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non-coding rnas modulate pyroptosis in diabetic cardiomyopathy: A comprehensive review

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2025年第Pt 2期309卷 142865页

作者： Shang, Wenyu Geng, Xiaofei Sun, Xitong Fan, Xinbiao Li, Aolin Zhang, Chi Kang, Yuxin Liang, Yongchun Zhang, Junping Tianjin Univ Tradit Chinese Med Teaching Hosp 1 Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu 88 Chang Ling Rd Tianjin 300000 Peoples R China

Diabetic cardiomyopathy (DCM) is a leading cause of heart failure (HF) among individuals with diabetes, presenting a significant medical challenge due to its complex pathophysiology and the lack of targeted therapies. Pyroptosis, a pro-inflammatory form of programmed cell death (PCD), is the predominant mode of cell death in the primary resident cells involved in DCM. It has been reported to be critical in DCM's onset, progression, and pathogenesis. non-coding rnas (ncrnas), diverse transcripts lacking protein-coding potential, are essential for cellular physiology and the progression of various diseases. Increasing evidence indicates that ncrnas are pivotal in the pathogenesis of DCM by regulating pyroptosis. This observation suggests that targeting the regulation of pyroptosis by ncrnas may offer a novel therapeutic approach for DCM. However, a comprehensive review of this topic is currently lacking. Our objective is to elucidate the regulatory role of ncrnas in pyroptosis associated with DCM and to elucidate the relationships among these factors. Additionally, we explored how ncrnas influence pyroptosis and contribute to the pathophysiology of DCM. By doing so, we aim to identify new research targets for the clinical diagnosis and treatment of DCM.

关键词： Diabetic cardiomyopathy non-coding rnas Pyroptosis

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non-coding rnas in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding rnas(ncrnas)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncrnas in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncrnas can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncrnas in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncrnas in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncrnas(micrornas,long ncrnas,and circular rnas)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncrnas to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncrnas in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular rnas excitatory toxicity long non-coding rnas micrornas neuroinflammation non-coding rnas oxidative stress

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non-coding rnas and their potential exploitation in cancer therapy-related cardiotoxicity

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BRITISH JOURNAL OF PHARMACOLOGY 2025年第2期182卷 296-315页

作者： Bernasconi, Riccardo Kuster, Gabriela M. Univ Hosp Basel Dept Biomed Myocardial Res Hebelstr 20 CH-4031 Basel Switzerland Univ Basel Hebelstr 20 CH-4031 Basel Switzerland Univ Hosp Basel Univ Heart Ctr Basel Dept Cardiol Basel Switzerland

Life expectancy in cancer patients has been extended in recent years, thanks to major breakthroughs in therapeutic developments. However, this also unmasked an increased incidence of cardiovascular diseases in cancer survivors, which is in part attributable to cancer therapy-related cardiovascular toxicity. non-coding rnas (ncrnas) have received much appreciation due to their impact on gene expression. Ncrnas, which include micrornas, long ncrnas and circular rnas, are non-protein-coding transcripts that are involved in the regulation of various biological processes, hence shaping cell identity and behaviour. They have also been implicated in disease development, including cardiovascular diseases, cancer and, more recently, cancer therapy-associated cardiotoxicity. This review outlines key features of cancer therapy-associated cardiotoxicity, what is known about the roles of ncrnas in these processes and how ncrnas could be exploited as therapeutic targets for cardioprotection.

关键词： cancer therapy-related cardiotoxicity cardiotoxicity cardiovascular diseases non-coding rnas

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non-coding rnas regulating endothelial progenitor cells for venous thrombosis: promising therapy and innovation

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STEM CELL RESEARCH & THERAPY 2024年第1期15卷 7页

作者： Sun, Li-Li Liu, Zhao Ran, Feng Huang, Dian Zhang, Ming Li, Xiao-Qiang Li, Wen-Dong Nanjing Univ Med Sch Nanjing Drum Tower Hosp Dept Vasc Surg Affiliate Hosp 321 Zhongshan Rd Nanjing 210008 Jiangsu Peoples R China

