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non-coding rna networks underlying cognitive disorders across the lifespan

TRENDS IN MOLECULAR MEDICINE 2011年第6期17卷 337-346页

作者： Qureshi, Irfan A. Mehler, Mark F. Albert Einstein Coll Med Rosyln & Leslie Goldstein Lab Stem Cell Biol & Re New York NY 10461 USA Albert Einstein Coll Med Inst Brain Disorders & Neural Regenerat New York NY 10461 USA Albert Einstein Coll Med Dept Neurol New York NY 10461 USA Albert Einstein Coll Med Dept Neurosci New York NY 10461 USA Albert Einstein Coll Med Dept Psychiat & Behav Sci New York NY 10461 USA Albert Einstein Coll Med Rose F Kennedy Ctr Res Intellectual & Dev Disabil New York NY 10461 USA

non-coding rnas (ncrnas) and their associated regulatory networks are increasingly being implicated in mediating a complex repertoire of neurobiological functions. Cognitive and behavioral processes are proving to be no exception. In this review, we discuss the emergence of many novel, diverse and rapidly expanding classes and subclasses of short and long ncrnas. We briefly review the life cycles and molecular functions of these ncrnas. We also examine how ncrna circuitry mediates brain development, plasticity, stress responses and aging, and highlight its potential roles in the pathophysiology of cognitive disorders, including neural developmental and age-associated neurodegenerative diseases, as well as those that manifest throughout the lifespan.

关键词： non-coding rna COGNITION disorders NEUROBIOLOGY NEURODEGENERATION PATHOLOGICAL physiology AGING

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non-coding rna involvement in the pathogenesis of diabetic cardiomyopathy

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JOUrnaL OF CELLULAR AND MOLECULAR MEDICINE 2019年第9期23卷 5859-5867页

作者： Zhang, Wei Xu, Weiting Feng, Yu Zhou, Xiang Soochow Univ Dept Cardiol Affiliated Hosp 2 1055 Sanxiang Rd Suzhou 215004 Peoples R China Soochow Univ Dept Endocrinol Affiliated Hosp 2 Suzhou Peoples R China

In recent years, the incidence of diabetes has been increasing rapidly, which seriously endangers human health. Diabetic cardiomyopathy, an important cardiovascular complication of diabetes, is characterized by myocardial fibrosis, ventricular remodelling and cardiac dysfunction. It has been documented that mitochondrial dysfunction, oxidative stress, inflammatory response, autophagy, apoptosis, diabetic microangiopathy and myocardial fibrosis are implicated in the pathogenesis of diabetic cardiomyopathy. With the development of molecular biology technology, accumulating evidence demonstrates that non-coding rnas (ncrnas) are critically involved in the molecular mechanisms of diabetic cardiomyopathy. In this review, we summarize the pathological roles of three types of ncrnas (microrna, long ncrna and circular rna) in the progression of diabetic cardiomyopathy, which may provide valuable insights into the pathogenesis of diabetic cardiovascular complications.

关键词： diabetic cardiomyopathy non-coding rna pathogenesis

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non-coding rna derived from a conservative subtelomeric tandem repeat in chicken and Japanese quail somatic cells

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MOLECULAR CYTOGENETICS 2014年第1期7卷 1-13页

作者： Trofimova, Irina Popova, Darya Vasilevskaya, Elena Krasikova, Alla St Petersburg State Univ Dept Cytol & Histol St Petersburg 198504 Russia

Background: Subtelomeres are located close to the ends of chromosomes and organized by tandemly repetitive sequences, duplicated copies of genes, pseudogenes and retrotransposons. Transcriptional activity of tandemly organized DNA at terminal chromosomal regions and the distribution of subtelomere-derived non-coding rnas are poorly investigated. Here we aimed to analyze transcriptional activity of subtelomeric tandem repeat in somatic tissues and cultured cells of birds. We focused on tissue-specific differences of subtelomeric repeats transcription, structure of the resulting transcripts and the behavior of subtelomere-derived rna during mitosis. Results: Transcriptional activity of short subtelomeric PO41 ("pattern of 41 bp") tandem repeat in the somatic and cultured cells of chicken (Gallus gallus domesticus) and Japanese quail (Coturnix coturnix japonica) was examined using rna fluorescence in situ hybridization approach. We discovered transcripts from both strands of the PO41 repeat in chicken MDCC-MSB1 cells as well as in chicken and Japanese quail somatic tissues, such as tissues of cerebellum, telencephalon, muscles, oviduct, small and large intestine. Normal somatic and transformed cells demonstrate similar distribution of PO41 repeat transcripts in interphase nuclei. We revealed one or two major foci of PO41 repeat transcripts associated with rna polymerase II, representing nascent rna, and dispersed PO41 repeat transcripts localized in euchromatin or interchromatin space, representing released rna. During mitosis PO41 non-coding rna distribute between condensed chromosomes till anaphase, when they concentrate at the cleavage plane. At telophase, clusters of PO41 rna surround terminal regions of chromosomes. Treatments with rnases of different substrate specificity indicate that PO41 repeat transcripts are single-stranded rnas with short double-stranded regions due to appearance of inverted repeats. Conclusion: Transcription of a subtelomeric tandem repeat

