The optical attenuation coefficient (OAC) reflects the optical properties of various tissues or tissues of the same type under different physiological conditions. Quantitative measurement of OAC from optical coherence...
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The optical attenuation coefficient (OAC) reflects the optical properties of various tissues or tissues of the same type under different physiological conditions. Quantitative measurement of OAC from optical coherence tomography (OCT) signals can provide additional information and can increase the potential for OCT applications. We present an optimized depth-resolved estimation (ODRE) method that derives a precise mapping between the measured OCT signal and the OAC. In contrast to previous depth-resolvedestimation (DRE) methods, the optimized method can estimate the OAC in any depth range and ignore whether the light is completely attenuated. Numerical simulations and phantom experiments are used to verify its validity, and this method is applied to detect cerebral damage. In combination with OCT angiography, real-time observation of the change of blood perfusion and the degree of cerebral damage in mice with focal cerebral ischemia provides important information to help us understand the temporal relationship between brain damage and ischemia. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License.
Optical coherence tomography (OCT) with a robust depth-resolved attenuation compensation method for a wide range of imaging applications is proposed and demonstrated. We derive a model for deducing the attenuation coe...
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ISBN:
(数字)9781510647787
ISBN:
(纸本)9781510647787;9781510647770
Optical coherence tomography (OCT) with a robust depth-resolved attenuation compensation method for a wide range of imaging applications is proposed and demonstrated. We derive a model for deducing the attenuation coefficients and the signal compensation value using the depth-dependent backscattering profiles, to mitigate under and overestimation in tissue imaging. We validated the method using numerical simulation and phantoms, where we achieved stable and robust compensation results over the entire depth of samples. The comparison between other attenuation characterization models and our proposed model is also performed.
Optical coherence tomography (OCT) with a robust depth-resolved attenuation compensation method for a wide range of imaging applications is proposed and demonstrated. The proposed novel OCT attenuation compensation al...
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ISBN:
(数字)9781510641068
ISBN:
(纸本)9781510641068
Optical coherence tomography (OCT) with a robust depth-resolved attenuation compensation method for a wide range of imaging applications is proposed and demonstrated. The proposed novel OCT attenuation compensation algorithm introduces an optimized axial point spread function (PSF) to modify existing depth-resolved methods and mitigates under and overestimation in biological tissues, providing a uniform resolution over the entire imaging range. The preliminary study is implemented using A-mode numerical simulation, where this method achieved stable and robust compensation results over the entire depth of samples. The experiment results using phantoms and corneal imaging exhibit agreement with the simulation result evaluated using signal-to-noise (SNR) and contrast-to-noise (CNR) metrics.
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