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检索条件"主题词=non-coding DNA"
119 条 记 录,以下是101-110 订阅
排序:
noncoding Genomics in Gastric Cancer and the Gastric Precancerous Cascade: Pathogenesis and Biomarkers
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DISEASE MARKERS 2015年 第1期2015卷 1-14页
作者: Sandoval-Borquez, Alejandra Saavedra, Kathleen Carrasco-Avino, Gonzalo Garcia-Bloj, Benjamin Fry, Jacqueline Wichmann, Ignacio Corvalan, Alejandro H. Pontificia Univ Catolica Chile Adv Ctr Chron Dis ACCDiS Santiago 8330034 Chile Univ La Frontera Sci & Technol Bioresource Nucleus BIOREN Temuco 4811230 Chile Univ La Frontera Grad Program Appl Cell & Mol Biol Temuco 4811230 Chile Pontificia Univ Catolica Chile UC Ctr Invest Oncol CITO Santiago 8330034 Chile Univ Chile Dept Pathol Santiago 8380453 Chile Icahn Sch Med Mt Sinai Dept Pathol New York NY 10029 USA Pontificia Univ Catolica Chile Fac Med Dept Hematol Oncol Santiago 8330034 Chile
Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death, whose patterns vary among geographical regions and ethnicities. It is a multifactorial disease, and its development d... 详细信息
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Cellular Senescence in Yeast Is Regulated by rdna noncoding Transcription
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CURRENT BIOLOGY 2013年 第18期23卷 1794-1798页
作者: Saka, Kimiko Ide, Satoru Ganley, Austen R. D. Kobayashi, Takehiko Grad Univ Adv Studies Natl Inst Genet Cytogenet Div Mishima Shizuoka 4118540 Japan Grad Univ Adv Studies Dept Genet Mishima Shizuoka 4118540 Japan Massey Univ Inst Nat & Math Sci Auckland 0632 New Zealand
Genomic instability is a conserved factor in lifespan reduction, although the molecular mechanism is not known [1]. Studies in the yeast Saccharomyces cerevisiae over the past 20 years have found a connection between ... 详细信息
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FATHMM-XF: accurate prediction of pathogenic point mutations via extended features
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BIOINFORMATICS 2018年 第3期34卷 511-513页
作者: Rogers, Mark F. Shihab, Hashem A. Mort, Matthew Cooper, David N. Gaunt, Tom R. Campbell, Colin Univ Bristol Intelligent Syst Lab Bristol BS8 1UB Avon England Univ Bristol MRC Integrat Epidemiol Unit IEU Bristol BS8 2BN Avon England Cardiff Univ Inst Med Genet Cardiff CF14 4XN Wales
aSummary: We present FATHMM-XF, a method for predicting pathogenic point mutations in the human genome. Drawing on an extensive feature set, FATHMM-XF outperforms competitors on benchmark tests, particularly in non-co... 详细信息
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non-coding regulatory elements: Potential roles in disease and the case of epilepsy
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NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 2022年 第3期48卷 e12775-e12775页
作者: Pagni, Susanna Mills, James D. Frankish, Adam Mudge, Jonathan M. Sisodiya, Sanjay M. UCL Queen Sq Inst Neurol Dept Clin & Expt Epilepsy Box 29Queen Sq London WC1N 3BG England Chalfont Ctr Epilepsy Gerrards Cross England Univ Amsterdam Dept Neuro Pathol Amsterdam Neurosci Amsterdam UMC Amsterdam Netherlands European Bioinformat Inst European Mol Biol Lab Cambridge England
non-coding dna (ncdna) refers to the portion of the genome that does not code for proteins and accounts for the greatest physical proportion of the human genome. ncdna includes sequences that are transcribed into RNA ... 详细信息
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The role of codons during a natural selection
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CHEMICAL PHYSICS 2021年 540卷 110986-110986页
作者: Pincak, Richard Bartos, Erik Slovak Acad Sci Inst Expt Phys Watsonova 47 Kosice 04353 Slovakia Joint Inst Nucl Res Bogoliubov Lab Theoret Phys Dubna 141980 Moscow Region Russia Slovak Acad Sci Inst Phys Dubravska Cesta 9 Bratislava 84511 Slovakia
We suggest the origin of coded amino acids in nature by using a new theory on the connection in lattice Pascal's triangle and adding some properties of cohomology theory to biological objects as dna, RNA, and prot... 详细信息