关键词： Cell cycle Cell nucleus Chicken Mitosis non-coding rna Subtelomere Tandem repeats Transcription

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non-coding rna Expression, Function, and Variation during Drosophila Embryogenesis

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CURRENT BIOLOGY 2018年第22期28卷 3547-+页

作者： Schor, Ignacio E. Bussotti, Giovanni Males, Matilda Forneris, Mattia Viales, Rebecca R. Enright, Anton J. Furlong, Eileen E. M. EMBL Genome Biol Unit D-69117 Heidelberg Germany EBI EMBL Hinxton CB10 1SD England Univ Buenos Aires Dept Fisiol Biol Mol & Celular Inst Fisiol Biol Mol & Neurociencias IFIBYNE CONICETFCEyN Buenos Aires DF Argentina Inst Pasteur HUB Team Paris France ZS Frankfurt Germany Univ Cambridge Dept Pathol Cambridge England

Long non-coding rnas (Incrnas) can often function in the regulation of gene expression during development;however, their generality as essential regulators in developmental processes and organismal phenotypes remains unclear. Here, we performed a tailored investigation of Incrna expression and function during Drosophila embryogenesis, interrogating multiple stages, tissue specificity, nuclear localization, and genetic backgrounds. Our results almost double the number of annotated Incrnas expressed at these embryonic stages. Incrna levels are generally positively correlated with those of their neighboring genes, with little evidence of transcriptional interference. Using fluorescent in situ hybridization, we report the spatiotemporal expression of 15 new Incrnas, revealing very dynamic tissue-specific patterns. Despite this, deletion of selected Incrna genes had no obvious developmental defects or effects on viability under standard and stressed conditions. However, two Incrna deletions resulted in modest expression changes of a small number of genes, suggesting that they fine-tune expression of non-essential genes. Several Incrnas have strain-specific expression, indicating that they are not fixed within the population. This intra-species variation across genetic backgrounds may thereby be a useful tool to distinguish rapidly evolving Incrnas with as yet non-essential roles.

关键词： non-coding rna lncrna non-essential genes embryonic development genetic variation transcription bystander expression

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non-coding rna-Associated cerna Networks in a New Contrast-Induced Acute Kidney Injury Rat Model

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MOLECULAR THERAPY-NUCLEIC ACIDS 2019年 17卷 102-112页

作者： Cheng, Wei Li, Xu-Wei Xiao, Ye-Qing Duan, Shao-Bin Cent S Univ Dept Nephrol Hunan Key Lab Kidney Dis & Blood Purificat Xiangya Hosp 2 139 Renmin Rd Changsha 410011 Hunan Peoples R China

Contrast-induced acute kidney injury (CI-AKI) is a severe complication of intravascular applied radial contrast media, and recent progress in interventional therapy and angiography has revived interest in explaining detailed mechanisms and developing effective treatment. Recent studies have indicated a potential link between CI-AKI and microrna (mirna). However, the potential non-coding rna-associated-competing endogenous rna (cerna) pairs involved in CI-AKI still remain unclear. In this study, we systematically explored the circrna or lncrna-associated-cerna mechanism in a new rat model of CI-AKI through deep rna sequencing. The results revealed that the expression of 38 circrnas, 12 lncrnas, 13 mirnas and 127 mrnas were significantly dysregulated. We performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses for mrnas with significantly different expression and then constructed comprehensive circrna or lncrna-associated cerna networks in kidney of CI-AKI rats. Thereafter, two constructed cerna regulatory pathways in this CI-AKI rat model-novel_circ_0004153/rnomiR-144-3p/Gpnmb or Naglu and LNC_000343/rno-miR1956-5p/KCP-were validated by real-time qPCR. This study is the first one to provide a systematic dissection of non-coding rna-associated cerna profiling in kidney of CI-AKI rats. The selected non-coding rna-associated cerna networks provide new insight for the underlying mechanism and may profoundly affect the diagnosis and therapy of CI-AKI.

关键词： CI-AKI cerna networks non-coding rna rat model

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non-coding rna enhances cardiac development

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JOUrnaL OF MOLECULAR AND CELLULAR CARDIOLOGY 2014年 76卷 205-207页

作者： Hofmann, Patrick Boon, Reinier A. Goethe Univ Frankfurt Ctr Mol Med Inst Cardiovasc Regenerat D-60054 Frankfurt Germany

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non-coding rna in control of gene regulatory programs in cardiac development and disease

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JOUrnaL OF MOLECULAR AND CELLULAR CARDIOLOGY 2015年第PT A期89卷 51-58页

作者： Philippen, Leonne E. Dirkx, Ellen da Costa-Martins, Paula A. De Windt, Leon J. Maastricht Univ CARIM Sch Cardiovasc Dis Dept Cardiol NL-6229 ER Maastricht Netherlands Int Ctr Engn & Biotechnol ICGEB Dept Mol Med I-34149 Trieste Italy

