Blood flow is essential for maintaining normal physiological functions of the human *** laser speckle contrast imaging(LSCI)can achieve rapid,high-resolution,label-free,and long-term blood flow perfusion velocity moni...
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Blood flow is essential for maintaining normal physiological functions of the human *** laser speckle contrast imaging(LSCI)can achieve rapid,high-resolution,label-free,and long-term blood flow perfusion velocity monitoring in minimally invasive ***,conventional endoscopic LSCI uses a lowcoherence laser illumination scheme,leading to restricted angles of illumination,compromised laser coherence,uneven laser illumination distribution,and low coupling efficiency,all of which degrade the quality of LSCI in the *** this paper,we propose that conical fiber(CF)-coupled high-coherence laser can be used to achieve large-angle,high-coherence,high-uniformity,and high coupling efficiency laser illumination in the ***,we establish an effective model for calculating the divergence angle of *** phantom and animal experiments,we reveal that laser illumination based on CF markedly enhances endoscopic LSCI *** technology broadens the imaging field of view,enhances the signal-to-noise ratio,enables more sensitive detection of minute blood flow changes,expands the detectable flow range,and improves signal-to-background ratio of endoscopic *** findings suggest that CF-based laser illumination stands as a highly promising advancement in endoscopic LSCI.
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