检索结果-内蒙古大学图书馆

REPRESENTATION OF TACTILE SCENES IN THE RODENT BARREL CORTEX

NEUROSCIENCE 2018年第0期368卷 81-94页

作者： Estebanez, Luc Ferezou, Isabelle Ego-Stengel, Valerie Shulz, Daniel E. CNRS UNIC FRE 3693 F-91198 Gif Sur Yvette France

After half a century of research, the sensory features coded by neurons of the rodent barrel cortex remain poorly understood. Still, views of the sensory representation of whisker information are increasingly shifting from a labeled line representation of single-whisker deflections to a selectivity for specific elements of the complex statistics of the multi-whisker deflection patterns that take place during spontaneous rodent behavior - so called natural tactile scenes. Here we review the current knowledge regarding the coding of patterns of whisker stimuli by barrel cortex neurons, from responses to single-whisker deflections to the representation of complex tactile scenes. A number of multi-whisker tunings have already been identified, including center-surround feature extraction, angular tuning during edge-like multi-whisker deflections, and even tuning to specific statistical properties of the tactile scene such as the level of correlation across whiskers. However, a more general model of the representation of multi-whisker information in the barrel cortex is still missing. This is in part because of the lack of a human intuition regarding the perception emerging from a whisker system, but also because in contrast to other primary sensory cortices such as the visual cortex, the spatial feature selectivity of barrel cortex neurons rests on highly nonlinear interactions that remained hidden to classical receptive field approaches. This article is part of a Special Issue entitled: Barrel Cortex. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

关键词： barrel cortex whisker stimulation naturalistic stimulus sensory responses neural coding

来源：评论

学校读者我要写书评

暂无评论

Taste coding of complex naturalistic taste stimuli and traditional taste stimuli in the parabrachial pons of the awake, freely licking rat

引用

JOURNAL OF NEUROPHYSIOLOGY 2016年第1期116卷 171-182页

作者： Sammons, Joshua D. Weiss, Michael S. Victor, Jonathan D. Di Lorenzo, Patricia M. Binghamton Univ Dept Psychol Box 6000 Binghamton NY 13902 USA Weill Cornell Med Coll Brain & Mind Res Inst New York NY USA

Several studies have shown that tasteresponsive cells in the brainstem taste nuclei of rodents respond to sensory qualities other than gustation. Such data suggest that cells in the classical gustatory brainstem may be better tuned to respond to stimuli that engage multiple sensory modalities than to stimuli that are purely gustatory. Here, we test this idea by recording the electrophysiological responses to complex, naturalistic stimuli in single neurons in the parabrachial pons (PbN, the second neural relay in the central gustatory pathway) in awake, freely licking rats. Following electrode implantation and recovery, we presented both prototypical and naturalistic taste stimuli and recorded the responses in the PbN. Prototypical taste stimuli (NaCl, sucrose, citric acid, and caffeine) and naturalistic stimuli (clam juice, grape juice, lemon juice, and coffee) were matched for taste quality and intensity (concentration). Umami (monosodium glutamate + inosine monophosphate) and fat (diluted heavy cream) were also tested. PbN neurons responded to naturalistic stimuli as much or more than to prototypical taste stimuli. Furthermore, they convey more information about naturalistic stimuli than about prototypical ones. Moreover, multidimensional scaling analyses showed that across unit responses to naturalistic stimuli were more widely separated than responses to prototypical taste stimuli. Interestingly, cream evoked a robust and widespread response in PbN cells. Collectively, these data suggest that natural foods are more potent stimulators of PbN cells than purely gustatory stimuli. Probing PbN cells with pure taste stimuli may underestimate the response repertoire of these cells.

关键词： taste gustatory neural coding temporal coding neurophysiology

来源：评论

学校读者我要写书评

暂无评论

Basolateral amygdala responds robustly to social calls: spiking characteristics of single unit activity

引用

JOURNAL OF NEUROPHYSIOLOGY 2011年第5期105卷 2389-2404页

作者： Naumann, Robert T. Kanwal, Jagmeet S. Georgetown Univ Dept Physiol & Biophys Washington DC 20057 USA