Venous thromboembolism, which includes deep venous thrombosis (DVT) and pulmonary embolism, is the third most common vascular disease in the world and seriously threatens the lives of patients. Currently, the effect of conventional treatments on DVT is limited. Endothelial progenitor cells (EPCs) play an important role in the resolution and recanalization of DVT, but an unfavorable microenvironment reduces EPC function. non-coding rnas, especially long non-coding rnas and micrornas, play a crucial role in improving the biological function of EPCs. non-coding rnas have become clinical biomarkers of diseases and are expected to serve as new targets for disease intervention. A theoretical and experimental basis for the development of new methods for preventing and treating DVT in the clinic will be provided by studies on the role and molecular mechanism of non-coding rnas regulating EPC function in the occurrence and development of DVT. To summarize, the characteristics of venous thrombosis, the regulatory role of EPCs in venous thrombosis, and the effect of non-coding rnas regulating EPCs on venous thrombosis are reviewed. This summary serves as a useful reference and theoretical basis for research into the diagnosis, prevention, treatment, and prognosis of venous thrombosis.

关键词： non-coding rnas Endothelial progenitor cells Deep venous thrombosis Regenerative medicine

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non-coding rnas as mediators of epithelial to mesenchymal transition in metastatic colorectal cancers

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CELLULAR SIGNALLING 2025年 127卷 111605页

作者： Nadukkandy, Aisha Shigna Blaize, Britny Kumar, Chethana D. Mori, Giulia Cordani, Marco Kumar, Lekha Dinesh CSIR Ctr Cellular & Mol Biol CCMB Canc Biol Hyderabad 500007 India Christian Med Coll & Hosp Dept Surg ICU Ida Scudder Rd Vellore 632004 Tamil Nadu India Univ Parma Dept Chem Life Sci & Environm Sustainabil Parma Italy Univ Complutense Madrid Fac Biol Sci Dept Biochem & Mol Biol Madrid 28040 Spain Inst Invest Sanit San Carlos IdISSC Madrid 28040 Spain

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, necessitating the development of innovative treatment strategies. Recent research has underscored the significant role of non-coding rnas (ncrnas) in CRC pathogenesis, offering new avenues for diagnosis and therapy. In this review, we delve into the intricate roles of various ncrnas, including micrornas (mirnas), long non-coding rnas (lncrnas), and circular rnas (circrnas), in CRC progression, epithelial-mesenchymal transition (EMT), metastasis, and drug resistance. We highlight the interaction of these ncrnas with and regulation of key signaling pathways, such as Wnt/(3-catenin, Notch, JAK-STAT, EGFR, and TGF-(3, and the functional relevance of these interactions in CRC progression. Additionally, the review highlights the emerging applications of nano- technology in enhancing the delivery and efficacy of ncRNA-based therapeutics, which could address existing challenges related to specificity and side effects. Future research directions, including advanced diagnostic tools, targeted therapeutics, strategies to overcome drug resistance, and the integration of personalized medicine approaches are discussed. Integrating nanotechnology with a deeper understanding of CRC biology offers the potential for more effective, targeted, and personalized strategies, though further research is essential to validate these approaches.

关键词： Colorectal cancer non-coding rnas Epithelial-mesenchymal transition Signaling pathways Cancer therapeutics

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non-coding rnas and their role in enhancing virus resistance in plants

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EUROPEAN JOURNAL OF PLANT PATHOLOGY 2025年第1期171卷 1-16页

作者： Majumdar, Anik ICAR Indian Agr Res Inst Adv Ctr Plant Virol Div Plant Pathol New Delhi 110012 India

Plants are vulnerable to several diseases that result in significant yield losses and pose a serious threat to food security. Through evolution, plants have developed various strategies to cope with viral infections. In addition to the involvement of protein-coding genes as key regulators of plant immunity, growing evidence suggests that non-coding rnas (ncrnas) play an important role in the plant immune response against viruses. This article summarizes the different types of ncrnas (Small ncrnas and long ncrnas), the classes within small ncrnas, their functions, biogenesis, long non-coding RNA (lncRNA) databases and their promising role in mediating virus resistance in plants. These findings will help understand how ncrnas regulate plant immunity and may lead to the development of new approaches for breeding virus-resistant crops in the future.

