咨询与建议

限定检索结果

文献类型

  • 113 篇 期刊文献
  • 4 篇 学位论文
  • 2 篇 会议

馆藏范围

  • 119 篇 电子文献
  • 0 种 纸本馆藏

日期分布

学科分类号

  • 97 篇 理学
    • 88 篇 生物学
    • 10 篇 统计学(可授理学、...
    • 4 篇 化学
    • 2 篇 生态学
    • 1 篇 数学
    • 1 篇 物理学
  • 48 篇 农学
    • 19 篇 作物学
  • 36 篇 工学
    • 23 篇 生物工程
    • 11 篇 计算机科学与技术...
    • 2 篇 化学工程与技术
    • 2 篇 食品科学与工程(可...
  • 28 篇 医学
    • 17 篇 基础医学(可授医学...
    • 14 篇 临床医学
    • 4 篇 药学(可授医学、理...
    • 2 篇 公共卫生与预防医...
    • 1 篇 中西医结合
  • 3 篇 管理学
    • 3 篇 管理科学与工程(可...
  • 1 篇 法学
    • 1 篇 社会学
  • 1 篇 教育学
    • 1 篇 教育学

主题

  • 119 篇 non-coding dna
  • 11 篇 gene expression
  • 9 篇 transcription fa...
  • 8 篇 genomes
  • 8 篇 genomics
  • 7 篇 human genome
  • 6 篇 non-coding rna
  • 5 篇 evolution
  • 5 篇 research
  • 5 篇 microrna
  • 5 篇 genetic regulati...
  • 5 篇 crisprs (genetic...
  • 5 篇 chromatin
  • 4 篇 dna repeats
  • 4 篇 molecular evolut...
  • 4 篇 comparative geno...
  • 4 篇 gene regulation
  • 4 篇 mutation (biolog...
  • 3 篇 single nucleotid...
  • 3 篇 cancer

机构

  • 3 篇 univ politecn ca...
  • 2 篇 harvard med sch ...
  • 2 篇 queen mary unive...
  • 2 篇 univ florida dep...
  • 2 篇 longyan univ col...
  • 2 篇 univ penn childr...
  • 1 篇 univ strasbourg ...
  • 1 篇 univ bonn nees i...
  • 1 篇 univ arizona ua ...
  • 1 篇 wayne state univ...
  • 1 篇 genome biology d...
  • 1 篇 indian inst sci ...
  • 1 篇 univ toronto mcl...
  • 1 篇 field museum nat...
  • 1 篇 swiss inst bioin...
  • 1 篇 howard florey in...
  • 1 篇 univ belgrade fa...
  • 1 篇 sci life lab upp...
  • 1 篇 univ haifa 199 a...
  • 1 篇 univ cambridge c...

作者

  • 5 篇 qiu guo-hua
  • 3 篇 zheng xintian
  • 3 篇 huang cuiqin
  • 3 篇 subirana juan a.
  • 3 篇 fu mingjun
  • 2 篇 coetzee gerhard ...
  • 2 篇 kimball rebecca ...
  • 2 篇 han kin-lan
  • 2 篇 braun michael j.
  • 2 篇 raoult didier
  • 2 篇 hazelett dennis ...
  • 2 篇 braun edward l.
  • 2 篇 yang xiaoyan
  • 2 篇 sinsheimer janet...
  • 2 篇 messeguer xavier
  • 2 篇 alfaro michael e...
  • 2 篇 gilbert princess...
  • 1 篇 rodio donatella ...
  • 1 篇 ko yunhee
  • 1 篇 shin susie