Naumann RT, Kanwal JS. Basolateral amygdala responds robustly to social calls: spiking characteristics of single unit activity. J Neurophysiol 105: 2389-2404, 2011. First published March 2, 2011;doi:10.1152/jn.00580.2010.-Vocalizations emitted within a social context can trigger call-specific changes in the emotional and physiological/autonomic state of the receiver. The amygdala is implicated in mediating these changes, but its role in call perception remains relatively unexplored. We examined call and pitch selectivity of single neurons within the basolateral amygdala (BLA) by recording spiking activity in response to 5 pitch variants of each of 14 species-specific calls presented to awake, head-restrained mustached bats, Pteronotus parnellii. A response-wise analysis across neurons revealed seven types of temporal response patterns based on the timing and duration of spiking. Roughly half of the responses to different call types were significantly affected by changes in call pitch. A neuron-wise analysis revealed that similar to 12% (8/69) of the neurons preferred the same pitch across all call types. Ninety-three percent (93/100) of neurons were excited by at least one call type and 76% exhibited either complete or transient suppression to one or more call types. The majority of neurons preferred fewer than half of the 14 different simple-syllabic calls. A call-wise analysis of spiking activity revealed that call types signaling either threat or fear most consistently evoked increases in the spike rate. In contrast, calls emitted during appeasement tended to evoke spike suppression. Our data suggest that BLA neurons participate in the processing of multiple call types and exhibit a rich variety of temporal response patterns that are neither neuron nor call specific.

关键词： auditory system affect communication pitch perception valence neural coding

来源：评论

学校读者我要写书评

暂无评论

Ecological expected utility and the mythical neural code

引用

COGNITIVE NEURODYNAMICS 2010年第1期4卷 25-35页

作者： Feldman, Jerome Univ Calif Berkeley Berkeley CA 94720 USA Int Comp Sci Inst Berkeley CA 94704 USA

neural spikes are an evolutionarily ancient innovation that remains nature's unique mechanism for rapid, long distance information transfer. It is now known that neural spikes sub serve a wide variety of functions and essentially all of the basic questions about the communication role of spikes have been answered. Current efforts focus on the neural communication of probabilities and utility values involved in decision making. Significant progress is being made, but many framing issues remain. One basic problem is that the metaphor of a neural code suggests a communication network rather than a recurrent computational system like the real brain. We propose studying the various manifestations of neural spike signaling as adaptations that optimize a utility function called ecological expected utility.

关键词： neural coding Ecological utility Neuroeconomics Spikes Grandmother cell Population code Binding problem

来源：评论

学校读者我要写书评

暂无评论

Continuous detection of weak sensory signals in afferent spike trains: the role of anti-correlated interspike intervals in detection performance

引用

JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY neural AND BEHAVIORAL PHYSIOLOGY 2003年第10期189卷 741-759页

作者： Goense, JBM Ratnam, R Univ Illinois Beckman Inst Urbana IL 61801 USA Univ Illinois Ctr Biophys & Computat Biol Urbana IL 61801 USA

An important problem in sensory processing is deciding whether fluctuating neural activity encodes a stimulus or is due to variability in baseline activity. Neurons that subserve detection must examine incoming spike trains continuously, and quickly and reliably differentiate signals from baseline activity. Here we demonstrate that a neural integrator can perform continuous signal detection, with performance exceeding that of trial-based procedures, where spike counts in signal- and baseline windows are compared. The procedure was applied to data from electrosensory afferents of weakly electric fish (Apteronotus leptorhynchus), where weak perturbations generated by small prey add similar to1 spike to a baseline of similar to300 spikes s(-1). The hypothetical postsynaptic neuron, modeling an electrosensory lateral line lobe cell, could detect an added spike within 10-15 ms, achieving near ideal detection performance (80-95%) at false alarm rates of 1-2 Hz, while trial-based testing resulted in only 30-35% correct detections at that false alarm rate. The performance improvement was due to anti-correlations in the afferent spike train, which reduced both the amplitude and duration of fluctuations in postsynaptic membrane activity, and so decreased the number of false alarms. Anti-correlations can be exploited to improve detection performance only if there is memory of prior decisions.