Organogenesis of the vertebrate heart is a highly specialized process involving progressive specification and differentiation of distinct embryonic cardiac progenitor cell populations driven by specialized gene programming events. Likewise, the onset of pathologies in the adult heart, including cardiac hypertrophy, involves the reactivation of embryonic gene programs. In both cases, these intricate genomic events are temporally and spatially regulated by complex signaling networks and gene regulatory networks. Apart from well-established transcriptional mechanisms, increasing evidence indicates that gene programming in both the developing and the diseased myocardium are under epigenetic control by non-coding rnas (ncrnas). Micrornas regulate gene expression at the post-transcriptional level, and numerous studies have now established critical roles for this species of tiny rnas in a broad range of aspects from cardiogenesis towards adult heart failure. Recent reports now also implicate the larger family of long non-coding rnas (lncrnas) in these processes as well. Here we discuss the involvement of these two ncrna classes in proper cardiac development and hypertrophic disease processes of the adult myocardium. This article is part of a Special Issue entitled: non-coding rnas. (c) 2015 Elsevier Ltd. All rights reserved.

关键词： non-coding rna Microrna lncrna Gene expression

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non-coding rna: insights into the mechanism of methamphetamine neurotoxicity

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MOLECULAR AND CELLULAR BIOCHEMISTRY 2021年第9期476卷 3319-3328页

作者： Gu, Ying-Jian Chen, Lei Cheng, Lin Zhou, Ming-Yuan Wang, Yun China Med Univ Sch Pharm Dept Clin Pharmacol 77 Puhe Rd Shenyang 110122 Liaoning Peoples R China

Chronic exposure of the methamphetamine has been shown to lead to neurotoxicity in rodents and humans. The manifestations of methamphetamine neurotoxicity include methamphetamine use disorder, methamphetamine abuse, methamphetamine addiction and methamphetamine behavioral sensitization. Repeated use of methamphetamine can cause methamphetamine use disorder. The abuse and addiction of methamphetamine are growing epidemic worldwide. Repeated intermittent exposure to methamphetamine can cause behavioral sensitization. In addition, many studies have shown that changes in the expression of non-coding rna in the ventral tegmental area and nucleus accumbens will affect the behavioral effects of methamphetamine. non-coding rna plays an important role in the behavioral effects of methamphetamine. Therefore, it is important to study the relationship between methamphetamine and non-coding rna. The purpose of this review is to study the non-coding rna associated with methamphetamine neurotoxicity to search for the possible therapeutic target of the methamphetamine neurotoxicity.

关键词： non-coding rna Methamphetamine Neurotoxicity Use disorder Drug abuse Addiction Locomotor sensitization

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non-coding rna A New Tool for the Diagnosis, Prognosis, and Therapy of Small Cell Lung Cancer

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JOUrnaL OF THORACIC ONCOLOGY 2015年第1期10卷 28-37页

作者： Huang, Jie Peng, Juan Guo, Linlang Southern Med Univ Dept Pathol Zhujiang Hosp Guangzhou 510282 Guangdong Peoples R China Guangzhou Med Univ Affiliated Hosp 3 Dept Pathol Guangzhou 510150 Guangdong Peoples R China

In recent years, novel classes of noncoding rnas (ncrnas) have been discovered, which are implicated in diverse functional and regulatory activities. Growing evidence indicates that deregulated ncrnas play crucial roles in the onset and progression of cancer, including small-cell lung cancer. In this review, we highlight nearly all of the findings regarding the roles and the possible mechanisms of ncrnas as oncogenes or tumor suppressors in small-cell lung cancer. Furthermore, we discuss the possible role of ncrnas as diagnostic biomarkers, their significant contribution to the prognosis, and their functions in regulating the response to therapy.

关键词： non-coding rna Small cell lung cancer

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non-coding rna in malignant tumors. A new world of tumor biomarkers and target structures in cancer cells

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PATHOLOGE 2010年第s2期31卷 258-262页

作者： Diederichs, S. Deutsch Krebsforschungszentrum DKFZ Helmholtz Hsch Grp Mol RNA Biol & Krebs D-69120 Heidelberg Germany Heidelberg Univ Inst Pathol D-69120 Heidelberg Germany

Only about 2% of the human genome constitute protein-coding genes - nevertheless, medical research has focused mainly on this portion in recent decades. Since up to 70% of the human genome is transcribed into rna, the genome contains much more non-coding information than coding, which is present in the cell as non-coding rna (ncrna). Many of these ncrnas are highly expressed, specifically regulated and evolutionarily conserved, arguing in favor of their functional significance. Micrornas are the most well-known ncrnas, but many other long ncrnas exist. Differential ncrna or microrna expression patterns correlate with diagnosis or prognosis in many tumor entities and can thus serve as an extensive source of new biomarkers. The expression of the long ncrna MALAT1 correlates with tumor development, progression or survival in lung, liver and breast cancer. Functionally active ncrnas can provide novel insights into the mechanisms underlying tumor development. The large number of different, often as yet unidentified ncrnas promises new stimuli for the diagnosis, prognosis and therapy of many diseases.

关键词： Transcriptomes Biomarkers non-coding rna microrna MALAT1

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