语言

  • 115 篇 英文
  • 4 篇 其他
检索条件"主题词=non-coding DNA"
119 条 记 录,以下是1-10 订阅
排序:
Protection of the genome and the central exome by peripheral non-coding dna against dna damage in health, ageing and age-related diseases
收藏 引用
BIOLOGICAL REVIEWS 2025年 第2期100卷 508-529页
作者: Qiu, Guo-Hua Fu, Mingjun Zheng, Xintian Huang, Cuiqin Longyan Univ Coll Life Sci Longyan 364012 Peoples R China Fujian Prov Univ Engn Res Ctr Prevent & Control Anim Origin Zoonosi Fujian Prov Key Lab Prevent Vet Med & Biotechnol Key Lab Prevent & Control Anim Infect Dis & Biotec Longyan Peoples R China
dna in eukaryotic genomes is under constant assault from both exogenous and endogenous sources, leading to dna damage, which is considered a major molecular driver of ageing. Fortunately, the genome and the central ex... 详细信息
来源: 评论
The protective function of non-coding dna in dna damage accumulation with age and its roles in age-related diseases
收藏 引用
BIOGERONTOLOGY 2019年 第6期20卷 741-761页
作者: Qiu, Guo-Hua Zheng, Xintian Fu, Mingjun Huang, Cuiqin Yang, Xiaoyan Longyan Univ Fujian Prov Key Lab Prevent & Control Anim Infect Longyan 364012 Peoples R China Longyan Univ Fujian Prov Univ Key Lab Prevent Vet Med & Biotechnol Longyan 364012 Peoples R China Longyan Univ Coll Life Sci Longyan 364012 Peoples R China
Aging is a progressive decline of physiological function in tissue and organ accompanying both accumulation of dna damage and reduction of non-coding dna. Peripheral non-coding dna/heterochromatin has been proposed to... 详细信息
来源: 评论
Functional interrogation of non-coding dna through CRISPR genome editing
收藏 引用
METHODS 2017年 121卷 118-129页
作者: Canver, Matthew C. Bauer, Daniel E. Orkin, Stuart H. Harvard Med Sch Boston MA 02115 USA Boston Childrens Hosp Div Hematol Oncol Boston MA 02115 USA Dana Farber Canc Inst Dept Pediat Oncol Boston MA 02115 USA Howard Hughes Med Inst Boston MA 02115 USA
Methodologies to interrogate non-coding regions have lagged behind coding regions despite comprising the vast majority of the genome. However, the rapid evolution of clustered regularly interspaced short palindromic r... 详细信息
来源: 评论
An Abundant Class of non-coding dna Can Prevent Stochastic Gene Silencing in the C. elegans Germline
收藏 引用
CELL 2016年 第2期166卷 343-357页
作者: Frokjaer-Jensen, Christian Jain, Nimit Hansen, Loren Davis, M. Wayne Li, Yongbin Zhao, Di Rebora, Karine Millet, Jonathan R. M. Liu, Xiao Kim, Stuart K. Dupuy, Denis Jorgensen, Erik M. Fire, Andrew Z. Univ Utah Howard Hughes Med Inst Dept Biol Salt Lake City UT 84112 USA Stanford Univ Dept Pathol Stanford CA 94305 USA Univ Copenhagen Dept Biomed Sci DK-2200 Copenhagen N Denmark Univ Copenhagen Danish Natl Res Fdn Ctr Cardiac Arrhythmia DK-2200 Copenhagen N Denmark Stanford Univ Sch Med Dept Bioengn Stanford CA 94305 USA Stanford Univ Med Ctr Dept Dev Biol Stanford CA 94305 USA Univ Bordeaux IECB Lab ARNA INSERMU869 F-33600 Pessac France Stanford Univ Dept Genet Stanford CA 94305 USA Tsinghua Univ Sch Life Sci Beijing 100084 Peoples R China
Cells benefit from silencing foreign genetic elements but must simultaneously avoid inactivating endogenous genes. Although chromatin modifications and RNAs contribute to maintenance of silenced states, the establishm... 详细信息
来源: 评论
Genome defense against exogenous nucleic acids in eukaryotes by non-coding dna occurs through CRISPR-like mechanisms in the cytosol and the bodyguard protection in the nucleus
收藏 引用
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 2016年 第0期767卷 31-41页