关键词： continuous detection electroreception interspike interval correlations neural coding sequential hypothesis testing

来源：评论

学校读者我要写书评

暂无评论

VIBRATION-EVOKED SENSORY NERVE ACTION-POTENTIALS DERIVED FROM PACINIAN CORPUSCLES

引用

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY 1993年第4期89卷 278-286页

作者： HAMANO, T KAJI, R DIAZ, AF KOHARA, N TAKAMATSU, N UCHIYAMA, T SHIBASAKI, H KIMURA, J KYOTO UNIV FAC MEDDEPT NEUROLKYOTO 606JAPAN UNIV SANTO TOMAS DEPT NEUROLMANILAPHILIPPINES NEC SAN EI INSTRUMENTS LTD KYOTOJAPAN KYOTO UNIV FAC MEDDEPT BRAIN PATHOPHYSIOLKYOTO 606JAPAN

To evaluate sensory response to natural stimuli, we developed a method to record sensory nerve action potentials evoked by high-frequency vibratory stimulation. Trains of 250 Hz sinusoidal indentations with a duration of 100 msec were applied to the finger tip at a rate of 3 Hz. The responses were obtained with surface electrodes placed over the median and ulnar nerves at the wrist. Averaged wave forms consisted of two components: an initial diphasic or triphasic potential and the following low amplitude trains of discharges phase-locked to vibratory stimuli. Anesthesia of the skin at the stimulation site or tourniquet-induced ischemia of the limb eventually diminished both components. Neither of them therefore represented artifacts from electrode movement or electromagnetic field intrinsic to the stimulator. Various kinds of mechanoreceptors may contribute to the first component. Pacinian corpuscles probably give rise to the second component as the only skin receptors that can respond to high-frequency vibratory stimuli of 250 Hz. This method helps examine neural coding of the receptor and the peripheral nerve fiber mediating vibration sense.

关键词： MECHANORECEPTOR neural coding SENSORY NERVE ACTION POTENTIAL PACINIAN CORPUSCLE VIBRATION SENSE VIBRATORY STIMULATION

来源：评论

学校读者我要写书评

暂无评论

Glomerular interactions in olfactory processing channels of the antennal lobes

引用

JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY neural AND BEHAVIORAL PHYSIOLOGY 2013年第11期199卷 929-946页

作者： Heinbockel, Thomas Shields, Vonnie D. C. Reisenman, Carolina E. Howard Univ Coll Med Dept Anat Washington DC 20059 USA Towson Univ Dept Biol Sci Towson MD 21252 USA Univ Arizona Dept Neurosci Tucson AZ 85721 USA

An open question in olfactory coding is the extent of interglomerular connectivity: do olfactory glomeruli and their neurons regulate the odorant responses of neurons innervating other glomeruli? In the olfactory system of the moth Manduca sexta, the response properties of different types of antennal olfactory receptor cells are known. Likewise, a subset of antennal lobe glomeruli has been functionally characterized and the olfactory tuning of their innervating neurons identified. This provides a unique opportunity to determine functional interactions between glomeruli of known input, specifically, (1) glomeruli processing plant odors and (2) glomeruli activated by antennal stimulation with pheromone components of conspecific females. Several studies describe reciprocal inhibitory effects between different types of pheromone-responsive projection neurons suggesting lateral inhibitory interactions between pheromone component-selective glomerular neural circuits. Furthermore, antennal lobe projection neurons that respond to host plant volatiles and innervate single, ordinary glomeruli are inhibited during antennal stimulation with the female's sex pheromone. The studies demonstrate the existence of lateral inhibitory effects in response to behaviorally significant odorant stimuli and irrespective of glomerular location in the antennal lobe. Inhibitory interactions are present within and between olfactory subsystems (pheromonal and non-pheromonal subsystems), potentially to enhance contrast and strengthen odorant discrimination.

关键词： Electrophysiology Glomerulus neural coding Olfaction Pheromone

来源：评论

学校读者我要写书评

暂无评论

Searching for optimal sensory signals:: Iterative stimulus reconstruction in closed-loop experiments

引用

JOURNAL OF COMPUTATIONAL NEUROSCIENCE 2004年第1期17卷 47-56页

作者： Edin, F Machens, CK Schütze, H Herz, AVM Humboldt Univ Inst Theoret Biol D-10115 Berlin Germany

Shaped by evolutionary processes, sensory systems often represent behaviorally relevant stimuli with higher fidelity than other stimuli. The stimulus dependence of neural reliability could therefore provide an important clue in a search for relevant sensory signals. We explore this relation and introduce a novel iterative algorithm that allows one to find stimuli that are reliably represented by the sensory system under study. To assess the quality of a neural representation, we use stimulus reconstruction methods. The algorithm starts with the presentation of an initial stimulus (e.g. white noise). The evoked spike train is recorded and used to reconstruct the stimulus online. Within a closed-loop setup, this reconstruction is then played back to the sensory system. Iterating this procedure, the newly generated stimuli can be better and better reconstructed. We demonstrate the feasibility of this method by applying it to auditory receptor neurons in locusts. Our data show that the optimal stimuli often exhibit pronounced sub-threshold periods that are interrupted by short, yet intense pulses. Similar results are obtained for simple model neurons and suggest that these stimuli are encoded with high reliability by a large class of neurons.

