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non-coding rnas modulate pyroptosis in diabetic cardiomyopathy: A comprehensive review

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2025年第Pt 2期309卷 142865页

作者： Shang, Wenyu Geng, Xiaofei Sun, Xitong Fan, Xinbiao Li, Aolin Zhang, Chi Kang, Yuxin Liang, Yongchun Zhang, Junping Tianjin Univ Tradit Chinese Med Teaching Hosp 1 Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu 88 Chang Ling Rd Tianjin 300000 Peoples R China

Diabetic cardiomyopathy (DCM) is a leading cause of heart failure (HF) among individuals with diabetes, presenting a significant medical challenge due to its complex pathophysiology and the lack of targeted therapies. Pyroptosis, a pro-inflammatory form of programmed cell death (PCD), is the predominant mode of cell death in the primary resident cells involved in DCM. It has been reported to be critical in DCM's onset, progression, and pathogenesis. non-coding rnas (ncrnas), diverse transcripts lacking protein-coding potential, are essential for cellular physiology and the progression of various diseases. Increasing evidence indicates that ncrnas are pivotal in the pathogenesis of DCM by regulating pyroptosis. This observation suggests that targeting the regulation of pyroptosis by ncrnas may offer a novel therapeutic approach for DCM. However, a comprehensive review of this topic is currently lacking. Our objective is to elucidate the regulatory role of ncrnas in pyroptosis associated with DCM and to elucidate the relationships among these factors. Additionally, we explored how ncrnas influence pyroptosis and contribute to the pathophysiology of DCM. By doing so, we aim to identify new research targets for the clinical diagnosis and treatment of DCM.

关键词： Diabetic cardiomyopathy non-coding rnas Pyroptosis

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non-coding rnas in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding rnas(ncrnas)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncrnas in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncrnas can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncrnas in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncrnas in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncrnas(micrornas,long ncrnas,and circular rnas)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncrnas to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncrnas in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular rnas excitatory toxicity long non-coding rnas micrornas neuroinflammation non-coding rnas oxidative stress

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non-coding rnas and their potential exploitation in cancer therapy-related cardiotoxicity

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BRITISH JOURNAL OF PHARMACOLOGY 2025年第2期182卷 296-315页

作者： Bernasconi, Riccardo Kuster, Gabriela M. Univ Hosp Basel Dept Biomed Myocardial Res Hebelstr 20 CH-4031 Basel Switzerland Univ Basel Hebelstr 20 CH-4031 Basel Switzerland Univ Hosp Basel Univ Heart Ctr Basel Dept Cardiol Basel Switzerland

Life expectancy in cancer patients has been extended in recent years, thanks to major breakthroughs in therapeutic developments. However, this also unmasked an increased incidence of cardiovascular diseases in cancer survivors, which is in part attributable to cancer therapy-related cardiovascular toxicity. non-coding rnas (ncrnas) have received much appreciation due to their impact on gene expression. Ncrnas, which include micrornas, long ncrnas and circular rnas, are non-protein-coding transcripts that are involved in the regulation of various biological processes, hence shaping cell identity and behaviour. They have also been implicated in disease development, including cardiovascular diseases, cancer and, more recently, cancer therapy-associated cardiotoxicity. This review outlines key features of cancer therapy-associated cardiotoxicity, what is known about the roles of ncrnas in these processes and how ncrnas could be exploited as therapeutic targets for cardioprotection.