作者: Qiu, Guo-Hua Changzhou Univ Changzhou Jiangsu Peoples R China
In this review, the protective function of the abundant non-coding dna in the eukaryotic genome is discussed from the perspective of genome defense against exogenous nucleic acids. Peripheral non coding dna has been p... 详细信息
来源: 评论
Protection of the genome and central protein-coding sequences by non-coding dna against dna damage from radiation
收藏 引用
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 2015年 764卷 108-117页
作者: Qiu, Guo-Hua Changzhou Univ Inst Biomed Engn & Hlth Sci Changzhou Jiangsu Peoples R China
non-coding dna comprises a very large proportion of the total genomic content in higher organisms, but its function remains largely unclear. non-coding dna sequences constitute the majority of peripheral heterochromat... 详细信息
来源: 评论
Eight Novel Microsatellite Loci in a Declining Grassland Songbird, the Bobolink (Dolichonyx oryzivorus)
收藏 引用
ECOLOGY AND EVOLUTION 2025年 第5期15卷 e71400页
作者: McGee, Kathryn Perlut, Noah G. Travis, Steven E. Univ New England Sch Biol Sci Biddeford ME 04005 USA Univ New England Sch Marine & Environm Programs Biddeford ME USA
Microsatellite loci in non-coding regions of nuclear dna provide an important tool for genetic diversity research, particularly when comparing relatedness between individuals. While microsatellites have been developed... 详细信息
来源: 评论
non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer
收藏 引用
GENOME MEDICINE 2024年 第1期16卷 1-17页
作者: Rospo, Giuseppe Chila, Rosaria Matafora, Vittoria Basso, Veronica Lamba, Simona Bartolini, Alice Bachi, Angela Di Nicolantonio, Federica Mondino, Anna Germano, Giovanni Bardelli, Alberto Univ Torino Mol Biotechnol Ctr Dept Oncol Turin Italy IFOM ETS AIRC Inst Mol Oncol I-20139 Milan Italy IRCCS San Raffaele Sci Inst Div Immunol Transplantat & Infect Dis Lymphocyte Activat Unit Via Olgettina 58 I-20132 Milan Italy FPO IRCCS Candiolo Canc Inst I-10060 Candiolo TO Italy Boehringer Ingelheim RCV GmbH & Co KG Vienna Austria
BackgroundImmunotherapy based on checkpoint inhibitors is highly effective in mismatch repair deficient (MMRd) colorectal cancer (CRC). These tumors carry a high number of mutations, which are predicted to translate i... 详细信息
来源: 评论
Design of an Efficient Model for Detecting Diseases using Genomics with Graph Relationship Networks  4
Design of an Efficient Model for Detecting Diseases using Ge...
收藏 引用
4th International Conference on Artificial Intelligence and Signal Processing
作者: Alparthi, Kumuda Panigrahy, Saroj Kumar VIT AP Univ Sch Comp Sci & Engn Amaravati Andhra Pradesh 522241 India
This paper introduces novel approaches utilizing Convolutional Neural Networks (CNNs), Recurrent Neural Networks (RNNs), Deep Autoencoders, and Graph Neural Networks (GNNs) in genomics. As the existing methods, while ... 详细信息
来源: 评论
Long-read dna sequencing reveals the organization of the mitochondrial genome in the early-branching dinoflagellate Oxyrrhis marina.
收藏 引用
PROTIST 2024年 第6期175卷 126071页
作者: Haro, Ronie Walunjkar, Nikita Jorapur, Soham Slamovits, Claudio H. Dalhousie Univ Inst Comparat Genom 5850 Coll St Halifax NS Canada Dalhousie Univ Dept Biochem & Mol Biol 5850 Coll StRm 8B1 Halifax NS B3H 4R2 Canada Indian Inst Sci Educ & Res Dept Biol Sci 77QG F7Q IISER Bhopal Rd Bhopal India
The mitochondrial genomes of dinoflagellate protists are remarkable for their highly fragmented and heterogeneous organization. Early attempts to determine their structure without 'next-generation' dna sequenc... 详细信息
来源: 评论