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Mechanism of Repeat-Associated MicroRNAs in Fragile X Syndrome
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NEURAL PLASTICITY 2012年 第2012期2012卷 104796-104796页
作者: Kelley, Karen Chang, Shin-Ju E. Lin, Shi-Lung WJWU & LYNN Inst Stem Cell Res Div Regenerat Med Santa Fe Springs CA 90670 USA
The majority of the human genome is comprised of non-coding dna, which frequently contains redundant microsatellite-like trinucleotide repeats. Many of these trinucleotide repeats are involved in triplet repeat expans... 详细信息
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A Statistical Framework to Predict Functional non-coding Regions in the Human Genome Through Integrated Analysis of Annotation Data
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SCIENTIFIC REPORTS 2015年 第1期5卷 10576-10576页
作者: Lu, Qiongshi Hu, Yiming Sun, Jiehuan Cheng, Yuwei Cheung, Kei-Hoi Zhao, Hongyu Yale Univ Sch Publ Hlth Dept Biostat New Haven CT 06520 USA Yale Univ Program Computat Biol & Bioinformat New Haven CT USA Yale Univ Sch Med Yale Ctr Med Informat New Haven CT USA Yale Univ Sch Med Dept Emergency Med New Haven CT USA VA Connecticut Healthcare Syst West Haven CT USA
Identifying functional regions in the human genome is a major goal in human genetics. Great efforts have been made to functionally annotate the human genome either through computational predictions, such as genomic co... 详细信息
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Application of artificial intelligence for detection of chemico-biological interactions associated with oxidative stress and dna damage
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CHEMICO-BIOLOGICAL INTERACTIONS 2021年 345卷 109533-109533页
作者: Davidovic, Lazar M. Laketic, Darko Cumic, Jelena Jordanova, Elena Pantic, Igor Univ Belgrade Studentski Trg 1 RS-11000 Belgrade Serbia Univ Belgrade Fac Med Inst Anat Niko Miljanic Dr Subotica 4-2 RS-11129 Belgrade Serbia Univ Belgrade Fac Med Clin Ctr Serbia Dr Koste Todorov 8 RS-11129 Belgrade Serbia Univ Belgrade Clin Hosp Ctr Fac Med Vukova 9 RS-11000 Belgrade Serbia Univ Belgrade Fac Med Inst Med Physiol Lab Cellular Physiol Visegradska 26-2 RS-11129 Belgrade Serbia Univ Haifa 199 Abba Hushi Blvd Mt Carmel IL-3498838 Haifa Israel
In recent years, various AI-based methods have been developed in order to uncover chemico-biological interactions associated with dna damage and oxidative stress. Various decision trees, bayesian networks, random fore... 详细信息
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TRRUST: a reference database of human transcriptional regulatory interactions
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SCIENTIFIC REPORTS 2015年 第1期5卷 11432-11432页
作者: Han, Heonjong Shim, Hongseok Shin, Donghyun Shim, Jung Eun Ko, Yunhee Shin, Junha Kim, Hanhae Cho, Ara Lee, Eiru Kim Tak Kim, Hyojin Kim, Kyungsoo Yang, Sunmo Bae, Dasom Yun, Ayoung Kim, Sunphil Kim, Chan Yeong Cho, Hyeon Jin Kang, Byunghee Shin, Susie Lee, Insuk Yonsei Univ Dept Biotechnol Coll Life Sci & Biotechnol Seoul 120749 South Korea
The reconstruction of transcriptional regulatory networks (TRNs) is a long-standing challenge in human genetics. Numerous computational methods have been developed to infer regulatory interactions between human transc... 详细信息
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Pleiotropic Enhancers are Ubiquitous Regulatory Elements in the Human Genome
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GENOME BIOLOGY AND EVOLUTION 2022年 第6期14卷 evac071页
作者: Laiker, Ian Frankel, Nicolas Consejo Nacl Invest Cient & Tecn CONICET Inst Fisiol Biol Mol & Neurociencias IFIBYNE RA-1428 Buenos Aires DF Argentina Univ Buenos Aires UBA RA-1428 Buenos Aires DF Argentina Univ Buenos Aires UBA Fac Ciencias Exactas & Nat FCEN Dept Ecol Genet & Evoluc RA-1428 Buenos Aires DF Argentina
Enhancers are regulatory elements of genomes that determine spatio-temporal patterns of gene expression. The human genome contains a vast number of enhancers, which largely outnumber protein-coding genes. Historically... 详细信息
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