关键词： cancer therapy-related cardiotoxicity cardiotoxicity cardiovascular diseases non-coding rnas

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non-coding rnas as mediators of epithelial to mesenchymal transition in metastatic colorectal cancers

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CELLULAR SIGNALLING 2025年 127卷 111605页

作者： Nadukkandy, Aisha Shigna Blaize, Britny Kumar, Chethana D. Mori, Giulia Cordani, Marco Kumar, Lekha Dinesh CSIR Ctr Cellular & Mol Biol CCMB Canc Biol Hyderabad 500007 India Christian Med Coll & Hosp Dept Surg ICU Ida Scudder Rd Vellore 632004 Tamil Nadu India Univ Parma Dept Chem Life Sci & Environm Sustainabil Parma Italy Univ Complutense Madrid Fac Biol Sci Dept Biochem & Mol Biol Madrid 28040 Spain Inst Invest Sanit San Carlos IdISSC Madrid 28040 Spain

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, necessitating the development of innovative treatment strategies. Recent research has underscored the significant role of non-coding rnas (ncrnas) in CRC pathogenesis, offering new avenues for diagnosis and therapy. In this review, we delve into the intricate roles of various ncrnas, including micrornas (mirnas), long non-coding rnas (lncrnas), and circular rnas (circrnas), in CRC progression, epithelial-mesenchymal transition (EMT), metastasis, and drug resistance. We highlight the interaction of these ncrnas with and regulation of key signaling pathways, such as Wnt/(3-catenin, Notch, JAK-STAT, EGFR, and TGF-(3, and the functional relevance of these interactions in CRC progression. Additionally, the review highlights the emerging applications of nano- technology in enhancing the delivery and efficacy of ncRNA-based therapeutics, which could address existing challenges related to specificity and side effects. Future research directions, including advanced diagnostic tools, targeted therapeutics, strategies to overcome drug resistance, and the integration of personalized medicine approaches are discussed. Integrating nanotechnology with a deeper understanding of CRC biology offers the potential for more effective, targeted, and personalized strategies, though further research is essential to validate these approaches.

关键词： Colorectal cancer non-coding rnas Epithelial-mesenchymal transition Signaling pathways Cancer therapeutics

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non-coding rnas and their role in enhancing virus resistance in plants

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EUROPEAN JOURNAL OF PLANT PATHOLOGY 2025年第1期171卷 1-16页

作者： Majumdar, Anik ICAR Indian Agr Res Inst Adv Ctr Plant Virol Div Plant Pathol New Delhi 110012 India

Plants are vulnerable to several diseases that result in significant yield losses and pose a serious threat to food security. Through evolution, plants have developed various strategies to cope with viral infections. In addition to the involvement of protein-coding genes as key regulators of plant immunity, growing evidence suggests that non-coding rnas (ncrnas) play an important role in the plant immune response against viruses. This article summarizes the different types of ncrnas (Small ncrnas and long ncrnas), the classes within small ncrnas, their functions, biogenesis, long non-coding RNA (lncRNA) databases and their promising role in mediating virus resistance in plants. These findings will help understand how ncrnas regulate plant immunity and may lead to the development of new approaches for breeding virus-resistant crops in the future.

关键词： non-coding rnas lncRNA Small ncrnas Plant immunity Virus resistance

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non-coding rnas in thoracic disease: Barrett's esophagus and esophageal adenocarcinoma

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CLINICA CHIMICA ACTA 2025年 571卷 120242页

作者： Sheng, Siyuan Guo, Jianhui Lu, Chuangang Hu, Xia Hunan Univ Arts & Sci Dept Med Changde 415000 Hunan Peoples R China Changde Second Peoples Hosp Spine Surg Changde 415000 Hunan Peoples R China Sanya Cent Hosp Sanya 572000 Hainan Peoples R China

