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non-coding rna derived from extracellular vesicles in cancer immune escape: Biological functions and potential clinical applications

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CANCER LETTERS 2021年 501卷 234-246页

作者： Huang, Mingyao Peng, Xueqiang Yang, Liang Yang, Shuo Li, Xinyu Tang, Shilei Li, Bowen Jin, Hongyuan Wu, Bo Liu, Jingang Li, Hangyu China Med Univ Affiliated Hosp 4 Dept Gen Surg Shenyang 110032 Peoples R China

The tumor microenvironment represents a dynamically composed matrix into which cancer cells and many other cell types are embedded to form organ-like structures. The tumor immune micmenvironment (TIME), composed of immune cells, is an inseparable part of the tumor microenvironment. Extracellular vesicles (EVs) participate in the occurrence and development of tumors by delivering various biologically active molecules between cells;their role in cancer immune escape in particular has been widely proven. EVs can carry a wide array of cargo, such as non-coding rnas (ncrnas), including mirnas, lncrnas, and circrnas, which are selectively loaded by EVs, secreted, and transported to participate in the proliferation of immune cells. Hence, strategies to specifically target EV-ncrnas could be attractive therapeutic options. In this review, we summarize the current research on the role of EV-ncrnas in cancer immune escape, and discuss the latest research on the function and regulation mechanism of EV-ncrnas in cancer immune escape, highlighting and elucidating the potential clinical applications of EV-ncrnas, including in diagnosis and immunotherapy.

关键词： Extracellular vesicles non-coding rna Immune escape Clinical applications

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non-coding rna in the wiring and remodeling of neural circuits

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NEURON 2023年第14期111卷 2140-2154页

作者： Soutschek, Michael Schratt, Gerhard Swiss Fed Inst Technol Inst Neurosci Dept Hlth Sci & Technol Lab Syst Neurosci CH-8057 Zurich Switzerland

The brain constantly adapts to changes in the environment, a capability that underlies memory and behavior. Long-term adaptations require the remodeling of neural circuits that are mediated by activity-dependent alterations in gene expression. Over the last two decades, it has been shown that the expression of proteincoding genes is significantly regulated by a complex layer of non-coding rna (ncrna) interactions. The aim of this review is to summarize recent discoveries regarding the functional involvement of ncrnas during different stages of neural circuit development, activity-dependent circuit remodeling, and circuit maladapations underlying neurological and neuropsychiatric disorders. In addition to the intensively studied microrna (mirna) family, we focus on more recently added ncrna classes, such as long ncrnas (lncrnas) and circular rnas (circrnas), and discuss the complex regulatory interactions between these different rnas. We conclude by discussing the potential relevance of ncrnas for cell-type and -state-specific regulation in the context of memory formation, the evolution of human cognitive abilities, and the development of new diagnostic and therapeutic tools in brain disorders.

关键词： non-coding rna microrna circular rna lincrna neural circuit synaptic plasticity neuropsychiatric disorder

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non-coding rna and the complex regulation of the trypanosome life cycle

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CURRENT OPINION IN MICROBIOLOGY 2014年 20卷 146-152页

作者： Michaeli, Shulamit Bar Ilan Univ Mina & Everard Goodman Fac Life Sci Adv Mat & Nanotechnol Inst IL-52900 Ramat Gan Israel

The protozoan parasite Trypanosoma brucei is the causative agent of African sleeping sickness and the wasting disease, nagana, in cattle. The parasite is transmitted to the mammalian host by the bite of a tsetse fly. These parasites lack transcriptional regulation, and their gene expression is mainly regulated post-transcriptionally. Changes in the transcriptome and proteome suggest that mrna stability and translation regulation operate to control cycling between the hosts. The review discusses the small RNome of T. brucei, and the potential involvement of these molecules in shaping the adaptation of the parasites to their hosts.

关键词： non-coding rna LIFE cycles (Biology) TRYPANOSOMA brucei AFRICAN trypanosomiasis WASTING syndrome CATTLE -- Diseases GENE expression in cattle

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non-coding rna regulation of synaptic plasticity and memory: Implications for aging

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AGEING RESEARCH REVIEWS 2014年 17卷 34-42页

作者： Earls, Laurie R. Westmoreland, Joby J. Zakharenko, Stanislav S. St Jude Childrens Res Hosp Dept Dev Neurobiol Memphis TN 38105 USA

Advancing age is associated with the loss of cognitive ability and vulnerability to debilitating mental diseases. Although much is known about the development of cognitive processes in the brain, the study of the molecular mechanisms governing memory decline with aging is still in its infancy. Recently, it has become apparent that most of the human genome is transcribed into non-coding rnas (ncrnas) rather than protein-coding mrnas. Multiple types of ncrnas are enriched in the central nervous system, and this large group of molecules may regulate the molecular complexity of the brain, its neurons, and synapses. Here, we review the current knowledge on the role of ncrnas in synaptic plasticity, learning, and memory in the broader context of the aging brain and associated memory loss. We also discuss future directions to study the role of ncrnas in the aging process. (C) 2014 Elsevier B.V. All rights reserved.