关键词： non-coding rnas lncRNA Small ncrnas Plant immunity Virus resistance

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non-coding rnas as modulators of radioresponse in triple-negative breast cancer: a systematic review

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JOURNAL OF BIOMEDICAL SCIENCE 2024年第1期31卷 1-17页

作者： Tofolo, Maria Vitoria Berti, Fernanda Costa Brandao Nunes-Souza, Emanuelle Ruthes, Mayara Oliveira Berti, Lucas Freitas Fonseca, Aline Simoneti Rosolen, Daiane Cavalli, Luciane Regina Inst Pesquisa Pele Pequeno Principe Res Inst Pele Pequeno Principe Fac Pequeno Principe Ave Silva Jardim1632 BR-80250060 Curitiba Brazil Univ Tecnol Fed Parana Dept Mech Engn Postgrad Program Mech & Mat Engn BR-81280340 Curitiba Brazil Lombardi Comprenhens Canc Ctr Dept Oncol Washington DC 20007 USA

Triple-negative breast cancer (TNBC), characterized by high invasiveness, is associated with poor prognosis and elevated mortality rates. Despite the development of effective therapeutic targets for TNBC, systemic chemotherapy and radiotherapy (RdT) remain prevalent treatment modalities. One notable challenge of RdT is the acquisition of radioresistance, which poses a significant obstacle in achieving optimal treatment response. Compelling evidence implicates non-coding rnas (ncrnas), gene expression regulators, in the development of radioresistance. This systematic review focuses on describing the role, association, and/or involvement of ncrnas in modulating radioresponse in TNBC. In adhrence to the PRISMA guidelines, an extensive and comprehensive search was conducted across four databases using carefully selected entry terms. Following the evaluation of the studies based on predefined inclusion and exclusion criteria, a refined selection of 37 original research articles published up to October 2023 was obtained. In total, 33 different ncrnas, including lncrnas, mirnas, and circrnas, were identified to be associated with radiation response impacting diverse molecular mechanisms, primarily the regulation of cell death and DNA damage repair. The findings highlighted in this review demonstrate the critical roles and the intricate network of ncrnas that significantly modulates TNBC's responsiveness to radiation. The understanding of these underlying mechanisms offers potential for the early identification of non-responders and patients prone to radioresistance during RdT, ultimately improving TNBC survival outcomes.

关键词： non-coding rnas Radiation Radiotherapy Radioresponse Triple-negative breast cancer

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non-coding rnas in thoracic disease: Barrett's esophagus and esophageal adenocarcinoma

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CLINICA CHIMICA ACTA 2025年 571卷 120242页

作者： Sheng, Siyuan Guo, Jianhui Lu, Chuangang Hu, Xia Hunan Univ Arts & Sci Dept Med Changde 415000 Hunan Peoples R China Changde Second Peoples Hosp Spine Surg Changde 415000 Hunan Peoples R China Sanya Cent Hosp Sanya 572000 Hainan Peoples R China

Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy with increasing incidence and poor survival rates, primarily due to late-stage diagnosis. This cancer often develops from Barrett's Esophagus (BE), a precancerous condition linked to chronic gastroesophageal reflux disease (GERD). The transition from BE to EAC is a complex multistep process involving numerous genetic, epigenetic, and molecular changes that lead to the malignant transformation of the esophageal epithelium. Despite advancements in understanding the molecular mechanisms underlying EAC, early detection and effective treatment options remain limited, highlighting an urgent need for innovative diagnostic and therapeutic strategies. Recent research has focused on non-coding rnas (ncrnas), which play crucial roles in regulating gene expression and cellular processes relevant to cancer progression. Various types of ncrnas, including micrornas, long non-coding rnas, and circular rnas, have been implicated in the development of BE and EAC by modulating key signaling pathways such as Wnt/(3-catenin and NF-kappa B. Additionally, ncrnas are stable in biological fluids, presenting opportunities for their use as noninvasive biomarkers for early detection and monitoring of EAC. This review aims to elucidate the involvement of ncrnas in the progression from BE to EAC, their potential as therapeutic targets, and their emerging roles in intercellular communication. We will also discuss the challenges in translating ncRNA research into clinical applications, emphasizing their promise in revolutionizing early detection and treatment strategies for EAC.