Esophageal adenocarcinoma (EAC) is a highly aggressive malignancy with increasing incidence and poor survival rates, primarily due to late-stage diagnosis. This cancer often develops from Barrett's Esophagus (BE), a precancerous condition linked to chronic gastroesophageal reflux disease (GERD). The transition from BE to EAC is a complex multistep process involving numerous genetic, epigenetic, and molecular changes that lead to the malignant transformation of the esophageal epithelium. Despite advancements in understanding the molecular mechanisms underlying EAC, early detection and effective treatment options remain limited, highlighting an urgent need for innovative diagnostic and therapeutic strategies. Recent research has focused on non-coding rnas (ncrnas), which play crucial roles in regulating gene expression and cellular processes relevant to cancer progression. Various types of ncrnas, including micrornas, long non-coding rnas, and circular rnas, have been implicated in the development of BE and EAC by modulating key signaling pathways such as Wnt/(3-catenin and NF-kappa B. Additionally, ncrnas are stable in biological fluids, presenting opportunities for their use as noninvasive biomarkers for early detection and monitoring of EAC. This review aims to elucidate the involvement of ncrnas in the progression from BE to EAC, their potential as therapeutic targets, and their emerging roles in intercellular communication. We will also discuss the challenges in translating ncRNA research into clinical applications, emphasizing their promise in revolutionizing early detection and treatment strategies for EAC.

关键词： Barrett's Esophagus Esophageal Adenocarcinoma non-coding rnas

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non-coding rnas affecting NLRP3 inflammasome pathway in diabetic cardiomyopathy: a comprehensive review of potential therapeutic options

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JOURNAL OF TRANSLATIONAL MEDICINE 2025年第1期23卷 1-14页

作者： Radmehr, Elahe Yazdanpanah, Niloufar Rezaei, Nima Univ Tehran Med Sci Imam Khomeini Hosp Complex Colorectal Res Ctr Tehran Iran Univ Tehran Med Sci Childrens Med Ctr Hosp Res Ctr Immunodeficiencies Dr Qarib StKeshavarz Blvd Tehran 14194 Iran Universal Sci Educ & Res Network USERN Network Immun Infect Malignancy & Autoimmun NIIMA Tehran Iran Univ Tehran Med Sci Sch Med Tehran Iran Univ Tehran Med Sci Sch Med Dept Immunol Tehran Iran

Cardiomyopathies are a heterogeneous group of disorders that can lead to fulminant heart failure and sudden cardiac death. In recent years, the prevalence of all types of cardiomyopathies has shown an upward trend globally. Up to 40% of patients with cardiomyopathy-related heart failure have diabetes mellitus (DM). With the fast global spread of DM, the prevalence of DCM is increasing accordingly and it remains the leading cause of morbidity and mortality in chronic diabetic patients. NLRP3 inflammasome significantly contributes to the development and pathological progression of DCM. Targeting the inflammasome or any of the mediators along its activation pathway provides new potential therapeutic targets for developing specialized drugs to treat *** this comprehensive review, we sought to introduce and summarize the non-coding rnas with potential therapeutic effects targeting NLRP3 inflammasome signaling in DCM. We hope this general overview can aid future research in developing new therapies for DCM.

关键词： Diabetic cardiomyopathies Inflammasomes NLRP3 Pyroptosis non-coding rnas

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non-coding rnas and Their Regulatory Systems: Evolutionary Origin and Putative Link with Ribozymes

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JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY 2025年第2期61卷 460-485页

作者： Markelov, V. A. Akhmadishina, L. Z. Solntsev, V. A. Danilko, K. V. Korytina, G. F. Russian Acad Sci Ufa Fed Res Ctr Inst Biochem & Genet Ufa Russia Bashkir State Med Univ Ufa Russia

This review addresses a hypothetical evolutionary scenario based on the self-organization of replicating RNA molecules, and substantiates their link with modern regulatory systems of noncoding rnas (ncrnas). We systematize modern scientific data that consider self-organizing RNA molecules as key evolutionary units of the prebiotic stage of life development, and analyze modern models of the formation of chemical RNA precursors in prebiotic conditions, as well as their further polymerization into functional rnas. The analysis of putative scenarios for the formation of emergent states reveals the regulatory function of early RNA replicators and their role in the development of sophisticated biological systems. The widespread prevalence of regulatory ncrnas across all groups of living organisms suggests their ancient origin. It is highly likely that modern RNA switches, group II introns, and spliceosomal introns, which are the source of most ncrnas, originate from a common ancient RNA infrastructure, which may have ensured a coordination of replication, compartmentalization and metabolism during the early stages of evolution. By combining insights from biochemistry, genomics, and evolutionary biology, our analysis offers a comprehensive perspective on the molecular mechanisms underlying the origin and diversification of ncrnas.