关键词： non-coding rna microrna Synaptic plasticity Learning Memory Aging

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non-coding rna as a trigger of neuropathologic disorder phenotypes in transgenic Drosophila

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JOUrnaL OF NEURAL TRANSMISSION 2008年第12期115卷 1629-1642页

作者： Savvateeva-Popova, Elena Popov, Andrej Grossman, Abraham Nikitina, Ekaterina Medvedeva, Anna Molotkov, Dmitry Kamyshev, Nicholas Pyatkov, Konstantin Zatsepina, Olga Schostak, Natalya Zelentsova, Elena Pavlova, Galina Panteleev, Dmitry Riederer, Peter Evgen'ev, Michail Russian Acad Sci IP Pavlov Physiol Inst St Petersburg 199034 Russia IM Sechenov Evolutionary Physiol & Biochem Inst St Petersburg 194223 Russia MNESIS Co LLC Pleasantville NY 10570 USA CALTECH Div Biol Pasadena CA 91125 USA VA Engelhardt Mol Biol Inst Moscow 119991 Russia Inst Gene Biol Moscow 119991 Russia Univ Wurzburg Inst Clin Neurochem Wurzburg Germany Univ Wurzburg Clin & Policlin Psychiat & Psychotherapy Natl Parkinson Fdn Ctr Excellence Labs Wurzburg Germany

At most, many protein-misfolding diseases develop as environmentally induced sporadic disorders. Recent studies indicate that the dynamic interplay between a wide repertoire of noncoding rnas and the environment play an important role in brain development and pathogenesis of brain disorders. To elucidate this new issue, novel animal models which reproduce the most prominent disease manifestations are required. For this, transgenic Drosophila strains were constructed to express small highly structured, non-coding rna under control of a heat shock promoter. Expression of the rna induced formation of intracellular aggregates revealed by Thioflafin T in embryonic cell culture and Congo Red in the brain of transgenic flies. Also, this strongly perturbed the brain control of locomotion monitored by the parameters of sound production and memory retention of young 5-day-old males. This novel model demonstrates that expression of non-coding rna alone is sufficient to trigger neuropathology.

关键词： Drosophila transgenic strains non-coding rna Intracellular aggregates Visuo-spatial orientation Locomotion Cognitive impairments

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non-coding rna transcripts: Sensors of neuronal stress, modulators of synaptic plasticity, and agents of change in the onset of Alzheimer's disease

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NEUROSCIENCE LETTERS 2009年第2期466卷 81-88页

作者： St Laurent, Georges, III Faghihi, Mohammad Ali Wahlestedt, Claes Scripps Res Inst MIND Jupiter FL 33458 USA George Washington Univ Sch Med & Hlth Sci Dept Biochem & Mol Biol Washington DC 20037 USA Univ Antioquia Immunovirol Biogenesis Grp Medellin 1226 Colombia

non-protein-coding rnas (ncrnas) play critical roles on many levels of cellular information processing and pervasive expression of ncrnas in the nervous system could help explain brain complexity. Ncrnas are enriched in the central nervous system and are associated with specific neuroanatomical regions. Additionally, several recent publications have revealed an important role for deregulation of ncrnas in various human neuropathologies, such as Alzheimer's disease, Parkinson's disease and Fragile X mental retardation. Herein, we summarize reports on functional ncrna molecules involved in cellular stress response, particularly related to Alzheimer's disease. We conclude that ncrnas have a prominent role in maintaining precise physiological levels of gene products directly implicated in Alzheimer's disease pathology. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

关键词： Transcriptome non-coding rna Neuronal stress Synaptic plasticity Alzheimer's disease

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non-coding rna in endothelial-to-mesenchymal transition

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CARDIOVASCULAR RESEARCH 2019年第12期115卷 1716-1731页

作者： Hulshoff, Melanie S. del Monte-Nieto, Gonzalo Kovacic, Jason Krenning, Guido Univ Groningen Univ Med Ctr Groningen Dept Pathol & Med Biol Lab Cardiovasc Regenerat Med Hanzepl 1EA11 NL-9713 GZ Groningen Netherlands Georg August Univ Univ Med Ctr Groningen Dept Cardiol & Pneumol Gottingen Germany German Ctr Cardiovasc Res DZHK Partner Site Gottingen Germany Monash Univ Australian Regenerat Med Inst Clayton Vic 3800 Australia Icahn Sch Med Mt Sinai Zena & Michael A Wiener Cardiovasc Inst Dept Cardiol New York NY 10029 USA

Endothelial-to-mesenchymal transition (EndMT) is the process wherein endothelial cells lose their typical endothelial cell markers and functions and adopt a mesenchymal-like phenotype. EndMT is required for development of the cardiac valves, the pulmonary and dorsal aorta, and arterial maturation, but activation of the EndMT programme during adulthood is believed to contribute to several pathologies including organ fibrosis, cardiovascular disease, and cancer. non-coding rnas, including micrornas, long non-coding rnas, and circular rnas, modulate EndMT during development and disease. Here, we review the mechanisms by which non-coding rnas facilitate or inhibit EndMT during development and disease and provide a perspective on the therapeutic application of non-coding rnas to treat fibroproliferative cardiovascular disease.

