine learning algorithms can significantly improve management efficiency and decision-making accuracy through advanced data analysis and automated decision-making. By analyzing the training duration and response efficiency of various algorithms, it was observed that the machine learning algorithm's training time is approximately 10.3 times longer than that of the non-optimized machine learning algorithm and 3.6 times longer than that of the intelligent management system, indicating strong time performance. Additionally, the response time of the classification model after applying feature selection is slightly improved compared to the original machine learning algorithm, measuring 225% of the non-optimized version and 98% of the response time of the intelligent HR management system. The key technologies involved in system development include neural network models and classification analysis techniques, and the implementation of these algorithms in the intelligent HR management system provides notable benefits.
In order to promote the development of personalized recommendation system in the tourism industry, this study adopts a machinelearning collaborative filtering algorithm model, and uses data provided by users and data...
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In order to promote the development of personalized recommendation system in the tourism industry, this study adopts a machinelearning collaborative filtering algorithm model, and uses data provided by users and data mining technology to reduce the overload of Internet messages and provide customized content recommendations. The construction of tourist attractions recommendation model based on machinelearning is 18% better than the traditional algorithm under the demand of tourists' "slow life". This research can effectively solve the problems of sparse data and cold start. It provides users with more personalized and people-centered travel route recommendations, which significantly enhancing the travel experience.
Carotid-femoral pulse wave velocity (cf-PWV) is an important but difficult to obtain measure of arterial stiffness and an independent predictor of cardiovascular events and all-cause mortality. The objective of this s...
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Carotid-femoral pulse wave velocity (cf-PWV) is an important but difficult to obtain measure of arterial stiffness and an independent predictor of cardiovascular events and all-cause mortality. The objective of this study was to develop a predictive model for cf-PWV based on brachial-ankle pulse wave velocity (baPWV) and other the accessible clinical *** model aims to allow patients to estimate their cf-PWV in advance without the need for direct measurement. We selected participants of the Northern Shanghai community from 2013 to 2022 as the study object. The Pearson correlation coefficient was employed for correlation analysis in feature selection. The linear regression models demonstrated low root mean square error (RMSE), error term (epsilon), and R2 values, indicating good predictive performance. A Cox proportional hazards model revealed a significant association between machinelearning-predicted cf-PWV and mortality risk, supporting the validity of prediction model. Using a threshold of cf-PWV greater than 10 m/s as the criterion, a classification prediction model was developed. Shapley Additive Explanations (SHAP) analysis was then applied to the Gradient Boosting model to elucidate the predictive mechanism of the optimal model. Without precise instruments, doctors often cannot determine a patient's cf-PWV. When the cf-PWV value predicted by the machine learning algorithm is high, patients can be recommended for more precise measurements to confirm the prediction and emphasize the importance of follow-up health management and psychological support. It is feasible to use a machine learning algorithm based on baPWV and other readily available clinical parameters to predict cf-PWV.
Due to the high cost of peak hour power generation and a push towards sustainability, the need for demand response (DR) is increasing. Compared to commercial-level DR, residential-level DR is more challenging. Residen...
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Due to the high cost of peak hour power generation and a push towards sustainability, the need for demand response (DR) is increasing. Compared to commercial-level DR, residential-level DR is more challenging. Residents are reluctant to participate, and DR controllers lack sufficient real-time activity information to balance energy savings with residents' need for comfort and convenience. To address the above challenges, we propose a sensor data-driven activity-based controller for heating, ventilation, and air conditioning devices. Using our proposed novel strategy, resident activities are recognized in real-time through a random forest machinelearning approach. Integrating activity information and forecasted electricity pricing, the proposed controller can simultaneously reduce energy consumption for sustainability and maintain resident constraints for comfort based on recognized activities. Results demonstrate the superiority of the proposed approach.
BACKGROUND: Recruiting patients for clinical trials of potential therapies for Alzheimer's disease (AD) remains a major challenge, with demand for trial participants at an all-time high. The AD treatment R&D p...
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BACKGROUND: Recruiting patients for clinical trials of potential therapies for Alzheimer's disease (AD) remains a major challenge, with demand for trial participants at an all-time high. The AD treatment R&D pipeline includes around 112 agents. In the United States alone, 150 clinical trials are seeking 70,000 participants. Most people with early cognitive impairment consult primary care providers, who may lack time, diagnostic skills and awareness of local clinical trials. machinelearning and predictive analytics offer promise to boost enrollment by predicting which patients have prodromal AD, and which will go on to develop AD. OBJECTIVES: The authors set out to develop a machinelearning predictive model that identifies prodromal AD patients in the general population, to aid early AD detection by primary care physicians and timely referral to expert sites for biomarker confirmation of diagnosis and clinical trial enrollment. DESIGN: The authors use a classification machine learning algorithm to extract patterns within healthcare claims and prescription data three years prior to AD diagnosis/AD drug initiation. SETTING: The study focused on subjects included within proprietary IQVIA US data assets (claims and prescription databases). Patient information was extracted from January 2010 to July 2018, for cohorts aged between 50 and 85 years. PARTICIPANTS: A total of 88,298,289 subjects aged between 50 and 85 years were identified. For the positive cohort, 667,288 subjects were identified who had 24 months of medical history and at least one record with AD or AD treatment. For the negative cohort, 3,670,254 patients were selected who had a similar length of medical history and who were matched to positive cohort subjects based on the prevalence rate. The scoring cohort was selected based on availability of recent medical data of 2-5 years and included 72,670,283 subjects between the ages of 50 and 85 years. INTERVENTION (if any): None. MEASUREMENTS: A list of clinic
Background The presence of significant liver fibrosis is a key determinant of long-term prognosis in non-alcoholic fatty liver disease (NAFLD). We aimed to develop a novel machine learning algorithm (MLA) to predict f...
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Background The presence of significant liver fibrosis is a key determinant of long-term prognosis in non-alcoholic fatty liver disease (NAFLD). We aimed to develop a novel machine learning algorithm (MLA) to predict fibrosis severity in NAFLD and compared it with the most widely used non-invasive fibrosis biomarkers. Methods We used a cohort of 553 adults with biopsy-proven NAFLD, who were randomly divided into a training cohort (n = 278) for the development of both logistic regression model (LRM) and MLA, and a validation cohort (n = 275). Significant fibrosis was defined as fibrosis stage F >= 2. MLA and LRM were derived from variables that were selected using a least absolute shrinkage and selection operator (LASSO) logistic regression algorithm. Results In the training cohort, the variables selected by LASSO algorithm were body mass index, pro-collagen type III, collagen type IV, aspartate aminotransferase and albumin-to-globulin ratio. The diagnostic accuracy of MLA showed the highest values of area under the receiver operator characteristic curve (AUROC: 0.902, 95% CI 0.869-0.904) for identifying fibrosis F >= 2. The LRM AUROC was 0.764, 95% CI 0.710-0.816 and significantly better than the AST-to-Platelet ratio (AUROC 0.684, 95% CI 0.605-0.762), FIB-4 score (AUROC 0.594, 95% CI 0.503-0.685) and NAFLD Fibrosis Score (AUROC 0.557, 95% CI 0.470-0.644). In the validation cohort, MLA also showed the highest AUROC (0.893, 95% CI 0.864-0.901). The diagnostic accuracy of MLA outperformed that of LRM in all subgroups considered. Conclusions Our newly developed MLA algorithm has excellent diagnostic performance for predicting fibrosis F >= 2 in patients with biopsy-confirmed NAFLD.
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