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检索条件"主题词=sequence-based methods"
6 条 记 录,以下是1-10 订阅
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Predicting protein-ligand binding residues with deep convolutional neural networks
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BMC BIOINFORMATICS 2019年 第1期20卷 1-12页
作者: Cui, Yifeng Dong, Qiwen Hong, Daocheng Wang, Xikun East China Normal Univ Fac Educ 3663 N Zhongshan Rd Shanghai 200062 Peoples R China East China Normal Univ Sch Data Sci & Engn 3663 N Zhongshan Rd Shanghai 200062 Peoples R China Liaoning Normal Univ High Sch Dalian Peoples R China
BackgroundLigand-binding proteins play key roles in many biological processes. Identification of protein-ligand binding residues is important in understanding the biological functions of proteins. Existing computation... 详细信息
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A Survey of Computational methods and Databases for lncRNA-MiRNA Interaction Prediction
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IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS 2023年 第5期20卷 2810-2826页
作者: Sheng, Nan Huang, Lan Gao, Ling Cao, Yangkun Xie, Xuping Wang, Yan Jilin Univ Coll Comp Sci & Technol Changchun 130012 Peoples R China Jilin Univ Sch Artificial Intelligence Changchun 130012 Peoples R China
Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are two prevalent non-coding RNAs in current research. They play critical regulatory roles in the life processes of animals and plants. Studies have shown that lnc... 详细信息
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Comparison of structure-based and threading-based approaches to protein functional annotation
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PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 2010年 第1期78卷 118-134页
作者: Brylinski, Michal Skolnick, Jeffrey Georgia Inst Technol Ctr Study Syst Biol Sch Biol Atlanta GA 30318 USA
To exploit the vast amount of sequence information provided by the Genomic revolution, the biological function of these sequences must be identified. As a practical matter, this is often accomplished by functional inf... 详细信息
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A comprehensive review and comparison of existing computational methods for protein function prediction
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BRIEFINGS IN BIOINFORMATICS 2024年 第4期25卷 bbae289页
作者: Lin, Baohui Luo, Xiaoling Liu, Yumeng Jin, Xiaopeng Shenzhen Technol Univ Coll Big Data & Internet Shenzhen 518118 Guangdong Peoples R China Guangdong Prov Key Lab Novel Secur Intelligence Te Shenzhen 518000 Guangdong Peoples R China Shenzhen Univ Coll Comp Sci & Software Engn Shenzhen 518061 Guangdong Peoples R China
Protein function prediction is critical for understanding the cellular physiological and biochemical processes, and it opens up new possibilities for advancements in fields such as disease research and drug discovery.... 详细信息
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Computational modeling of membrane proteins
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PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 2015年 第1期83卷 1-24页
作者: Leman, Julia Koehler Ulmschneider, Martin B. Gray, Jeffrey J. Johns Hopkins Univ Dept Chem & Biomol Engn Baltimore MD 21218 USA Johns Hopkins Univ Dept Mat Sci & Engn Baltimore MD 21218 USA
The determination of membrane protein (MP) structures has always trailed that of soluble proteins due to difficulties in their overexpression, reconstitution into membrane mimetics, and subsequent structure determinat... 详细信息
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Protein-peptide binding residue prediction based on protein language models and cross-attention mechanism
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ANALYTICAL BIOCHEMISTRY 2024年 694卷 115637页
作者: Hu, Jun Chen, Kai-Xin Rao, Bing Ni, Jing-Yuan Thafar, Maha A. Albaradei, Somayah Arif, Muhammad Zhejiang Univ Technol Coll Informat Engn Hangzhou 310023 Peoples R China Suzhou Inst Syst Med Ctr AI & Computat Biol Suzhou 215123 Peoples R China Hangzhou City Univ Sch Informat & Elect Engn Hangzhou 310015 Peoples R China Nanjing Univ Informat Sci & Technol NUIST Reading Acad Nanjing 210044 Peoples R China Taif Univ Coll Comp & Informat Technol Dept Comp Sci Taif 21944 Saudi Arabia King Abdulaziz Univ Fac Comp & Informat Technol Dept Comp Sci Jeddah Saudi Arabia Hamad Bin Khalifa Univ Coll Sci & Engn Doha 34110 Qatar
Accurate identifications of protein-peptide binding residues are essential for protein-peptide interactions and advancing drug discovery. To address this problem, extensive research efforts have been made to design mo... 详细信息
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