关键词： Barrett's Esophagus Esophageal Adenocarcinoma non-coding rnas

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non-coding rnas affecting NLRP3 inflammasome pathway in diabetic cardiomyopathy: a comprehensive review of potential therapeutic options

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JOURNAL OF TRANSLATIONAL MEDICINE 2025年第1期23卷 1-14页

作者： Radmehr, Elahe Yazdanpanah, Niloufar Rezaei, Nima Univ Tehran Med Sci Imam Khomeini Hosp Complex Colorectal Res Ctr Tehran Iran Univ Tehran Med Sci Childrens Med Ctr Hosp Res Ctr Immunodeficiencies Dr Qarib StKeshavarz Blvd Tehran 14194 Iran Universal Sci Educ & Res Network USERN Network Immun Infect Malignancy & Autoimmun NIIMA Tehran Iran Univ Tehran Med Sci Sch Med Tehran Iran Univ Tehran Med Sci Sch Med Dept Immunol Tehran Iran

Cardiomyopathies are a heterogeneous group of disorders that can lead to fulminant heart failure and sudden cardiac death. In recent years, the prevalence of all types of cardiomyopathies has shown an upward trend globally. Up to 40% of patients with cardiomyopathy-related heart failure have diabetes mellitus (DM). With the fast global spread of DM, the prevalence of DCM is increasing accordingly and it remains the leading cause of morbidity and mortality in chronic diabetic patients. NLRP3 inflammasome significantly contributes to the development and pathological progression of DCM. Targeting the inflammasome or any of the mediators along its activation pathway provides new potential therapeutic targets for developing specialized drugs to treat *** this comprehensive review, we sought to introduce and summarize the non-coding rnas with potential therapeutic effects targeting NLRP3 inflammasome signaling in DCM. We hope this general overview can aid future research in developing new therapies for DCM.

关键词： Diabetic cardiomyopathies Inflammasomes NLRP3 Pyroptosis non-coding rnas

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non-coding rnas and Aquaporin 4: Their Role in the Pathogenesis of Neurological Disorders

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NEUROCHEMICAL RESEARCH 2024年第3期49卷 583-596页

作者： Yaghoobi, Zahra Seyed Bagher Nazeri, Shahrzad Sadat Asadi, Amir Derafsh, Ehsan Taheri, Abdolkarim Talebi Tamtaji, Zeinab Dadgostar, Ehsan Rahmati-Dehkordi, Fatemeh Aschner, Michael Mirzaei, Hamed Tamtaji, Omid Reza Nabavizadeh, Fatemeh Univ Tehran Med Sci Neurosci Inst Electrophysiol Res Ctr Tehran Iran Univ Tehran Med Sci Sch Med Dept Physiol Tehran Iran Univ Tehran Med Sci Sch Med Tehran Iran Mazandaran Univ Med Sci Addict Inst Psychiat & Behav Sci Res Ctr Sch Med Sari Iran Mazandaran Univ Med Sci Dept Psychiat Sari Iran Windsor Univ Sch Med Cayon St Kitts & Nevi Shahid Beheshti Univ Med Sci Student Res Comm Sch Med Tehran Iran Kashan Univ Med Sci Student Res Comm Kashan Iran Isfahan Univ Med Sci Behav Sci Res Ctr Esfahan Iran Isfahan Univ Med Sci Student Res Comm Esfahan Iran Albert Einstein Coll Med Dept Mol Pharmacol Bronx NY 10461 USA Kashan Univ Med Sci Res Ctr Biochem & Nutr Metab Dis Kashan Iran

Neurological disorders are a major group of non-communicable diseases affecting quality of life. non-coding rnas (ncrnas) have an important role in the etiology of neurological disorders. In studies on the genesis of neurological diseases, aquaporin 4 (AQP4) expression and activity have both been linked to ncrnas. The upregulation or downregulation of several ncrnas leads to neurological disorder progression by targeting AQP4. The role of ncrnas and AQP4 in neurological disorders is discussed in this review.

关键词： Neurological disorders Aquaporin-4 non-coding rnas microRNA Long non-coding RNA

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