关键词： non-coding rna Endothelial-mesenchymal transition (EndMT) Cardiac development Cardiovascular disease Plasticity

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non-coding rna: a new frontier in regulatory biology

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National Science Review 2014年第2期1卷 190-204页

作者： Xiang-Dong Fu Department of Cellular and Molecular Medicine Institute of Genomic Medicine University of California

A striking inding in the past decade is the production of numerous non-coding rnas(nc rnas) from mammalian genomes. While it is entirely possible that many of those nc rnas are transcription noises or by-products of rna processing, increasing evidence suggests that a large fraction of them are functional and provide various regulatory activities in the cell. hus, functional genomics and proteomics are incomplete without understanding functional ribonomics. As has been long suggested by the ‘rna world’hypothesis, many nc rnas have the capacity to act like proteins in diverse biochemical processes. he enormous amount of information residing in the primary sequences and secondary structures of nc rnas makes them particularly suited to function as scafolds for molecular interactions. In addition, their functions appear to be stringently controlled by default via abundant nucleases when not engaged in speciic interactions. his review focuses on the functional properties of regulatory nc rnas in comparison with proteins and emphasizes both the opportunities and challenges in future nc rna research.

关键词： the rna world non-coding rna biological functions regulatory mechanisms experimental approaches functional genomics

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non-coding rna notations, regulations and interactive resources

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FUNCTIONAL & INTEGRATIVE GENOMICS 2024年第6期24卷 1-18页

作者： Cheng, Mengwei Zhu, Yinhuan Yu, Han Shao, Linlin Zhang, Yiming Li, Lanxing Tu, Haohong Xie, Luyao Chao, Haoyu Zhang, Peijing Xin, Saige Feng, Cong Ivanisenko, Vladimir Orlov, Yuriy Chen, Dijun Wong, Aloysius Yang, Yixin Eric Chen, Ming Wenzhou Kean Univ Coll Sci Math & Technol Wenzhou 325060 Peoples R China Univ Chinese Acad Sci Wenzhou Inst Wenzhou 325001 Peoples R China Zhejiang Univ Coll Life Sci Dept Bioinformat Hangzhou 310058 Peoples R China Russian Acad Sci Inst Cytol & Genet Siberian Branch Novosibirsk 630060 Russia IM Sechenov First Moscow State Med Univ Sechenov Univ Digital Hlth Inst Minist Hlth Russian Federat Moscow 119991 Russia Nanjing Univ Sch Life Sci Nanjing 210023 Peoples R China

An increasing number of non-coding rnas (ncrnas) are found to have roles in gene expression and cellular regulations. However, there are still a large number of ncrnas whose functions remain to be studied. Despite decades of research, the field continues to evolve, with each newly identified ncrna undergoing processes such as biogenesis, identification, and functional annotation. Bioinformatics methodologies, alongside traditional biochemical experimental methods, have played an important role in advancing ncrna research across various stages. Presently, over 50 types of ncrnas have been characterized, each exhibiting diverse functions. However, there remains a need for standardization and integration of these ncrnas within a unified framework. In response to this gap, this review traces the historical trajectory of ncrna research and proposes a unified notation system. Additionally, we comprehensively elucidate the ncrna interactome, detailing its associations with DNAs, rnas, proteins, complexes, and chromatin. A web portal named ncrna Hub (https://***/nchub/) is also constructed to provide detailed notations of ncrnas and share a collection of bioinformatics resources. This review aims to provide a broader perspective and standardized paradigm for advancing ncrna research.

关键词： non-coding rna Notation Interactome Bioinformatics resource

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non-coding rna regulates the immune microenvironment in recurrent spontaneous abortion (RSA): new insights into immune mechanisms

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BIOLOGY OF REPRODUCTION 2024年第2期110卷 220-229页

作者： Tang, Cen Hu, Wanqin Kunming Med Univ Obstet Dept Affiliated Hosp 2 Kunming Yunnan Peoples R China Kunming Med Univ Obstet Dept Affiliated Hosp 2 Kunming 650000 Yunnan Peoples R China

Recurrent spontaneous abortion (RSA) has various causes, including chromosomal abnormalities, prethrombotic state, and abnormal uterine anatomical factors. However, the pathogenesis of RSA is still unclear. Surprisingly, non-coding rna can stably express at the maternal-fetal interface and regulate immune cells' proliferation, apoptosis, invasion, metastasis, and angiogenesis. Accumulating evidence suggests that the competing endogenous rna (cerna) regulatory network between non-coding rnas complicates RSA's pathological process and maybe a new starting point for exploring RSA. In this review, we mainly discuss the regulatory network and potential significance of non-coding rna in the immune microenvironment of RSA patients. In addition, the cellular interactions of non-coding rna transported through vesicles were introduced from aspects of trophoblast function and immune regulation. Finally, we analyze previous studies and further discuss that the stable expression of non-coding rna may be used as a biomarker of some disease states and a prediction target of RSA.

关键词： non-coding rna recurrent spontaneous abortion maternal-fetal immune trophoblast cells cerna

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