关键词： neural coding stimulus reconstruction insect auditory receptor

来源：评论

学校读者我要写书评

暂无评论

Correlations and Neuronal Population Information

引用

ANNUAL REVIEW OF NEUROSCIENCE, VOL 39 2016年第1期39卷 237-256页

作者： Kohn, Adam Coen-Cagli, Ruben Kanitscheider, Ingmar Pouget, Alexandre Albert Einstein Coll Med Dominick Purpura Dept Neurosci Bronx NY 10461 USA Albert Einstein Coll Med Dept Ophthalmol & Visual Sci Bronx NY 10461 USA Univ Geneva Dept Basic Neurosci CH-1211 Geneva Switzerland Univ Texas Austin Ctr Learning & Memory Austin TX 78712 USA Univ Texas Austin Dept Neurosci Austin TX 78712 USA Univ Rochester Dept Brain & Cognit Sci 601 Elmwood Ave Rochester NY 14627 USA UCL Gatsby Computat Neurosci Unit London W1T 4JG England

Brain function involves the activity of neuronal populations. Much recent effort has been devoted to measuring the activity of neuronal populations in different parts of the brain under various experimental conditions. Population activity patterns contain rich structure, yet many studies have focused on measuring pairwise relationships between members of a larger population-termed noise correlations. Here we review recent progress in understanding how these correlations affect population information, how information should be quantified, and what mechanisms may give rise to correlations. As population coding theory has improved, it has made clear that some forms of correlation are more important for information than others. We argue that this is a critical lesson for those interested in neuronal population responses more generally: Descriptions of population responses should be motivated by and linked to well-specified function. Within this context, we offer suggestions of where current theoretical frameworks fall short.

关键词： neural coding theoretical neuroscience perception Fisher information decoding neural variability

来源：评论

学校读者我要写书评

暂无评论

Population-wide distributions of neural activity during perceptual decision-making

引用

PROGRESS IN NEUROBIOLOGY 2013年 103卷 156-193页

作者： Wohrer, Adrien Humphries, Mark D. Machens, Christian K. Ecole Normale Super Grp Neural Theory INSERM U960 Dept Etud Cognit F-75005 Paris France Univ Manchester Fac Life Sci Manchester M60 1QD Lancs England Champalimaud Ctr Unknown Champalimaud Neurosci Programme P-1400038 Lisbon Portugal

Cortical activity involves large populations of neurons, even when it is limited to functionally coherent areas. Electrophysiological recordings, on the other hand, involve comparatively small neural ensembles, even when modern-day techniques are used. Here we review results which have started to fill the gap between these two scales of inquiry, by shedding light on the statistical distributions of activity in large populations of cells. We put our main focus on data recorded in awake animals that perform simple decision-making tasks and consider statistical distributions of activity throughout cortex, across sensory, associative, and motor areas. We transversally review the complexity of these distributions, from distributions of firing rates and metrics of spike-train structure, through distributions of tuning to stimuli or actions and of choice signals, and finally the dynamical evolution of neural population activity and the distributions of (pairwise) neural interactions. This approach reveals shared patterns of statistical organization across cortex, including: (i) long-tailed distributions of activity, where quasi-silence seems to be the rule for a majority of neurons;that are barely distinguishable between spontaneous and active states;(ii) distributions of tuning parameters for sensory (and motor) variables, which show an extensive extrapolation and fragmentation of their representations in the periphery;and (iii) population-wide dynamics that reveal rotations of internal representations overtime, whose traces can be found both in stimulus-driven and internally generated activity. We discuss how these insights are leading us away from the notion of discrete classes of cells, and are acting as powerful constraints on theories and models of cortical organization and population coding. (C) 2012 Elsevier Ltd. All rights reserved.

关键词： neural populations Cell-to-cell variability Perceptual decision-making Long-tailed distributions neural coding Population dynamics

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：