关键词： evolution non-coding rnas replication compartmentalization metabolism

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non-coding rnas and regulation of the PI3K signaling pathway in lung cancer: Recent insights and potential clinical applications

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non-coding RNA RESEARCH 2025年第1期11卷 1-21页

作者： Hashemi, Mehrdad Fard, Asal Abolghasemi Pakshad, Bita Asheghabadi, Pezhman Shafiei Hosseinkhani, Amineh Hosseini, Atena Sadat Moradi, Parham Niye, Mohammadreza Mohammadbeygi Najafi, Ghazal Farahzadi, Mohadeseh Khoushab, Saloomeh Taheriazam, Afshin Farahani, Najma Mohammadi, Mahya Daneshi, Salman Nabavi, Noushin Entezari, Maliheh Islamic Azad Univ Farhikhtegan Hosp Tehran Med Sci Farhikhtegan Med Convergence Sci Res Ctr Tehran Iran Islamic Azad Univ Fac Adv Sci & Technol Dept Genet Tehran Med Sci Tehran Iran Islamic Azad Univ Fac Med Tehran Med Sci Tehran Iran Shahid Beheshti Univ Med Sci Sch Med Tehran Iran Jiroft Univ Med Sci Sch Hlth Dept Publ Hlth Jiroft Iran Islamic Azad Univ Fac Med Dept Orthoped Tehran Med Sci Tehran Iran

Lung cancer (LC) is one of the most common causes of cancer-related death worldwide. It has been demonstrated that the prognosis of current drug treatments is affected by a variety of factors, including late stage, tumor recurrence, inaccessibility to appropriate treatments, and, most importantly, chemotherapy resistance. non- coding rnas (ncrnas) contribute to tumor development, with some acting as tumor suppressors and others as oncogenes. The phosphoinositide 3-kinase (PI3Ks)/AKT serine/threonine kinase pathway is one of the most important common targets of ncrnas in cancer, which is widely applied to modulate the cell cycle and a variety of biological processes, including cell growth, mobility survival, metabolic activity, and protein production. Discovering the biology of ncRNA-PI3K/AKT signaling may lead to advances in cancer diagnosis and treatment. As a result, we investigated the expression and role of PI3K/AKT-related ncrnas in clinical characteristics of lung cancer, as well as their functions as potential biomarkers in lung cancer diagnosis, prognosis, and treatment.

关键词： Lung cancer non-coding rnas Molecular mechanisms PI3K Signaling pathway

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The crosstalk between non-coding rnas and oxidative stress in cancer progression

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Genes & Diseases 2025年第3期12卷 146-167页

作者： Qiqi Sun Xiaoyong Lei Xiaoyan Yang School of Pharmaceutical Science Hengyang Medical CollegeUniversity of South ChinaHengyangHunan 421001China

As living standards elevate,cancers are appearing in growing numbers among younger individuals globally and these risks escalate with advancing *** of the reasons is that instability in the cancer genome reduces the effectiveness of conventional drug treatments and chemotherapy,compared with more targeted *** research has discovered non-coding rnas’crucial role in shaping genetic networks involved in cancer cell growth and invasion through their influence on messenger RNA production or protein ***,the interaction between non-coding rnas and oxidative stress,a crucial process in cancer advancement,cannot be ***,oxidative stress results from the negative effects of radicals within the body and ties directly to cancer gene expression and ***,this review focuses on the mechanism between non-coding rnas and oxidative stress in cancer progression,which is conducive to finding new cancer treatment strategies.

关键词： Angiogenesis Autophagy Cancer Cancer energy metabolism Epithelial mesenchymal transformation non-coding rnas Oxidative stress

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